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Cancer Biology & Therapy Volume 15, 2014 - Issue 8
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Research Paper

Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma

Jesse L Cox Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA
,
Phillip J Wilder Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA
,
Erin L Wuebben Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA
,
Michel M Ouellette Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA
,
Michael A Hollingsworth Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA
&
Angie Rizzino Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USACorrespondence[email protected]
Pages 1042-1052 | Received 18 Mar 2014, Accepted 09 May 2014, Published online: 19 May 2014

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Bailee H. Sliker, Benjamin T. Goetz, Haley L. Peters, Brittany J. Poelaert, Gloria E. O. Borgstahl & Joyce C. Solheim. (2019) Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells. Cancer Biology & Therapy 20:6, pages 931-940.
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Deepa Kushwaha, Colin O’Leary, Kyle R Cron, Peter Deraska, Kaya Zhu, Alan D D’Andrea & David Kozono. (2015) USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1. Cancer Biology & Therapy 16:3, pages 392-401.
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Articles from other publishers (22)

Wenyan Yang, Shiqun Wang, Shengqiang Tong, Wei-Dong Zhang & Jiang-Jiang Qin. (2024) Expanding the ubiquitin code in pancreatic cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870:1, pages 166884.
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Olga Blaževitš, Maira Di Tano & Valter D. Longo. (2023) Fasting and fasting mimicking diets in cancer prevention and therapy. Trends in Cancer 9:3, pages 212-222.
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Jiaqi LIU, Chi Tim LEUNG, Luyun LIANG, Yuqin WANG, Jian CHEN, Keng Po LAI & William Ka Fai TSE. (2022) Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis. Cancers 14:14, pages 3547.
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雅丽 张. (2022) Research Progress of Ubiquitin-Specific Pep-tidases in Head and Neck Squamous Cell Carcinoma. Advances in Clinical Medicine 12:10, pages 9596-9604.
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Xue Zhang, Peng Wang, Kai Yuan, Maoran Li, Yiting Shen, Huafa Que, Yunfei Wang & Wei Liang. (2021) Hsa_circ_0024093 accelerates VSMC proliferation via miR-4677-3p/miR-889-3p/USP9X/YAP1 axis in in vitro model of lower extremity ASO. Molecular Therapy - Nucleic Acids 26, pages 511-522.
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Jia Guo & Jianglin Zhang. 2020. Ubiquitin - Proteasome Pathway. Ubiquitin - Proteasome Pathway.
Parthasaradhireddy Tanguturi, Kye-Seong Kim & Suresh Ramakrishna. (2020) The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemotherapy and Pharmacology 85:4, pages 627-639.
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Rachel O'Dea & Corrado Santocanale. (2020) Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitinase. Journal of Cell Science.
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Leena Arpalahti, Caj Haglund & Carina I. Holmberg. 2020. Proteostasis and Disease. Proteostasis and Disease 101 115 .
Yijin Xiang, Shaoyan Zhang, Jia Lu, Wen Zhang, Min Cai, Dongze Qiu & Dingfang Cai. (2019) USP9X promotes LPS-induced pulmonary epithelial barrier breakdown and hyperpermeability by activating an NF-κBp65 feedback loop. American Journal of Physiology-Cell Physiology 317:3, pages C534-C543.
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E. Bianchetti, S. J. Bates, S. L. Carroll, M. D. Siegelin & K. A. Roth. (2018) Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors. Scientific Reports 8:1.
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Tao Ma, Wei Chen, Xiao Zhi, Hao Liu, Yue Zhou, Brayant Wei Chen, Liqiang Hu, Jian Shen, Xiaoxiao Zheng, Shufen Zhang, Bo Zhang, Haijun Li & Tingbo Liang. (2018) USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy. Cancer Letters 436, pages 129-138.
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Erin L. Wuebben & Angie Rizzino. (2017) The dark side of SOX2: cancer - a comprehensive overview. Oncotarget 8:27, pages 44917-44943.
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Wei-Lin Jin, Xiao-Yuan Mao & Guan-Zhong Qiu. (2017) Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges. Medicinal Research Reviews 37:3, pages 627-661.
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Lisa J. Russell, Lisa Jones, Amir Enshaei, Stefano Tonin, Sarra L. Ryan, Jeyanthy Eswaran, Sirintra Nakjang, Elli Papaemmanuil, Jose M. C. Tubio, Adele K. Fielding, Ajay Vora, Peter J. Campbell, Anthony V. Moorman & Christine J. Harrison. (2017) Characterisation of the genomic landscape of CRLF2 -rearranged acute lymphoblastic leukemia . Genes, Chromosomes and Cancer 56:5, pages 363-372.
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Caitlin R. Bridges, Men-Chee Tan, Susitha Premarathne, Devathri Nanayakkara, Bernadette Bellette, Dusan Zencak, Deepti Domingo, Jozef Gecz, Mariyam Murtaza, Lachlan A. Jolly & Stephen A. Wood. (2017) USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors. Scientific Reports 7:1.
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Harish Potu, Luke F. Peterson, Malathi Kandarpa, Anupama Pal, Hanshi Sun, Alison Durham, Paul W. Harms, Peter C. Hollenhorst, Ugur Eskiocak, Moshe Talpaz & Nicholas J. Donato. (2017) Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma. Nature Communications 8:1.
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D. M. Nanayakkara, M. N. Nguyen & S. A. Wood. (2016) Deubiquitylating enzyme, USP9X, regulates proliferation of cells of head and neck cancer lines. Cell Proliferation 49:4, pages 494-502.
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Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Christel Larbouret, Marie-Alix Poul, Philippe Mondon, Gerry Melino, André Pèlegrin & Thierry Chardès. (2016) The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation. Oncotarget 7:24, pages 37013-37029.
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Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, James A. Grunkemeyer, Thomas Caffrey, Michael A. Hollingsworth & Angie Rizzino. (2016) SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells. Oncotarget 7:23, pages 34890-34906.
Crossref
Key-Hwan Lim, Myoung-Hyun Song & Kwang-Hyun Baek. (2016) Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint. Cellular and Molecular Life Sciences 73:7, pages 1439-1455.
Crossref
Georg Karpel-Massler, Matei A. Banu, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N. Bruce, Peter Canoll & Markus D. Siegelin. (2016) Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo . Oncotarget 7:11, pages 12791-12805.
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