1,412
Views
48
CrossRef citations to date
0
Altmetric
Research Paper

AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer

, , &
Pages 804-811 | Received 29 Feb 2012, Accepted 29 Apr 2012, Published online: 06 Jun 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Mojgan Nejabat, Fatemeh Soltani, Mona Alibolandi, Masoud Nejabat, Khalil Abnous, Farzin Hadizadeh & Mohammad Ramezani. (2022) Smac peptide and doxorubicin-encapsulated nanoparticles: design, preparation, computational molecular approach and in vitro studies on cancer cells. Journal of Biomolecular Structure and Dynamics 40:2, pages 807-819.
Read now
Shadia Zaman, Rui Wang & Varsha Gandhi. (2014) Targeting the apoptosis pathway in hematologic malignancies. Leukemia & Lymphoma 55:9, pages 1980-1992.
Read now
Laurence Dubrez, Jean Berthelet & Valérie Glorian. (2013) IAP proteins as targets for drug development in oncology. OncoTargets and Therapy 6, pages 1285-1304.
Read now

Articles from other publishers (45)

Robert I. Haddad, Kevin Harrington, Makoto Tahara, Petr Szturz, Christophe Le Tourneau, Satu Salmio, Marcis Bajars & Nancy Y. Lee. (2023) Managing cisplatin-ineligible patients with resected, high-risk, locally advanced squamous cell carcinoma of the head and neck: Is there a standard of care?. Cancer Treatment Reviews 119, pages 102585.
Crossref
Julia Fleischmann, Laura S. Hildebrand, Lukas Kuhlmann, Rainer Fietkau & Luitpold V. Distel. (2023) The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP. Cells 12:12, pages 1653.
Crossref
Zi‐Ning Lei, Qin Tian, Qiu‐Xu Teng, John N. D. Wurpel, Leli Zeng, Yihang Pan & Zhe‐Sheng Chen. (2023) Understanding and targeting resistance mechanisms in cancer. MedComm 4:3.
Crossref
Samar Imbaby, Shereen E. Elkholy, Salwa Faisal, Asmaa K.K. Abdelmaogood, Amir E. Mehana, Basma S.A. Mansour, Samar M. Abd El-moneam & Samah M. Elaidy. (2023) The GSTP1/MAPKs/BIM/SMAC modulatory actions of nitazoxanide: Bioinformatics and experimental evidence in subcutaneous solid Ehrlich carcinoma-inoculated mice. Life Sciences 319, pages 121496.
Crossref
Pratibha S. Binder, Yassar M. Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Suwanna Vangveravong, David G. Mutch, William G. Hawkins, Matthew A. Powell & Dirk Spitzer. (2022) The targeted SMAC mimetic SW IV-134 augments platinum-based chemotherapy in pre-clinical models of ovarian cancer. BMC Cancer 22:1.
Crossref
Xin Liu, Jimmy J. Yao, Zhongxuan Chen, Wei Lei, Rong Duan & Zhenqiang Yao. (2022) Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist. Frontiers in Immunology 13.
Crossref
Jean Bourhis, Barbara Burtness, Lisa F Licitra, Christopher Nutting, Jonathan D Schoenfeld, Mokhtar Omar, Florilene Bouisset, Heidi Nauwelaerts, Yulia Urfer, Claudio Zanna & Ezra EW Cohen. (2022) Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design. Future Oncology 18:14, pages 1669-1678.
Crossref
Pierina Cetraro, Julio Plaza-Diaz, Alex MacKenzie & Francisco Abadía-Molina. (2022) A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer. Cancers 14:7, pages 1671.
Crossref
Yuedan Zhou, Sophie Espenel, Samir Achkar, Alexandra Leary, Sebastien Gouy & Cyrus Chargari. (2022) Combined modality including novel sensitizers in gynecological cancers. International Journal of Gynecologic Cancer 32:3, pages 389-401.
Crossref
Gabriel LaPlante & Wei Zhang. (2021) Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors. Cancers 13:12, pages 3079.
Crossref
Claudia Hamilton, Jennifer P. Fox, Daniel B. Longley & Catherine A. Higgins. (2021) Therapeutics Targeting the Core Apoptotic Machinery. Cancers 13:11, pages 2618.
Crossref
Chun Hei Antonio Cheung, Yung-Chieh Chang, Tzu-Yu Lin, Siao Muk Cheng & Euphemia Leung. (2020) Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE. Journal of Biomedical Science 27:1.
Crossref
Mojgan Nejabat, Farhad Eisvand, Fatemeh Soltani, Mona Alibolandi, Seyed Mohammad Taghdisi, Khalil Abnous, Farzin Hadizadeh & Mohammad Ramezani. (2020) Combination therapy using Smac peptide and doxorubicin-encapsulated MUC 1-targeted polymeric nanoparticles to sensitize cancer cells to chemotherapy: An in vitro and in vivo study. International Journal of Pharmaceutics 587, pages 119650.
Crossref
Nir Shahar & Sarit Larisch. (2020) Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance. Drug Resistance Updates 52, pages 100712.
Crossref
Congwen Li, Guodong Zhu, Zihong Cui, Jihong Zhang, Shengting Zhang & Yunlin Wei. (2020) The strong inhibitory effect of combining anti-cancer drugs AT406 and rocaglamide with blue LED irradiation on colorectal cancer cells. Photodiagnosis and Photodynamic Therapy 30, pages 101797.
Crossref
Yung-Chih Kuo & Rajendiran Rajesh. (2020) Biomaterial-based drug delivery systems used to improve chemotherapeutic activity of pharmaceuticals and to target inhibitors of apoptosis proteins. Journal of the Taiwan Institute of Chemical Engineers 111, pages 1-10.
Crossref
Wei Lei, Rong Duan, Jinbo Li, Xin Liu, Alissa Huston, Brendan F. Boyce & Zhenqiang Yao. (2020) The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice. Scientific Reports 10:1.
Crossref
Emma Morrish, Gabriela Brumatti & John Silke. (2020) Future Therapeutic Directions for Smac-Mimetics. Cells 9:2, pages 406.
Crossref
Berrin Tuğrul & Merve İşseven. (2020) Tamoxifen - DEBIO 1143 kombinasyonunun östrojen reseptörü pozitif meme kanseri hücre hatlarındaki etkisi.. Pamukkale Medical Journal.
Crossref
Mudra Binju, Monica Angelica Amaya-Padilla, Graeme Wan, Hendra Gunosewoyo, Yohan Suryo Rahmanto & Yu Yu. (2019) Therapeutic Inducers of Apoptosis in Ovarian Cancer. Cancers 11:11, pages 1786.
Crossref
Rui Ding, Xin Wang, Wei Chen, Zhi Li, Ai-li Wei, Qing-bin Wang, Ai-hua Nie & Li-li Wang. (2019) WX20120108, a novel IAP antagonist, induces tumor cell autophagy via activating ROS-FOXO pathway. Acta Pharmacologica Sinica 40:11, pages 1466-1479.
Crossref
Carlo Baggio, Parima Udompholkul, Luca Gambini, Ahmed F. Salem, Jennifer Jossart, J. Jefferson P. Perry & Maurizio Pellecchia. (2019) Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy. Journal of Medicinal Chemistry 62:20, pages 9188-9200.
Crossref
Pei‐Yao Fu, Bo Hu, Xiao‐Lu Ma, Zhang‐Fu Yang, Min‐Cheng Yu, Hai‐Xiang Sun, Ao Huang, Xin Zhang, Jian Wang, Zhi‐Qiang Hu, Chen‐Hao Zhou, Wei‐Guo Tang, Ren Ning, Yang Xu & Jian Zhou. (2018) New insight into BIRC3: A novel prognostic indicator and a potential therapeutic target for liver cancer. Journal of Cellular Biochemistry 120:4, pages 6035-6045.
Crossref
Benoît Thibault, Ludivine Genre, Augustin Le Naour, Clothilde Broca, Eliane Mery, Grégoire Vuagniaux, Jean Pierre Delord, Norbert Wiedemann & Bettina Couderc. (2018) DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death. Scientific Reports 8:1.
Crossref
Stacey-Lynn Paiva, Sara R. da Silva, Elvin D. de Araujo & Patrick T. Gunning. (2017) Regulating the Master Regulator: Controlling Ubiquitination by Thinking Outside the Active Site. Journal of Medicinal Chemistry 61:2, pages 405-421.
Crossref
Atsushi Yoshimori & Sei-Ichi Tanuma. 2018. Regulation of Signal Transduction in Human Cell Research. Regulation of Signal Transduction in Human Cell Research 199 218 .
Tomomi ToubaiCorinne RossiKatherine Oravecz-WilsonChen LiuCynthia ZajacShin-Rong Julia WuYaping SunHideaki FujiwaraHiroya Tamaki, Daniel PeltierMary RiwesIsrael HenigStuart BrabbsColin S. Duckett, Shaomeng WangPavan Reddy. (2017) IAPs protect host target tissues from graft-versus-host disease in mice. Blood Advances 1:19, pages 1517-1532.
Crossref
Rama Rathore, Jennifer E. McCallum, Elizabeth Varghese, Ana-Maria Florea & Dietrich Büsselberg. (2017) Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs). Apoptosis 22:7, pages 898-919.
Crossref
Taku Watanabe, Tatsuya Seki, Takashi Fukano, Asako Sakaue-Sawano, Satoshi Karasawa, Misaki Kubota, Hiroshi Kurokawa, Ken Inoue, Junichi Akatsuka & Atsushi Miyawaki. (2017) Genetic visualization of protein interactions harnessing liquid phase transitions. Scientific Reports 7:1.
Crossref
Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa & Alexander Pintzas. (2016) IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis. BMC Cancer 16:1.
Crossref
Yin Xu, Kaiqiang Wang & Qin Yu. (2016) FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases. Oncotarget 7:43, pages 70080-70091.
Crossref
Rahul Kumar & Gajendra P. S. Raghava. (2016) ApoCanD: Database of human apoptotic proteins in the context of cancer. Scientific Reports 6:1.
Crossref
Oscar Matzinger, David Viertl, Pelagia Tsoutsou, Linda Kadi, Stefania Rigotti, Claudio Zanna, Norbert Wiedemann, Marie-Catherine Vozenin, Grégoire Vuagniaux & Jean Bourhis. (2015) The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma. Radiotherapy and Oncology 116:3, pages 495-503.
Crossref
Tanmay M. Shekhar, Maja M. Green, David M. Rayner, Mark A. Miles, Suzanne M. Cutts & Christine J. Hawkins. (2015) Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 777, pages 23-32.
Crossref
Herbert I. Hurwitz, David C. Smith, Henry C. Pitot, Jeffrey M. Brill, Rashmi Chugh, Elisabeth Rouits, Joseph Rubin, John Strickler, Gregoire Vuagniaux, J. Mel Sorensen & Claudio Zanna. (2015) Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study. Cancer Chemotherapy and Pharmacology 75:4, pages 851-859.
Crossref
Wen-Pin Kao, Chao-Yu Yang, Tsung-Wei Su, Yin-Ting Wang, Yu-Chih Lo & Su-Chang Lin. (2014) The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling. Apoptosis 20:2, pages 174-195.
Crossref
Chien-An A. Hu, Kirsten White, Salina Torres, Mohammed-Ali Ishak, Laurel Sillerud, Yubin Miao, Zhihe Liu, Zhenglong Wu, Larry Sklar & Marianne Berwick. 2015. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 161 181 .
K E McCabe, K Bacos, D Lu, J R Delaney, J Axelrod, M D Potter, M Vamos, V Wong, N D P Cosford, R Xiang & D G Stupack. (2014) Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. Cell Death & Disease 5:10, pages e1496-e1496.
Crossref
Melissa K. Brunckhorst, Yin Xu, Rong Lu & Qin Yu. (2014) Angiopoietins Promote Ovarian Cancer Progression by Establishing a Procancer Microenvironment. The American Journal of Pathology 184:8, pages 2285-2296.
Crossref
Petra Obexer & Michael J. Ausserlechner. (2014) X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy. Frontiers in Oncology 4.
Crossref
Sebastian Stintzing & Heinz-Josef Lenz. (2014) Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach. Clinical Cancer Research 20:12, pages 3064-3070.
Crossref
Jing Lu, Qin Qin, Liang-Liang Zhan, Jia Liu, Hong-Cheng Zhu, Xi Yang, Chi Zhang, Li-Ping Xu, Zhe-Ming Liu, Di Wang, He-Qing Cui, Ciu-Ciu Meng, Jing Cai, Hong-Yan Cheng & Xin-Chen Sun. (2014) AT-406, an IAP Inhibitor, Activates Apoptosis and Induces Radiosensitization of Normoxic and Hypoxic Cervical Cancer Cells. Journal of Pharmacological Sciences 126:1, pages 56-65.
Crossref
Zahid H. Siddik. 2014. Cancer Drug Design and Discovery. Cancer Drug Design and Discovery 357 390 .
M Castells, D Milhas, C Gandy, B Thibault, A Rafii, J-P Delord & B Couderc. (2013) Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation. Cell Death & Disease 4:10, pages e887-e887.
Crossref
Darcy J. P. Bates & Lionel D. Lewis. (2013) Manipulating the apoptotic pathway: potential therapeutics for cancer patients. British Journal of Clinical Pharmacology 76:3, pages 381-395.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.