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Cancer Biology & Therapy Volume 13, 2012 - Issue 10
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Research Paper

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth

YiWei Zhang Department of Biochemistry and Molecular Biology and Tulane Cancer Center; Tulane University School of Medicine; New Orleans, LA USA
,
Qi Zhang Department of Biochemistry and Molecular Biology and Tulane Cancer Center; Tulane University School of Medicine; New Orleans, LA USA
,
Shelya X. Zeng Department of Biochemistry and Molecular Biology and Tulane Cancer Center; Tulane University School of Medicine; New Orleans, LA USA
,
Yu Zhang Department of Obstetrics and Gynecology; Xiangya Hospital; Central South University; Changsha, China
,
Lindsey D. Mayo Herman B. Wells Center for Pediatric Research; Department of Pediatrics; Indiana University School of Medicine-Simon Cancer Center; Indianapolis, IN USA
&
Hua Lu Department of Biochemistry and Molecular Biology and Tulane Cancer Center; Tulane University School of Medicine; New Orleans, LA USACorrespondence[email protected]
Pages 915-924 | Received 14 Mar 2012, Accepted 22 May 2012, Published online: 01 Aug 2012

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Mohammad A. Alfhili, Essa Alsalmi, Abdullah Aljedai, Jawaher Alsughayyir, Manal Abudawood & Ahmed M. Basudan. (2022) Calcium-oxidative stress signaling axis and casein kinase 1α mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin. Journal of Chemotherapy 34:4, pages 247-257.
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Ji Hoon Jung, Jun-Ming Liao, Qi Zhang, Shelya Zeng, Daniel Nguyen, Qian Hao, Xiang Zhou, Bo Cao, Sung-Hoon Kim & Hua Lu. (2015) Inauhzin(c) Inactivates c-Myc Independently of p53. Cancer Biology & Therapy 16:3, pages 412-419.
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Shailendra Kapoor. (2013) The emerging anti-proliferative role of Nutlin-3 in the pathogenesis of systemic malignancies. Cancer Biology & Therapy 14:1, pages 5-5.
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Articles from other publishers (15)

Jia-yi Yin, Xin-tong Lu, Meng-ling Hou, Ting Cao & Zhen Tian. (2023) Sirtuin1-p53: A potential axis for cancer therapy. Biochemical Pharmacology 212, pages 115543.
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Tao Zhang, Ling Hu, Jia-Feng Tang, Hang Xu, Kuan Tian, Meng-Na Wu, Shi-Ying Huang, Yu-Mei Du, Peng Zhou, Rui-Jin Lu, Shuang He, Jia-Mei Xu, Jian-Jun Si, Jing Li, Di-Long Chen & Jian-Hua Ran. (2021) Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines. Molecules 26:7, pages 1990.
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Hongsai Chen, Lu Xue, He Huang, Hantao Wang, Xiaoman Zhang, Weidong Zhu, Zhigang Wang, Zhaoyan Wang & Hao Wu. (2018) Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors. EBioMedicine 36, pages 252-265.
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Daniel Nguyen, Wenjuan Liao, Shelya X. Zeng & Hua Lu. (2017) Reviving the guardian of the genome: Small molecule activators of p53. Pharmacology & Therapeutics 178, pages 92-108.
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Shang-Jui Wang, Dawei Li, Yang Ou, Le Jiang, Yue Chen, Yingming Zhao & Wei Gu. (2016) Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression. Cell Reports 17:2, pages 366-373.
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Jun-Ming Liao, Bo Cao, Jun Deng, Xiang Zhou, Michael Strong, Shelya Zeng, Jianping Xiong, Erik Flemington & Hua Lu. (2016) TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. Scientific Reports 6:1.
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Wen-Ying Lee, Wai-Theng Lee, Chia-Hsiung Cheng, Ku-Chung Chen, Chih-Ming Chou, Chu-Hung Chung, Min-Siou Sun, Hung-Wei Cheng, Meng-Ni Ho & Cheng-Wei Lin. (2015) Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget 6:29, pages 27580-27595.
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Xiao-Lan Li. (2015) p53 mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation . World Journal of Gastroenterology 21:1, pages 84.
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Qi Zhang, Shelya X. Zeng & Hua Lu. (2015) Determination of maximum tolerated dose and toxicity of Inauhzin in mice. Toxicology Reports 2, pages 546-554.
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LIJIA ZHU, JI QI, CHRISTINE YA-CHI CHIAO, QIANG ZHANG, JOHN A. PORCOJrJr, DOUGLAS V. FALLER & YAN DAI. (2014) Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities. International Journal of Oncology 45:5, pages 2128-2136.
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Qi Zhang, Xiang Zhou, RuiZhi Wu, Amber Mosley, Shelya X Zeng, Zhen Xing & Hua Lu. (2014) The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. eLife 3.
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Qi Zhang, Shelya X. Zeng & Hua Lu. 2014. Mutant p53 and MDM2 in Cancer. Mutant p53 and MDM2 in Cancer 281 319 .
Yiwei Zhang, Qi Zhang, Shelya X Zeng, Qian Hao & Hua Lu. (2013) Inauhzin Sensitizes p53-Dependent Cytotoxicity and Tumor Suppression of Chemotherapeutic Agents. Neoplasia 15:5, pages 523-IN19.
Crossref
Jun-Ming Liao, Shelya X. Zeng, Xiang Zhou & Hua Lu. (2012) Global Effect of Inauhzin on Human p53-Responsive Transcriptome. PLoS ONE 7:12, pages e52172.
Crossref
Qi Zhang, Derong Ding, Shelya X. Zeng, Qi-Zhuang Ye & Hua Lu. (2012) Structure and Activity Analysis of Inauhzin Analogs as Novel Antitumor Compounds That Induce p53 and Inhibit Cell Growth. PLoS ONE 7:10, pages e46294.
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