2,789
Views
62
CrossRef citations to date
0
Altmetric
Research Paper

Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo

, , , , , & show all
Pages 1425-1435 | Received 04 May 2012, Accepted 29 Aug 2012, Published online: 06 Sep 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Paul M Bingham, Shawn D Stuart & Zuzana Zachar. (2014) Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy. Expert Review of Clinical Pharmacology 7:6, pages 837-846.
Read now
Antonio Macciò & Clelia Madeddu. (2013) Cisplatin: an old drug with a newfound efficacy – from mechanisms of action to cytotoxicity. Expert Opinion on Pharmacotherapy 14:13, pages 1839-1857.
Read now

Articles from other publishers (59)

Yaoyun Duan, Juan Yu, Miaojuan Chen, Qinsheng Lu, Fen Ning, Xiaowen Gan, Hanbo Liu, Yixin Ye, Shenjiao Lu & Gendie E. Lash. (2023) Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). Journal of Ovarian Research 16:1.
Crossref
Amit Kumar Tripathi, Anup Kumar Ray, Sunil Kumar Mishra, Siddharth Mall Bishen, Hirdyesh Mishra & Aman Khurana. (2023) Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention. Revista Brasileira de Farmacognosia 33:2, pages 272-287.
Crossref
Tomas Koltai, Larry Fliegel, Fátima Baltazar, Stephan J. Reshkin, Khalid O. Alfarouk, Rosa Angela Cardone & Julieta Afonso. 2023. pH Deregulation as the Eleventh Hallmark of Cancer. pH Deregulation as the Eleventh Hallmark of Cancer 137 150 .
Anja Divković, Kristina Radić, Damir Sabitović, Nikolina Golub, Marija Grdić Rajković, Ivana Rumora Samarin, Zinaida Karasalihović, Adnan Šerak, Emir Trnačević, Petra Turčić, Dražan Butorac & Dubravka Vitali Čepo. (2022) Effect of Alpha-Lipoic Acid Supplementation on Low-Grade Squamous Intraepithelial Lesions—Double-Blind, Randomized, Placebo-Controlled Trial. Healthcare 10:12, pages 2434.
Crossref
Weiyu Chen, Lingyun Xu, Edwin Chang, Gayatri Gowrishankar, Katherine W. Ferrara & Sanjiv Sam Gambhir. (2022) Alternative medicine: therapeutic effects on gastric original signet ring carcinoma via ascorbate and combination with sodium alpha lipoate. BMC Complementary Medicine and Therapies 22:1.
Crossref
Xiao Liu, Dominik Wenisch, Marie-Christin Barth, Klaudia Cseh, Christian R. Kowol, Michael A. Jakupec, Dan Gibson, Bernhard K. Keppler & Wolfgang Weigand. (2022) Novel oxaliplatin( iv ) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs . Dalton Transactions 51:44, pages 16824-16835.
Crossref
Shao-yang Lv, Suisui He, Xiao-li Ling, Yue-qin Wang, Cong Huang, Jin-rong Long, Jia-qi Wang, Yang Qin, Hua Wei & Cui-Yun Yu. (2022) Review of lipoic acid: From a clinical therapeutic agent to various emerging biomaterials. International Journal of Pharmaceutics 627, pages 122201.
Crossref
Xiao Liu, Marie‐Christin Barth, Klaudia Cseh, Christian R. Kowol, Michael A. Jakupec, Bernhard K. Keppler, Dan Gibson & Wolfgang Weigand. (2022) Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity. Chemistry & Biodiversity 19:10.
Crossref
Zhili Ding, Yunfeng Xiong, Jinxian Zheng, Dongsheng Zhou, Youqin Kong, Changle Qi, Yan Liu, Jinyun Ye & Samwel Mchele Limbu. (2022) Modulation of growth, antioxidant status, hepatopancreas morphology, and carbohydrate metabolism mediated by alpha-lipoic acid in juvenile freshwater prawns Macrobrachium nipponense under two dietary carbohydrate levels. Aquaculture 546, pages 737314.
Crossref
Aleksandar Rašović. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 766 833 .
Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand & Javad Heshmati. (2021) Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis. Journal of Functional Foods 87, pages 104774.
Crossref
Panagiotis Theodosis-Nobelos, Georgios Papagiouvannis, Paraskevi Tziona & Eleni A. Rekka. (2021) Lipoic acid. Kinetics and pluripotent biological properties and derivatives. Molecular Biology Reports 48:9, pages 6539-6550.
Crossref
Philippe Icard, Mauro Loi, Zherui Wu, Antonin Ginguay, Hubert Lincet, Edouard Robin, Antoine Coquerel, Diana Berzan, Ludovic Fournel & Marco Alifano. (2021) Metabolic Strategies for Inhibiting Cancer Development. Advances in Nutrition 12:4, pages 1461-1480.
Crossref
Benedikt Feuerecker, Philipp Biechl, Christian Veltkamp, Dieter Saur & Wolfgang Eisenreich. (2021) Metabolic Response of Pancreatic Carcinoma Cells under Treatment with Dichloroacetate. Metabolites 11:6, pages 350.
Crossref
Nadezhda T. Zhilinskaya, Vladimir G. Bespalov, Alexander L. Semenov, Elena D. Ermakova, Grigory V. Tochilnikov, Nadezhda V. Barakova, Valerii A. Alexandrov & Denis A. Baranenko. (2021) Cisplatin effect on digital cytomorphometric and bioinformatic tumor cell characteristics in rat ovarian cancer model–a preliminary study. Pharmacological Reports 73:2, pages 642-649.
Crossref
Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy & Shadab Md. (2021) Development and In Vitro Evaluation of 2-Methoxyestradiol Loaded Polymeric Micelles for Enhancing Anticancer Activities in Prostate Cancer. Polymers 13:6, pages 884.
Crossref
Rati Kailash Prasad Tripathi & Senthil Raja Ayyannan. (2020) Emerging chemical scaffolds with potential SHP2 phosphatase inhibitory capabilities – A comprehensive review. Chemical Biology & Drug Design 97:3, pages 721-773.
Crossref
Anca Pop, Simona Crișan, Maria Bârcă, Anne-Marie Ciobanu, Valentin Varlas, Coriolan Pop, Mariana-Ana Pali, Dumitru Cauni, Emma Ozon, Denisa Udeanu, Simona Trifu & Bogdana Năsui. (2021) Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid. Processes 9:1, pages 176.
Crossref
Ilya V. Ozhogin, Peter V. Zolotukhin, Eugene L. Mukhanov, Irina A. Rostovtseva, Nadezhda I. Makarova, Valery V. Tkachev, Darya K. Beseda, Anatoly V. Metelitsa & Boris S. Lukyanov. (2021) Novel molecular hybrids of indoline spiropyrans and α-lipoic acid as potential photopharmacological agents: Synthesis, structure, photochromic and biological properties. Bioorganic & Medicinal Chemistry Letters 31, pages 127709.
Crossref
Hoon Sik Choi, Jin Hyun Kim, Si Jung Jang, Jeong Won Yun, Ki Mun Kang, Hojin Jeong, In Bong Ha & Bae Kwon Jeong. (2020) Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells Via HMGB1. Cancer Research and Treatment.
Crossref
Olga Cuenca-Micó & Carmen Aceves. (2020) Micronutrients and Breast Cancer Progression: A Systematic Review. Nutrients 12:12, pages 3613.
Crossref
Daniely V. S. Costa, Deiziane V. S. Costa, Caren N. S. Sousa, Angeline M. H. P. Silva, Ingridy S. Medeiros, Dainesy S. Martins, Conceição S. Martins, Ana L. V. Pequeno, Roberto C. P. Lima-Júnior, Pedro M. G. Soares, Silvânia M. M. Vasconcelos, Gerly A. C. Brito & Emmanuel P. Souza. (2020) The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice. Pharmaceuticals 13:11, pages 361.
Crossref
Monica Pibiri, Pia Sulas, Tania Camboni, Vera Piera Leoni & Gabriella Simbula. (2020) α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Scientific Reports 10:1.
Crossref
Mohamed Attia, Ebtessam Ahmed Essa, Randa Mohammed Zaki & Amal Ali Elkordy. (2020) An Overview of the Antioxidant Effects of Ascorbic Acid and Alpha Lipoic Acid (in Liposomal Forms) as Adjuvant in Cancer Treatment. Antioxidants 9:5, pages 359.
Crossref
Diana Farhat, Sophie Léon, Sandra E. Ghayad, Nicolas Gadot, Philippe Icard, Muriel Le Romancer, Nader Hussein & Hubert Lincet. (2020) Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation. British Journal of Cancer 122:6, pages 885-894.
Crossref
Kamila Borowczyk, Patrycja Olejarz, Grażyna Chwatko, Marcin Szylberg & Rafał Głowacki. (2020) A Simplified Method for Simultaneous Determination of α-Lipoic Acid and Low-Molecular-Mass Thiols in Human Plasma. International Journal of Molecular Sciences 21:3, pages 1049.
Crossref
Meng-Meng Wang, Xu-Ling Xue, Xi-Xi Sheng, Yan Su, Ya-Qiong Kong, Yong Qian, Jian-Chun Bao, Zhi Su & Hong-Ke Liu. (2020) Unveiling the anti-cancer mechanism for half-sandwich and cyclometalated Ir( iii )-based complexes with functionalized α-lipoic acid . RSC Advances 10:9, pages 5392-5398.
Crossref
Tomas Koltai, Stephan J. Reshkin & Salvador Harguindey. 2020. An Innovative Approach to Understanding and Treating Cancer: Targeting pH. An Innovative Approach to Understanding and Treating Cancer: Targeting pH 361 416 .
Samar Yabes, Mohamed EL-Adl, Mohamed Hamed & Gehad El-Sayed. (2019) Protective effect of alpha lipoic acid on diabetic nephropathy in rats. Mansoura Veterinary Medical Journal 20:3, pages 19-23.
Crossref
U. Aksoy, G. Savtekin, A. Ö. Şehirli, F. Kermeoğlu, A. Kalender, H. Özkayalar, S. Sayıner & K. Orhan. (2019) Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis. International Endodontic Journal 52:9, pages 1317-1326.
Crossref
Bahare Salehi, Yakup Berkay Yılmaz, Gizem Antika, Tugba Boyunegmez Tumer, Mohamad Fawzi Mahomoodally, Devina Lobine, Muhammad Akram, Muhammad Riaz, Esra Capanoglu, Farukh Sharopov, Natália Martins, William C. Cho & Javad Sharifi-Rad. (2019) Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules 9:8, pages 356.
Crossref
Mehran Rahimlou, Maryam Asadi, Nasrin Banaei Jahromi & Anahita Mansoori. (2019) Alpha-lipoic acid (ALA) supplementation effect on glycemic and inflammatory biomarkers: A Systematic Review and meta- analysis. Clinical Nutrition ESPEN 32, pages 16-28.
Crossref
Carina Neitzel, Nina Seiwert, Anja Göder, Erika Diehl, Carina Weber, Georg Nagel, Svenja Stroh, Birgit Rasenberger, Markus Christmann & Jörg Fahrer. (2019) Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation. Cells 8:8, pages 794.
Crossref
Monira M. Rageh & Reem H. El-Gebaly. (2019) Antioxidant activities of α-lipoic acid free and nano-capsule inhibit the growth of Ehrlich carcinoma. Molecular Biology Reports 46:3, pages 3141-3148.
Crossref
Fahimeh Haghighatdoost & Mitra Hariri. (2019) The effect of alpha-lipoic acid on inflammatory mediators: a systematic review and meta-analysis on randomized clinical trials. European Journal of Pharmacology 849, pages 115-123.
Crossref
Sepideh Aminzadeh-Gohari, René Günther Feichtinger & Barbara Kofler. 2019. Neuroblastoma. Neuroblastoma 113 132 .
Chunyan Liao, Xin Dai, Ying Chen, Jie Liu, Yongchao Yao & Shiyong Zhang. (2019) Biogenic ( R )-(+)-Lipoic Acid Only Constructed Cross-Linked Vesicles with Synergistic Anticancer Potency . Advanced Functional Materials 29:3, pages 1806567.
Crossref
Navid Nobakht-Haghighi, Mahban Rahimifard, Maryam Baeeri, Mohammad Amin Rezvanfar, Shermineh Moini Nodeh, Hamed Haghi-Aminjan, Emre Hamurtekin & Mohammad Abdollahi. (2018) Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid. Molecular and Cellular Biochemistry 449:1-2, pages 267-276.
Crossref
Yuri L. Dorokhov, Ekaterina V. Sheshukova, Tatiana E. Bialik & Tatiana V. Komarova. (2018) Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy. BioEssays 40:12, pages 1800136.
Crossref
Salvatore Savino, Cristina Marzano, Valentina Gandin, James Hoeschele, Giovanni Natile & Nicola Margiotta. (2018) Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions. International Journal of Molecular Sciences 19:7, pages 2050.
Crossref
Daniele Tibullo, Giovanni Li Volti, Cesarina Giallongo, Sonia Grasso, Daniele Tomassoni, Carmelina Daniela Anfuso, Gabriella Lupo, Francesco Amenta, Roberto Avola & Vincenzo Bramanti. (2017) Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential. Inflammation Research 66:11, pages 947-959.
Crossref
Simona Dinicola, Sara Proietti, Alessandra Cucina, Mariano Bizzarri & Andrea Fuso. (2017) Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells. Antioxidants 6:4, pages 74.
Crossref
Naoko IkutaKeita ChikamotoYuya AsanoYoshiaki YasuiHaruka YokokawaKeiji TeraoGerald RimbachSeiichi Matsugo. (2017) Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells. Journal of Medicinal Food 20:3, pages 211-222.
Crossref
Sohely Sikdar, Maria Papadopoulou & Jacques Dubois. (2017) Effect of -Lipoic Acid on Proteasomal Induction: Protection against Oxidative Damage in Human Skin Fibroblasts Cell Line NHDF. Pharmacology & Pharmacy 08:09, pages 292-305.
Crossref
Punyawee Puchsaka, Chatchai Chaotham & Pithi Chanvorachote. (2016) α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation. International Journal of Oncology 49:4, pages 1445-1456.
Crossref
Jun Guo, Shixing Gao, Zhiqing Liu, Ruqian Zhao & Xiaojing Yang. (2016) Alpha-Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice. Lipids 51:10, pages 1145-1152.
Crossref
Nikola Milašinović, Bojan Čalija, Bojana Vidović, Milkica Crevar Sakač, Zorica Vujić & Zorica Knežević-Jugović. (2016) Sustained release of α-lipoic acid from chitosan microbeads synthetized by inverse emulsion method. Journal of the Taiwan Institute of Chemical Engineers 60, pages 106-112.
Crossref
Bastian Dörsam & Jörg Fahrer. (2016) The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria. Cancer Letters 371:1, pages 12-19.
Crossref
Perrine Kafara, Philippe Icard, Marilyne Guillamin, Laurent Schwartz & Hubert Lincet. (2015) Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death. Journal of Ovarian Research 8:1.
Crossref
Ola M. Omran & Osama H. Omer. (2015) The effects of alpha-lipoic acid on breast of female albino rats exposed to malathion: Histopathological and immunohistochemical study. Pathology - Research and Practice 211:6, pages 462-469.
Crossref
Guofu Li, Jiahong Fu, Yang Zhao, Kaiqiang Ji, Ting Luan & Bin Zang. (2014) Alpha-Lipoic Acid Exerts Anti-Inflammatory Effects on Lipopolysaccharide-Stimulated Rat Mesangial Cells via Inhibition of Nuclear Factor Kappa B (NF-κB) Signaling Pathway. Inflammation 38:2, pages 510-519.
Crossref
Pouyan Ghaffari, Adil Mardinoglu, Anna Asplund, Saeed Shoaie, Caroline Kampf, Mathias Uhlen & Jens Nielsen. (2015) Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling. Scientific Reports 5:1.
Crossref
Marilia Brito Gomes & Carlos Antonio Negrato. (2014) Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetology & Metabolic Syndrome 6:1.
Crossref
Shyam Kankotia & Peter W. Stacpoole. (2014) Dichloroacetate and cancer: New home for an orphan drug?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:2, pages 617-629.
Crossref
Zsolt Török, Tim Crul, Bruno Maresca, Gerhard J. Schütz, Felix Viana, Laura Dindia, Stefano Piotto, Mario Brameshuber, Gábor Balogh, Mária Péter, Amalia Porta, Alfonso Trapani, Imre Gombos, Attila Glatz, Burcin Gungor, Begüm Peksel, László VighJr.Jr., Bálint Csoboz, Ibolya Horváth, Mathilakath M. Vijayan, Phillip L. Hooper, John L. Harwood & László Vigh. (2014) Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:6, pages 1594-1618.
Crossref
Edward B. Garon, Heather R. Christofk, Wylie Hosmer, Carolyn D. Britten, Agnes Bahng, Matthew J. Crabtree, Candice Sun Hong, Naeimeh Kamranpour, Sharon Pitts, Fairooz Kabbinavar, Cecil Patel, Erika von Euw, Alexander Black, Evangelos D. Michelakis, Steven M. Dubinett & Dennis J. Slamon. (2014) Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. Journal of Cancer Research and Clinical Oncology 140:3, pages 443-452.
Crossref
Ivana Damnjanović, Dušica Stojanović, Gordana Kocić, Stevo Najman, Sanja Stojanović & Srđan Pesić. (2014) Pharmacotherapeutic aspects of the application of Alpha-lipoic acid as an antioxidant. Hrana i ishrana 55:2, pages 48-53.
Crossref
Antonio Macciò & Clelia Madeddu. (2013) The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications—a review. Journal of Molecular Medicine 91:12, pages 1355-1368.
Crossref
Robert E Click. (2013) Anticancer activity and chemoprevention of xenobiotic organosulfurs in preclinical model systems. Oncology Discovery 1:1, pages 4.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.