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Review

AMP-activated protein kinase (AMPK) beyond metabolism

A novel genomic stress sensor participating in the DNA damage response pathway

, , &
Pages 156-169 | Received 26 Aug 2013, Accepted 06 Oct 2013, Published online: 01 Nov 2013

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Shalini Singh, Ekta Kumari, Ruchika Bhardwaj, Ritesh Kumar & Vikash Kumar Dubey. (2017) Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment . Chemical Biology & Drug Design 90:5, pages 962-971.
Crossref
Hai-feng Qian, Yan Li & Li Wang. (2017) Vaccinium bracteatum Thunb. Leaves’ polysaccharide alleviates hepatic gluconeogenesis via the downregulation of miR-137. Biomedicine & Pharmacotherapy 95, pages 1397-1403.
Crossref
Mariwan M. M. Al-Bajalan, Dong Xia, Stuart Armstrong, Nadine Randle & Jonathan M. Wastling. (2017) Toxoplasma gondii and Neospora caninum induce different host cell responses at proteome-wide phosphorylation events; a step forward for uncovering the biological differences between these closely related parasites. Parasitology Research 116:10, pages 2707-2719.
Crossref
Michael Troncone, Stephanie M. Cargnelli, Linda A. Villani, Naghmeh Isfahanian, Lindsay A. Broadfield, Laura Zychla, Jim Wright, Gregory Pond, Gregory R. Steinberg & Theodoros Tsakiridis. (2017) Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials. Oncotarget 8:34, pages 57733-57754.
Crossref
Zhihui Li, Daochuan Li, Eun Yong Choi, Rena Lapidus, Lei Zhang, Shiew-Mei Huang, Paul Shapiro & Hongbing Wang. (2017) Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells. Journal of Biological Chemistry 292:33, pages 13890-13901.
Crossref
Konomi Shimoda, Masakazu Mimaki, Shuhei Fujino, Masato Takeuchi, Rumi Hino, Hiroshi Uozaki, Masaharu Hayashi, Akira Oka & Masashi Mizuguchi. (2017) Brain edema with clasmatodendrosis complicating ataxia telangiectasia. Brain and Development 39:7, pages 629-632.
Crossref
Laura Bonanno, Angela De Paoli, Elisabetta Zulato, Giovanni Esposito, Fiorella Calabrese, Adolfo Favaretto, Antonio Santo, Alessandro Del Conte, Marco Chilosi, Francesco Oniga, Gabriella Sozzi, Massimo Moro, Francesco Ciccarese, Giorgia Nardo, Roberta Bertorelle, Cinzia Candiotto, Gian Luca De Salvo, Alberto Amadori, PierFranco Conte & Stefano Indraccolo. (2017) LKB1 Expression Correlates with Increased Survival in Patients with Advanced Non–Small Cell Lung Cancer Treated with Chemotherapy and Bevacizumab. Clinical Cancer Research 23:13, pages 3316-3324.
Crossref
Eric Eidelman, Jeffrey Twum-Ampofo, Jamal Ansari & Mohummad Minhaj Siddiqui. (2017) The Metabolic Phenotype of Prostate Cancer. Frontiers in Oncology 7.
Crossref
Robert A.H. van de Ven, Daniel Santos & Marcia C. Haigis. (2017) Mitochondrial Sirtuins and Molecular Mechanisms of Aging. Trends in Molecular Medicine 23:4, pages 320-331.
Crossref
Ayesha S. Khan & Daniel E. Frigo. (2017) A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer. Nature Reviews Urology 14:3, pages 164-180.
Crossref
Hans-Uwe Simon, Robert Friis, Stephen W. G. Tait & Kevin M. Ryan. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling 10:468.
Crossref
Min Jeong Chun, Hana Choi, Dong Wha Jun, Sunshin Kim, Yong-Nyun Kim, Soo-Youl Kim & Chang-Hun Lee. (2017) Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism. FEBS Open Bio 7:2, pages 284-292.
Crossref
Hui ZengRong FuLinxia YanJian Huang. (2017) Lycorine Induces Apoptosis of A549 Cells via AMPK-Mammalian Target of Rapamycin (mTOR)-S6K Signaling Pathway. Medical Science Monitor 23, pages 2035-2041.
Crossref
Yu YANG, Zhongliang JIANG, Alan BOLNICK, Jing DAI, Elizabeth E PUSCHECK & Daniel A RAPPOLEE. (2017) Departure from optimal O<sub>2</sub> level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation. Journal of Reproduction and Development 63:1, pages 87-94.
Crossref
Fan Yao, Ming Zhang & Li Chen. (2017) Adipose Tissue-Specialized Immunologic Features Might Be the Potential Therapeutic Target of Prospective Medicines for Obesity. Journal of Diabetes Research 2017, pages 1-8.
Crossref
Aleksandra V. Borodkina, Alla N. Shatrova, Pavel I. Deryabin, Anastasiia A. Griukova, Polina A. Abushik, Sergei M. Antonov, Nikolay N. Nikolsky & Elena B. Burova. (2016) Calcium alterations signal either to senescence or to autophagy induction in stem cells upon oxidative stress. Aging 8:12, pages 3400-3418.
Crossref
Li-Hao Cheng, Kai-Feng Hung, Te-Chang Lee, Chih-Yang Huang, Wen-Ting Chiu, Jeng-Fan Lo & Tung-Fu Huang. (2016) Mitochondrial co-chaperone protein Tid1 is required for energy homeostasis during skeletal myogenesis. Stem Cell Research & Therapy 7:1.
Crossref
D. A. Knorre & F. F. Severin. (2016) Uncouplers of oxidation and phosphorylation as antiaging compounds. Biochemistry (Moscow) 81:12, pages 1438-1444.
Crossref
Guillermo Mazzolini, Jan-Peter Sowa & Ali Canbay. (2016) Cell death mechanisms in human chronic liver diseases: a far cry from clinical applicability. Clinical Science 130:23, pages 2121-2138.
Crossref
Francesco Perrone, Gustavo Baldassarre, Stefano Indraccolo, Simona Signoriello, Gennaro Chiappetta, Franca Esposito, Gabriella Ferrandina, Renato Franco, Delia Mezzanzanica, Maura Sonego, Elisabetta Zulato, Gian F. Zannoni, Vincenzo Canzonieri, Giovanni Scambia, Roberto Sorio, Antonella Savarese, Enrico Breda, Paolo Scollo, Antonella Ferro, Stefano Tamberi, Antonio Febbraro, Donato Natale, Massimo Di Maio, Daniela Califano, Giosuè Scognamiglio, Domenica Lorusso, Silvana Canevari, Simona Losito, Ciro Gallo & Sandro Pignata. (2016) Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC. Oncotarget 7:45, pages 72654-72661.
Crossref
Wenyan Sun, Chunhong Yan, Bess Frost, Xin Wang, Chen Hou, Mengqi Zeng, Hongli Gao, Yuming Kang & Jiankang Liu. (2016) Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Scientific Reports 6:1.
Crossref
Hyung Sik Kim, Sam Kacew & Byung Mu Lee. (2016) Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis. Archives of Toxicology 90:10, pages 2389-2404.
Crossref
Yi Liao, Hsueh-Ping Chu, Zhixian Hu, Jason J. Merkin, Jianmin Chen, Zuguo Liu, Kurt Degenhardt, Eileen White & Alexey G. Ryazanov. (2016) Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival. Journal of Biological Chemistry 291:37, pages 19545-19557.
Crossref
Mi Huang, Ping Zhao, Mingrui Xiong, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang & Tong-Cun Zhang. (2016) Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambusicola in KK-Ay mice with spontaneous type 2 diabetes mellitus. Journal of Ethnopharmacology 191, pages 71-81.
Crossref
Jingchen Lu, Min Tang, Hongde Li, Zhijie Xu, Xinxian Weng, Jiangjiang Li, Xinfang Yu, Luqing Zhao, Hongwei Liu, Yongbin Hu, Zheqiong Tan, Lifang Yang, Meizuo Zhong, Jian Zhou, Jia Fan, Ann M. Bode, Wei Yi, Jinghe Gao, Lunquan Sun & Ya Cao. (2016) EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma. Cancer Letters 380:1, pages 191-200.
Crossref
Min Jeong Chun, Sunshin Kim, Soo Kyung Hwang, Bong Sub Kim, Hyoun Geun Kim, Hae In Choi, Jong Heon Kim, Sung Ho Goh & Chang-Hun Lee. (2016) AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks. Oncotarget 7:33, pages 53642-53653.
Crossref
Theodoros Tsakiridis, Heath Skinner, Gregory Pond, Anand Swaminath & James Wright. (2016) Metformin for chemo-radio-sensitization of NSCLC. Radiotherapy and Oncology 120:2, pages 363-364.
Crossref
Kai Lei, Hanh Thi-Kim Vu, Ryan D. Mohan, Sean A. McKinney, Chris W. Seidel, Richard Alexander, Kirsten Gotting, Jerry L. Workman & Alejandro Sánchez Alvarado. (2016) Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians. Developmental Cell 38:4, pages 413-429.
Crossref
Antero Salminen, Anu Kauppinen & Kai Kaarniranta. (2016) AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. Cellular Signalling 28:8, pages 887-895.
Crossref
Antero Salminen, Kai Kaarniranta & Anu Kauppinen. (2016) Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Research Reviews 28, pages 15-26.
Crossref
CHI LU & CONGHUA XIE. (2016) Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway. Oncology Reports 35:6, pages 3559-3565.
Crossref
Stefania Rigacci & Massimo Stefani. (2016) Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans. International Journal of Molecular Sciences 17:6, pages 843.
Crossref
Handoo Rhee, Ian Vela & Eric Chung. (2015) Metabolic Syndrome and Prostate Cancer: a Review of Complex Interplay Amongst Various Endocrine Factors in the Pathophysiology and Progression of Prostate Cancer. Hormones and Cancer 7:2, pages 75-83.
Crossref
Yi-Ze Zhang, Xi Chen, Xing-Xing Fan, Jian-Xing He, Jun Huang, Da-Kai Xiao, Yan-Ling Zhou, Sen-You Zheng, Jia-Hui Xu, Xiao-Jun Yao, Liang Liu & Elaine Leung. (2016) Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation. Molecules 21:3, pages 374.
Crossref
Vincent Kam Wai Wong, Hang Dong, Xu Liang, Li-Ping Bai, Zhi-Hong Jiang, Yue Guo, Ah-Ng Tony Kong, Rui Wang, Richard Kin Ting Kam, Betty Yuen Kwan Law, Wendy Wen Luen Hsiao, Ka Man Chan, Jingrong Wang, Rick Wai Kit Chan, Jianru Guo, Wei Zhang, Feng Gen Yen, Hua Zhou, Elaine Lai Han Leung, Zhiling Yu & Liang Liu. (2016) Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells. Oncotarget 7:9, pages 9907-9924.
Crossref
Azhub Gaziev, Serazhutdin Abdullaev, Gulchachak Minkabirova & Kristina Kamenskikh. (2016) X-rays and metformin cause increased urinary excretion of cell-free nuclear and mitochondrial DNA in aged rats. Journal of Circulating Biomarkers 5, pages 184945441667078.
Crossref
Zhiyu Wang, Neng Wang, Pengxi Liu & Xiaoming Xie. 2016. AMP-activated Protein Kinase. AMP-activated Protein Kinase 203 226 .
Kenneth S. Brooks, Eric C. Woolf & Adrienne C. Scheck. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 89 109 .
Claudia Lennicke, Jette Rahn, Rudolf Lichtenfels, Ludger A. Wessjohann & Barbara Seliger. (2015) Hydrogen peroxide – production, fate and role in redox signaling of tumor cells. Cell Communication and Signaling 13:1.
Crossref
Wei-Ling Chang, Lih-Ching Hsu, Wohn-Jenn Leu, Ching-Shih Chen & Jih-Hwa Guh. (2015) Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation. Oncotarget 6:37, pages 39806-39820.
Crossref
Ioannis S. Pateras, Sophia Havaki, Xenia Nikitopoulou, Konstantinos Vougas, Paul A. Townsend, Michalis I. Panayiotidis, Alexandros G. Georgakilas & Vassilis G. Gorgoulis. (2015) The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where. Pharmacology & Therapeutics 154, pages 36-56.
Crossref
Mounia Guerram, Zhen-Zhou Jiang, Bashir Alsiddig Yousef, Aida Mejda Hamdi, Hozeifa Mohamed Hassan, Zi-Qiao Yuan, Hou-Wei Luo, Xiong Zhu & Lu-Yong Zhang. (2015) The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways. Oncotarget 6:26, pages 21865-21877.
Crossref
Dong Xin Zhang, Chong Hui Li, Ai Qun Zhang, Shan Jiang, Yan Hua Lai, Xin Lan Ge, Ke Pan & Jia Hong Dong. (2015) mTOR-Dependent Suppression of Remnant Liver Regeneration in Liver Failure After Massive Liver Resection in Rats. Digestive Diseases and Sciences 60:9, pages 2718-2729.
Crossref
Deepa S. Valsangkar & Stephen M. Downs. (2015) Acetyl CoA carboxylase inactivation and meiotic maturation in mouse oocytes. Molecular Reproduction and Development 82:9, pages 679-693.
Crossref
Erica S. Lovelace, Jessica Wagoner, James MacDonald, Theo Bammler, Jacob Bruckner, Jessica Brownell, Richard P. Beyer, Erika M. Zink, Young-Mo Kim, Jennifer E. Kyle, Bobbie-Jo M. Webb-Robertson, Katrina M. Waters, Thomas O. Metz, Federico Farin, Nicholas H. Oberlies & Stephen J. Polyak. (2015) Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling. Journal of Natural Products 78:8, pages 1990-2000.
Crossref
Xiuying Wang, Yulan Liu, Shuang Li, Dingan Pi, Huiling Zhu, Yongqing Hou, Haifeng Shi & Weibo Leng. (2015) Asparagine attenuates intestinal injury, improves energy status and inhibits AMP-activated protein kinase signalling pathways in weaned piglets challenged with Escherichia coli lipopolysaccharide . British Journal of Nutrition 114:4, pages 553-565.
Crossref
Alper Y. Kearney, You-Hong Fan, Uma Giri, Babita Saigal, Varsha Gandhi, John V. Heymach & Amado J. Zurita. (2015) 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PLOS ONE 10:8, pages e0135962.
Crossref
Quinn Matthews, Martin Isabelle, Samantha J. Harder, Julian Smazynski, Wayne Beckham, Alexandre G. Brolo, Andrew Jirasek & Julian J. Lum. (2015) Radiation-Induced Glycogen Accumulation Detected by Single Cell Raman Spectroscopy Is Associated with Radioresistance that Can Be Reversed by Metformin. PLOS ONE 10:8, pages e0135356.
Crossref
Agnieszka Bronisz, E. Antonio Chiocca & Jakub Godlewski. (2015) Response to energy depletion: miR-451/AMPK loop. Oncotarget 6:20, pages 17851-17852.
Crossref
Khairul I. Ansari, Daisuke Ogawa, Arun K. Rooj, Sean E. Lawler, Anna M. Krichevsky, Mark D. Johnson, E. Antonio Chiocca, Agnieszka Bronisz & Jakub Godlewski. (2015) Glucose-Based Regulation of miR-451/AMPK Signaling Depends on the OCT1 Transcription Factor. Cell Reports 11:6, pages 902-909.
Crossref
HAK-SU KIM, JIHYUN LIM, DA YEON LEE, JAE-HA RYU & JONG-SEOK LIM. (2015) Kazinol C from Broussonetia kazinoki activates AMP-activated protein kinase to induce antitumorigenic effects in HT-29 colon cancer cells. Oncology Reports 33:1, pages 223-229.
Crossref
Narayana Kilarkaje & Maie M. Al-Bader. (2015) Diabetes-Induced Oxidative DNA Damage Alters p53-p21CIP1/Waf1 Signaling in the Rat Testis. Reproductive Sciences 22:1, pages 102-112.
Crossref
Eric C. Woolf & Adrienne C. Scheck. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 125 135 .
InYoung Kim & Yu-Ying He. (2014) Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes & Diseases 1:2, pages 188-198.
Crossref
Thomas Shenk & James C. Alwine. (2014) Human Cytomegalovirus: Coordinating Cellular Stress, Signaling, and Metabolic Pathways. Annual Review of Virology 1:1, pages 355-374.
Crossref
Faya M. Millimouno, Jia Dong, Liu Yang, Jiang Li & Xiaomeng Li. (2014) Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature. Cancer Prevention Research 7:11, pages 1081-1107.
Crossref
Wei Zhou, Jun Zhang & Adam I. Marcus. (2014) LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated. Genes & Diseases 1:1, pages 64-74.
Crossref
Sunmin Park, Da Sol Kim, Suna Kang & Bae Keun Shin. (2014) Chronic activation of central AMPK attenuates glucose-stimulated insulin secretion and exacerbates hepatic insulin resistance in diabetic rats. Brain Research Bulletin 108, pages 18-26.
Crossref
S. Roy & R. Arav-Boger. (2014) New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication. American Journal of Transplantation 14:6, pages 1249-1258.
Crossref
Simona PisantiPaola PicardiElena CiagliaLuigi MargarucciRoberto Ronca, Arianna Giacomini, Anna Maria MalfitanoAgostino CasapulloChiara Laezza, Patrizia GazzerroMaurizio Bifulco. (2014) Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation. The FASEB Journal 28:3, pages 1132-1144.
Crossref
Paola Maycotte. (2014) Targeting autophagy in breast cancer. World Journal of Clinical Oncology 5:3, pages 224.
Crossref
Natália Feofanova, Jony Marques Geraldo & Lídia Maria de Andrade. (2014) Radiation Oncology In Vitro : Trends to Improve Radiotherapy through Molecular Targets . BioMed Research International 2014, pages 1-13.
Crossref