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Research Paper

Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells

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Pages 657-670 | Received 08 Nov 2011, Accepted 20 Mar 2012, Published online: 01 Jun 2012

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Meng Wang, Tie Lin, Yicun Wang, Song Gao, Zhaoyang Yang, Xuan Hong & Gongyan Chen. (2017) CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells. OncoTargets and Therapy 10, pages 3215-3224.
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Celine S. Nicolas, Mascia Amici, Zuner A. Bortolotto, Andrew Doherty, Zsolt Csaba, Assia Fafouri, Pascal Dournaud, Pierre Gressens, Graham L. Collingridge & Stephane Peineau. (2013) The role of JAK-STAT signaling within the CNS. JAK-STAT 2:1.
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Huiying Li, Qianqian Yao, Li Min, Shengnan Huang, Haoming Wu, Huaigu Yang, Linlin Fan, Jiaqi Wang & Nan Zheng. (2020) The Combination of Two Bioactive Constituents, Lactoferrin and Linolenic Acid, Inhibits Mouse Xenograft Esophageal Tumor Growth by Downregulating Lithocholyltaurine and Inhibiting the JAK2/STAT3-Related Pathway. ACS Omega 5:33, pages 20755-20764.
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Iwona Anna Ciechomska, Bartlomiej Gielniewski, Bartosz Wojtas, Bozena Kaminska & Jakub Mieczkowski. (2020) EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide. Experimental & Molecular Medicine 52:8, pages 1326-1340.
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Yong-Xi Ge, Yan-Hong Wang, Juan Zhang, Zhi-Pu Yu, Xin Mu, Jia-Li Song, Yin-Yin Wang, Feifei Yang, Ning Meng, Cheng-Shi Jiang & Hua Zhang. (2019) New cinnamic acid-pregenolone hybrids as potential antiproliferative agents: Design, synthesis and biological evaluation. Steroids 152, pages 108499.
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Liang Zhang, Timothy E. Peterson, Victor M. Lu, Ian F. Parney & David J. Daniels. (2019) Antitumor activity of novel pyrazole-based small molecular inhibitors of the STAT3 pathway in patient derived high grade glioma cells. PLOS ONE 14:7, pages e0220569.
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Jatin Sharma & Joseph LarkinIIIIII. (2019) Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer. Frontiers in Pharmacology 10.
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Seyed Mohammad Nabavi, Touqeer Ahmed, Maheen Nawaz, Kasi Pandima Devi, Devasahayam Jaya Balan, Valeria Pittalà, Sandro Argüelles-Castilla, Lara Testai, Haroon Khan, Antoni Sureda, Marcos Roberto de Oliveira, Rosa Anna Vacca, Suowen Xu, Bahman Yousefi, Valeria Curti, Maria Daglia, Eduardo Sobarzo-Sánchez, Rosanna Filosa, Seyed Fazel Nabavi, Maryam Majidinia, Ahmad Reza Dehpour & Samira Shirooie. (2019) Targeting STATs in neuroinflammation: The road less traveled!. Pharmacological Research 141, pages 73-84.
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Zhiwen Huang, Wei Lei, Hai‐Bo Hu, Hongyan Zhang & Yehan Zhu. (2018) H19 promotes non‐small‐cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR‐17. Journal of Cellular Physiology 233:10, pages 6768-6776.
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Hyun‐Ji Cho, Ji‐Hyun Park, Jin Han Nam, Young‐Chae Chang, Byoungduck Park & Hyang‐Sook Hoe. (2017) Ascochlorin Suppresses MMP‐2‐Mediated Migration and Invasion by Targeting FAK and JAK‐STAT Signaling Cascades. Journal of Cellular Biochemistry 119:1, pages 300-313.
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Wei He, Yi Zhu, Ruoyu Mu, Jinzhi Xu, Xiaoyi Zhang, Chunming Wang, Qiu Li, Zhen Huang, Junfeng Zhang, Yi Pan, Jianlin Han & Lei Dong. (2017) A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy. Biochemical Pharmacology 145, pages 132-146.
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Matthew G. LaPorte, Dimas José da Paz Lima, Feng Zhang, Malabika Sen, Jennifer R. Grandis, Daniel Camarco, Yun Hua, Paul A. Johnston, John S. Lazo, Lynn O. Resnick, Peter Wipf & Donna M. Huryn. (2014) 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorganic & Medicinal Chemistry Letters 24:21, pages 5081-5085.
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G Wang, J J Wang, X L Chen, S M Du, D S Li, Z J Pei, H Lan & L B Wu. (2013) The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death. Cell Death & Disease 4:8, pages e746-e746.
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Marcin Mielecki, Krzysztof Krawiec, Irene Kiburu, Krystyna Grzelak, Włodzimierz Zagórski, Borys Kierdaszuk, Kamila Kowa, Izabela Fokt, Slawomir Szymanski, Piotr Świerk, Wiesław Szeja, Waldemar Priebe, Bogdan Lesyng & Nicole LaRonde-LeBlanc. (2013) Development of novel molecular probes of the Rio1 atypical protein kinase. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:7, pages 1292-1301.
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Ahmed Sadeque, Nicola VL Serão, Bruce R Southey, Kristin R Delfino & Sandra L Rodriguez-Zas. (2012) Identification and characterization of alternative exon usage linked glioblastoma multiforme survival. BMC Medical Genomics 5:1.
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