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Cancer Biology & Therapy Volume 15, 2014 - Issue 5
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Research Paper

Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma

Jinke Xu Department of Oral and Maxillofacial Surgery; School of Stomatology; the Fourth Military Medical University; Xi’an, PR China; State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR China; Department of Oral and Maxillofacial Surgery; Jinling Hospital; Clinical School of Medical College; Nanjing University; Nanjing, PR China
,
Wei Lu Department of Oral and Maxillofacial Surgery; School of Stomatology; the Fourth Military Medical University; Xi’an, PR China; State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR China
,
Senlin Zhang Department of Oral and Maxillofacial Surgery; Jinling Hospital; Clinical School of Medical College; Nanjing University; Nanjing, PR China
,
Chuchao Zhu State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR China
,
Tingting Ren State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR China
,
Tong Zhu State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR China
,
Hu Zhao State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR China
,
Yanpu Liu Department of Oral and Maxillofacial Surgery; School of Stomatology; the Fourth Military Medical University; Xi’an, PR ChinaCorrespondence[email protected] [email protected]
&
Jin Su State Key Laboratory of Cancer Biology; Department of Biochemistry and Molecular Biology; The Fourth Military Medical University; Xi’an, PR ChinaCorrespondence[email protected] [email protected]
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Pages 612-622 | Received 19 Jan 2014, Accepted 10 Feb 2014, Published online: 20 Feb 2014

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Elodie Henriet, Margaux Sala, Aya Abou Hammoud, Adjanie Tuariihionoa, Julie Di Martino, Manon Ros & Frédéric Saltel. (2018) Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer. Cell Adhesion & Migration 12:4, pages 363-377.
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Sankar Jagadeeshan, Ofra Z. Novoplansky, Oded Cohen, Ina Kurth, Jochen Hess, Ari J. Rosenberg, Jennifer R. Grandis & Moshe Elkabets. (2023) New insights into RAS in head and neck cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:6, pages 188963.
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Anbu Liu, Shaoting Zhang, Ming Wang, Liangying Zhang, Shidong Xu, Ahmad Nasimian, Shujing Li, Sien Zhao, Xu Cao, Jinhai Tian, Yuanyuan Yu, Zhaoyang Fan, Kun Xiao, Hui Zhao, Julhash U. Kazi, Lijun Ma & Jianmin Sun. (2023) DDR1/2 enhance KIT activation and imatinib resistance of primary and secondary KIT mutants in gastrointestinal stromal tumors. Molecular Carcinogenesis.
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Hua Su & Michael Karin. (2023) Multifaceted collagen-DDR1 signaling in cancer. Trends in Cell Biology.
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Lixiao Xie, Kaiwen Zhang, Bo You, Haimeng Yin, Panpan Zhang, Ying Shan, Zhifeng Gu & Qicheng Zhang. (2023) Hypoxic nasopharyngeal carcinoma‐derived exosomal miR‐455 increases vascular permeability by targeting ZO‐1 to promote metastasis. Molecular Carcinogenesis 62:6, pages 803-819.
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Leili Tapak, Mohammad Kazem Ghasemi, Saeid Afshar, Hossein Mahjub, Alireza Soltanian & Hassan Khotanlou. (2023) Identification of gene profiles related to the development of oral cancer using a deep learning technique. BMC Medical Genomics 16:1.
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Zhihui Wen, Jingbo Sun, Junjie Luo, Yun Fu, Yue Qiu, Yanyan Li, Yangwei Xu, Hongmei Wu & Qingling Zhang. (2022) COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction. Frontiers in Oncology 12.
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Favour A. Akinjiyan, Ritu M. Dave, Emily Alpert, Gregory D. Longmore & Katherine C. Fuh. (2022) DDR2 Expression in Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion and Metastasis through Periostin-ITGB1. Cancers 14:14, pages 3482.
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Anna Kasperska, Jędrzej Borowczak, Krzysztof Szczerbowski, Ewa Stec, Navid Ahmadi & Łukasz Szylber. (2021) Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy. Current Cancer Drug Targets 21:11, pages 919-931.
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V. Mehta, H. Chander & A. Munshi. (2021) Complex roles of discoidin domain receptor tyrosine kinases in cancer. Clinical and Translational Oncology 23:8, pages 1497-1510.
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Ahmed Elkamhawy, Qili Lu, Hossam Nada, Jiyu Woo, Guofeng Quan & Kyeong Lee. (2021) The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer. International Journal of Molecular Sciences 22:12, pages 6535.
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Sandra Majo & Patrick Auguste. (2021) The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development. Cancers 13:7, pages 1725.
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İ̇pek ATAK, Leyla BOZDAĞ, Reinhard BUETTNER & Sibel Elif GÜLTEKİN. (2020) Oral Kanserde Tümör Nekrozis Faktör-Alfa (Tnf-α) Ekspresyonunun Moleküler Subtipleme ile İlişkisi. OSMANGAZİ JOURNAL OF MEDICINE, pages 1-7.
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Heewa Shakib, Sadegh Rajabi, Mohammad Hossien Dehghan, Farideh Jalali Mashayekhi, Nahid Safari-Alighiarloo & Mehdi Hedayati. (2019) Epithelial-to-mesenchymal transition in thyroid cancer: a comprehensive review. Endocrine 66:3, pages 435-455.
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Joshua D. Smith, Andrew C. Birkeland, Andrew J. Rosko, Rebecca C. Hoesli, Susan K. Foltin, Paul Swiecicki, Michelle Mierzwa, Steven B. Chinn, Andrew G. Shuman, Kelly M. Malloy, Keith A. Casper, Scott A. McLean, Gregory T. Wolf, Carol R. Bradford, Mark E. Prince, John Chad Brenner & Matthew E. Spector. (2018) Mutational profiles of persistent/recurrent laryngeal squamous cell carcinoma. Head & Neck 41:2, pages 423-428.
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Susana Ramalho, Liliana AL De Angelo Andrade, Cássio Cardoso Filho, Rodrigo de Andrade Natal, Marina Pavanello, Amanda Canato Ferracini, Luis Felipe Sallum, Luis Otávio Sarian & Sophie Derchain. (2019) Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer. Tumor Biology 41:1, pages 101042831882398.
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Bharath Kumar Velmurugan, Wei-Hsiang Chang, Chia-Min ChungChung-Min YehChien-Hsun LeeKun-Tu YehShu-Hui Lin. (2018) DDR2 overexpression in oral squamous cell carcinoma is associated to lymph node metastasis. Cancer Biomarkers 22:4, pages 747-753.
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Whitney R. GritherGregory D. Longmore. (2018) Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proceedings of the National Academy of Sciences 115:33.
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Cecilia Lezcano, Alexander N. Shoushtari, Charlotte Ariyan, Travis J. Hollmann & Klaus J. Busam. (2018) Primary and Metastatic Melanoma With NTRK Fusions. American Journal of Surgical Pathology 42:8, pages 1052-1058.
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Jin'e Liu, Xiaoxue Xie, Chunxiao Xuan, Tingting Li, Lanlan Wang, Lianghong TengJun Liu. (2018) High-Density Infiltration of V-domain Immunoglobulin Suppressor of T-cell Activation Up-regulated Immune Cells in Human Pancreatic Cancer. Pancreas 47:6, pages 725-731.
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Whitney R. Grither, Laura M. Divine, Eric H. Meller, Daniel J. Wilke, Riva A. Desai, Andrew J. Loza, Peinan Zhao, Anne Lohrey, Gregory D. Longmore & Katherine C. Fuh. (2018) TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis. Oncogene 37:13, pages 1714-1729.
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Zhong Liang, Wen‑Jun Xie, Ming Zhao, Guo‑Ping Cheng & Mei‑Juan Wu. (2017) DDR2 facilitates papillary thyroid carcinoma epithelial mesenchymal transition by activating ERK2/Snail1 pathway. Oncology Letters.
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Anne von Mässenhausen, Christine Sanders, Johannes Brägelmann, Martina Konantz, Angela Queisser, Wenzel Vogel, Glen Kristiansen, Stefan Duensing, Andreas Schröck, Friedrich Bootz, Peter Brossart, Jutta Kirfel, Claudia Lengerke & Sven Perner. (2016) Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib. International Journal of Cancer 139:10, pages 2359-2369.
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Martina Raudenska, Jaromir Gumulec, Andrew M. Fribley & Michal Masarik. 2016. Targeting Oral Cancer. Targeting Oral Cancer 115 160 .
Yingtao Zhang, Agnes Malysa & Gerold Bepler. 2016. Discoidin Domain Receptors in Health and Disease. Discoidin Domain Receptors in Health and Disease 145 154 .
Binhui Xie, Weihao Lin, Junming Ye, Xiaonong Wang, Bing Zhang, Shiqiu Xiong, Heping Li & Guosheng Tan. (2015) DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1. Journal of Experimental & Clinical Cancer Research 34:1.
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Matthew L. Hedberg, Gerald Goh, Simion I. Chiosea, Julie E. Bauman, Maria L. Freilino, Yan Zeng, Lin Wang, Brenda B. Diergaarde, William E. Gooding, Vivian W.Y. Lui, Roy S. Herbst, Richard P. Lifton & Jennifer R. Grandis. (2015) Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. Journal of Clinical Investigation 126:1, pages 169-180.
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Morten A. KarsdalTina Manon-JensenFederica GenoveseJacob H. KristensenMette J. NielsenJannie Marie B. SandNiels-Ulrik B. HansenAnne-Christine Bay-JensenCecilie L. BagerAleksander KragAndy BlanchardHenrik KrarupDiana J. LeemingDetlef Schuppan. (2015) Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:10, pages G807-G830.
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Yupeng Li, Xiaoyun Lu, Xiaomei Ren & Ke Ding. (2015) Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications. Journal of Medicinal Chemistry 58:8, pages 3287-3301.
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Emmanuel Reyes-Uribe, Nathalia Serna-Marquez & Eduardo Perez Salazar. (2015) DDRs: receptors that mediate adhesion, migration and invasion in breast cancer cells. AIMS Biophysics 2:3, pages 303-317.
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