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Letter to the Editor

BAG3 Protein Regulates Cell Survival in Childhood Acute Lymphoblastic Leukemia Cells

Pages 508-510 | Published online: 04 May 2003

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Anna Ulbricht, Verena Arndt & Jörg Höhfeld. (2013) Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells. Communicative & Integrative Biology 6:4.
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Bao-Qin Liu, Zhen-Xian Du, Zhi-Hong Zong, Chao Li, Ning Li, Qiang Zhang, De-Hui Kong & Hua-Qin Wang. (2013) BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells. Autophagy 9:6, pages 905-916.
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Articles from other publishers (56)

Qinghan Liu, Jinde Liu & Xinyue Huang. (2022) Unraveling the mystery: How bad is BAG3 in hematological malignancies?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:5, pages 188781.
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Lena Avinery, Valid Gahramanov, Arkadi Hesin & Michael Y. Sherman. (2022) Hsp70–Bag3 Module Regulates Macrophage Motility and Tumor Infiltration via Transcription Factor LITAF and CSF1. Cancers 14:17, pages 4168.
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Jufang Guo, Xuelian Du & Chaolin Li. (2022) BAG family proteins contributes to autophagy-mediated multidrug resistance of tumor. Clinical and Translational Oncology 24:8, pages 1492-1500.
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Ting Liu, Shanmeng Lin, Yaoyao Du, Yi Gong & Shengkang Li. (2022) SpBAG3 assisted WSSV infection in mud crab (Scylla paramamosain) by inhibiting apoptosis. Developmental & Comparative Immunology 129, pages 104349.
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Margot De Marco, Antonia Falco, Roberta Iaccarino, Antonio Raffone, Antonio Mollo, Maurizio Guida, Alessandra Rosati, Massimiliano Chetta, Giovanni Genovese, Francesco De Caro, Mario Capunzo, Maria Caterina Turco, Vladimir N. Uversky & Liberato Marzullo. (2021) An emerging role for BAG3 in gynaecological malignancies. British Journal of Cancer 125:6, pages 789-797.
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Elena Mariotto, Diana Corallo, Marcella Pantile, Emanuela Giarin, Martina Pigazzi, Giuseppe Basso, Giampietro Viola & Sanja Aveic. (2021) BAG1 down‐regulation increases chemo‐sensitivity of acute lymphoblastic leukaemia cells. Journal of Cellular and Molecular Medicine 25:18, pages 9060-9065.
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Margot De Marco, Maria Caterina Turco & Liberato Marzullo. (2020) BAG3 in Tumor Resistance to Therapy. Trends in Cancer 6:12, pages 985-988.
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Riccardo Cristofani, Valeria Crippa, Maria Elena Cicardi, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Elena Casarotto, Margherita Piccolella, Elio Messi, Mariarita Galbiati, Paola Rusmini & Angelo Poletti. (2020) A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases. Frontiers in Aging Neuroscience 12.
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Xin-Yu Li, Jing Yan, Jia Sun, Chao Li, Jing-Yi Jiang, Jia-Mei Wang, Xiao-Na Meng, Jia-Jian Liang & Hua-Qin Wang. (2019) BAG3 deletion suppresses stem cell-like features of pancreatic ductal adenocarcinoma via translational suppression of ISG15. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:5, pages 819-827.
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Chao Li, Ming-Xin An, Jing-Yi Jiang, Han-Bing Yao, Si Li, Jing Yan, Xin-Yu Li & Hua-Qin Wang. (2019) BAG3 Suppresses Loading of Ago2 to IL6 mRNA in Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology 9.
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Ting Yuan, Feng Zhang, Xiangxiang Zhou, Ying Li, Ya Zhang, Yangyang Xu & Xin Wang. (2019) Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3. Oncology Letters.
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Chao Li, Jing-Yi Jiang, Jia-Mei Wang, Jia Sun, Ming-Xin An, Si Li, Jing Yan & Hua-Qin Wang. (2018) BAG3 regulates stability of IL-8 mRNA via interplay between HuR and miR-4312 in PDACs. Cell Death & Disease 9:9.
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Margot De Marco, Anna Basile, Vittoria Iorio, Michelina Festa, Antonia Falco, Bianca Ranieri, Maria Pascale, Gianluca Sala, Paolo Remondelli, Mario Capunzo, Matthew A. Firpo, Raffaele Pezzilli, Liberato Marzullo, Pierpaolo Cavallo, Vincenzo De Laurenzi, Maria Caterina Turco & Alessandra Rosati. (2018) Role of BAG3 in cancer progression: A therapeutic opportunity. Seminars in Cell & Developmental Biology 78, pages 85-92.
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Ming-Xin An, Si Li, Han-Bing Yao, Chao Li, Jia-Mei Wang, Jia Sun, Xin-Yu Li, Xiao-Na Meng & Hua-Qin Wang. (2017) BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. Journal of Cell Biology 216:12, pages 4091-4105.
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Luana Guerriero, Giuseppe Palmieri, Margot De Marco, Antonio Cossu, Paolo Remondelli, Mario Capunzo, Maria Caterina Turco & Alessandra Rosati. (2017) The anti-apoptotic BAG3 protein is involved in BRAF inhibitor resistance in melanoma cells. Oncotarget 8:46, pages 80393-80404.
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Jing Yan, Chuan Liu, Jing-Yi Jiang, Hans Liu, Chao Li, Xin-Yu Li, Ye Yuan, Zhi-Hong Zong & Hua-Qin Wang. (2017) BAG3 promotes proliferation of ovarian cancer cells via post-transcriptional regulation of Skp2 expression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:10, pages 1668-1678.
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Bao-Qin Liu, Song Zhang, Si Li, Ming-Xin An, Chao Li, Jing Yan, Jia-Mei Wang & Hua-Qin Wang. (2017) BAG3 promotes stem cell-like phenotype in breast cancer by upregulation of CXCR4 via interaction with its transcript. Cell Death & Disease 8:7, pages e2933-e2933.
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Paola Rusmini, Riccardo Cristofani, Mariarita Galbiati, Maria E. Cicardi, Marco Meroni, Veronica Ferrari, Giulia Vezzoli, Barbara Tedesco, Elio Messi, Margherita Piccolella, Serena Carra, Valeria Crippa & Angelo Poletti. (2017) The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases. Frontiers in Molecular Neuroscience 10.
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De-Hui Kong, Si Li, Zhen-Xian Du, Chuan Liu, Bao-Qin Liu, Chao Li, Zhi-Hong Zong & Hua-Qin Wang. (2015) BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas. Oncotarget 7:1, pages 700-711.
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Georg Bartsch, Lukas Jennewein, Patrick Harter, Patrick Antonietti, Roman Blaheta, Hans-Michael Kvasnicka, Donat K�gel, Axel Haferkamp, Michel Mittelbronn & Jens Mani. (2015) Autophagy-associated proteins BAG3 and p62 in testicular cancer. Oncology Reports.
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M Y Sherman & V L Gabai. (2014) Hsp70 in cancer: back to the future. Oncogene 34:32, pages 4153-4161.
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Si Li, Hai-Yan Zhang, Tian Wang, Xin Meng, Zhi-Hong Zong, De-Hui Kong, Hua-Qin Wang & Zhen-Xian Du. (2014) BAG3 Promoted Starvation-Induced Apoptosis of Thyroid Cancer Cells via Attenuation of Autophagy. The Journal of Clinical Endocrinology & Metabolism 99:11, pages E2298-E2307.
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F Rapino, M Jung & S Fulda. (2013) BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways. Oncogene 33:13, pages 1713-1724.
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Heng Xiao, Shaobing Cheng, Rongliang Tong, Zheng Lv, Chaofeng Ding, Chengli Du, Haiyang Xie, Lin Zhou, Jian Wu & Shusen Zheng. (2014) BAG3 regulates epithelial–mesenchymal transition and angiogenesis in human hepatocellular carcinoma. Laboratory Investigation 94:3, pages 252-261.
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Huayuan Zhu, Wei Wu, Yuan Fu, Wenyi Shen, Kourong Miao, Min Hong, Wei Xu, Ken H. Young, Peng Liu & Jianyong Li. (2013) Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia. Annals of Hematology 93:3, pages 425-435.
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X Meng, D-H Kong, N Li, Z-H Zong, B-Q Liu, Z-X Du, Y Guan, L Cao & H-Q Wang. (2014) Knockdown of BAG3 induces epithelial–mesenchymal transition in thyroid cancer cells through ZEB1 activation. Cell Death & Disease 5:2, pages e1092-e1092.
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Ji Hee Lim, Dong-Ye Youn, Hyung Jae Yoo, Hye Hyeon Yoon, Min Young Kim, Sungjin Chung, Yong-Soo Kim, Yoon Sik Chang, Cheol Whee Park & Jeong-Hwa Lee. (2013) Aggravation of diabetic nephropathy in BCL-2 interacting cell death suppressor (BIS)-haploinsufficient mice together with impaired induction of superoxide dismutase (SOD) activity. Diabetologia 57:1, pages 214-223.
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Gavin D. Grant, Lionel Brooks3rd3rd, Xiaoyang Zhang, J. Matthew Mahoney, Viktor Martyanov, Tammara A. Wood, Gavin Sherlock, Chao Cheng & Michael L. Whitfield. (2013) Identification of cell cycle–regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors. Molecular Biology of the Cell 24:23, pages 3634-3650.
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Chao Li, Si Li, De-Hui Kong, Xin Meng, Zhi-Hong Zong, Bao-Qin Liu, Yifu Guan, Zhen-Xian Du & Hua-Qin Wang. (2013) BAG3 is upregulated by c-Jun and stabilizes JunD. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:12, pages 3346-3354.
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De-Hui Kong, Qiang Zhang, Xin Meng, Zhi-Hong Zong, Chao Li, Bao-Qin Liu, Yifu Guan & Hua-Qin Wang. (2013) BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:12, pages 3245-3253.
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N Li, Z-X Du, Z-H Zong, B-Q Liu, C Li, Q Zhang & H-Q Wang. (2012) PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial−mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells. Oncogene 32:38, pages 4539-4548.
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A Falco, M Festa, A Basile, A Rosati, M Pascale, F Florenzano, S L Nori, V Nicolin, M Di Benedetto, M L Vecchione, C Arra, A Barbieri, V De Laurenzi & M C Turco. (2012) BAG3 controls angiogenesis through regulation of ERK phosphorylation. Oncogene 31:50, pages 5153-5161.
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Alessandra Rosati, Anna Basile, Antonia Falco, Morena d'Avenia, Michelina Festa, Vincenzo Graziano, Vincenzo De Laurenzi, Claudio Arra, Maria Pascale & Maria Caterina Turco. (2012) Role of BAG3 protein in leukemia cell survival and response to therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:2, pages 365-369.
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Alessandra Rosati, Samantha Bersani, Francesca Tavano, Elisa Dalla Pozza, Margot De Marco, Marta Palmieri, Vincenzo De Laurenzi, Renato Franco, Giosuè Scognamiglio, Raffaele Palaia, Andrea Fontana, Pierluigi di Sebastiano, Massimo Donadelli, Ilaria Dando, Jan Paul Medema, Frederike Dijk, Lieke Welling, Fabio Francesco di Mola, Raffaele Pezzilli, Maria Caterina Turco & Aldo Scarpa. (2012) Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival. The American Journal of Pathology 181:5, pages 1524-1529.
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HC Lee, SW Cherk, SK Chan, S Wong, TW Tong, WS Ho, AY Chan, KC Lee & CM Mak. (2011) BAG3‐related myofibrillar myopathy in a Chinese family. Clinical Genetics 81:4, pages 394-398.
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Anna Basile, Rosario Zeppa, Nicola Pasquino, Claudio Arra, Massimo Ammirante, Michelina Festa, Antonio Barbieri, Aldo Giudice, Maria Pascale, Maria Caterina Turco & Alessandra Rosati. (2011) Exposure to 50 Hz electromagnetic field raises the levels of the anti-apoptotic protein BAG3 in melanoma cells. Journal of Cellular Physiology 226:11, pages 2901-2907.
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Dong-Ye YounJung-Sook Yoon, Yong Kwan KimChung Eun Yeum, Seong-Beom Lee, Ho-Joong Youn, Yoshihide Tsujimoto & Jeong-Hwa Lee. (2011) Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy in mice . American Journal of Physiology-Endocrinology and Metabolism 301:1, pages E223-E231.
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Michelina Festa, Luis Del Valle, Kamel Khalili, Renato Franco, Giosuè Scognamiglio, Vincenzo Graziano, Vincenzo De Laurenzi, Maria Caterina Turco & Alessandra Rosati. (2011) BAG3 Protein Is Overexpressed in Human Glioblastoma and Is a Potential Target for Therapy. The American Journal of Pathology 178:6, pages 2504-2512.
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A Rosati, V Graziano, V De Laurenzi, M Pascale & M C Turco. (2011) BAG3: a multifaceted protein that regulates major cell pathways. Cell Death & Disease 2:4, pages e141-e141.
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Shaoming Song, Sutapa Kole, Patricia Precht, Michael J. Pazin & Michel Bernier. (2010) Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3. The International Journal of Biochemistry & Cell Biology 42:11, pages 1856-1863.
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Massimo AmmiranteAlessandra RosatiClaudio Arra, Anna BasileAntonia FalcoMichela FestaMaria PascaleMorena d'AveniaLiberato MarzulloMaria Antonietta BelisarioMargot De MarcoAntonio Barbieri, Aldo Giudice, Gennaro ChiappettaEmilia VuttarielloMario MonacoPatrizia Bonelli, Gaetano Salvatore, Maria Di Benedetto, Satish L. Deshmane, Kamel Khalili, Maria Caterina TurcoArturo Leone. (2010) IKKγ protein is a target of BAG3 regulatory activity in human tumor growth. Proceedings of the National Academy of Sciences 107:16, pages 7497-7502.
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Kyung-rim Kwon, Ji-Yeon Ahn, Myung-Shin Kim, Joo-Young Jung, Jeong-Hwa Lee & Il-Hoan Oh. (2010) Disruption of Bis Leads to the Deterioration of the Vascular Niche for Hematopoietic Stem Cells . Stem Cells 28:2, pages 268-278.
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Jeong-Sun Choi, Jeong-Hwa Lee, Yoo-Jin Shin, Ji-Yeon Lee, Hou Yun, Myung-Hoon Chun & Mun-Yong Lee. (2009) Transient expression of Bis protein in midline radial glia in developing rat brainstem and spinal cord. Cell and Tissue Research 337:1, pages 27-36.
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Aaron T. Jacobs & Lawrence J. Marnett. (2009) HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins. Journal of Biological Chemistry 284:14, pages 9176-9183.
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Zhen‐Xian Du, Hai‐Yan Zhang, Xin Meng, Yan‐Yan Gao, Ren‐Long Zou, Bao‐Qin Liu, Yifu Guan & Hua‐Qin Wang. (2008) Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1. Journal of Cellular Physiology 218:3, pages 631-637.
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Alessandra Rosati, Kamel Khalili, Satish L. Deshmane, Sujatha Radhakrishnan, Maria Pascale, M. Caterina Turco & Liberato Marzullo. (2009) BAG3 protein regulates caspase-3 activation in HIV-1-infected human primary microglial cells. Journal of Cellular Physiology 218:2, pages 264-267.
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Dong-Ye Youn, Dong-Hyoung Lee, Mi-Hyun Lim, Jung-Sook Yoon, Ji Hee Lim, Seung Eun Jung, Chung Eun Yeum, Cheol Whee Park, Ho-Joong Youn, Jae-Seon Lee, Seong-Beom Lee, Masahito Ikawa, Masaru Okabe, Yoshihide Tsujimoto & Jeong-Hwa Lee. (2008) Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus. American Journal of Physiology-Endocrinology and Metabolism 295:6, pages E1349-E1357.
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Gennaro Chiappetta, Massimo Ammirante, Anna Basile, Alessandra Rosati, Michela Festa, Mario Monaco, Emilia Vuttariello, Rosa Pasquinelli, Claudio Arra, Monica Zerilli, Matilde Todaro, Giorgio Stassi, Luciano Pezzullo, Antonio Gentilella, Alessandra Tosco, Maria Pascale, Liberato Marzullo, Maria Antonietta Belisario, Maria Caterina Turco & Arturo Leone. (2007) The Antiapoptotic Protein BAG3 Is Expressed in Thyroid Carcinomas and Modulates Apoptosis Mediated by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. The Journal of Clinical Endocrinology & Metabolism 92:3, pages 1159-1163.
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Alessandra Rosati, Arturo Leone, Luis Del Valle, Shohreh Amini, Kamel Khalili & Maria Caterina Turco. (2007) Evidence for BAG3 modulation of HIV-1 gene transcription. Journal of Cellular Physiology 210:3, pages 676-683.
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