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Research Paper

The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models

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Pages 812-821 | Received 05 Mar 2012, Accepted 29 Apr 2012, Published online: 06 Jun 2012

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Jonay Poveda, Sara Vázquez‐Sánchez, Ana B Sanz, Alberto Ortiz, Luis M Ruilope & Gema Ruiz‐Hurtado. (2021) TWEAK–Fn14 as a common pathway in the heart and the kidneys in cardiorenal syndrome . The Journal of Pathology.
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Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Timothy G Whitsett, Jeffrey A Winkles, Walter N Hittlerman & Michael G Rosenblum. (2020) Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B. Journal for ImmunoTherapy of Cancer 8:2, pages e001138.
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Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Maria D. Sanchez-Niño, Maria C. Izquierdo, Alvaro C. Ucero, Alberto Ortiz & Ana B. Sanz. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1790 1800 .
Guanglei Hu, Weihui Zeng & Yumin Xia. (2017) TWEAK/Fn14 signaling in tumors. Tumor Biology 39:6, pages 101042831771462.
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Cheryl L. Armstrong, Rebeca Galisteo, Sharron A.N. Brown & Jeffrey A. Winkles. (2016) TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion. Oncotarget 7:49, pages 81474-81492.
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Didier Meulendijks, Ulrik N. Lassen, Lillian L. Siu, Alwin D.R. Huitema, Vaios Karanikas, Morten Mau-Sorensen, Derek J. Jonker, Aaron R. Hansen, Mary E. Simcox, Kathleen J. Schostack, Dean Bottino, Hua Zhong, Markus Roessler, Suzana M. Vega-Harring, Tiantom Jarutat, David Geho, Karen Wang, Mark DeMario, Glenwood D. Goss & Jan H.M. Schellens. (2016) Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors. Clinical Cancer Research 22:4, pages 858-867.
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Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Maria D. Sanchez-Niño, Maria C. Izquierdo, Alvaro C. Ucero, Alberto Ortiz & Ana B. Sanz. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 11 .
Francesc Xavier Avilés-Jurado, Ximena Terra, David Gómez, Joan Carles Flores, Antoni Raventós, Elsa Maymó-Masip, Xavier León, Vicente Serrano-Gonzalvo, Joan Vendrell, Enric Figuerola & Matilde R. Chacón. (2014) Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer. European Archives of Oto-Rhino-Laryngology 272:7, pages 1733-1741.
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Ulrik N. Lassen, Didier Meulendijks, Lilian L. Siu, Vaios Karanikas, Morten Mau-Sorensen, Jan H.M. Schellens, Derek J. Jonker, Aaron R. Hansen, Mary E. Simcox, Kathleen J. Schostack, Dean Bottino, Hua Zhong, Markus Roessler, Suzana M. Vega-Harring, Tiantom Jarutat, David Geho, Ka Wang, Mark DeMario & Glenwood D. Goss. (2015) A Phase I Monotherapy Study of RG7212, a First-in-Class Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Cancers. Clinical Cancer Research 21:2, pages 258-266.
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Ludmilla de Plater, Anne Vincent-Salomon, Frédérique Berger, André Nicolas, Sophie Vacher, Eléonore Gravier, Aurélie Thuleau, Narjesse Karboul, Marion Richardson, Clément Elbaz, Elisabetta Marangoni, Ivan Bièche, Xavier Paoletti, Sergio Roman-Roman, Patricia A. Culp, Bernard Asselain, Véronique Diéras & Didier Decaudin. (2014) Predictive Gene Signature of Response to the Anti-TweakR mAb PDL192 in Patient-Derived Breast Cancer Xenografts. PLoS ONE 9:11, pages e104227.
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Hong Zhou, Khalid A. Mohamedali, Ana Maria Gonzalez-Angulo, Yu Cao, Mary Migliorini, Lawrence H. Cheung, Janine LoBello, Xiudong Lei, Yuan Qi, Walter N. Hittelman, Jeffrey A. Winkles, Nhan L. Tran & Michael G. Rosenblum. (2014) Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC. Molecular Cancer Therapeutics 13:11, pages 2688-2705.
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Hong Zhou, Walter N. Hittelman, Hideo Yagita, Lawrence H. Cheung, Stuart S. Martin, Jeffrey A. Winkles & Michael G. Rosenblum. (2013) Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors. Cancer Research 73:14, pages 4439-4450.
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Sharron A. N. Brown, Emily Cheng, Mark S. Williams & Jeffrey A. Winkles. (2013) TWEAK-Independent Fn14 Self-Association and NF-κB Activation Is Mediated by the C-Terminal Region of the Fn14 Cytoplasmic Domain. PLoS ONE 8:6, pages e65248.
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INGVILD PETTERSEN, NINIB BARYAWNO, FRIDA ABEL, WENCHE HELEN BAKKELUND, SVETLANA N. ZYKOVA, JAN-OLOF WINBERG, UGO MOENS, AGNES RASMUSON, PER KOGNER, JOHN INGE JOHNSEN & BALDUR SVEINBJÖRNSSON. (2013) Expression of TWEAK/Fn14 in neuroblastoma: Implications in tumorigenesis. International Journal of Oncology 42:4, pages 1239-1248.
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Michael Croft, Chris A. Benedict & Carl F. Ware. (2013) Clinical targeting of the TNF and TNFR superfamilies. Nature Reviews Drug Discovery 12:2, pages 147-168.
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Mark S. Chapman, Lan Wu, Aldo Amatucci, Steffan N. Ho & Jennifer S. Michaelson. (2013) TWEAK signals through JAK–STAT to induce tumor cell apoptosis. Cytokine 61:1, pages 210-217.
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