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Cancer Biology & Therapy Volume 13, 2012 - Issue 14
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Research Paper

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

Valentina Grossi Cancer Genetics Laboratory; IRCCS “S. de Bellis”; Castellana Grotte, Italy
,
Micaela Liuzzi Division of Pathological Anatomy; DIM; University of Bari; Bari, Italy
,
Stefania Murzilli Laboratory of Lipid Metabolism and Cancer; Department of Translational Pharmacology (DTP); Consorzio Mario NegriSud; Santa Maria Imbaro, Italy; Animal Care Facility; Department of Translational Pharmacology (DTP); Consorzio Mario NegriSud; Santa Maria Imbaro, Italy
,
Nicola Martelli Laboratory of Lipid Metabolism and Cancer; Department of Translational Pharmacology (DTP); Consorzio Mario NegriSud; Santa Maria Imbaro, Italy; Flow Cytometry Facility; Department of Translational Pharmacology (DTP); Consorzio Mario NegriSud; Santa Maria Imbaro, Italy
,
Anna Napoli Division of Pathological Anatomy; DIM; University of Bari; Bari, Italy
,
Giuseppe Ingravallo Division of Pathological Anatomy; DIM; University of Bari; Bari, Italy
,
Alberto Del Rio Laboratory of Biochemoinformatics; Department of Experimental Pathology; Alma Mater Studiorum University of Bologna; Bologna, ItalyCorrespondence[email protected] [email protected]
&
Cristiano Simone Division of Medical Genetics; DIM; University of Bari; Bari, Italy; Laboratory of Signal-dependent Transcription; Department of Translational Pharmacology (DTP); Consorzio Mario NegriSud; Santa Maria Imbaro, ItalyCorrespondence[email protected] [email protected]
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Pages 1471-1481 | Received 19 Jul 2012, Accepted 17 Sep 2012, Published online: 17 Sep 2012

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Raj J. Ahiwale, Bothiraja Chellampillai & Atmaram P. Pawar. (2022) Investigation of novel sorafenib tosylate loaded biomaterial based nano-cochleates dispersion system for treatment of hepatocellular carcinoma. Journal of Dispersion Science and Technology 43:10, pages 1568-1586.
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Yi Xiao, Fang Liu, Sanhua Li, Nian Jiang, Changyan Yu, Xinting Zhu, Ying Qin, Jing Hui, Lingjie Meng, Changwei Song, Xiao-Fei Li & Yun Liu. (2020) Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway. Virulence 11:1, pages 39-48.
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Articles from other publishers (16)

Matthew Lowerison, Wei Zhang, Xi Chen, Timothy Fan & Pengfei Song. (2022) Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts. IEEE Transactions on Biomedical Engineering 69:4, pages 1449-1460.
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Jie Pan, Mengxin Lin, Zongbin Xu, Meifang Xu, Junrong Zhang, Zongqi Weng, Bingqiang Lin & Xiaoyan Lin. (2021) CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1. Carcinogenesis 42:11, pages 1399-1409.
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Martina Lepore Signorile, Valentina Grossi, Simone Di Franco, Giovanna Forte, Vittoria Disciglio, Candida Fasano, Paola Sanese, Katia De Marco, Francesco Claudio Susca, Laura Rosa Mangiapane, Annalisa Nicotra, Gabriella Di Carlo, Francesco Dituri, Gianluigi Giannelli, Giuseppe Ingravallo, Gianluca Canettieri, Giorgio Stassi & Cristiano Simone. (2021) Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids. Cell Death & Disease 12:4.
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Randa Naffa, Lisa Vogel, Luca Hegedűs, Katalin Pászty, Sarolta Tóth, Kornélia Kelemen, Neha Singh, Attila Reményi, Enikő Kállay, Mihály Cserepes, József Tóvári, Michael Grusch & Ágnes Enyedi. (2020) P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b. Cells 9:5, pages 1209.
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Luca Pinzi & Giulio Rastelli. (2019) Identification of Target Associations for Polypharmacology from Analysis of Crystallographic Ligands of the Protein Data Bank. Journal of Chemical Information and Modeling 60:1, pages 372-390.
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Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore & George Perry. (2019) MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents. Seminars in Cancer Biology 56, pages 185-195.
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Vivek Modi & Roland L. DunbrackJr.Jr.. (2019) Defining a new nomenclature for the structures of active and inactive kinases. Proceedings of the National Academy of Sciences 116:14, pages 6818-6827.
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Valentina Grossi, Candida Fasano, Valentina Celestini, Martina Lepore Signorile, Paola Sanese & Cristiano Simone. (2019) Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape. Cancers 11:3, pages 414.
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Kai Guo, Jingxin Ma & Wenyong Liang. (2018) Effects of SB202190 on expression levels of IL-6 and NF-κB in flap ischemia-reperfusion injury. Experimental and Therapeutic Medicine.
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Dongxu KangZhezhu HanGeun-Hyeok OhYeonsoo JooHye Jin ChoiJae J. Song. (2017) Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib. Yonsei Medical Journal 58:5, pages 899.
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L Marzi, E Combes, N Vié, A Ayrolles-Torro, D Tosi, D Desigaud, E Perez-Gracia, C Larbouret, C Montagut, M Iglesias, M Jarlier, V Denis, L K Linares, E W-F Lam, P Martineau, M Del Rio & C Gongora. (2016) FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer. British Journal of Cancer 115:10, pages 1223-1233.
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A J Browne, A Göbel, S Thiele, L C Hofbauer, M Rauner & T D Rachner. (2016) p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells. Cell Death & Disease 7:2, pages e2119-e2119.
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R. S. K. Vijayan, Peng He, Vivek Modi, Krisna C. Duong-Ly, Haiching Ma, Jeffrey R. Peterson, Roland L. DunbrackJr.Jr. & Ronald M. Levy. (2014) Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors. Journal of Medicinal Chemistry 58:1, pages 466-479.
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Aldo Germani, Antonio Matrone, Valentina Grossi, Alessia Peserico, Paola Sanese, Micaela Liuzzi, Rocco Palermo, Stefania Murzilli, Antonio Francesco Campese, Giuseppe Ingravallo, Gianluca Canettieri, Tugsan Tezil & Cristiano Simone. (2014) Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. Cancer Letters 344:1, pages 110-118.
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Valentina Grossi. (2014) p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance. World Journal of Gastroenterology 20:29, pages 9744.
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Thibault Mazard, Annick Causse, Joelle Simony, Wilhem Leconet, Nadia Vezzio-Vie, Adeline Torro, Marta Jarlier, Alexandre Evrard, Maguy Del Rio, Eric Assenat, Pierre Martineau, Marc Ychou, Bruno Robert & Celine Gongora. (2013) Sorafenib Overcomes Irinotecan Resistance in Colorectal Cancer by Inhibiting the ABCG2 Drug-Efflux Pump. Molecular Cancer Therapeutics 12:10, pages 2121-2134.
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