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Cancer Biology & Therapy Volume 13, 2012 - Issue 10
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Research Paper

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

Olga Frolova Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Ismael Samudio Ponitificia Universidad Javeriana; Bogota, Colombia
,
Juliana Maria Benito Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Rodrigo Jacamo Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Steven M. Kornblau Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Lymphoma/Myeloma; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Ana Markovic Department of Stem Cell Transplantation and Cellular Therapy; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Wendy Schober Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Hongbo Lu Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Yi Hua Qiu Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Daniela Buglio Department of Lymphoma/Myeloma; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Teresa McQueen Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Sherry Pierce Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Elizabeth J. Shpall Department of Stem Cell Transplantation and Cellular Therapy; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Sergej Konoplev Department of Hematopathology; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Deborah Thomas Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Hagop Kantarjian Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Richard Lock Department of Stem Cell Transplantation and Cellular Therapy; The University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Michael Andreeff Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Stem Cell Transplantation and Cellular Therapy; The University of Texas MD Anderson Cancer Center; Houston, TX USA
&
Marina Konopleva Department of Leukemia; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Stem Cell Transplantation and Cellular Therapy; The University of Texas MD Anderson Cancer Center; Houston, TX USACorrespondence[email protected]
 show all
Pages 858-870 | Received 19 Dec 2011, Accepted 22 May 2012, Published online: 01 Aug 2012

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Daniela Magliulo & Rosa Bernardi. (2018) HIF-α factors as potential therapeutic targets in leukemia. Expert Opinion on Therapeutic Targets 22:11, pages 917-928.
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Ping Liu, Haijun Zhang, Xue Wu, Liting Guo, Fei Wang, Guohua Xia, Baoan Chen, HaiXiang Yin, Yonglu Wang & Xueming Li. (2016) Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells. OncoTargets and Therapy 9, pages 5049-5059.
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Kevin Rouault-Pierre, Ashley Hamilton & Dominique Bonnet. (2016) Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact. Expert Opinion on Biological Therapy 16:4, pages 463-476.
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Yu-Yang Pang, Ting Wang, Fang-Yuan Chen, Ying-Li Wu, Xia Shao, Fei Xiao, Hong-Hui Huang, Hua Zhong & Ji-Hua Zhong. (2015) Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC. Leukemia & Lymphoma 56:6, pages 1821-1830.
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Vanessa S. Silveira, Bruno M. R. Freire, Kleiton S. Borges, Augusto F. Andrade, Gustavo A. V. Cruzeiro, João Paulo J. Sabino, Mogens Lesner Glass, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone & Carlos Alberto Scrideli. (2014) Hypoxia-related gene expression profile in childhood acute lymphoblastic leukemia: prognostic implications. Leukemia & Lymphoma 55:8, pages 1751-1757.
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Wei Zhang, Bao-an Chen, Jun-fei Jin, You-ji He & Yi-qi Niu. (2013) Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells in hypoxia by 5-bromotetrandrine. Leukemia & Lymphoma 54:11, pages 2506-2516.
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