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Research Paper

Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner

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Pages 1221-1228 | Received 06 Jan 2012, Accepted 10 Jul 2012, Published online: 24 Aug 2012

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Jiali Yang, Juan Chen, Jinxi He, Jing Li, Juan Shi, William C. Cho & Xiaoming Liu. (2016) Wnt signaling as potential therapeutic target in lung cancer. Expert Opinion on Therapeutic Targets 20:8, pages 999-1015.
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Miribane Dërmaku-Sopjani, Selim Kolgeci, Sokol Abazi & Mentor Sopjani. (2013) Significance of the anti-aging protein Klotho. Molecular Membrane Biology 30:8, pages 369-385.
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Marana Abboud, Keren Merenbakh-Lamin, Hadas Volkov, Shira Ben-Neriah, Hagai Ligumsky, Sarai Bronfeld, Noa Keren-Khadmy, Moshe Giladi, Noam Shomron, Ido Wolf & Tami Rubinek. (2023) Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho. Oncogene.
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Kristina I. Nesterova, Yelena Yu. Glinka, Valentina N. Perfilova, Alla A. Nesterova & Kamil D. Kaplanov. (2023) Antiaging Klotho Protein as a Prospective Novel Tumor Suppressor. Annals of the Russian academy of medical sciences 78:1, pages 24-44.
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Emmanuelle Charrin, Dina Dabaghie, Ilke Sen, David Unnersjö-Jess, Katja Möller-Hackbarth, Mikhail Burmakin, Rik Mencke, Sonia Zambrano, Jaakko Patrakka & Hannes Olauson. (2023) Soluble Klotho protects against glomerular injury through regulation of ER stress response. Communications Biology 6:1.
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Hagai Ligumsky, Keren Merenbakh-Lamin, Noa Keren-Khadmy, Ido Wolf & Tami Rubinek. (2022) The role of α-klotho in human cancer: molecular and clinical aspects. Oncogene 41:40, pages 4487-4497.
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Bo Chen, Hongye Zhao, Min Li, Quan She, Wen Liu, Jiayi Zhang, Weihong Zhao, Shuhong Huang & Jianqing Wu. (2022) SHANK1 facilitates non-small cell lung cancer processes through modulating the ubiquitination of Klotho by interacting with MDM2. Cell Death & Disease 13:4.
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Bruna Borges, Pedro Do Amaral, Luiz Soldi, Victor Silva, Fernanda De Souza, Felipe Cordeiro Da Luz, Rogério De Araújo & Marcelo Silva. (2022) Undetected αKlotho in serum is associated with the most aggressive phenotype of breast cancer. Molecular and Clinical Oncology 16:4.
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Vsevolod V. Melekhin, Alexander I. Ponomarev, Maria A. Desyatova & Oleg G. Makeev. (2022) Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma Cells. Journal of Molecular Neuroscience 72:2, pages 401-409.
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Jiayi Shen, Huaqiang Zhou, Jiaqing Liu, Yaxiong Zhang, Ting Zhou, Gang Chen, Wenfeng Fang, Yunpeng Yang, Yan Huang & Li Zhang. (2021) Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis. Frontiers in Genetics 12.
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Chou-Long Huang & Orson W. Moe. 2021. Fibroblast Growth Factor 23. Fibroblast Growth Factor 23 233 240 .
Judit Pako, Andras Bikov, Imre Barta, Hideyo Matsueda, Rita Puskas, Gabriella Galffy, Anna Kerpel-Fronius, Balazs Antus & Ildiko Horvath. (2018) Assessment of the circulating klotho protein in lung cancer patients. Pathology & Oncology Research 26:1, pages 233-238.
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Liyan Lv, Min Zhou, Jian Zhang, Fang Liu, Li Qi, Shuai Zhang, Yi Bi & Yan Yu. (2019) SOX6 suppresses the development of lung adenocarcinoma by regulating expression of p53, p21 CIPI , cyclin D1 and β‐catenin . FEBS Open Bio 10:1, pages 135-146.
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Jianning Zhang, Khoa Cao, Johanne V. Pastor, Liping Li, Orson W. Moe & Connie C. W. Hsia. (2019) Alpha‐Klotho, a critical protein for lung health, is not expressed in normal lung. FASEB BioAdvances 1:11, pages 675-687.
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Bo Chen, Shuhong Huang, Thomas R. Pisanic, II, Alejandro Stark, Yong Tao, Bei Cheng, Yue Li, Yunyan Wei, Weihong Zhao, Tza-Huei Wang & Jianqing Wu. (2019) Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer. eBioMedicine 49, pages 118-132.
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Naama Peshes-Yeloz, Lior Ungar, Anton Wohl, Elad Jacoby, Tamar Fisher, Moshe Leitner, Dvora Nass, Tamar Rubinek, Ido Wolf & Zvi R. Cohen. (2019) Role of Klotho Protein in Tumor Genesis, Cancer Progression, and Prognosis in Patients with High-Grade Glioma. World Neurosurgery 130, pages e324-e332.
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Zikuan Song, Haoyu Wang & Shuang Zhang. (2019) Negative regulators of Wnt signaling in non-small cell lung cancer: Theoretical basis and therapeutic potency. Biomedicine & Pharmacotherapy 118, pages 109336.
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Maryam Abolghasemi, Tooba Yousefi, Mahmood Maniati & Durdi Qujeq. (2019) The interplay of Klotho with signaling pathway and microRNAs in cancers. Journal of Cellular Biochemistry 120:9, pages 14306-14317.
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Tammi Arbel Rubinstein, Shiri Shahmoon, Ehud Zigmond, Tal Etan, Keren Merenbakh-Lamin, Metsada Pasmanik-Chor, Gil Har-Zahav, Iris Barshack, Gilad W. Vainer, Nir Skalka, Rina Rosin-Arbesfeld, Chen Varol, Tami Rubinek & Ido Wolf. (2018) Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene 38:6, pages 794-807.
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Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai & Xinxiang Li. (2018) Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis. Cell Communication and Signaling 16:1.
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Lu‐Hong Cong, Shi‐Yu Du, Yi‐Na Wu, Ying Liu, Tao Li, Hui Wang, Gang Li & Jun Duan. (2018) Retracted : Upregulation of Klotho potentially inhibits pulmonary vascular remodeling by blocking the activation of the Wnt signaling pathway in rats with PM2.5‐induced pulmonary arterial hypertension . Journal of Cellular Biochemistry 119:7, pages 5581-5597.
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Amiq Gazdhar, Priya Ravikumar, Johanne Pastor, Manfred Heller, Jianfeng Ye, Jianning Zhang, Orson W. Moe, Thomas Geiser & Connie C. W. Hsia. (2018) Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury. Stem Cells 36:4, pages 616-625.
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Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv & Xin Wang. (2017) Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma. Journal of Hematology & Oncology 10:1.
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Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei & Judit E. Pongracz. (2017) WNT signaling – lung cancer is no exception. Respiratory Research 18:1.
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George D. Dalton, Jian Xie, Sung-Wan An & Chou-Long Huang. (2017) New Insights into the Mechanism of Action of Soluble Klotho. Frontiers in Endocrinology 8.
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Rik Mencke, Hannes Olauson & Jan-Luuk Hillebrands. (2017) Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies. Advanced Drug Delivery Reviews 121, pages 85-100.
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. 2017. Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects. Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects 13 30 .
Hannes Olauson, Rik Mencke, Jan-Luuk Hillebrands & Tobias E. Larsson. (2017) Tissue expression and source of circulating αKlotho. Bone 100, pages 19-35.
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Xiangxiang Zhou, Ya Zhang, Ying Li, Yangyang Xu, Lingyan Zhang, Ying Li & Xin Wang. (2017) Klotho suppresses tumor progression via inhibiting IGF-1R signaling in T-cell lymphoma. Oncology Reports 38:2, pages 967-974.
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TianJun ChenHui RenAsmitanand ThakurTian YangYang LiShuo ZhangTing WangMingWei Chen. (2016) Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy. DNA and Cell Biology 35:12, pages 751-757.
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Yan Huang, Qiang Du, Weibao Wu, Feifei She & Yanling Chen. (2016) Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins. Molecular Medicine Reports 14:3, pages 2573-2581.
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DONG DAI, QI WANG, XIAOFENG LI, JIANJING LIU, XIAOYING MA & WENGUI XU. (2016) Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1. Oncology Reports 35:1, pages 552-558.
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T. Rubinek & I. Wolf. 2016. Klotho. Klotho 197 214 .
Huidong Sun, Yanchao Gao, Kemei Lu, Guimei Zhao, Xuehua Li, Zhu Li & Hong Chang. (2015) Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway. World Journal of Surgical Oncology 13:1.
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Margherita Gigante, Giuseppe Lucarelli, Chiara Divella, Giuseppe Stefano Netti, Paola Pontrelli, Cesira Cafiero, Giuseppe Grandaliano, Giuseppe Castellano, Monica Rutigliano, Giovanni Stallone, Carlo Bettocchi, Pasquale Ditonno, Loreto Gesualdo, Michele Battaglia & Elena Ranieri. (2015) Soluble Serum αKlotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma. Medicine 94:45, pages e1917.
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Hagai Ligumsky, Tami Rubinek, Keren Merenbakh-Lamin, Adva Yeheskel, Rotem Sertchook, Shiri Shahmoon, Sarit Aviel-Ronen & Ido Wolf. (2015) Tumor Suppressor Activity of Klotho in Breast Cancer Is Revealed by Structure–Function Analysis. Molecular Cancer Research 13:10, pages 1398-1407.
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Xiangxiang Zhou & Xin Wang. (2014) Klotho: a novel biomarker for cancer. Journal of Cancer Research and Clinical Oncology 141:6, pages 961-969.
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Junchao Huang, Chengchao Sun, Suqing Wang, Qiqiang He & Dejia Li. (2015) microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells. Molecular BioSystems 11:7, pages 2051-2059.
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Ci-Di Chen, Hu Li, Jennifer Liang, Kathryn Hixson, Ella Zeldich & Carmela R. Abraham. (2014) The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line. Journal of Molecular Neuroscience 55:1, pages 76-90.
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XIN-XIANG LI, LI-YONG HUANG, JUN-JIE PENG, LEI LIANG, DE-BING SHI, HONG-TU ZHENG & SAN-JUN CAI. (2014) Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway. International Journal of Oncology 45:2, pages 611-618.
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Christoph Schmid, Marian C Neidert, Oliver Tschopp, Lisa Sze & René L Bernays. (2013) Growth hormone and Klotho. Journal of Endocrinology 219:2, pages R37-R57.
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Martina Feger, Abul Fajol, Aleksandra Lebedeva, Adrian Meissner, Diana Michael, Jakob Voelkl, Ioana Alesutan, Erwin Schleicher, Christoph Reichetzeder, Berthold Hocher, Syed M. Qadri & Florian Lang. (2013) Effect of Carbon Monoxide Donor CORM-2 on Vitamin D<sub>3</sub> Metabolism. Kidney and Blood Pressure Research 37:4-5, pages 496-505.
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