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Review

Targeting Bcl-2 Related Proteins in Cancer Therapy

Pages 104-113 | Published online: 01 Mar 2003

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A.K. Zhu, H. Zhou, J.Z. Xia, H.C. Jin, K. Wang, J. Yan, J.B. Zuo, X. Zhu & T. Shan. (2013) Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway. Brazilian Journal of Medical and Biological Research 46:8, pages 670-675.
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Fei Xu, Jia Zang, Daozhen Chen, Ting Zhang, Huiying Zhan, Mudan Lu & Hongxiang Zhuge. (2012) Neohesperidin Induces Cellular Apoptosis in Human Breast Adenocarcinoma MDA-MB-231 Cells via Activating the Bcl-2/Bax-mediated Signaling Pathway. Natural Product Communications 7:11, pages 1934578X1200701.
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K.F. Huang, G.D. zhang, Y.Q. Huang & Y. Diao. (2012) Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K–AKT pathway. International Immunopharmacology 12:2, pages 334-341.
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Carole Brosseau, Kay Colston, Angus George Dalgleish & Christine Galustian. (2011) The immunomodulatory drug lenalidomide restores a vitamin D sensitive phenotype to the vitamin D resistant breast cancer cell line MDA-MB-231 through inhibition of BCL-2: potential for breast cancer therapeutics. Apoptosis 17:2, pages 164-173.
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Haruo Nakano, Tatsuya Miyazawa, Keita Kinoshita, Yoji Yamada & Tetsuo Yoshida. (2010) Functional screening identifies a microRNA, miR‐491 that induces apoptosis by targeting Bcl‐X L in colorectal cancer cells . International Journal of Cancer 127:5, pages 1072-1080.
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Feng Wang, Marcia A. Ogasawara & Peng Huang. (2010) Small mitochondria-targeting molecules as anti-cancer agents. Molecular Aspects of Medicine 31:1, pages 75-92.
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Carsten Zwick, Gerhard Held, Vera Hammermeister, Adnan AlAhmad, Boris Kubuschok, Joerg Bittenbring, Manfred Ahlgrimm, Frank Neumann, Klaus-Dieter Preuss & Michael Pfreundschuh. (2009) Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas. Journal of Cancer Research and Clinical Oncology 135:9, pages 1207-1213.
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Jia-Jun Liu, Yan-Xu, Yong Zhang, Ruo-Zhi Xiao & Dong-Jun Lin. (2009) Peroxisome Proliferator-Activated Receptor γ (PPAR-γ) Agonist Rosiglitazone (RGZ) Inhibits HL-60 Cell Growth by Induction of Apoptosis. Laboratory Medicine 40:5, pages 297-302.
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Markus D. Siegelin, David E. Reuss, Antje Habel, Abdelhaq Rami & Andreas von Deimling. (2009) Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells. Neuro-Oncology 11:2, pages 122-131.
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Nathan Susnow, Liyun Zeng, Daciana Margineantu & David M. Hockenbery. (2009) Bcl-2 family proteins as regulators of oxidative stress. Seminars in Cancer Biology 19:1, pages 42-49.
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Markus D. Siegelin, David E. Reuss, Antje Habel, Christel Herold-Mende & Andreas von Deimling. (2008) The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin. Molecular Cancer Therapeutics 7:11, pages 3566-3574.
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Marju Gruno, Nadezhda Peet, Andres Tein, Riina Salupere, Meeli Sirotkina, Julio Valle, Ants Peetsalu & Enn K. Seppet. (2008) Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells. Journal of Gastroenterology 43:10, pages 780-788.
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Baorui Liu, Tingting Wang, Xiaoping Qian, Guangxia Liu, Lixia Yu & Yitao Ding. (2008) Anticancer effect of tetrandrine on primary cancer cells isolated from ascites and pleural fluids. Cancer Letters 268:1, pages 166-175.
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Tingting Wang, Jia Wei, Xiaoping Qian, Yitao Ding, Lixia Yu & Baorui Liu. (2008) Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells. Cancer Letters 262:2, pages 214-222.
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Abbes Belkhiri, Altaf A. Dar, Alexander Zaika, Mark Kelley & Wael El-Rifai. (2008) t-Darpp Promotes Cancer Cell Survival by Up-regulation of Bcl2 through Akt-Dependent Mechanism. Cancer Research 68:2, pages 395-403.
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Derek L. Stirewalt, Soheil Meshinchi, Kenneth J. Kopecky, Wenhong Fan, Era L. Pogosova-Agadjanyan, Julia H. Engel, Michelle R. Cronk, Kathleen Shannon Dorcy, Amy R. McQuary, David Hockenbery, Brent Wood, Shelly Heimfeld & Jerald P. Radich. (2008) Identification of genes with abnormal expression changes in acute myeloid leukemia. Genes, Chromosomes and Cancer 47:1, pages 8-20.
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Sebastian Bredow, Daniel E. Juri, Karen Cardon & Yohannes Tesfaigzi. (2007) Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region. Gene 404:1-2, pages 110-116.
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Pamela S. Schwartz, Michael K. Manion, Christine B. Emerson, John S. Fry, Craig M. Schulz, Ian R. Sweet & David M. Hockenbery. (2007) 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition. Molecular Cancer Therapeutics 6:7, pages 2073-2080.
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Jun-Feng Zhang, Jia-Jun Liu, Min-Qiang Lu, Chang-Jie Cai, Yang Yang, Hua Li, Chi Xu & Gui-Hua Chen. (2007) Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro. Transplant Immunology 17:3, pages 162-168.
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Kunihiko Nakazawa, Takahiro Nemoto, Tomoko Hata, Yousuke Seyama, Shunji Nagahara, Akihiko Sano, Hiroshi Itoh, Yutaka Nagai & Shunichiro Kubota. (2007) Single‐injection ornithine decarboxylase‐directed antisense therapy using atelocollagen to suppress human cancer growth. Cancer 109:5, pages 993-1002.
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J.-F. Zhang, P.-Q. Liu, G.-H. Chen, M.-Q. Lu, C.-J. Cai, Y. Yang & H. Li. (2007) Ponicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosis. Digestive and Liver Disease 39:2, pages 160-166.
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Jia-Jun Liu, Ren-Wei Huang, Dong-Jun Lin, Xiang-Yuan Wu, Jun Peng, Xiang-Lin Pan, Qu Lin, Ming Hou, Mao-Hong Zhang & Feng Chen. (2006) Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action. American Journal of Hematology 81:2, pages 86-94.
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Anumantha G. Kanthasamy, Masashi Kitazawa, Arthi Kanthasamy & Vellareddy Anantharam. (2005) Dieldrin-Induced Neurotoxicity: Relevance to Parkinson's Disease Pathogenesis. NeuroToxicology 26:4, pages 701-719.
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Mads Hald AndersenInge Marie SvanePia KvistborgOve Juul NielsenEva BalslevSine RekerJürgen C. BeckerPer thor Straten. (2005) Immunogenicity of Bcl-2 in patients with cancer. Blood 105:2, pages 728-734.
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