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Cancer Biology & Therapy Volume 13, 2012 - Issue 13
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Research Paper

Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea

Joanne M. Bowen School of Medical Sciences; University of Adelaide; Adelaide, SA AustraliaCorrespondence[email protected]
,
Bronwen J. Mayo RAH Cancer Centre; Royal Adelaide Hospital; Adelaide, SA Australia
,
Erin Plews RAH Cancer Centre; Royal Adelaide Hospital; Adelaide, SA Australia
,
Emma Bateman RAH Cancer Centre; Royal Adelaide Hospital; Adelaide, SA Australia
,
Andrea M. Stringer School of Pharmacy and Medical Sciences; University of South Australia; Adelaide, SA Australia
,
Frances M. Boyle Sydney Medical School (Northern); University of Sydney; Sydney, NSW Australia
,
John W. Finnie Hanson Institute; SA Pathology; Adelaide, SA Australia
&
Dorothy M.K. Keefe RAH Cancer Centre; Royal Adelaide Hospital; Adelaide, SA Australia; Hanson Institute; SA Pathology; Adelaide, SA Australia
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Pages 1269-1275 | Received 30 Mar 2012, Accepted 08 Aug 2012, Published online: 16 Aug 2012

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Omar Abdel-Rahman & Mona Fouad. (2014) Risk of selected gastrointestinal toxicities in breast cancer patients treated with regimens containing lapatinib; a pooled analysis of randomized controlled studies. Expert Review of Anticancer Therapy 14:10, pages 1229-1242.
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Articles from other publishers (25)

Jingjiang Lai, Xiaoli Zhuo, Ke Yin, Fengxian Jiang, Lei Liu, Xiaoying Xu, Hongjing Liu, Jingliang Wang, Jing Zhao, Wei Xu, Shuping Yang, Honglin Guo, Xiaotian Yuan, Xiaoyan Lin, Fanghua Qi & Guobin Fu. (2023) Potential mechanism of pyrotinib-induced diarrhea was explored by gut microbiome and ileum metabolomics. Anti-Cancer Drugs 34:6, pages 747-762.
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Jingjiang Lai, Fengxian Jiang, Xiaoli Zhuo, Xiaoying Xu, Lei Liu, Ke Yin, Jingliang Wang, Jing Zhao, Wei Xu, Hongjing Liu, Xuan Wang, Wen Jiang, Ke Wang, Shuping Yang, Honglin Guo, Fanghua Qi, Xiaotian Yuan, Xiaoyan Lin & Guobin Fu. (2022) Effects of Shenling Baizhu powder on pyrotinib-induced diarrhea: analysis of gut microbiota, metabonomics, and network pharmacology. Chinese Medicine 17:1.
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Kate R. Secombe, Imogen A. Ball, Anthony D. Wignall, Emma Bateman, Dorothy M. Keefe & Joanne M. Bowen. (2022) Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats. Neoplasia 30, pages 100806.
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Raja Nur Firzanah Syaza Raja Sharin, Jesmine Khan, Mohamad Johari Ibahim, Mudiana Muhamad, Joanne Bowen & Wan Nor I’zzah Wan Mohamad Zain. (2022) Role of ErbB1 in the Underlying Mechanism of Lapatinib-Induced Diarrhoea: A Review. BioMed Research International 2022, pages 1-13.
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Yumi Harada, Hitomi Sekine, Kunitsugu Kubota, Daichi Sadatomi, Seiichi Iizuka & Naoki Fujitsuka. (2021) Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats. Biomedicine & Pharmacotherapy 141, pages 111860.
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Gabriel Tao & Pavan Kumar Chityala. (2021) Epidermal growth factor receptor inhibitor-induced diarrhea: clinical incidence, toxicological mechanism, and management. Toxicology Research 10:3, pages 476-486.
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Kate R. Secombe, Imogen A. Ball, Joseph Shirren, Anthony D. Wignall, Dorothy M. Keefe & Joanne M. Bowen. (2020) Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant. Breast Cancer 28:1, pages 99-109.
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Bronwen J. Mayo, Kate R. Secombe, Anthony D. Wignall, Emma Bateman, Daniel Thorpe, Claudio Pietra, Dorothy M. Keefe & Joanne M. Bowen. (2020) The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats. Cancer Chemotherapy and Pharmacology 85:4, pages 793-803.
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Tomoki Yoneyama, Kojo Abdul‐Hadi, Adam Brown, Emily Guan, Matt Wagoner & Andy Z.X. Zhu. (2019) A Citrulline‐Based Translational Population System Toxicology Model for Gastrointestinal‐Related Adverse Events Associated With Anticancer Treatments. CPT: Pharmacometrics & Systems Pharmacology 8:12, pages 951-961.
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Jame Abraham, Albert J. Montero, Rachel C. Jankowitz, Mohamad Adham Salkeni, Jan H. Beumer, Brian F. Kiesel, Fanny Piette, Laura M. Adamson, Rebecca J. Nagy, Richard B. Lanman, Jeff Sperinde, Weidong Huang, Carmen J. Allegra, Ashok Srinivasan, Ying Wang, Katherine L. Pogue-Geile, Peter C. Lucas & Samuel A. Jacobs. (2019) Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10. Journal of Clinical Oncology 37:29, pages 2601-2609.
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Hope S. Rugo, Jack A. Di Palma, Debu Tripathy, Richard Bryce, Susan Moran, Elizabeth Olek & Linda Bosserman. (2019) The characterization, management, and future considerations for ErbB-family TKI-associated diarrhea. Breast Cancer Research and Treatment 175:1, pages 5-15.
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Kate R. Secombe, Imogen A. Ball, Joseph Shirren, Anthony D. Wignall, John Finnie, Dorothy Keefe, Francesca Avogadri-Connors, Elizabeth Olek, David Martin, Susan Moran & Joanne M. Bowen. (2018) Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model. Cancer Chemotherapy and Pharmacology 83:3, pages 531-543.
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Alice M. C. Lee, Joanne M. Bowen, Yu‐Wen Su, Erin Plews, Rosa Chung, Dorothy M. K. Keefe & Cory J. Xian. (2018) Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats. Journal of Cellular Biochemistry 120:3, pages 4180-4191.
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Tianying Duan, Onur Cil, Jay R. Thiagarajah & Alan S. Verkman. (2019) Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight 4:4.
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Rachel L. Kovac, Gregory Ballash, Joelle Fenger, Cheryl London & Emma Warry. (2018) Plasma cytokeratin-18 concentrations as noninvasive biomarker of early gastrointestinal toxicosis in dogs receiving toceranib. Journal of Veterinary Internal Medicine 32:6, pages 2061-2068.
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Ysabella Z.A. Van Sebille, Rachel J. Gibson, Hannah R. Wardill, Imogen A. Ball, Dorothy M.K. Keefe & Joanne M. Bowen. (2018) Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer. International Journal of Cancer 142:2, pages 369-380.
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Rachel J.  Gibson, Ysabella Z.A. van Sebille, Hannah R. Wardill, Anthony Wignall, Joseph Shirren, Imogen A. Ball, Nicole Williams, Kiara Wanner & Joanne M. Bowen. (2018) Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model. Chemotherapy 63:5, pages 284-292.
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Ysabella Z.A. Van Sebille, Rachel J. Gibson, Hannah R. Wardill, Kate R. Secombe, Imogen A. Ball, Dorothy M.K. Keefe, John W. Finnie & Joanne M. Bowen. (2017) Dacomitinib‐induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats. International Journal of Cancer 140:12, pages 2820-2829.
Crossref
Ysabella Z.A. Van Sebille, Rachel J. Gibson, Hannah R. Wardill & Joanne M. Bowen. (2016) Gastrointestinal toxicities of first and second-generation small molecule human epidermal growth factor receptor tyrosine kinase inhibitors in advanced nonsmall cell lung cancer. Current Opinion in Supportive & Palliative Care 10:2, pages 152-156.
Crossref
Ysabella Z.A. Van Sebille, Rachel J. Gibson, Hannah R. Wardill & Joanne M. Bowen. (2015) ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis. Cancer Treatment Reviews 41:7, pages 646-652.
Crossref
Joanne M. Bowen, Bronwen J. Mayo, Erin Plews, Emma Bateman, Anthony Wignall, Andrea M. Stringer, Frances M. Boyle & Dorothy M. K. Keefe. (2014) Determining the mechanisms of lapatinib-induced diarrhoea using a rat model. Cancer Chemotherapy and Pharmacology 74:3, pages 617-627.
Crossref
Joanne M. Bowen. (2014) Development of the Rat Model of Lapatinib-Induced Diarrhoea. Scientifica 2014, pages 1-6.
Crossref
Noor Al-Dasooqi, Stephen T. Sonis, Joanne M. Bowen, Emma Bateman, Nicole Blijlevens, Rachel J. Gibson, Richard M. Logan, Raj G. Nair, Andrea M. Stringer, Roger Yazbeck, Sharon Elad & Rajesh V. Lalla. (2013) Emerging evidence on the pathobiology of mucositis. Supportive Care in Cancer 21:11, pages 3233-3241.
Crossref
Noor Al-Dasooqi, Stephen T. Sonis, Joanne M. Bowen, Emma Bateman, Nicole Blijlevens, Rachel J. Gibson, Richard M. Logan, Raj G. Nair, Andrea M. Stringer, Roger Yazbeck, Sharon Elad & Rajesh V. Lalla. (2013) Emerging evidence on the pathobiology of mucositis. Supportive Care in Cancer 21:7, pages 2075-2083.
Crossref
Joanne M. Bowen. (2013) Mechanisms of TKI-induced diarrhea in cancer patients. Current Opinion in Supportive & Palliative Care 7:2, pages 162-167.
Crossref

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