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Cancer Biology & Therapy Volume 14, 2013 - Issue 4
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Research Paper

The translocator protein (TSPO) ligand PK11195 induces apoptosis and cell cycle arrest and sensitizes to chemotherapy treatment in pre- and post-relapse neuroblastoma cell lines

Maria Mendonça-Torres Department of Pediatrics; Division of Hematology/Oncology; Uniformed Services University of the Health Sciences; Bethesda, MD USA
&
Stephen Roberts Department of Pediatrics; Division of Hematology/Oncology; Uniformed Services University of the Health Sciences; Bethesda, MD USA; Department of Pediatrics; Memorial Sloan-Kettering Cancer Center; New York, NY USACorrespondence[email protected]
Pages 319-326 | Received 19 Apr 2012, Accepted 15 Jan 2013, Published online: 28 Jan 2013

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Guo-Jun Liu, Ryan J. Middleton, Winnie Wai-Ying Kam, David Y. Chin, Claire R. Hatty, Ronald H. Y. Chan & Richard B. Banati. (2017) Functional gains in energy and cell metabolism after TSPO gene insertion. Cell Cycle 16:5, pages 436-447.
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Articles from other publishers (21)

Jia-Hao Pan, Yin-Qian Kang, Qiang Li, Wei Xing, Yong-Hua Chen, Yan Yan, De-Xing Luo, Yue Qiu, Yun-Fei Yuan, Wei-An Zeng & Dong-Tai Chen. (2023) TSPO is a novel biomarker for prognosis that regulates cell proliferation through influencing mitochondrial functions in HCC. Heliyon 9:12, pages e22590.
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Garett Cheung, Yiqi Christina Lin & Vassilios Papadopoulos. (2023) Translocator protein in the rise and fall of central nervous system neurons. Frontiers in Cellular Neuroscience 17.
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Jaekyung Park, Sobia Wasim, Jae Ho Jung, Mi-hyun Kim, Byung Chul Lee, Mohammad Maqusood Alam & Sang-Yoon Lee. (2023) Synthesis, In Silico and In Vitro Characterization of Novel N,N-Substituted Pyrazolopyrimidine Acetamide Derivatives for the 18KDa Translocator Protein (TSPO). Pharmaceuticals 16:4, pages 576.
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Michael T. Patterson, Natalia S. Nunes, Lucas P. Wachsmuth, Amrit Panjabi, Rochelle E. Fletcher, Shanzay M. Khan, Dimana Dimitrova, Jennifer A. Kanakry, Leo Luznik & Christopher G. Kanakry. (2022) Efflux capacity and aldehyde dehydrogenase both contribute to CD8+ T-cell resistance to posttransplant cyclophosphamide. Blood Advances 6:17, pages 4994-5008.
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Sara Zięba, Mateusz Maciejczyk & Anna Zalewska. (2022) Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis. Frontiers in Physiology 12.
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Chao Yang, Yong Zhang & Baofeng Yang. (2021) MIAT, a potent CVD-promoting lncRNA. Cellular and Molecular Life Sciences 79:1.
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Sheelu Monga, Nunzio Denora, Valentino Laquintana, Rami Yashaev, Abraham Weizman & Moshe Gavish. (2021) The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson’s Disease. Biology 10:11, pages 1183.
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Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Viktoria Ruf, Christian H. Wetzel, Markus J. Riemenschneider, Nathalie L. Albert, Philipp Beckhove & Peter Hau. (2020) The Role of Translocator Protein TSPO in Hallmarks of Glioblastoma. Cancers 12:10, pages 2973.
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Anjali Sharma, Kevin Liaw, Rishi Sharma, Ajit G. Thomas, Barbara S. Slusher, Sujatha Kannan & Rangaramanujam M. Kannan. (2020) Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma. Biomacromolecules 21:9, pages 3909-3922.
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Lian-pan Wu, Zheng-fan Gong, He Wang, Zhong-shu Zhou, Ming-ming Zhang, Chao Liu, Hong-mei Ren, Jian Yang, Yu Han & Chun-yu Zeng. (2019) TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation. Acta Pharmacologica Sinica 41:1, pages 34-46.
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Meden F. Isaac-Lam & Dewana M. Hammonds. (2019) Synthesis and Photodynamic Activity of Vitamin–Chlorin Conjugates at Nanomolar Concentrations against Prostate Cancer Cells. ACS Omega 4:26, pages 21712-21723.
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Stefanie Bader, Luisa Wolf, Vladimir M. Milenkovic, Michael Gruber, Caroline Nothdurfter, Rainer Rupprecht & Christian H. Wetzel. (2019) Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells. Psychoneuroendocrinology 106, pages 65-76.
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Neydher Berroterán-Infante, Theresa Balber, Petra Fürlinger, Michael Bergmann, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser & Wolfgang Wadsak. (2018) [ 18 F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer . ACS Medicinal Chemistry Letters 9:3, pages 177-181.
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Moshe Gavish & Leo Veenman. 2018. Apprentices to Genius: A tribute to Solomon H. Snyder. Apprentices to Genius: A tribute to Solomon H. Snyder 103 136 .
Lijuan Bo, Bo Wei, Zhanfeng Wang, Daliang Kong, Zheng Gao & Zhuang Miao. (2017) Bioinformatics analysis of the CDK2 functions in neuroblastoma. Molecular Medicine Reports.
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Lijuan Bo, Bo Wei, Zhanfeng Wang, Daliang Kong, Zheng Gao & Zhuang Miao. (2017) WITHDRAWN: Bioinformatic analysis of the roles of CDK2 in neuroblastoma. Clinical Neurology and Neurosurgery.
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Moshe Gavish, Shiri Cohen & Rafael Nagler. (2016) Cigarette smoke effects on TSPO and VDAC expression in a cellular lung cancer model. European Journal of Cancer Prevention 25:5, pages 361-367.
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Simona Daniele, Valeria La Pietra, Elisabetta Barresi, Salvatore Di Maro, Eleonora Da Pozzo, Marco Robello, Concettina La Motta, Sandro Cosconati, Sabrina Taliani, Luciana Marinelli, Ettore Novellino, Claudia Martini & Federico Da Settimo. (2016) Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas. Journal of Medicinal Chemistry 59:10, pages 4526-4538.
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Jinzi Zheng, Alexandra Winkeler, Marie-Anne Peyronneau, Frédéric Dollé & Raphaël Boisgard. (2015) Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation. Molecular Imaging and Biology 18:1, pages 127-134.
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M.P. Ween, M.A. Armstrong, M.K. Oehler & C. Ricciardelli. (2015) The role of ABC transporters in ovarian cancer progression and chemoresistance. Critical Reviews in Oncology/Hematology 96:2, pages 220-256.
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Samuel D. Banister, Corinne Beinat, Shane M. Wilkinson, Bin Shen, Cecilia Bartoli, Silvia Selleri, Eleonora Da Pozzo, Claudia Martini, Frederick T. Chin & Michael Kassiou. (2015) Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). European Journal of Medicinal Chemistry 93, pages 392-400.
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