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Cancer Biology & Therapy Volume 15, 2014 - Issue 1
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Research Paper

Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target

Jing Li Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Sufang Han Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Ziliang Qian Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Xinying Su Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Shuqiong Fan Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Jiangang Fu Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Yuanjie Liu Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Xiaolu Yin Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Zeren Gao Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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Jingchuan Zhang Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR China
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De-Hua Yu Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR ChinaCorrespondence[email protected] [email protected]
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Qunsheng Ji Innovation Center China; Asia & Emerging Market iMed; AstraZeneca Innovation Medicines and Early Development; Shanghai, PR ChinaCorrespondence[email protected] [email protected]
 show all
Pages 128-134 | Received 10 Oct 2013, Accepted 10 Nov 2013, Published online: 19 Nov 2013

Citations (21)

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Baoying Du, Hongfeng Liao & Sheng Zhang. (2020) Expression Pattern and Prognostic Utility of PME-1 in Patients with Hepatocellular Carcinoma. Cancer Management and Research 12, pages 2937-2945.
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Articles from other publishers (20)

Howard Yu, Sahil Zaveri, Zeeshan Sattar, Michael Schaible, Brais Perez Gandara, Anwar Uddin, Lucas R. McGarvey, Michael Ohlmeyer & Patrick Geraghty. (2023) Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases. Medicina 59:9, pages 1552.
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Liesbeth Guffens, Rita Derua & Veerle Janssens. (2023) PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling. Cell Death Discovery 9:1.
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Haohan Liu, Deliang Fang, Chaoyue Zhang, Zirui Zhao, Yinan Liu, Shaoji Zhao, Nu Zhang & Jianbo Xu. (2023) Circular MTHFD2L RNA-encoded CM-248aa inhibits gastric cancer progression by targeting the SET-PP2A interaction. Molecular Therapy 31:6, pages 1739-1755.
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Farhoodeh Ghaedrahmati, Ava Nasrolahi, Sajad Najafi, Mohammad Mighani, Omid Anbiyaee, Habib Haybar, Ahmad Reza Assareh, Bartosz Kempisty, Piotr Dzięgiel, Shirin Azizidoost & Maryam Farzaneh. (2023) Circular RNAs-mediated angiogenesis in human cancers. Clinical and Translational Oncology.
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Sami Zaqout, Atef Mannaa, Oliver Klein, Angelika Krajewski, Joachim Klose, Lena Luise‐Becker, Ahmed Elsabagh, Khaled Ferih, Nadine Kraemer, Ethiraj Ravindran, Konstantin Makridis & Angela M. Kaindl. (2022) Proteome changes in autosomal recessive primary microcephaly. Annals of Human Genetics 87:1-2, pages 50-62.
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Ningning Feng, Zhikai Jiao, Yueshan Zhang & Baoming Yang. (2022) Hsa_circ_0050102 regulates the pancreatic cancer development via miR‐218‐5p/PPME1 axis. Journal of Clinical Laboratory Analysis 36:3.
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Runsheng Guo, Yong Ning, Ye Ma, Qianhuang Lin, Na Shen & Peidong Shi. (2021) Long non‐coding RNA HOTAIR / microRNA ‐761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma . Laryngoscope Investigative Otolaryngology 6:3, pages 438-445.
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Goce Taleski, Diana Schuhmacher, Henry Su, Jean-Marie Sontag & Estelle Sontag. (2021) Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation. Journal of Biological Chemistry 296, pages 100237.
Crossref
Raffaella Pippa, Silvia Boffo, Maria D. Odero & Antonio Giordano. (2019) Data mining analysis of the PP2A cell cycle axis in mesothelioma patients. Journal of Cellular Physiology 235:6, pages 5284-5292.
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Sydney A. Labuzan, Sarah A. Lynch, Lisa M. Cooper & David S. Waddell. (2020) Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation. Gene 739, pages 144515.
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Tao Xu, Ting Lei, Si-Qiao Li, Er-Hui Mai, Fei-Hu Ding & Bin Niu. (2020) DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p . World Journal of Gastroenterology 26:15, pages 1745-1757.
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Simona Punzi, Chiara Balestrieri, Carolina D’Alesio, Daniela Bossi, Gaetano Ivan Dellino, Elena Gatti, Giancarlo Pruneri, Carmen Criscitiello, Giulia Lovati, Marine Meliksetyan, Alessandro Carugo, Giuseppe Curigliano, Gioacchino Natoli, Pier Giuseppe Pelicci & Luisa Lanfrancone. (2019) WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells. Breast Cancer Research 21:1.
Crossref
Cassandra P. Nader, Aylin Cidem, Nicole M. Verrills & Alaina J. Ammit. (2019) Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer. Respiratory Research 20:1.
Crossref
Shen Tang, Cailing Lu, Laiming Mo, Xinhang Wang, Ziwei Liang, Fu Qin, Yinpin Liu, Yuyang Liu, Haiyan Huang, Yue Huang, Haiqing Cai, Deqiang Xiao, Songchao Guo, Yiqiang Ouyang, Bin Sun & Xiyi Li. (2018) Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1. Life Sciences 213, pages 166-173.
Crossref
Soo‐Yeon Kim, Jihye Choi, Da‐Hye Lee, Jun‐Hyeok Park, Young‐Jae Hwang & Kwang‐Hyun Baek. (2018) PME ‐1 is regulated by USP 36 in ERK and Akt signaling pathways . FEBS Letters 592:9, pages 1575-1588.
Crossref
Caitlin M. O’Connor, Abbey Perl, Daniel Leonard, Jaya Sangodkar & Goutham Narla. (2018) Therapeutic targeting of PP2A. The International Journal of Biochemistry & Cell Biology 96, pages 182-193.
Crossref
Amanpreet Kaur & Jukka Westermarck. (2016) Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1. Biochemical Society Transactions 44:6, pages 1683-1693.
Crossref
Amanpreet Kaur, Adam Elzagheid, Eva‐Maria Birkman, Tuulia Avoranta, Ville Kytölä, Eija Korkeila, Kari Syrjänen, Jukka Westermarck & Jari Sundström. (2015) Protein phosphatase methylesterase‐1 ( PME ‐1) expression predicts a favorable clinical outcome in colorectal cancer . Cancer Medicine 4:12, pages 1798-1808.
Crossref
Rebecca A. Kohnz, Melinda M. Mulvihill, Jae Won Chang, Ku-Lung Hsu, Antonio Sorrentino, Benjamin F. Cravatt, Sourav Bandyopadhyay, Andrei Goga & Daniel K. Nomura. (2015) Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. ACS Chemical Biology 10:7, pages 1624-1630.
Crossref
Takashi Ohama
. (2015) Targeting PP2A inhibitors as a novel anti-cancer strategy
. Folia Pharmacologica Japonica 145:6, pages 293-298.
Crossref

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