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Research Paper

Repression of IR-Inducible Clusterin Expression by the p53 Tumor Suppressor Protein

Pages 372-380 | Published online: 20 Mar 2003

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Read on this site (5)

Mei Peng, Jun Deng, Sichun Zhou, Ting Tao, Qiongli Su, Xue Yang & Xiaoping Yang. (2019) The role of Clusterin in cancer metastasis. Cancer Management and Research 11, pages 2405-2414.
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Mark R. Wilson & Amina Zoubeidi. (2017) Clusterin as a therapeutic target. Expert Opinion on Therapeutic Targets 21:2, pages 201-213.
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Tomas Koltai. (2014) Clusterin: a key player in cancer chemoresistance and its inhibition. OncoTargets and Therapy 7, pages 447-456.
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Damon Sutton, Saejeong Kim, Xintao Shuai, Konstantin Leskov, Joao T Marques, Bryan RG Williams, David A Boothman & Jinming Gao. (2006) Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro. International Journal of Nanomedicine 1:2, pages 155-162.
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Hideaki Miyake, Isao Hara, Masato Fujisawa & Martin E Gleave. (2006) The potential of clusterin inhibiting antisense oligodeoxynucleotide therapy for prostate cancer. Expert Opinion on Investigational Drugs 15:5, pages 507-517.
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Articles from other publishers (70)

Christelle Gross, Louis-Philippe Guérin, Bianca G. Socol, Lucie Germain & Sylvain L. Guérin. (2023) The Ins and Outs of Clusterin: Its Role in Cancer, Eye Diseases and Wound Healing. International Journal of Molecular Sciences 24:17, pages 13182.
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Patrik Kovács, Peter Natesan Pushparaj, Roland Takács, Ali Mobasheri & Csaba Matta. (2023) The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis. Frontiers in Immunology 14.
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AV Timofeeva, IS Fedorov, AM Tarasova, KA Gorina, YuV Suhova, VA Gusar & TYu Ivanets. (2022) Role of clusterin in predicting development of early- and late-onset preeclampsia in the first trimester of pregnancy. Bulletin of Russian State Medical University:2022(6).
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Yefei Zhang, Xiang Lv, Liming Chen & Yan Liu. (2022) The role and function of CLU in cancer biology and therapy. Clinical and Experimental Medicine 23:5, pages 1375-1391.
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Prakash Priyadarshi Praharaj, Srimanta Patra, Debasna Pritimanjari Panigrahi, Samir Kumar Patra & Sujit Kumar Bhutia. (2021) Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:2, pages 188500.
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Angelika V. Timofeeva, Ivan S. Fedorov, Mariya M. Pirogova, Oksana N. Vasilchenko, Vitaliy V. Chagovets, Larisa S. Ezhova, Tatiana M. Zabelina, Roman G. Shmakov & Gennadiy T. Sukhikh. (2021) Clusterin and Its Potential Regulatory microRNAs as a Part of Secretome for the Diagnosis of Abnormally Invasive Placenta: Accreta, Increta, and Percreta Cases. Life 11:4, pages 270.
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Zujian Xiong, Xuejun Li & Qi Yang. (2019) PTTG has a Dual Role of Promotion-Inhibition in the Development of Pituitary Adenomas. Protein & Peptide Letters 26:11, pages 800-818.
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Evangeline M. Foster, Adrià Dangla-Valls, Simon Lovestone, Elena M. Ribe & Noel J. Buckley. (2019) Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies. Frontiers in Neuroscience 13.
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Xin Ming, Chenyi Bao, Tao Hong, Ying Yang, Xinbin Chen, Yong-Sam Jung & Yingjuan Qian. (2018) Clusterin, a Novel DEC1 Target, Modulates DNA Damage–Mediated Cell Death. Molecular Cancer Research 16:11, pages 1641-1651.
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Najat Mourra, Malika Bennis, Pierre-Yves Boelle, Beatrix Cochand-Priollet, Marine Lefevre, Charles Lepine, Andre Balaton, Jerzy Klijanienko, Fabrice Menegaux & Frederique Tissier. (2017) Clusterin expression in medullary thyroid carcinoma is inversely correlated with the presence of lymph node metastases. Human Pathology 64, pages 37-43.
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Chen Abramovitch-Dahan, Hila Asraf, Milos Bogdanovic, Israel Sekler, Ashley I. Bush & Michal Hershfinkel. (2016) Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca 2+ , ERK1/2 and Clusterin signaling in neurons . Journal of Neurochemistry 139:2, pages 221-233.
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Valerie Vanhooren, Alexander Navarrete Santos, Konstantinos Voutetakis, Isabelle Petropoulos, Claude Libert, Andreas Simm, Efstathios S. Gonos & Bertrand Friguet. (2015) Protein modification and maintenance systems as biomarkers of ageing. Mechanisms of Ageing and Development 151, pages 71-84.
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Hai Huang, Linna Wang, Mingyu Li, Xiaohui Wang & Lin Zhang. (2014) Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells. World Journal of Surgical Oncology 12:1.
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Najat Mourra, Aurelie Scriva, Yohann Mansiaux, Sarah Gozlan, Malika Bennis & Andre Balaton. (2014) Clusterin expression in gastrointestinal neuroendocrine tumours is highly correlated with location and is helpful in determining the origin of liver metastases. Histopathology 65:5, pages 642-650.
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Soojin Hwang, Dong-Hoon Lee, In-Kyu Lee, Young Mi Park & Inho Jo. (2014) Far-infrared radiation inhibits proliferation, migration, and angiogenesis of human umbilical vein endothelial cells by suppressing secretory clusterin levels. Cancer Letters 346:1, pages 74-83.
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Amina Zoubeidi & Martin Gleave. 2014. Management of Castration Resistant Prostate Cancer. Management of Castration Resistant Prostate Cancer 233 248 .
Emma H Wall, Jeffrey P Bond & Thomas B McFadden. (2013) Milk yield responses to changes in milking frequency during early lactation are associated with coordinated and persistent changes in mammary gene expression. BMC Genomics 14:1.
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Catherine OryNicolas UgolinPaul HofmanMartin SchlumbergerIllya A. LikhtarevSylvie Chevillard. (2013) Comparison of Transcriptomic Signature of Post-Chernobyl and Postradiotherapy Thyroid Tumors. Thyroid 23:11, pages 1390-1400.
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D Klokov, K Leskov, S Araki, Y Zou, E M Goetz, X Luo, D Willson & D A Boothman. (2012) Low dose IR-induced IGF-1-sCLU expression: a p53-repressed expression cascade that interferes with TGFβ1 signaling to confer a pro-survival bystander effect. Oncogene 32:4, pages 479-490.
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Amina Zoubeidi & Martin Gleave. 2013. Androgen-Responsive Genes in Prostate Cancer. Androgen-Responsive Genes in Prostate Cancer 329 340 .
Francois Lamoureux, Amina Zoubeidi & Martin E. Gleave. 2013. Prostate Cancer: A Comprehensive Perspective. Prostate Cancer: A Comprehensive Perspective 43 64 .
Vera Chesnokova, Svetlana Zonis, Kolja Wawrowsky, Yuji Tani, Anat Ben-Shlomo, Vladimir Ljubimov, Adam Mamelak, Serguei Bannykh & Shlomo Melmed. (2012) Clusterin and FOXL2 Act Concordantly to Regulate Pituitary Gonadotroph Adenoma Growth. Molecular Endocrinology 26:12, pages 2092-2103.
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Z. Niu, X. Li, B. Hu, R. Li, L. Wang, L. Wu & X. Wang. (2012) Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer. Acta Biochimica et Biophysica Sinica 44:12, pages 991-998.
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Amina Zoubeidi & Martin Gleave. (2012) Small heat shock proteins in cancer therapy and prognosis. The International Journal of Biochemistry & Cell Biology 44:10, pages 1646-1656.
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E M Goetz, B Shankar, Y Zou, J C Morales, X Luo, S Araki, R Bachoo, L D Mayo & D A Boothman. (2011) ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene 30:35, pages 3745-3754.
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Sinan Ekici, Alper Eroğlu, A. Işın Doğan Ekici & Levent Türkeri. (2011) Clusterin Immunoreactivity as a Predictive Factor for Progression of Non-Muscle-Invasive Bladder Carcinoma. Urologia Internationalis 86:1, pages 31-35.
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Levin Böhlig & Karen Rother. (2011) One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor. Journal of Biomedicine and Biotechnology 2011, pages 1-15.
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A.A. Rommel, E. Goetz, M. Suzuki, S. Araki, J. Morales, Y. Zou, X. Luo, D.A. Boothman, K.S. Leskov, S. Matsuyama, M.W. Jackson, G. Veneziano & L.D. Mayo. 2011. Encyclopedia of Environmental Health. Encyclopedia of Environmental Health 543 552 .
Hecheng Li, Shilei Liu, XiaoLi Zhu, Shuo Yang, Jiaqing Xiang & Haiquan Chen. (2010) Clusterin Immunoexpression and its Clinical Significance in Patients with Non-Small Cell Lung Cancer. Lung 188:5, pages 423-431.
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David Murray & Michael Weinfeld. 2010. Monoclonal Antibody and Peptide‐Targeted Radiotherapy of Cancer. Monoclonal Antibody and Peptide‐Targeted Radiotherapy of Cancer 419 471 .
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Mee Lee Looi, Saiful Anuar Karsani, Mariati Abdul Rahman, Ahmad Zailani Hatta Mohd Dali, Siti Aishah Md Ali, Wan Zurinah Wan Ngah & Yasmin Anum Mohd Yusof. (2009) Plasma proteome analysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma. Journal of Biosciences 34:6, pages 917-925.
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Jérôme Chenau, Sylvie Michelland, Florence de Fraipont, Véronique Josserand, Jean-Luc Coll, Marie-Christine Favrot & Michel Seve. (2009) The Cell Line Secretome, a Suitable Tool for Investigating Proteins Released in Vivo by Tumors: Application to the Study of p53-Modulated Proteins Secreted in Lung Cancer Cells . Journal of Proteome Research 8:10, pages 4579-4591.
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Soultana Markopoulou, Evangelos Kontargiris, Christina Batsi, Theodore Tzavaras, Ioannis Trougakos, David A. Boothman, Efstathios S. Gonos & Evangelos Kolettas. (2009) Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin . FEBS Journal 276:14, pages 3784-3799.
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F.-T. Liao, Y.-J. Lee, J.-L. Ko, C.-C. Tsai, C.-J. Tseng & G.-T. Sheu. (2009) Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells. Journal of General Virology 90:5, pages 1124-1134.
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David Kevans, Jane Foley, Martin Tenniswood, Kieran Sheahan, John Hyland, Diarmuid O'Donoghue, Hugh Mulcahy & Jacintha O'Sullivan. (2009) High Clusterin Expression Correlates with a Poor Outcome in Stage II Colorectal Cancers. Cancer Epidemiology, Biomarkers & Prevention 18:2, pages 393-399.
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Richard D. Sowery, Boris A. Hadaschik, Alan I. So, Amina Zoubeidi, Ladan Fazli, Antonio Hurtado-Coll & Martin E. Gleave. (2008) Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy. BJU International 102:3, pages 389-397.
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Baocun Sun, Shiwu Zhang, Danfang Zhang, Yanqing Liu, Yan Li, Zhe Rong, Yue Zhu & Xinghong Jia. (2007) Clusterin is associated with spontaneous breast cancer in TA2 mice. FEBS Letters 581:17, pages 3277-3282.
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B. Shannan, M. Seifert, D. A. Boothman, W. Tilgen & J. Reichrath. (2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control. Journal of Molecular Histology 37:5-7, pages 183-188.
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Alessandro E. Caccamo, Silvia Desenzani, Lucia Belloni, Angelo F. Borghetti & Saverio Bettuzzi. (2005) Nuclear clusterin accumulation during heat shock response: Implications for cell survival and thermo‐tolerance induction in immortalized and prostate cancer cells. Journal of Cellular Physiology 207:1, pages 208-219.
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Dmitry Klokov, Tracy Criswell, Konstantin S. Leskov, Shinako Araki, Lindsey Mayo & David A. Boothman. (2004) IR-inducible clusterin gene expression: a protein with potential roles in ionizing radiation-induced adaptive responses, genomic instability, and bystander effects. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 568:1, pages 97-110.
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Dmitry Klokov, Tracy Criswell, Lakshmi Sampath, Konstantin S. Leskov, Kristin Frinkley, Shinako Araki, Meghan Beman, David L. Wilson & David A. Boothman. (2003) Clusterin: a protein with multiple functions as a potential ionizing radiation exposure marker. International Congress Series 1258, pages 219-232.
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