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Research Paper

Epidermal Growth Factor Receptor Mediates Silibinin-Induced Cytotoxicity in a Rat Glioma Cell Line

Pages 526-531 | Published online: 04 May 2003

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Lei Li, Jin Zeng, Ye Gao & Dalin He. (2010) Targeting silibinin in the antiproliferative pathway. Expert Opinion on Investigational Drugs 19:2, pages 243-255.
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Articles from other publishers (22)

Simon Bernard Iloki Assanga, Lidianys María Lewis Luján & Mark F. McCarty. (2023) Targeting beta-catenin signaling for prevention of colorectal cancer – Nutraceutical, drug, and dietary options. European Journal of Pharmacology 956, pages 175898.
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Mahdi Mashhadi Akbar Boojar, Massoud Mashhadi Akbar Boojar & Sepide Golmohammad. (2020) Overview of Silibinin anti-tumor effects. Journal of Herbal Medicine 23, pages 100375.
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Taro Koike, Susumu Tanaka, Yukie Hirahara, Souichi Oe, Kiyoshi Kurokawa, Mitsuyo Maeda, Mitsuo Suga, Yosky Kataoka & Hisao Yamada. (2019) Morphological characteristics of p75 neurotrophin receptor‐positive cells define a new type of glial cell in the rat dorsal root ganglia. Journal of Comparative Neurology 527:12, pages 2047-2060.
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Anum Munir, Sana Elahi & Nayyer Masood. (2018) Clustering based drug-drug interaction networks for possible repositioning of drugs against EGFR mutations: Clustering based DDI networks for EGFR mutations. Computational Biology and Chemistry 75, pages 24-31.
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Jenny L. Pokorny, Gaspar J. Kitange & Daniel J. Ma. 2016. Resistance to Targeted Therapies Against Adult Brain Cancers. Resistance to Targeted Therapies Against Adult Brain Cancers 145 174 .
R.N. Gacche, R.J. Meshram, H.D. Shegokar, D.S. Gond, S.S. Kamble, V.N. Dhabadge, B.G. Utage, K.K. Patil & R.A. More. (2015) Flavonoids as a scaffold for development of novel anti-angiogenic agents: An experimental and computational enquiry. Archives of Biochemistry and Biophysics 577-578, pages 35-48.
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Alex E. Grill, Brenda Koniar & Jayanth Panyam. (2014) Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin. Drug Delivery and Translational Research 4:4, pages 344-352.
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Caterina Grillo, Silvia Chichiarelli, Elisa Gaucci, Fabio Altieri, Carlo Turano & Laura Cervoni. (2014) The binding of silibinin to ERp57. Chemico-Biological Interactions 213, pages 37-43.
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Harold Ting, Gagan Deep & Rajesh Agarwal. (2013) Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer. The AAPS Journal 15:3, pages 707-716.
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Weiwei Liu, Wuxiyar Otkur, Lingzhi Li, Qiong Wang, Hao He, Linghe Zang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Mingyu Xia & Takashi Ikejima. (2013) Interference of silibinin with IGF-1R signalling pathways protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis. Biochemical and Biophysical Research Communications 432:2, pages 314-319.
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Jin Kyung Rho, Yun Jung Choi, Byung-Suk Jeon, Su Jin Choi, Gi Jeong Cheon, Sang-Keun Woo, Hye-Ryoun Kim, Cheol Hyeon Kim, Chang-Min Choi & Jae Cheol Lee. (2010) Combined Treatment with Silibinin and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Overcomes Drug Resistance Caused by T790M Mutation. Molecular Cancer Therapeutics 9:12, pages 3233-3243.
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Gagan Deep & Rajesh Agarwal. (2010) Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer and Metastasis Reviews 29:3, pages 447-463.
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Kwang Won Kim, Chang Hwa Choi, Thae Hyun Kim, Chae Hwa Kwon, Jae Suk Woo & Yong Keun Kim. (2009) Silibinin Inhibits Glioma Cell Proliferation via Ca2+/ROS/MAPK-Dependent Mechanism In Vitro and Glioma Tumor Growth In Vivo. Neurochemical Research 34:8, pages 1479-1490.
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Lei Li, Ye Gao, Linlin Zhang, Jin Zeng, Dalin He & Yi Sun. (2008) Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR–ERK activation in renal cell carcinoma. Cancer Letters 272:1, pages 61-69.
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Rajesh Agarwal & Gagan Deep. (2008) Kava, a Tonic for Relieving the Irrational Development of Natural Preventive Agents. Cancer Prevention Research 1:6, pages 409-412.
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Marjan Gharagozloo & Zahra Amirghofran. (2007) Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells. Journal of Cancer Research and Clinical Oncology 133:8, pages 525-532.
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Maria Cristina ComelliUlrich Mengs, Carl Schneider & Marco Prosdocimi. (2016) Toward the Definition of the Mechanism of Action of Silymarin: Activities Related to Cellular Protection From Toxic Damage Induced by Chemotherapy. Integrative Cancer Therapies 6:2, pages 120-129.
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Justin M. Saul, Ananth V. Annapragada & Ravi V. Bellamkonda. (2006) A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. Journal of Controlled Release 114:3, pages 277-287.
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Rana P. Singh & Rajesh Agarwal. (2006) Prostate cancer chemoprevention by silibinin: Bench to bedside. Molecular Carcinogenesis 45:6, pages 436-442.
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I. Petrová, R. Rajmon, M. Sedmíková, Z. Kuthanová, F. Jílek & J. Rozinek. (2005) Improvement of developmental competence of aged porcine oocytes by means of the synergistic effect of insulin-like growth factor-1 (IGF-1) and epidermal growth factor (EGF). Czech Journal of Animal Science 50:7, pages 300-310.
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Munenori Takaoka, Hideki Harada, Claudia D. Andl, Kenji Oyama, Yoshio Naomoto, Kelly L. Dempsey, Andres J. Klein-Szanto, Wafik S. El-Deiry, Adda Grimberg & Hiroshi Nakagawa. (2004) Epidermal Growth Factor Receptor Regulates Aberrant Expression of Insulin-Like Growth Factor-Binding Protein 3. Cancer Research 64:21, pages 7711-7723.
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Rana P. Singh & Rajesh Agarwal. (2004) A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 555:1-2, pages 21-32.
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