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Research Paper

Maspin Regulates Different Signaling Pathways for Motility and Adhesion in Aggressive Breast Cancer Cells

Pages 398-403 | Published online: 20 Mar 2003

Keep up to date with the latest research on this topic with citation updates for this article.

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Veronica Henderson, Basil Smith, Liza J Burton, Diandra Randle, Marisha Morris & Valerie A Odero-Marah. (2015) Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression. Cell Adhesion & Migration 9:4, pages 255-264.
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Andreas M. Stark, Christian Schem, Nicolai Maass, H. H. Hugo, Walter Jonat, H. Maximilian Mehdorn & Janka Held-Feindt. (2010) Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status. Neurological Research 32:3, pages 303-308.
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Caleb M. Bailey, Daniel E. Abbott, Naira V. Margaryan, Zhila Khalkhali-Ellis & Mary J. C. Hendrix. (2008) Interferon Regulatory Factor 6 Promotes Cell Cycle Arrest and Is Regulated by the Proteasome in a Cell Cycle-Dependent Manner. Molecular and Cellular Biology 28:7, pages 2235-2243.
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Articles from other publishers (53)

Takahiro Matsushige, Tomohiko Sakabe & Yoshihisa Umekita. (2022) Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line. Yonago Acta Medica 65:1, pages 44-52.
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M. T. Longhi, L. E. Silva, M. Pereira, M. Magalhães, J. Reina, F. N. L. Vitorino, B. M. Gumbiner, J. P. C. da Cunha & N. Cella. (2021) PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization. Cell Communication and Signaling 19:1.
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Xiao-Fei Wang, Bo Liang, Da-Xiong Zeng, Wei Lei, Cheng Chen, Yan-Bin Chen, Jian-An Huang, Ning Gu & Ye-Han Zhu. (2020) The roles of MASPIN expression and subcellular localization in non-small cell lung cancer. Bioscience Reports 40:5.
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Kavita Baghel, Hasan Raza Kazmi, Abhijit Chandra, Saloni Raj & Rajeshwar Nath Srivastava. (2019) Significance of methylation status of MASPIN gene and its protein expression in prognosis of gallbladder cancer. Asia-Pacific Journal of Clinical Oncology 15:5.
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I. Y. Zhitnyak, N. I. Litovka, S. N. Rubtsova & N. A. Gloushankova. (2018) INDUCTION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION IN MCF-7-SNAI1 CELLS LEADS TO REORGANIZATION OF ADHERENS JUNCTIONS AND ACQUISITION OF MIGRATORY ACTIVITY. Siberian journal of oncology 17:4, pages 24-29.
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Mohammad A. Al-Mamun, Worawut Srisukkham, Dewan Md Farid, Lorna Ravenhill, Li Zhang, Alamgir Hossain & Rosemary Bass. (2018) A quantitative image analysis for the cellular cytoskeleton during in vitro tumor growth. Expert Systems with Applications 92, pages 39-51.
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Hua-Chuan Zheng & Bao-Cheng Gong. (2017) The roles of maspin expression in gastric cancer: a meta- and bioinformatics analysis. Oncotarget 8:39, pages 66476-66490.
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Y D Huang, H W Yu, S W Xia, Z H Kang, Y S He & D Y Han. (2016) Expression of maspin in invasive fungal rhinosinusitis. The Journal of Laryngology & Otology 131:2, pages 150-154.
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S.E. Jenkinson, L.J. Brown, J. Ombor, J.A. Milburn, T. Smulders-Srinivasan, S. Veuger, D.R. Edwards & R. Bass. (2017) Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:2, pages 336-344.
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Ivory Dean, Sijana H. Dzinic, M. Margarida Bernardo, Yi Zou, Vickie Kimler, Xiaohua Li, Alexander Kaplun, James Granneman, Guangzhao Mao & Shijie Sheng. (2016) The secretion and biological function of tumor suppressor maspin as an exosome cargo protein. Oncotarget 8:5, pages 8043-8056.
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Mohammed Al-Mamun, Lorna Ravenhill, Worawut Srisukkham, Alamgir Hossain, Charles Fall, Vincent Ellis & Rosemary Bass. (2016) Effects of Noninhibitory Serpin Maspin on the Actin Cytoskeleton: A Quantitative Image Modeling Approach. Microscopy and Microanalysis 22:2, pages 394-409.
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Eiman Adel Hasby. (2015) Mammary serine protease inhibitor and CD138 immunohistochemical expression in ovarian serous and clear cell carcinomas. Tumor Biology 37:4, pages 4889-4900.
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Patrick R. Brambert, Daniel J. Kelpsch, Rabia Hameed, Charmi V. Desai, Gianfranco Calafiore, Lucy A. Godley & Stacey L. Raimondi. (2015) DNMT3B7 Expression Promotes Tumor Progression to a More Aggressive Phenotype in Breast Cancer Cells. PLOS ONE 10:1, pages e0117310.
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Magdalena Machowska, Katarzyna Wachowicz, Mirosław Sopel & Ryszard Rzepecki. (2014) Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells. BMC Cancer 14:1.
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Chiara Martinoli, Sara Gandini, Chiara Luise, Giovanni Mazzarol, Stefano Confalonieri, Pier Giuseppe Pelicci, Alessandro Testori & Pier Francesco Ferrucci. (2014) Maspin expression and melanoma progression: a matter of sub-cellular localization. Modern Pathology 27:3, pages 412-419.
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Sonia S. Y. Teoh, Jessica Vieusseux, Monica Prakash, Susan Berkowicz, Jennii Luu, Catherina H. Bird, Ruby H. P. Law, Carlos Rosado, John T. Price, James C. Whisstock & Phillip I. Bird. (2014) Maspin is not required for embryonic development or tumour suppression. Nature Communications 5:1.
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Rossana Berardi, Francesca Morgese, Azzurra Onofri, Paola Mazzanti, Mirco Pistelli, Zelmira Ballatore, Agnese Savini, Mariagrazia De Lisa, Miriam Caramanti, Silvia Rinaldi, Silvia Pagliaretta, Matteo Santoni, Chiara Pierantoni & Stefano Cascinu. (2013) Role of maspin in cancer. Clinical and Translational Medicine 2:1.
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Yang Wang, Shijie Sheng, Jianzhi Zhang, Sijana Dzinic, Shaolei Li, Fang Fang, Nan Wu, Qingfeng Zheng & Yue Yang. (2013) Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC). PLoS ONE 8:5, pages e63581.
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Huihui ZhangFan QiYouhan CaoXiongbing ZuMinfeng ChenZhuo LiLin Qi. (2013) 5-Aza-2′-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line . Cancer Biotherapy and Radiopharmaceuticals 28:4, pages 343-350.
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Corey L Neal, Veronica Henderson, Bethany N Smith, Danielle McKeithen, Tisheeka Graham, Baohan T Vo & Valerie A Odero-Marah. (2012) Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells. BMC Cancer 12:1.
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Haydee Lara, Yuhua Wang, Adriana S. Beltran, Karla Juárez-Moreno, Xinni Yuan, Sumie Kato, Andrea V. Leisewitz, Mauricio Cuello Fredes, Alexei F. Licea, Denise C. Connolly, Leaf Huang & Pilar Blancafort. (2012) Targeting Serous Epithelial Ovarian Cancer with Designer Zinc Finger Transcription Factors. Journal of Biological Chemistry 287:35, pages 29873-29886.
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Shiwu Wu, Lan Yu, Zenong Cheng, Wenqing Song, Lei Zhou & Yisheng Tao. (2012) Expression of maspin in non-small cell lung cancer and its relationship to vasculogenic mimicry. Journal of Huazhong University of Science and Technology [Medical Sciences] 32:3, pages 346-352.
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Brigitte GouletGabriel ChanAnn F. ChambersJohn D. Lewis. (2012) An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis 1 This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process. . Biochemistry and Cell Biology 90:1, pages 22-38.
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Hui-hui Zhang, Fan Qi, Xiong-bing Zu, You-han Cao, Jian-guang Miao, Liang Xu & Lin Qi. (2012) A proteomic study of potential VEGF-C-associated proteins in bladder cancer T24 cells. Medical Science Monitor 18:11, pages BR441-BR449.
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Lauren Reinke & Ming Zhang. 2012. Genetically Engineered Mice for Cancer Research. Genetically Engineered Mice for Cancer Research 353 373 .
Michael P. Endsley, Yanqiu Hu, Yong Deng, Xiaolin He, Debra J. Warejcka, Sally S. Twining, Steven L. Gonias & Ming Zhang. (2011) Maspin, the Molecular Bridge between the Plasminogen Activator System and β1 Integrin That Facilitates Cell Adhesion. Journal of Biological Chemistry 286:28, pages 24599-24607.
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Yanyuan Wu, Monica Alvarez, Dennis J Slamon, Phillip Koeffler & Jaydutt V Vadgama. (2010) Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer 10:1.
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Lorna Ravenhill, Laura Wagstaff, Dylan R. Edwards, Vincent Ellis & Rosemary Bass. (2010) G-helix of Maspin Mediates Effects on Cell Migration and Adhesion. Journal of Biological Chemistry 285:47, pages 36285-36292.
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Li Qin & Ming Zhang. (2010) Maspin Regulates Endothelial Cell Adhesion and Migration through an Integrin Signaling Pathway. Journal of Biological Chemistry 285:42, pages 32360-32369.
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MARIO W. KRAMER, SANDRA WAALKES, JÖRG HENNENLOTTER, JÜRGEN SERTH, ARNULF STENZL, MARKUS A. KUCZYK & AXEL S. MERSEBURGER. (2010) Maspin protein expression correlates with tumor progression in non-muscle invasive bladder cancer. Oncology Letters 1:4, pages 621-626.
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Sonia S.Y. Teoh, James C. Whisstock & Phillip I. Bird. (2010) Maspin (SERPINB5) Is an Obligate Intracellular Serpin. Journal of Biological Chemistry 285:14, pages 10862-10869.
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Rosemary Bass, Laura Wagstaff, Lorna Ravenhill & Vincent Ellis. (2009) Binding of Extracellular Maspin to β1 Integrins Inhibits Vascular Smooth Muscle Cell Migration. Journal of Biological Chemistry 284:40, pages 27712-27720.
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Caleb M. Bailey, Naira V. Margaryan, Daniel E. Abbott, Brian C. Schutte, Baoli Yang, Zhila Khalkhali-Ellis & Mary J. C. Hendrix. (2009) Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development. Development, Growth & Differentiation 51:5, pages 473-481.
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Ramon Chua, Shannon Setzer, Baskaran Govindarajan, Debbie Sexton, Cynthia Cohen & Jack L. Arbiser. (2009) Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma. Journal of the American Academy of Dermatology 60:5, pages 758-766.
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Zhen Cai, Yuan Zhou, Ting Lei, Jen‐Fu Chiu & Qing‐Yu He. (2008) Mammary serine protease inhibitor inhibits epithelial growth factor‐induced epithelial‐mesenchymal transition of esophageal carcinoma cells. Cancer 115:1, pages 36-48.
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A. Buchwalter, C. Van Dort, S. Schultz, R. Smith, I.P. Le, J.L. Abbott, E. Oosterhouse, A.E. Johnson, F. Hansen-Smith & M. Burnatowska-Hledin. (2008) Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Microvascular Research 75:2, pages 155-168.
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Wei Deng, Yong-fen Yi, Ya-ying Yang, Dan-dan Liu & Xiao Lin. (2008) Expression of maspin, uPA and MMP-7 in human gastric carcinoma. Chinese Journal of Cancer Research 20:1, pages 62-68.
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Robert-Alain Toillon, Chann Lagadec, Adeline Page, Valérie Chopin, Pierre-Eric Sautiére, Jean-Marc Ricort, Jérôme Lemoine, Ming Zhang, Hubert Hondermarck & Xuefen Le Bourhis. (2007) Proteomics Demonstration That Normal Breast Epithelial Cells Can Induce Apoptosis of Breast Cancer Cells through Insulin-like Growth Factor-binding Protein-3 and Maspin. Molecular & Cellular Proteomics 6:7, pages 1239-1247.
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Heidi Y. Shi, Lewis Joe Stafford, Zhisheng Liu, Mingyao Liu & Ming Zhang. (2007) Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase. Cell Motility 64:5, pages 338-346.
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Shizhen Emily Wang, Archana Narasanna, Corbin W. Whitell, Frederick Y. Wu, David B. Friedman & Carlos L. Arteaga. (2007) Convergence of p53 and Transforming Growth Factor β (TGFβ) Signaling on Activating Expression of the Tumor Suppressor Gene maspin in Mammary Epithelial Cells. Journal of Biological Chemistry 282:8, pages 5661-5669.
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Da-Qiang Li, Yi-Feng Hou, Jiong Wu, Yi Chen, Jin-Song Lu, Gen-Hong Di, Zhou-Luo Ou, Zhen-Zhou Shen, Jian Ding & Zhi-Min Shao. (2006) Gene expression profile analysis of an isogenic tumour metastasis model reveals a functional role for oncogene AF1Q in breast cancer metastasis. European Journal of Cancer 42:18, pages 3274-3286.
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