Citations (121)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (4)
Larry H. Matherly, Mathew Schneider, Aleem Gangjee & Zhanjun Hou. (2022) Biology and therapeutic applications of the proton-coupled folate transporter. Expert Opinion on Drug Metabolism & Toxicology 18:10, pages 695-706.
Read now
Read now
Stéphanie Lebreton, Chiara Zurzolo & Simona Paladino. (2018) Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance. Critical Reviews in Biochemistry and Molecular Biology 53:4, pages 403-419.
Read now
Read now
Samantha E. Day, Richard L. Coletta, Joon Young Kim, Luis A. Garcia, Latoya E. Campbell, Tonya R. Benjamin, Lori R. Roust, Elena A. De Filippis, Lawrence J. Mandarino & Dawn K. Coletta. (2017) Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood. Epigenetics 12:4, pages 254-263.
Read now
Read now
Gerard Walls & Martin Gore. (2016) Farletuzumab in the treatment of ovarian cancer. Expert Opinion on Orphan Drugs 4:3, pages 327-331.
Read now
Read now
Articles from other publishers (117)
Krishna Kaku, Manasa P. Ravindra, Nian Tong, Shruti Choudhary, Xinxin Li, Jianming Yu, Mohammad Karim, Madelyn Brzezinski, Carrie O’Connor, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2023) Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport. ACS Medicinal Chemistry Letters.
Crossref
Crossref
Samarth Kumar, Neeraj Kumar Garg, Ashay Jain, Ajay Khopade, Prachi Pandey & Krutika K. Sawant. (2023) Nanocarriers mediated delivery of methotrexate is instrumental in treating auto-immune diseases and cancer. Journal of Drug Delivery Science and Technology 88, pages 104969.
Crossref
Crossref
Mohsina Patwekar, Faheem Patwekar, Anuradha Medikeri, Shaikh Daniyal, Mohammad A. Kamal, Gulzar Ahmed Rather & Rohit Sharma. (2023) Mechanistic insights on anticancer drugs with specific biological targets and signalling pathways. Exploration of Medicine, pages 637-663.
Crossref
Crossref
Md. Junayed Nayeen, Jade M. Katinas, Tejashree Magdum, Khushbu Shah, Jennifer E. Wong, Carrie E. O’Connor, Alexandra N. Fifer, Adrianne Wallace-Povirk, Zhanjun Hou, Larry H. Matherly, Charles E. DannIIIIII & Aleem Gangjee. (2023) Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. Journal of Medicinal Chemistry 66:16, pages 11294-11323.
Crossref
Crossref
Cameron Adams, Nisha Nair, Darren Plant, Suzanne M. M. Verstappen, Hong L. Quach, Diana L. Quach, Alex Carvidi, Joanne Nititham, Mary Nakamura, Jonathan Graf, Anne Barton, Lindsey A. Criswell & Lisa F. Barcellos. (2023)
Identification of
Cell‐Specific
Differential
DNA
Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis
. Arthritis & Rheumatology 75:7, pages 1088-1097.
Crossref
Crossref
Nian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, Yesha Shah, Morgan C. Nyman, Jade M. Katinas, Mathew Schneider, Carrie O’Connor, Xun Bao, Seongho Kim, Jing Li, Zhanjun Hou, Larry H. Matherly, Charles E. DannIIIIII & Aleem Gangjee. (2023)
Multitargeted 6-Substituted Thieno[2,3-
d
]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism
. ACS Pharmacology & Translational Science 6:5, pages 748-770.
Crossref
Crossref
Diana Karen Mendiola-Soto, Diego Alberto Bárcenas-López, Carlos Jhovani Pérez-Amado, Gabriela Marisol Cruz-Miranda, Juan Manuel Mejía-Aranguré, Julian Ramírez-Bello, Alfredo Hidalgo-Miranda & Silvia Jiménez-Morales. (2023) MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences 24:6, pages 5436.
Crossref
Crossref
Juan Chang, Ke Wang, Jue Chen & Yinxia Chang. (2022) Binding behavior and in vitro cytotoxicity of inclusion complexes between aminopterin and cucurbit[7]uril. Journal of Inclusion Phenomena and Macrocyclic Chemistry 103:1-2, pages 45-55.
Crossref
Crossref
Elena Puris, Gert Fricker & Mikko Gynther. (2023) The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy. Pharmaceutics 15:2, pages 364.
Crossref
Crossref
Veysel Gök, Şerife Erdem, Yeşim Haliloğlu, Atıl Bişgin, Serkan Belkaya, Kemal Erdem Başaran, Mehmed Fatih Canatan, Alper Özcan, Ebru Yılmaz, Can Acıpayam, Musa Karakükcü, Halit Canatan, Hüseyin Per, Türkan Patıroğlu, Ahmet Eken & Ekrem Ünal. (2022) Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment. Genes & Immunity 24:1, pages 12-20.
Crossref
Crossref
Adrianne Wallace-Povirk, Lisa Rubinsak, Agnes Malysa, Sijana H. Dzinic, Manasa Ravindra, Mathew Schneider, James Glassbrook, Carrie O’Connor, Zhanjun Hou, Seongho Kim, Jessica Back, Lisa Polin, Robert T. Morris, Aleem Gangjee, Heather Gibson & Larry H. Matherly. (2022) Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment. Scientific Reports 12:1.
Crossref
Crossref
Carlynne Choy, Lee Yong Lim, Lai Wah Chan, Zhixiang Cui, Shirui Mao & Tin Wui Wong. (2022) Exploring Intestinal Surface Receptors in Oral Nanoinsulin Delivery. Pharmacological Reviews 74:4, pages 962-983.
Crossref
Crossref
Nicholas J. Wright, Justin G. Fedor, Han Zhang, Pyeonghwa Jeong, Yang Suo, Jiho Yoo, Jiyong Hong, Wonpil Im & Seok-Yong Lee. (2022) Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature 609:7929, pages 1056-1062.
Crossref
Crossref
Janthima Methaneethorn, Rowan AlEjielat & Nattawut Leelakanok. (2022) Factors influencing methotrexate and methotrexate polyglutamate in patients with rheumatoid arthritis: a systematic review of population pharmacokinetics. Drug Metabolism and Personalized Therapy 37:3, pages 229-240.
Crossref
Crossref
Jinzhang Gao, Ning Xiao, Qianlei Wang, Zhengkun Xu, Feng Xiao, Zhaoyi Yang, Wei Wei & Chun Wang. (2022) OAT3 mediates methotrexate resistance in the treatment of rheumatoid arthritis. Biomedicine & Pharmacotherapy 153, pages 113558.
Crossref
Crossref
Simon Newstead. (2022) Structural basis for recognition and transport of folic acid in mammalian cells. Current Opinion in Structural Biology 74, pages 102353.
Crossref
Crossref
Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson & Reina Bendayan. 2022. Drug Transporters. Drug Transporters
283
317
.
Zhanjun Hou, Aleem Gangjee & Larry H. Matherly. (2022) The evolving biology of the proton‐coupled folate transporter: New insights into regulation, structure, and mechanism. The FASEB Journal 36:2.
Crossref
Crossref
Roberto Altieri, Francesco Certo, Marco Garozzo, Giacomo Cammarata, Massimiliano Maione, Giuseppa Fiuman� Giuseppe Broggi, Giada Maria Vecchio, Rosario Caltabiano, Gaetano Magro & Giuseppe Barbagallo. (2022) The Neurosurgical Challenge of Primary Central Nervous System Lymphoma Diagnosis: A Multimodal Intraoperative Imaging Approach to Overcome Frameless Neuronavigated Biopsy Sampling Errors. Oncologie 24:4, pages 693-706.
Crossref
Crossref
Adrianne Wallace-Povirk, Zhanjun Hou, Md. Junayed Nayeen, Aleem Gangjee & Larry H. Matherly. (2021) Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer. Cancers 14:1, pages 191.
Crossref
Crossref
Tomoya Narawa, Yuuki Narita, Sayuri Hosokawa & Tomoo Itoh. (2021) Functional role of serine 318 of the proton-coupled folate transporter in methotrexate transport. Drug Metabolism and Pharmacokinetics 41, pages 100421.
Crossref
Crossref
Hoa Quynh Do, Carla M. Bassil, Elizabeth I. Andersen & Michaela Jansen. (2021) Impact of nanodisc lipid composition on cell-free expression of proton-coupled folate transporter. PLOS ONE 16:11, pages e0253184.
Crossref
Crossref
Alexey А. Kubanov, Anastasiia V. Asoskova & Dmitriy A. Sychev. (2021) Pharmacogenetic approach to methotrexate-related toxicity prediction in psoriasis. Russian Journal of Skin and Venereal Diseases 24:2, pages 119-132.
Crossref
Crossref
Ahmed M Abdelaal & Andrea L Kasinski. (2021) Ligand-mediated delivery of RNAi-based therapeutics for the treatment of oncological diseases. NAR Cancer 3:3.
Crossref
Crossref
Joanne L. Parker, Justin C. Deme, Gabriel Kuteyi, Zhiyi Wu, Jiandong Huo, I. David Goldman, Raymond J. Owens, Philip C. Biggin, Susan M. Lea & Simon Newstead. (2021) Structural basis of antifolate recognition and transport by PCFT. Nature 595:7865, pages 130-134.
Crossref
Crossref
Yulia Shulpekova, Vladimir Nechaev, Svetlana Kardasheva, Alla Sedova, Anastasia Kurbatova, Elena Bueverova, Arthur Kopylov, Kristina Malsagova, Jabulani Clement Dlamini & Vladimir Ivashkin. (2021) The Concept of Folic Acid in Health and Disease. Molecules 26:12, pages 3731.
Crossref
Crossref
Muhammad Asghar, Hasan Shoaib, Woosun Kang, Irfa Tariq & Tulika Chatterjee. (2021) Methotrexate Toxicity: A Simple Solution to a Complex Problem. Cureus.
Crossref
Crossref
Carrie O’Connor, Adrianne Wallace-Povirk, Changwen Ning, Josephine Frühauf, Nian Tong, Aleem Gangjee, Larry H. Matherly & Zhanjun Hou. (2021) Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. Scientific Reports 11:1.
Crossref
Crossref
Jinzhang Gao, Chun Wang & Wei Wei. (2021) The effects of drug transporters on the efficacy of methotrexate in the treatment of rheumatoid arthritis. Life Sciences 268, pages 118907.
Crossref
Crossref
Tracy R. Ediger & Steven H. Erdman. 2021. Pediatric Gastrointestinal and Liver Disease. Pediatric Gastrointestinal and Liver Disease
321
338.e5
.
Aamod S. Dekhne, Zhanjun Hou, Aleem Gangjee & Larry H. Matherly. (2020) Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer. Molecular Cancer Therapeutics 19:11, pages 2245-2255.
Crossref
Crossref
He-Qin Zhan, Mitra Najmi, Kai Lin, Srinivas Aluri, Andras Fiser, I.David Goldman & Rongbao Zhao. (2020) A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. Journal of Biological Chemistry 295:46, pages 15650-15661.
Crossref
Crossref
Liudmyla Parkhomenko, Larysa Strashok & Olga Pavlova. (2020) BASIC FIBROBLAST GROWTH FACTOR AND ADIPONECTIN IN ADOLESCENCE WITH JUVENILE IDIOPATHIC ARTHRITIS TREATED WITH METHOTREXATE. EUREKA: Health Sciences 4, pages 70-76.
Crossref
Crossref
Silvan D. Boss & Simon Mensah Ametamey. (2020) Development of Folate Receptor−Targeted PET Radiopharmaceuticals for Tumor Imaging—A Bench-to-Bedside Journey. Cancers 12:6, pages 1508.
Crossref
Crossref
Mariana Scaranti, Elena Cojocaru, Susana Banerjee & Udai Banerji. (2020) Exploiting the folate receptor α in oncology. Nature Reviews Clinical Oncology 17:6, pages 349-359.
Crossref
Crossref
Lalit K. Golani, Farhana Islam, Carrie O'Connor, Aamod S. Dekhne, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2020) Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorganic & Medicinal Chemistry 28:12, pages 115544.
Crossref
Crossref
Shinichi Saito, Yoshihiro Koya, Hiroaki Kajiyama, Mamoru Yamashita, Fumitaka Kikkawa & Akihiro Nawa. (2020) Folate‐appended cyclodextrin carrier targets ovarian cancer cells expressing the proton‐coupled folate transporter. Cancer Science 111:5, pages 1794-1804.
Crossref
Crossref
Benjamin Friedman & Bruce Cronstein. (2020) Mécanisme d’action du méthotrexate dans le traitement de la polyarthrite rhumatoïde. Revue du Rhumatisme 87:2, pages 92-98.
Crossref
Crossref
Batoul Farran, Raquel Carvalho Montenegro, Prameswari Kasa, Eluri Pavitra, Yun Suk Huh, Young-Kyu Han, Mohammad Amjad Kamal, Ganji Purnachandra Nagaraju & Ganji Seeta Rama Raju. (2020) Folate-conjugated nanovehicles: Strategies for cancer therapy. Materials Science and Engineering: C 107, pages 110341.
Crossref
Crossref
Aamod S. Dekhne, Changwen Ning, Md. Junayed Nayeen, Khushbu Shah, Hasini Kalpage, Josephine Frühauf, Adrianne Wallace-Povirk, Carrie O’Connor, Zhanjun Hou, Seongho Kim, Maik Hüttemann, Aleem Gangjee & Larry H. Matherly. (2020)
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-
d
]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism
. Molecular Pharmacology 97:1, pages 9-22.
Crossref
Crossref
Xinjie Lu. (2019) The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer. Current Cancer Drug Targets 19:11, pages 863-876.
Crossref
Crossref
Weiguo Xiang, Aamod Dekhne, Arpit Doshi, Carrie O'Connor, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2019) Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis. Bioorganic & Medicinal Chemistry 27:23, pages 115125.
Crossref
Crossref
Biljana Jekic, Nela Maksimovic & Tatjana Damnjanovic. (2019) Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis. Pharmacogenomics 20:17, pages 1235-1245.
Crossref
Crossref
Yosra Bedoui, Xavier Guillot, Jimmy Sélambarom, Pascale Guiraud, Claude Giry, Marie Christine Jaffar-Bandjee, Stéphane Ralandison & Philippe Gasque. (2019) Methotrexate an Old Drug with New Tricks. International Journal of Molecular Sciences 20:20, pages 5023.
Crossref
Crossref
Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker, Jade M. Katinas, Jennifer Wong-Roushar, Md. Junayed Nayeen, Arpit Doshi, Changwen Ning, Xun Bao, Josephine Frühauf, Jenney Liu, Adrianne Wallace-Povirk, Carrie O'Connor, Sijana H. Dzinic, Kathryn White, Juiwanna Kushner, Seongho Kim, Maik Hüttemann, Lisa Polin, Joshua D. Rabinowitz, Jing Li, Zhanjun Hou, Charles E. DannIIIIII, Aleem Gangjee & Larry H. Matherly. (2019)
Novel Pyrrolo[3,2-
d
]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy
. Molecular Cancer Therapeutics 18:10, pages 1787-1799.
Crossref
Crossref
Claudia Fasolato, Sabrina Giantulli, Angela Capocefalo, Yosra Toumia, Daniele Notariello, Flavia Mazzarda, Ida Silvestri, Paolo Postorino & Fabio Domenici. (2019) Antifolate SERS-active nanovectors: quantitative drug nanostructuring and selective cell targeting for effective theranostics. Nanoscale 11:32, pages 15224-15233.
Crossref
Crossref
Arjan Geersing, Reinder H. de Vries, Gerrit Jansen, Marianne G. Rots & Gerard Roelfes. (2019) Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells. Bioorganic & Medicinal Chemistry Letters 29:15, pages 1922-1927.
Crossref
Crossref
Yu-Lian Xu, Xiao-Ming Jiang, Le-Le Zhang, Xiuping Chen, Zhang-Jian Huang & Jin-Jian Lu. (2019) Establishment and Characterization of Pemetrexed-resistant NCI-H460/PMT Cells. Anti-Cancer Agents in Medicinal Chemistry 19:6, pages 731-739.
Crossref
Crossref
Joanna Goral, Kayla Cuadros, Lenore Pitstick, Alice Meyer, Bruno Correia Jham, Eduardo Pereira Guimaraes, João Adolfo Costa Hanemann & Jacalyn M. Green. (2019) Decreased expression of folate transport proteins in oral cancer. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 127:5, pages 417-424.
Crossref
Crossref
Benjamin Friedman & Bruce Cronstein. (2019) Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine 86:3, pages 301-307.
Crossref
Crossref
Junjun Ni, Li Xu, Wei Li, Chunmei Zheng & Lijun Wu. (2019) Targeted metabolomics for serum amino acids and acylcarnitines in patients with lung cancer. Experimental and Therapeutic Medicine.
Crossref
Crossref
Zhanjun Hou, Carrie O'ConnorJosephine FrühaufSteve OrrSeongho KimAleem GangjeeLarry H. Matherly. (2019) Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1. Biochemical Journal 476:8, pages 1247-1266.
Crossref
Crossref
Yuriy V. Kucheryavykh, Josue Davila, Jescelica Ortiz-Rivera, Mikhael Inyushin, Luis Almodovar, Miguel Mayol, Moraima Morales-Cruz, Alejandra Cruz-Montañez, Vanessa Barcelo-Bovea, Kai Griebenow & Lilia Y. Kucheryavykh. (2019) Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter. Biomolecules 9:4, pages 154.
Crossref
Crossref
Lisa Bartmann, David Schumacher, Saskia von Stillfried, Marieke Sternkopf, Setareh Alampour-Rajabi, Marc A. M. J. van Zandvoort, Fabian Kiessling & Zhuojun Wu. (2019) Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics. Frontiers in Pharmacology 10.
Crossref
Crossref
So Young JiJin Wook KimChul-Kee Park. (2019) Experience Profiling of Fluorescence-Guided Surgery II: Non-Glioma Pathologies. Brain Tumor Research and Treatment 7:2, pages 105.
Crossref
Crossref
Hideo Otsubo, Yasuhiro Tsuneyoshi, Tadashi Nakamura, Takemasa Matsuda, Setsuro Komiya & Takami Matsuyama. (2018) Serum-soluble folate receptor β as a biomarker for the activity of rheumatoid arthritis synovitis and the response to anti-TNF agents. Clinical Rheumatology 37:11, pages 2939-2945.
Crossref
Crossref
Manuel Macías-González, Gracia María Martín-Núñez, Lourdes Garrido-Sánchez, Eduardo García-Fuentes, Francisco José Tinahones & Sonsoles Morcillo. (2018) Decreased blood pressure is related to changes in NF-kB promoter methylation levels after bariatric surgery. Surgery for Obesity and Related Diseases 14:9, pages 1327-1334.
Crossref
Crossref
Barbara Kiesel, Matthias Millesi, Adelheid Woehrer, Julia Furtner, Anahita BavandThomas RoetzerMario MischkulnigStefan Wolfsberger, Matthias Preusser, Engelbert Knosp & Georg Widhalm. (2018) 5-ALA–induced fluorescence as a marker for diagnostic tissue in stereotactic biopsies of intracranial lymphomas: experience in 41 patients. Neurosurgical Focus 44:6, pages E7.
Crossref
Crossref
Manasa Ravindra, Mike R. Wilson, Nian Tong, Carrie O’Connor, Mohammad Karim, Lisa Polin, Adrianne Wallace-Povirk, Kathryn White, Juiwanna Kushner, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2018)
Fluorine-Substituted Pyrrolo[2,3-
d
]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of
de Novo
Purine Nucleotide Biosynthesis
. Journal of Medicinal Chemistry 61:9, pages 4228-4248.
Crossref
Crossref
Khushbu Shah, Sudhir Raghavan, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2018) Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores). Journal of Molecular Graphics and Modelling 81, pages 125-133.
Crossref
Crossref
Ryosuke Tanino, Yukari Tsubata, Nanae Harashima, Mamoru Harada & Takeshi Isobe. (2018) Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. Oncotarget 9:24, pages 16807-16821.
Crossref
Crossref
Manasa Ravindra, Adrianne Wallace-Povirk, Mohammad A. Karim, Mike R. Wilson, Carrie O’Connor, Kathryn White, Juiwanna Kushner, Lisa Polin, Christina George, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2018)
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-
d
]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of
De Novo
Purine Nucleotide Biosynthesis
. Journal of Medicinal Chemistry 61:5, pages 2027-2040.
Crossref
Crossref
Srinivas Aluri, Rongbao Zhao, Andras Fiser & I. David Goldman. (2018) Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1). American Journal of Physiology-Cell Physiology 314:3, pages C289-C296.
Crossref
Crossref
Rongbao Zhao, Mitra Najmi, Srinivas Aluri, David C. Spray & I. David Goldman. (2018) Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer. Molecular Pharmacology 93:3, pages 208-215.
Crossref
Crossref
Kathleen N Moore, Lainie P Martin, David M O'Malley, Ursula A Matulonis, Jason A Konner, Ignace Vergote, Jose F Ponte & Michael J Birrer. (2018) A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer. Future Oncology 14:2, pages 123-136.
Crossref
Crossref
Nanda G. Aduri, Heidi A. Ernst, Bala K. Prabhala, Shweta Bhatt, Thomas Boesen, Michael Gajhede & Osman Mirza. (2018) Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state. Biochemical and Biophysical Research Communications 495:2, pages 1738-1743.
Crossref
Crossref
Larry H. Matherly, Zhanjun Hou & Aleem Gangjee. (2017) The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. Cancer Chemotherapy and Pharmacology 81:1, pages 1-15.
Crossref
Crossref
Menizibeya Osain WelcomeMenizibeya Osain Welcome. 2018. Gastrointestinal Physiology. Gastrointestinal Physiology
871
972
.
Claudia FasolatoClaudia Fasolato. 2018. Surface Enhanced Raman Spectroscopy for Biophysical Applications. Surface Enhanced Raman Spectroscopy for Biophysical Applications
113
135
.
Claudia FasolatoClaudia Fasolato. 2018. Surface Enhanced Raman Spectroscopy for Biophysical Applications. Surface Enhanced Raman Spectroscopy for Biophysical Applications
9
56
.
Jianmin Tan, Xiujuan Li, Yi Guo, Lingling Xie, Juan Wang, Jiannan Ma & Li Jiang. (2017) Hereditary folate malabsorption with a novel mutation on SLC46A1. Medicine 96:50, pages e8712.
Crossref
Crossref
Srinivas Aluri, Rongbao Zhao, Andras Fiser & I. David Goldman. (2017) Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:11, pages 2193-2202.
Crossref
Crossref
Fredrick J. Rosario, Theresa L. Powell & Thomas Jansson. (2017) mTOR folate sensing links folate availability to trophoblast cell function. The Journal of Physiology 595:13, pages 4189-4206.
Crossref
Crossref
Swapneeta S. Date, Mariana C. Fiori, Guillermo A. Altenberg & Michaela Jansen. (2017) Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1). PLOS ONE 12:5, pages e0177572.
Crossref
Crossref
Zhanjun Hou, Leda Gattoc, Carrie O'Connor, Si Yang, Adrianne Wallace-Povirk, Christina George, Steve Orr, Lisa Polin, Kathryn White, Juiwanna Kushner, Robert T. Morris, Aleem Gangjee & Larry H. Matherly. (2017)
Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-
d
]pyrimidine Antifolates
. Molecular Cancer Therapeutics 16:5, pages 819-830.
Crossref
Crossref
Oleg Shuvalov, Alexey Petukhov, Alexandra Daks, Olga Fedorova, Elena Vasileva & Nickolai A. Barlev. (2017) One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy. Oncotarget 8:14, pages 23955-23977.
Crossref
Crossref
Georg Evers, Marcel Kamp, Nils Warneke, Wolfgang Berdel, Michael Sabel, Walter Stummer & Christian Ewelt. (2017) 5-Aminolaevulinic Acid–Induced Fluorescence in Primary Central Nervous System Lymphoma. World Neurosurgery 98, pages 375-380.
Crossref
Crossref
Rongbao Zhao, Srinivas Aluri & I. David Goldman. (2017) The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption. Molecular Aspects of Medicine 53, pages 57-72.
Crossref
Crossref
Philip M. Brown, Arthur G. Pratt & John D. Isaacs. (2016) Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers. Nature Reviews Rheumatology 12:12, pages 731-742.
Crossref
Crossref
Leire Iparraguirre, Angela Gutierrez-Camino, Maitane Umerez, Idoia Martin-Guerrero, Itziar Astigarraga, Aurora Navajas, Ana Sastre, Nagore Garcia de Andoin & Africa Garcia-Orad. (2016) MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia. Pharmacogenetics and Genomics 26:11, pages 517-525.
Crossref
Crossref
Mike R. WilsonZhanjun HouLucas J. WilsonJun Ye & Larry H. Matherly. (2016) Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6–7 linker. Biochemical Journal 473:20, pages 3545-3562.
Crossref
Crossref
Kruti S. Soni, Swapnil S. Desale & Tatiana K. Bronich. (2016) Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation. Journal of Controlled Release 240, pages 109-126.
Crossref
Crossref
Peter V. Danenberg, Bengt Gustavsson, Patrick Johnston, Per Lindberg, Rudolf Moser, Elisabeth Odin, Godefridus J. Peters & Nicholas Petrelli. (2016) Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Critical Reviews in Oncology/Hematology 106, pages 118-131.
Crossref
Crossref
Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, Jennifer Wong, Jiyuan Ke, Xin Gu, Sudhir Raghavan, Mike R. Wilson, Xinxin Li, Lisa Polin, Parker W. de Waal, Kathryn White, Juiwanna Kushner, Carrie O’Connor, Zhanjun Hou, H. Eric Xu, Karsten Melcher, Charles E. DannIIIIII, Larry H. Matherly & Aleem Gangjee. (2016)
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-
d
] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis
. Journal of Medicinal Chemistry 59:17, pages 7856-7876.
Crossref
Crossref
Siobhan M. Deis, Arpit Doshi, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee & Charles E. DannIIIIII. (2016) Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase. Biochemistry 55:32, pages 4574-4582.
Crossref
Crossref
Mitra NajmiRongbao ZhaoAndras Fiser & I. David Goldman. (2016) Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function. American Journal of Physiology-Cell Physiology 311:1, pages C150-C157.
Crossref
Crossref
Snehal N. Chaudhari, Madhumati Mukherjee, Alexandra S. Vagasi, Gaofeng Bi, Mohammad M. Rahman, Christine Q. Nguyen, Ligi Paul, Jacob Selhub & Edward T. Kipreos. (2016) Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation. Developmental Cell 38:1, pages 33-46.
Crossref
Crossref
Ankuri Desai, Jeffrey M. Sequeira & Edward V. Quadros. (2016) The metabolic basis for developmental disorders due to defective folate transport. Biochimie 126, pages 31-42.
Crossref
Crossref
Mike R. Wilson, Zhanjun Hou, Si Yang, Lisa Polin, Juiwanna Kushner, Kathryn White, Jenny Huang, Manohar Ratnam, Aleem Gangjee & Larry H. Matherly. (2016)
Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-
d
]Pyrimidine Thienoyl Antifolates
. Molecular Pharmacology 89:4, pages 425-434.
Crossref
Crossref
Swapneeta S. Date, Cheng‐Yen Charles Chen, Yidong Chen & Michaela Jansen. (2016) Experimentally optimized threading structures of the proton‐coupled folate transporter. FEBS Open Bio 6:3, pages 216-230.
Crossref
Crossref
Silvan D. Boss, Thomas Betzel, Cristina Müller, Cindy R. Fischer, Stephanie Haller, Josefine Reber, Viola Groehn, Roger Schibli & Simon M. Ametamey. (2015) Comparative Studies of Three Pairs of α- and γ-Conjugated Folic Acid Derivatives Labeled with Fluorine-18. Bioconjugate Chemistry 27:1, pages 74-86.
Crossref
Crossref
C. Fasolato, S. Giantulli, I. Silvestri, F. Mazzarda, Y. Toumia, F. Ripanti, F. Mura, F. Luongo, F. Costantini, F. Bordi, P. Postorino & F. Domenici. (2016) Folate-based single cell screening using surface enhanced Raman microimaging. Nanoscale 8:39, pages 17304-17313.
Crossref
Crossref
Kevin J. Hamblett, Allison P. Jacob, Jesse L. Gurgel, Mark E. Tometsko, Brooke M. Rock, Sonal K. Patel, Robert R. Milburn, Sophia Siu, Seamus P. Ragan, Dan A. Rock, Christopher J. Borths, Jason W. O'Neill, Wesley S. Chang, Margaret F. Weidner, Matthew M. Bio, Kim C. Quon & William C. Fanslow. (2015) SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm. Cancer Research 75:24, pages 5329-5340.
Crossref
Crossref
Swapnil S. Desale, Kruti S. Soni, Svetlana Romanova, Samuel M. Cohen & Tatiana K. Bronich. (2015) Targeted delivery of platinum-taxane combination therapy in ovarian cancer. Journal of Controlled Release 220, pages 651-659.
Crossref
Crossref
Tetsuya Yamamoto, Eiichi Ishikawa, Shunichiro Miki, Noriaki Sakamoto, Alexander Zaboronok, Masahide Matsuda, Hiroyoshi Akutsu, Kei Nakai, Wataro Tsuruta & Akira Matsumura. (2015) Photodynamic Diagnosis Using 5-Aminolevulinic Acid in 41 Biopsies for Primary Central Nervous System Lymphoma. Photochemistry and Photobiology 91:6, pages 1452-1457.
Crossref
Crossref
Lei Wang, Adrianne Wallace, Sudhir Raghavan, Siobhan M. Deis, Mike R. Wilson, Si Yang, Lisa Polin, Kathryn White, Juiwanna Kushner, Steven Orr, Christina George, Carrie O’Connor, Zhanjun Hou, Shermaine Mitchell-Ryan, Charles E. DannIIIIII, Larry H. Matherly & Aleem Gangjee. (2015)
6-Substituted Pyrrolo[2,3-
d
]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
. Journal of Medicinal Chemistry 58:17, pages 6938-6959.
Crossref
Crossref
Mike R. WilsonSita KugelJenny HuangLucas J. WilsonPatrick A. WloszczynskiJun Ye, Larry H. MatherlyZhanjun Hou. (2015) Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochemical Journal 469:1, pages 33-44.
Crossref
Crossref
Gerrit Jansen & Godefridus J. Peters. (2015) Novel insights in folate receptors and transporters: implications for disease and treatment of immune diseases and cancer. Pteridines 26:2, pages 41-53.
Crossref
Crossref
Taku NagaiYuko FurushoHua LiKazuhisa HasuiSumika MatsukitaKazunobu SueyoshiMasakazu YanagiMasaki HataeSonshin TakaoTakami Matsuyama. (2015) Production of a High-affinity Monoclonal Antibody Reactive with Folate Receptors Alpha and Beta. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 34:3, pages 181-190.
Crossref
Crossref
Rongbao Zhao, Michele Visentin & I. David Goldman. (2015) Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis. Cancer Chemotherapy and Pharmacology 75:6, pages 1163-1173.
Crossref
Crossref
Michele VisentinErsin Selcuk UnalMitra NajmiAndras Fiser, Rongbao ZhaoI. David Goldman. (2015) Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1). American Journal of Physiology-Cell Physiology 308:8, pages C631-C641.
Crossref
Crossref
Ignace B. Vergote, Christian Marth & Robert L. Coleman. (2015) Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications. Cancer and Metastasis Reviews 34:1, pages 41-52.
Crossref
Crossref
Yiqiang Wang, Shermaine Mitchell-Ryan, Sudhir Raghavan, Christina George, Steven Orr, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2015)
Novel 5-Substituted Pyrrolo[2,3-
d
]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents
. Journal of Medicinal Chemistry 58:3, pages 1479-1493.
Crossref
Crossref
Lalit K. Golani, Christina George, Sai Zhao, Sudhir Raghavan, Steven Orr, Adrianne Wallace, Mike R. Wilson, Zhanjun Hou, Larry H. Matherly & Aleem Gangjee. (2014)
Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-
d
]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter
. Journal of Medicinal Chemistry 57:19, pages 8152-8166.
Crossref
Crossref
Mike R. Wilson, Zhanjun Hou & Larry H. Matherly. (2014) Substituted Cysteine Accessibility Reveals a Novel Transmembrane 2–3 Reentrant Loop and Functional Role for Transmembrane Domain 2 in the Human Proton-coupled Folate Transporter. Journal of Biological Chemistry 289:36, pages 25287-25295.
Crossref
Crossref
Zhanjun HouSteve OrrLarry H. Matherly. (2014) Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency. Bioscience Reports 34:4.
Crossref
Crossref
Larry H. Matherly, Mike R. Wilson & Zhanjun Hou. (2014) The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer. Drug Metabolism and Disposition 42:4, pages 632-649.
Crossref
Crossref
Michele VisentinNdeye Diop-BoveRongbao ZhaoI. David Goldman. (2014) The Intestinal Absorption of Folates. Annual Review of Physiology 76:1, pages 251-274.
Crossref
Crossref
Katsuhisa Inoue & Hiroaki Yuasa. (2014) Molecular Basis for Pharmacokinetics and Pharmacodynamics of Methotrexate in Rheumatoid Arthritis Therapy. Drug Metabolism and Pharmacokinetics 29:1, pages 12-19.
Crossref
Crossref
Qing Li & Yan Shu. (2014) Role of solute carriers in response to anticancer drugs. Molecular and Cellular Therapies 2:1, pages 15.
Crossref
Crossref
Yingjuan Lu, Kristin N. Wollak, Vicky A. Cross, Elaine Westrick, Leroy W. Wheeler, Torian W. Stinnette, Jeremy F. Vaughn, Spencer J. Hahn, Le-Cun Xu, Iontcho R. Vlahov & Christopher P. Leamon. (2014) Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis. Clinical Immunology 150:1, pages 64-77.
Crossref
Crossref
Zhanjun Hou & Larry H. Matherly. 2014. Exchangers. Exchangers
175
204
.
Andrew J Clifford, Gonzalo Rincon, Janel E Owens, Juan F Medrano, Alanna J Moshfegh, David J Baer & Janet A Novotny. (2013) Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults. Lipids in Health and Disease 12:1.
Crossref
Crossref
Rongbao Zhao & I David Goldman. (2013) The proton-coupled folate transporter: physiological and pharmacological roles. Current Opinion in Pharmacology 13:6, pages 875-880.
Crossref
Crossref
Michele Visentin, Ersin Selcuk Unal, Rongbao Zhao & I. David Goldman. (2013) The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor. Cancer Chemotherapy and Pharmacology 72:3, pages 597-606.
Crossref
Crossref
Stephen Connelly, Jessica K. DeMartino, Dale L. Boger & Ian A. Wilson. (2013)
Biological and Structural Evaluation of 10
R
- and 10
S
-Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide Transformylase
. Biochemistry 52:30, pages 5133-5144.
Crossref
Crossref
Christina Cherian, Sita Kugel Desmoulin, Lei Wang, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Aleem Gangjee & Larry H. Matherly. (2013) Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter. Cancer Chemotherapy and Pharmacology 71:4, pages 999-1011.
Crossref
Crossref