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Cancer Biology & Therapy Volume 15, 2014 - Issue 5
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Research Paper

Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer

Cheng Ji Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA; Department of Respiratory Medicine; The First Affiliated Hospital of Soochow University; Suzhou, Jiangsu, PR China
,
Li Zhang Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Yan Cheng Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Raj Patel Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Hao Wu Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Yi Zhang Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Mian Wang Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Shundong Ji Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Chandra P Belani Department of Medicine; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USA
,
Jin-Ming Yang Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USACorrespondence[email protected] [email protected]
&
Xingcong Ren Department of Pharmacology; Penn State Hershey Cancer Institute; The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center; Hershey, PA USACorrespondence[email protected] [email protected]
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Pages 570-577 | Received 21 Jan 2014, Accepted 09 Feb 2014, Published online: 20 Feb 2014

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Menghua Gao, Yuzhen Xu & Liyan Qiu. (2017) Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition. Journal of Liposome Research 27:2, pages 151-160.
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Subhadip Mukhopadhyay, Niharika Sinha, Durgesh Nandini Das, Prashanta Kumar Panda, Prajna Paramita Naik & Sujit Kumar Bhutia. (2016) Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects. Critical Reviews in Clinical Laboratory Sciences 53:4, pages 228-252.
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Janaki Sharma, Vipul Pareek, Huijie Liu & Haiying Cheng. (2016) Emerging treatment for ALK-positive lung cancer. Expert Opinion on Emerging Drugs 21:2, pages 147-155.
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Paul Dent. (2014) Met in lung cancer. Cancer Biology & Therapy 15:6, pages 653-654.
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Articles from other publishers (54)

Asha Tonkin-Reeves, Charlett M. Giuliani & John T. Price. (2023) Inhibition of autophagy; an opportunity for the treatment of cancer resistance. Frontiers in Cell and Developmental Biology 11.
Crossref
Wenxin He, Xiankun Cao, Keyu Kong, Kewei Rong, Shuai Han & An Qin. (2022) Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation. Frontiers in Endocrinology 13.
Crossref
Yu-Zheng He, Shan-Ling Yu, Xiao-Ning Li, Xian-Hua Bai, Hai-Tao Li, Yan-Chao Liu, Bao-Lei Lv, Xiu-Min Zhao, Dong Wei, He-Lin Zhang, Fan-Nian Li, GuoLei Li & Shuai Li. (2022) Curcumin increases crizotinib sensitivity through the inactivation of autophagy via epigenetic modulation of the miR-142-5p/Ulk1 axis in non-small cell lung cancer. Cancer Biomarkers 34:2, pages 297-307.
Crossref
Weina Guo, Keye Du, Shanshan Luo & Desheng Hu. (2022) Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application. Frontiers in Oncology 12.
Crossref
Zhen Li, Fang Liu, Shuang Wu, Shi Ding, Ye Chen & Ju Liu. (2022) Research Progress on the Drug Resistance of ALK Kinase Inhibitors. Current Medicinal Chemistry 29:14, pages 2456-2475.
Crossref
Anchala Pandey, Pooja Yadav & Sanjeev Shukla. (2021) Unfolding the role of autophagy in the cancer metabolism. Biochemistry and Biophysics Reports 28, pages 101158.
Crossref
Lucy Hare, G. A. Amos Burke & Suzanne D. Turner. (2021) Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL. Cancers 13:23, pages 6003.
Crossref
Habib Ghaznavi, Milad Shirvaliloo, Amir Zarebkohan, Zinat Shams, Fatemeh Radnia, Zahra Bahmanpour, Saman Sargazi, Ramin Saravani, Sakine Shirvalilou, Omolbanin Shahraki, Sheida Shahraki, Ziba Nazarlou & Roghayeh Sheervalilou. (2021) An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy. Molecular Pharmacology 100:2, pages 119-143.
Crossref
Ming Shao, Run Shi, Zhen-Xing Gao, Shan-Shan Gao, Jing-Feng Li, Huan Li, Shu-Zhong Cui, Wei-Min Hu, Tian-Yun Chen, Gui-Ru Wu, Jie Zhang, Jiang Xu, Man-Sun Sy & Chaoyang Li. (2021) Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death. Frontiers in Oncology 11.
Crossref
Anna M. Schläfli, Igor Tokarchuk, Sarah Parejo, Susanne Jutzi, Sabina Berezowska, Nikolai Engedal & Mario P. Tschan. (2021) ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells. Scientific Reports 11:1.
Crossref
Luigi Mele, Vitale del Vecchio, Davide Liccardo, Claudia Prisco, Melanie Schwerdtfeger, Nirmal Robinson, Vincenzo Desiderio, Virginia Tirino, Gianpaolo Papaccio & Marcella La Noce. (2020) The role of autophagy in resistance to targeted therapies. Cancer Treatment Reviews 88, pages 102043.
Crossref
Yanrong Li, Kai Wang, Na Song, Kezuo Hou, Xiaofang Che, Yang Zhou, Yunpeng Liu & Jingdong Zhang. (2019) Activation of IGF-1R pathway and NPM-ALK G1269A mutation confer resistance to crizotinib treatment in NPM-ALK positive lymphoma. Investigational New Drugs 38:3, pages 599-609.
Crossref
Xin Lyu, Lizhong Zeng, Hua Zhang, Yue Ke, Xuan Liu, Nannan Zhao, Jingyan Yuan, Guoan Chen & Shuanying Yang. (2020) Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation. Life Sciences 246, pages 117366.
Crossref
Tareq Saleh, Liliya Tyutyunyk-Massey, Nipa H. Patel, Emmanuel K. CudjoeJr.Jr., Moureq Alotaibi & David A. Gewirtz. (2020) Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. International Journal of Molecular Sciences 21:4, pages 1427.
Crossref
Jie Zhu, Min Wang & Daixing Hu. (2020) Development of an autophagy-related gene prognostic signature in lung adenocarcinoma and lung squamous cell carcinoma. PeerJ 8, pages e8288.
Crossref
Paolo Grumati, Gian Paolo Tonini & Sanja Aveic. 2019. Neuroblastoma. Neuroblastoma 95 112 .
Zhifa Cao, Qian Gao, Meixian Fu, Nan Ni, Yuting Pei & Wen‑Bin Ou. (2018) Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives (Review). Oncology Letters.
Crossref
Carminia Maria Della Corte, Giuseppe Viscardi, Raimondo Di Liello, Morena Fasano, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello & Floriana Morgillo. (2018) Role and targeting of anaplastic lymphoma kinase in cancer. Molecular Cancer 17:1.
Crossref
Chandan Kanta Das, Mahitosh Mandal & Donat Kögel. (2018) Pro-survival autophagy and cancer cell resistance to therapy. Cancer and Metastasis Reviews 37:4, pages 749-766.
Crossref
Christina Alidousty, Till Baar, Luciano G Martelotto, Carina Heydt, Svenja Wagener, Jana Fassunke, Nicolai Duerbaum, Andreas H Scheel, Sandra Frank, Barbara Holz, Elke Binot, Anna Kron, Sabine Merkelbach-Bruse, Michaela A Ihle, Jürgen Wolf, Reinhard Buettner & Anne Maria Schultheis. (2018) Genetic instability and recurrent MYC amplification in ALK- translocated NSCLC: a central role of TP53 mutations . The Journal of Pathology 246:1, pages 67-76.
Crossref
Zachary Schrank, Gagan Chhabra, Leo Lin, Tsatsral Iderzorig, Chike Osude, Nabiha Khan, Adijan Kuckovic, Sanjana Singh, Rachel Miller & Neelu Puri. (2018) Current Molecular-Targeted Therapies in NSCLC and Their Mechanism of Resistance. Cancers 10:7, pages 224.
Crossref
Biagio Ricciuti, Andrea De Giglio, Carmen Mecca, Cataldo Arcuri, Sabrina Marini, Giulio Metro, Sara Baglivo, Angelo Sidoni, Guido Bellezza, Lucio Crinò & Rita Chiari. (2018) Precision medicine against ALK-positive non-small cell lung cancer: beyond crizotinib. Medical Oncology 35:5.
Crossref
Ricky Trigg & Suzanne Turner. (2018) ALK in Neuroblastoma: Biological and Therapeutic Implications. Cancers 10:4, pages 113.
Crossref
Yuki Uchihara, Takayuki Kidokoro, Kenji Tago, Tadahiko Mashino, Hiroomi Tamura & Megumi Funakoshi-Tago. (2018) A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK. European Journal of Pharmacology 825, pages 1-9.
Crossref
Kadri Valter, Boris Zhivotovsky & Vladimir Gogvadze. (2018) Cell death-based treatment of neuroblastoma. Cell Death & Disease 9:2.
Crossref
Julie Frentzel, Domenico Sorrentino & Sylvie Giuriato. (2017) Targeting Autophagy in ALK-Associated Cancers. Cancers 9:12, pages 161.
Crossref
Jean M. Mulcahy Levy, Christina G. Towers & Andrew Thorburn. (2017) Targeting autophagy in cancer. Nature Reviews Cancer 17:9, pages 528-542.
Crossref
Vijaykumar R. Holla, Yasir Y. Elamin, Ann Marie Bailey, Amber M. Johnson, Beate C. Litzenburger, Yekaterina B. Khotskaya, Nora S. Sanchez, Jia Zeng, Md Abu Shufean, Kenna R. Shaw, John Mendelsohn, Gordon B. Mills, Funda Meric-Bernstam & George R. Simon. (2017) ALK: a tyrosine kinase target for cancer therapy. Molecular Case Studies 3:1, pages a001115.
Crossref
Sanja Aveic & Gian Paolo Tonini. (2016) Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?. Cancer Cell International 16:1.
Crossref
Alexios Matikas, Nikolaos Kentepozidis, Vassilis Georgoulias & Athanasios Kotsakis. (2016) Management of Resistance to Crizotinib in Anaplastic Lymphoma Kinase-Positive Non–Small-cell Lung Cancer. Clinical Lung Cancer 17:6, pages 474-482.
Crossref
Tareq Saleh, Laurie Cuttino & David A. Gewirtz. (2016) Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:10, pages 2130-2136.
Crossref
Rajani Kanteti, Jacob J. Riehm, Immanuel Dhanasingh, Frances E. Lennon, Tamara Mirzapoiazova, Bolot Mambetsariev, Hedy L. Kindler & Ravi Salgia. (2016) PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma. Scientific Reports 6:1.
Crossref
Bing Liang, Xiaodong Liu, Yang Liu, Dejuan Kong, Xiaomei Liu, Rui Zhong & Shumei Ma. (2016) Inhibition of autophagy sensitizes MDR-phenotype ovarian cancer SKVCR cells to chemotherapy. Biomedicine & Pharmacotherapy 82, pages 98-105.
Crossref
Paola Ulivi. (2016) Non-Invasive Methods to Monitor Mechanisms of Resistance to Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer: Where Do We Stand?. International Journal of Molecular Sciences 17:7, pages 1186.
Crossref
Cui Yang, Chao Wu, Dujuan Xu, Meng Wang & Quan Xia. (2016) AstragalosideII inhibits autophagic flux and enhance chemosensitivity of cisplatin in human cancer cells. Biomedicine & Pharmacotherapy 81, pages 166-175.
Crossref
Li Li, Yubo Wang, Tao Peng, Kejun Zhang, Caiyu Lin, Rui Han, Conghua Lu & Yong He. (2016) Metformin restores crizotinib sensitivity in crizotinib-resistant human lung cancer cells through inhibition of IGF1-R signaling pathway. Oncotarget 7:23, pages 34442-34452.
Crossref
A.J. van der -->Wekken, A. Saber, T.J.N. Hiltermann, K. Kok, A. van den -->Berg & H.J.M. Groen. (2016) Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature. Critical Reviews in Oncology/Hematology 100, pages 107-116.
Crossref
Sanja Aveic, Marcella Pantile, Anke Seydel, Maria Rosaria Esposito, Carlo Zanon, Gary Li & Gian Paolo Tonini. (2015) Combating autophagy is a strategy to increase cytotoxic effects of novel ALK inhibitor entrectinib in neuroblastoma cells. Oncotarget 7:5, pages 5646-5663.
Crossref
Jing Xu, Xiumei Zhu & Liyan Qiu. (2016) Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal. International Journal of Pharmaceutics 498:1-2, pages 70-81.
Crossref
Francesca Simionato, Carmine Carbone, Giampaolo Tortora & Davide Melisi. 2016. Resistance to Tyrosine Kinase Inhibitors. Resistance to Tyrosine Kinase Inhibitors 147 163 .
Etienne Giroux Leprieur, Vincent Fallet & Marie Wislez. (2015) Modalités d’utilisation du ceritinib (Zykadia™), inhibiteur de ALK de 2e génération, dans le cancer bronchique non à petites cellules de stade avancé. Bulletin du Cancer 102:12, pages 1053-1057.
Crossref
Liangkun You, Jiawei Shou, Danchen Deng, Liming Jiang, Zhao Jing, Junlin Yao, Hongsen Li, Jiansheng Xie, Zhanggui Wang, Qin Pan, Hongming Pan, Wendong Huang & Weidong Han. (2015) Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Oncotarget 6:37, pages 40268-40282.
Crossref
Géraldine Mitou, Julie Frentzel, Aurore Desquesnes, Sophie Le Gonidec, Talal AlSaati, Isabelle Beau, Laurence Lamant, Fabienne MeggettoEstelle EspinosPatrice Codogno, Pierre Brousset & Sylvie Giuriato. (2015) Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma. Oncotarget 6:30, pages 30149-30164.
Crossref
Boris Duchemann, Luc Friboulet & Benjamin Besse. (2015) Therapeutic management of ALK + nonsmall cell lung cancer patients . European Respiratory Journal 46:1, pages 230-242.
Crossref
Monica Cojoc, Katrin Mäbert, Michael H. Muders & Anna Dubrovska. (2015) A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms. Seminars in Cancer Biology 31, pages 16-27.
Crossref
Steven L. Wood, Maria Pernemalm, Philip A. Crosbie & Anthony D. Whetton. (2015) Molecular histology of lung cancer: From targets to treatments. Cancer Treatment Reviews 41:4, pages 361-375.
Crossref
Daniele Vergara, Stefania de Domenico, Michele Maffia, Gabriella Piro & Gian-Pietro Sansebastiano. (2015) Transgenic Plants as Low-Cost Platform for Chemotherapeutic Drugs Screening. International Journal of Molecular Sciences 16:1, pages 2174-2186.
Crossref
Gouji Toyokawa & Takashi Seto. (2015) Updated Evidence on the Mechanisms of Resistance to ALK Inhibitors and Strategies to Overcome Such Resistance: Clinical and Preclinical Data. Oncology Research and Treatment 38:6, pages 291-298.
Crossref
Ke Jiang, Yingchun Li, Qiumin Zhu, Jiansheng Xu, Yupeng Wang, Wuguo Deng, Quentin Liu, Guirong Zhang & Songshu Meng. (2014) Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells. BMC Cancer 14:1.
Crossref
Ammad Farooqi, Sundas Fayyaz, Ming-Feng Hou, Kun-Tzu Li, Jen-Yang Tang & Hsueh-Wei Chang. (2014) Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs. Marine Drugs 12:11, pages 5408-5424.
Crossref
Gouji Toyokawa & Takashi Seto. (2014) Anaplastic lymphoma kinase rearrangement in lung Cancer: Its biological and clinical significance. Respiratory Investigation 52:6, pages 330-338.
Crossref
Hongming Pan, Zhanggui Wang, Liming Jiang, Xinbing Sui, Liangkun You, Jiawei Shou, Zhao Jing, Jiansheng Xie, Weiting Ge, Xiujun Cai, Wendong Huang & Weidong Han. (2014) Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib. Scientific Reports 4:1.
Crossref
Khashayar Esfahani, Jason Scott Agulnik & Victor Cohen. (2014) A Systemic Review of Resistance Mechanisms and Ongoing Clinical Trials in ALK-Rearranged Non-Small Cell Lung Cancer. Frontiers in Oncology 4.
Crossref
Yan Lin, Keming Wang, Chunping Hu, Lin Lin, Shukui Qin & Xueting Cai. (2014) Elemene Injection Induced Autophagy Protects Human Hepatoma Cancer Cells from Starvation and Undergoing Apoptosis. Evidence-Based Complementary and Alternative Medicine 2014, pages 1-8.
Crossref

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