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Research Paper

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia

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Pages 1102-1111 | Received 18 May 2012, Accepted 17 Jun 2012, Published online: 16 Aug 2012

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Qing-jun Liu, Hong-liang Shen, Jun Lin, Xiu-hong Xu, Zheng-guo Ji, Xiao Han, Dong-hao Shang & Pei-qian Yang. (2016) Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways. Drug Design, Development and Therapy 10, pages 745-755.
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Sergey V Karakashev & Mauricio J Reginato. (2015) Progress toward overcoming hypoxia-induced resistance to solid tumor therapy. Cancer Management and Research 7, pages 253-264.
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