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Research Paper

Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells

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Pages 184-192 | Received 12 Nov 2012, Accepted 18 Nov 2012, Published online: 28 Nov 2012

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Laura Rosanò, Roberta Cianfrocca, Rosanna Sestito, Piera Tocci, Valeriana Di Castro & Anna Bagnato. (2017) Targeting endothelin-1 receptor/β-arrestin1 network for the treatment of ovarian cancer. Expert Opinion on Therapeutic Targets 21:10, pages 925-932.
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Laura Rosanò & Anna Bagnato. (2015) Disrupting the endothelin and Wnt relationship to overcome chemoresistance. Molecular & Cellular Oncology 2:3.
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Ivan Lučić, Matea Kurtović, Monika Mlinarić, Nikolina Piteša, Ana Čipak Čipak Gašparović, Maja Sabol & Lidija Milković. (2023) Deciphering Common Traits of Breast and Ovarian Cancer Stem Cells and Possible Therapeutic Approaches. International Journal of Molecular Sciences 24:13, pages 10683.
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Ignacio Niechi, José I. Erices, Diego Carrillo-Beltrán, Atenea Uribe-Ojeda, Ángelo Torres, José Dellis Rocha, Daniel Uribe, María A. Toro, Karla Villalobos-Nova, Belén Gaete-Ramírez, Gabriel Mingo, Gareth I. Owen, Manuel Varas-Godoy, Lilian Jara, Francisco Aguayo, Verónica A. Burzio, Claudia Quezada-Monrás & Julio C. Tapia. (2023) Cancer Stem Cell and Aggressiveness Traits Are Promoted by Stable Endothelin-Converting Enzyme-1c in Glioblastoma Cells. Cells 12:3, pages 506.
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Chrysovalantis Voutouri, Myrofora Panagi, Fotios Mpekris, Andreas Stylianou, Christina Michael, Michalakis A. Averkiou, John D. Martin & Triantafyllos Stylianopoulos. (2021) Endothelin Inhibition Potentiates Cancer Immunotherapy Revealing Mechanical Biomarkers Predictive of Response. Advanced Therapeutics 4:9, pages 2000289.
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Ilenia Masi, Valentina Caprara, Francesca Spadaro, Lidia Chellini, Rosanna Sestito, Andrea Zancla, Alberto Rainer, Anna Bagnato & Laura Rosanò. (2021) Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK. Cell Reports 34:9, pages 108800.
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Rodrigo Zebadúa, Andrea Priscila Hernández-Pérez, Antonio García, Nayeli Zayas, Julio Sandoval, Julio López & Tomás Pulido. (2021) Macitentan in the treatment of pulmonary arterial hypertension. Future Cardiology 17:1, pages 49-58.
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Georgia Koutsoumpli, Oana Draghiciu, Hans W Nijman, Cesar Oyarce & Toos Daemen. 2021. Cancer Immunology. Cancer Immunology 61 83 .
Frederik C. Enevoldsen, Jayashree Sahana, Markus Wehland, Daniela Grimm, Manfred Infanger & Marcus Krüger. (2020) Endothelin Receptor Antagonists: Status Quo and Future Perspectives for Targeted Therapy. Journal of Clinical Medicine 9:3, pages 824.
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Pablo Pérez‐Moreno, Sebastián Indo, Ignacio Niechi, Hernán Huerta, Pablo Cabello, Lilian Jara, Francisco Aguayo, Manuel Varas‐Godoy, Verónica A. Burzio & Julio C. Tapia. (2019) Endothelin‐converting enzyme‐1c promotes stem cell traits and aggressiveness in colorectal cancer cells. Molecular Oncology 14:2, pages 347-362.
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Sara I. Pai, Alessandra Cesano & Francesco M. Marincola. 2020. Tumor Microenvironment. Tumor Microenvironment 173 195 .
Jiri Hatina, Maximilian Boesch, Sieghart Sopper, Michaela Kripnerova, Dominik Wolf, Daniel Reimer, Christian Marth & Alain G. Zeimet. 2019. Stem Cells Heterogeneity in Cancer. Stem Cells Heterogeneity in Cancer 201 221 .
Rossana Maffei, Stefania Fiorcari, Tiziana Vaisitti, Silvia Martinelli, Stefania Benatti, Giulia Debbia, Davide Rossi, Patrizia Zucchini, Leonardo Potenza, Mario Luppi, Gianluca Gaidano, Silvia Deaglio & Roberto Marasca. (2017) Macitentan, a double antagonist of endothelin receptors, efficiently impairs migration and microenvironmental survival signals in chronic lymphocytic leukemia. Oncotarget 8:52, pages 90013-90027.
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Roberta Cianfrocca, Laura Rosanò, Piera Tocci, Rosanna Sestito, Valentina Caprara, Valeriana Di Castro, Ruggero De Maria & Anna Bagnato. (2017) Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancer. Cell Death & Differentiation 24:10, pages 1811-1820.
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Luwei Wei, Fuqiang Yin, Wei Zhang & Li Li. (2017) STROBE-compliant integrin through focal adhesion involve in cancer stem cell and multidrug resistance of ovarian cancer. Medicine 96:12, pages e6345.
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Laura Rosanò & Anna Bagnato. (2016) β-arrestin1 at the cross-road of endothelin-1 signaling in cancer. Journal of Experimental & Clinical Cancer Research 35:1.
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John-David Aubert & Lucienne Juillerat-Jeanneret. (2016) Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis. Journal of Medicinal Chemistry 59:18, pages 8168-8188.
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Vasile Foris, Gabor Kovacs, Leigh M. Marsh, Zoltán Bálint, Martin Tötsch, Alexander Avian, Philipp Douschan, Bahil Ghanim, Walter Klepetko, Andrea Olschewski & Horst Olschewski. (2016) CD133 + cells in pulmonary arterial hypertension . European Respiratory Journal 48:2, pages 459-469.
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Rosanna Sestito, Roberta Cianfrocca, Laura Rosanò, Piera Tocci, Valeriana Di Castro, Valentina Caprara & Anna Bagnato. (2016) Macitentan blocks endothelin-1 receptor activation required for chemoresistant ovarian cancer cell plasticity and metastasis. Life Sciences 159, pages 43-48.
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E Semprucci, P Tocci, R Cianfrocca, R Sestito, V Caprara, M Veglione, V Di Castro, F Spadaro, G Ferrandina, A Bagnato & L Rosanò. (2015) Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma. Oncogene 35:26, pages 3432-3442.
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Roberta Cianfrocca, Piera Tocci, Laura Rosanò, Valentina Caprara, Rosanna Sestito, Valeriana Di Castro & Anna Bagnato. (2016) Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression. Oncotarget 7:14, pages 17790-17804.
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Laura Rosanò & Anna Bagnato. (2016) Endothelin therapeutics in cancer: Where are we?. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 310:6, pages R469-R475.
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Lan G. Coffman, Yun-Jung Choi, Karen McLean, Benjamin L. Allen, Marina Pasca di Magliano & Ronald J. Buckanovich. (2016) Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop . Oncotarget 7:6, pages 6916-6932.
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Rosanna Sestito, Roberta Cianfrocca, Laura Rosanò, Piera Tocci, Elisa Semprucci, Valeriana Di Castro, Valentina Caprara, Gabriella Ferrandina, Andrea Sacconi, Giovanni Blandino & Anna Bagnato. (2015) miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma. Oncotarget 7:4, pages 4009-4023.
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Z.L. Neumann, H.C. Pondenis, A. Masyr, M.L. Byrum, K.L. Wycislo & T.M. Fan. (2015) The Association of Endothelin‐1 Signaling with Bone Alkaline Phosphatase Expression and Protumorigenic Activities in Canine Osteosarcoma. Journal of Veterinary Internal Medicine 29:6, pages 1584-1594.
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Youssef A. Rezk, Kun Yang, Shoumei Bai, Karen Mclean, Carolyn Johnston, R. Kevin Reynolds & Ronald J. Buckanovich. (2015) Disulfiram’s Antineoplastic Effects on Ovarian Cancer. Journal of Cancer Therapy 06:14, pages 1196-1205.
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Laura Rosanò, Roberta Cianfrocca, Piera Tocci, Francesca Spinella, Valeriana Di Castro, Valentina Caprara, Elisa Semprucci, Gabriella Ferrandina, Pier Giorgio Natali & Anna Bagnato. (2014) Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy. Cancer Research 74:24, pages 7453-7464.
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Hui Zhang, Xinping Gao, Yongan Yang, Weiming Wang, Jin Liu, Yijuan Liang, Hongli Wu, Jinjin Qin, Kun Pan, Yifeng Wang, Junrong Shi & Youju Ma. (2014) New construction of an animal model for the orthotopic transplantation of an ovarian tumor. Journal of Ovarian Research 7:1.
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Luis Fernando Tume Farfán. (2014) La inmunoterapia en la búsqueda de antígenos contra las células madre del cáncer. Inmunología 33:3, pages 96-109.
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Irene S. Hong, Holly V. Coe & Linda M. Catanzaro. (2014) Macitentan for the Treatment of Pulmonary Arterial Hypertension. Annals of Pharmacotherapy 48:4, pages 538-547.
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Jaeyoung Lim, Kun Yang, Barbie Taylor-Harding, W. Ruprecht Wiedemeyer & Ronald J. Buckanovich. (2014) VEGFR3 Inhibition Chemosensitizes Ovarian Cancer Stemlike Cells through Down-Regulation of BRCA1 and BRCA2. Neoplasia 16:4, pages 343-353.e2.
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Laura Rosanò, Francesca Spinella & Anna Bagnato. (2013) Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nature Reviews Cancer 13:9, pages 637-651.
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Mirjana Kessler, Christina Fotopoulou & Thomas Meyer. (2013) The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin. International Journal of Molecular Sciences 14:4, pages 6571-6596.
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Mariana Bianchi, Javier Adur, Maria F. Izaguirre, Silvia Viale, Carlos L. Cesar & Víctor H. Casco. (2013) Endothelin-2 Differential Expression in Normal and Early-Stages of Colon Cancer Development. Journal of Cancer Therapy 04:06, pages 26-33.
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