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Review

Targeting DNA Checkpoint Kinases in Cancer Therapy

Pages 15-21 | Published online: 01 Mar 2003

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Christine Didier, Cécile Demur, Fanny Grimal, Denis Jullien, Stéphane Manenti & Bernard Ducommun. (2012) Evaluation of checkpoint kinase targeting therapy in Acute Myeloid Leukemia with complex karyotype. Cancer Biology & Therapy 13:5, pages 307-313.
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Articles from other publishers (29)

Feifei Wang, Odjo G. Gouttia, Ling Wang & Aimin Peng. (2022) PARP1 Upregulation in Recurrent Oral Cancer and Treatment Resistance. Frontiers in Cell and Developmental Biology 9.
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Payal Gupta, R.C. Meena & Navin Kumar. (2020) Functional characterization of Candida glabrata ORF, CAGL0M02233g for its role in stress tolerance and virulence. Microbial Pathogenesis 149, pages 104469.
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Jiyun Kwon, Suhee Lee, Yong-Nyun Kim & In Hye Lee. (2019) Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response. Experimental & Molecular Medicine 51:3, pages 1-9.
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Ummi Ammarah, Amit Kumar, Rajesh Pal, Naresh C. Bal & Gauri Misra. (2018) Identification of new inhibitors against human Great wall kinase using in silico approaches. Scientific Reports 8:1.
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Ling Wang, Adam J. Mosel, Gregory G. Oakley & Aimin Peng. (2012) Deficient DNA Damage Signaling Leads to Chemoresistance to Cisplatin in Oral Cancer. Molecular Cancer Therapeutics 11:11, pages 2401-2409.
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Sonali S. Patil, Stanislaw R. Burzynski, Emilia Mrowczynski, Krzysztof Grela & Sridar V. Chittur. (2012) Phenylacetylglutaminate and Phenylacetate in Combination Upregulate VDUP1, Cause Cell Cycle Blockade and Apoptosis in U87 Glioblastoma Cells. Journal of Cancer Therapy 03:03, pages 192-200.
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Jun Wu, Guozheng Lai, Feng Wan, Zhengzheng Xiao, Lingcheng Zeng, Xiongwei Wang, Fei Ye & Ting Lei. (2012) Knockdown of Checkpoint Kinase 1 Is Associated with the Increased Radiosensitivity of Glioblastoma Stem-Like Cells. The Tohoku Journal of Experimental Medicine 226:4, pages 267-274.
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Monika Gupta, Sunil Gupta, Harish Dureja & Anil Kumar Madan. (2012) Superaugmented Eccentric Distance Sum Connectivity Indices: Novel Highly Discriminating Topological Descriptors for QSAR/QSPR. Chemical Biology & Drug Design 79:1, pages 38-52.
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Susan Ashwell. 2012. DNA Repair in Cancer Therapy. DNA Repair in Cancer Therapy 211 234 .
George T. Lountos, Andrew G. Jobson, Joseph E. Tropea, Christopher R. Self, Guangtao Zhang, Yves Pommier, Robert H. Shoemaker & David S. Waugh. (2011) Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy. Journal of Structural Biology 176:3, pages 292-301.
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Gilles Ferry, Aurélie Studeny, Céline Bossard, Philip M. Kubara, Denis Zeyer, Jean-Paul Renaud, Patrick Casara, Guillaume de Nanteuil, Michel Wierzbicki, Bruno Pfeiffer, Michelle Prudhomme, Stephane Leonce, Alain Pierré, Jean A. Boutin & Roy M. Golsteyn. (2011) Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors. Life Sciences 89:7-8, pages 259-268.
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Loic P. Deleyrolle, Angus Harding, Kathleen Cato, Florian A. Siebzehnrubl, Maryam Rahman, Hassan Azari, Sarah Olson, Brian Gabrielli, Geoffrey Osborne, Angelo Vescovi & Brent A. Reynolds. (2011) Evidence for label-retaining tumour-initiating cells in human glioblastoma. Brain 134:5, pages 1331-1343.
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S Zenvirt, N Kravchenko-Balasha & A Levitzki. (2010) Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents. Oncogene 29:46, pages 6149-6159.
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Yun Dai & Steven Grant. (2010) New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network. Clinical Cancer Research 16:2, pages 376-383.
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Yun DaiShuang ChenXin-Yan PeiJorge A. AlmenaraLora B. KramerCharis A. VendittiPaul Dent & Steven Grant. (2008) Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells. Blood 112:6, pages 2439-2449.
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Susan Ashwell & Sonya Zabludoff. (2008) DNA Damage Detection and Repair Pathways—Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clinical Cancer Research 14:13, pages 4032-4037.
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Bradley A. Stohr & Elizabeth H. Blackburn. (2008) ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells. Cancer Research 68:13, pages 5309-5317.
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Michael Goldstein, Wynand P. Roos & Bernd Kaina. (2008) Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: Contribution of DNA replication, transcription inhibition and Chk/p53 signaling. Toxicology and Applied Pharmacology 229:1, pages 20-32.
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George T. Lountos, Joseph E. Tropea, Di Zhang, Andrew G. Jobson, Yves Pommier, Robert H. Shoemaker & David S. Waugh. (2008) Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Science, pages NA-NA.
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Deborah Wilsker & Fred Bunz. (2007) Loss of ataxia telangiectasia mutated– and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival. Molecular Cancer Therapeutics 6:4, pages 1406-1413.
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Ana I. Robles, Mollie H. Wright, Bheru Gandhi, Steven S. Feis, Christin L. Hanigan, Adrian Wiestner & Lyuba Varticovski. (2006) Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines. Clinical Cancer Research 12:21, pages 6547-6556.
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Korden Walter, Gabriele Warnecke, Richard Bowater, Wolfgang Deppert & Ella Kim. (2005) Tumor Suppressor p53 Binds with High Affinity to CTG·CAG Trinucleotide Repeats and Induces Topological Alterations in Mismatched Duplexes. Journal of Biological Chemistry 280:52, pages 42497-42507.
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Catriona A. L. CLARKEPaul R. CLARKE. (2005) DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochemical Journal 388:2, pages 705-712.
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Mikhail V. Blagosklonny. (2005) Overcoming limitations of natural anticancer drugs by combining with artificial agents. Trends in Pharmacological Sciences 26:2, pages 77-81.
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Abdelhadi Rebbaa. (2005) Targeting senescence pathways to reverse drug resistance in cancer. Cancer Letters 219:1, pages 1-13.
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Michal O. NowickiRafal FalinskiMateusz KoptyraArtur SlupianekTomasz StoklosaEwa GlocMargaret Nieborowska-SkorskaJanusz BlasiakTomasz Skorski. (2004) BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks. Blood 104:12, pages 3746-3753.
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Jinwoo Ahn, Marshall Urist & Carol Prives. (2004) The Chk2 protein kinase. DNA Repair 3:8-9, pages 1039-1047.
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Vasudha Sharma & Jetze J. Tepe. (2004) Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. Bioorganic & Medicinal Chemistry Letters 14:16, pages 4319-4321.
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Michael H Lam, Qinghua Liu, Stephen J Elledge & Jeffrey M Rosen. (2004) Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 6:1, pages 45-59.
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