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Research Paper

Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions

Pages 740-746 | Published online: 25 May 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Anne M. Delany. (2010) Matricellular proteins osteopontin and osteonectin/SPARC in pancreatic carcinoma. Cancer Biology & Therapy 10:1, pages 65-67.
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Vitor Faca & Samir Hanash. (2007) In-depth quantitative proteomics for pancreatic cancer biomarker discovery. Expert Opinion on Medical Diagnostics 1:1, pages 81-89.
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Shalini Jain, Goutam Chakraborty, Anuradha Bulbule, Rajinder Kaur & Gopal C Kundu. (2007) Osteopontin: an emerging therapeutic target for anticancer therapy. Expert Opinion on Therapeutic Targets 11:1, pages 81-90.
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Articles from other publishers (65)

Yue-Chao Qin, Xin Yan, Xiao-Lin Yuan, Wei-Wei Yu & Fan-Jie Qu. (2023) Osteopontin promotes gastric cancer progression via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway . World Journal of Gastrointestinal Oncology 15:9, pages 1544-1555.
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Tomas Koltai. (2023) Earlier Diagnosis of Pancreatic Cancer: Is It Possible?. Cancers 15:18, pages 4430.
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Shigeki Fukusada, Takaya Shimura, Makoto Natsume, Ruriko Nishigaki, Yusuke Okuda, Hiroyasu Iwasaki, Naomi Sugimura, Mika Kitagawa, Takahito Katano, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Kazuki Hayashi & Hiromi Kataoka. (2023) Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesity. Cellular Oncology.
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Sai V. Chitti, Taeyoung Kang, Pamali Fonseka, Akbar L. Marzan, Sarah Stewart, Sanjay Shahi, Kyle Bramich, Ching‐Seng Ang, Mohashin Pathan, Sriram Gummadi & Suresh Mathivanan. (2023) Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non‐inducing cancer cells. PROTEOMICS 23:15.
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Ashish Manne, Anup Kasi, Ashwini Kumar Esnakula & Ravi Kumar Paluri. (2023) Predictive Value of MUC5AC Signature in Pancreatic Ductal Adenocarcinoma: A Hypothesis Based on Preclinical Evidence. International Journal of Molecular Sciences 24:9, pages 8087.
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Matthew A. Firpo, Kenneth M. Boucher, Josh Bleicher, Gayatri D. Khanderao, Alessandra Rosati, Katherine E. Poruk, Sama Kamal, Liberato Marzullo, Margot De Marco, Antonia Falco, Armando Genovese, Jessica M. Adler, Vincenzo De Laurenzi, Douglas G. Adler, Kajsa E. Affolter, Ignacio Garrido-Laguna, Courtney L. Scaife, M. Caterina Turco & Sean J. Mulvihill. (2023) Multianalyte Serum Biomarker Panel for Early Detection of Pancreatic Adenocarcinoma. JCO Clinical Cancer Informatics:7.
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Zhuce Shao & Shuxiong Bi. (2023) Endocrine regulation and metabolic mechanisms of osteopontin in the development and progression of osteosarcoma, metastasis and prognosis. Frontiers in Endocrinology 13.
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Wen Gao, Dongli Liu, Haiyan Sun, Zhuyan Shao, Peipei Shi, Tingting Li, Sheng Yin & Tao Zhu. (2022) SPP1 is a prognostic related biomarker and correlated with tumor-infiltrating immune cells in ovarian cancer. BMC Cancer 22:1.
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Qi Wang, Huizhi Wang, Yuntao Ding, Mengtian Wan & Min Xu. (2022) The Role of Adipokines in Pancreatic Cancer. Frontiers in Oncology 12.
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Weijiang WuHanqing YangZhutao WangZhijian ZhangXiaodong LuWenjing YangXiayue XuYinuo JiangYan LiXin Fan & Qixiang Shao. (2021) A Noncanonical Hedgehog Signaling Exerts a Tumor-Promoting Effect on Pancreatic Cancer Cells Via Induction of Osteopontin Expression. Cancer Biotherapy and Radiopharmaceuticals.
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Malak Hassn Mesrati, Saiful Effendi Syafruddin, M. Aiman Mohtar & Amir Syahir. (2021) CD44: A Multifunctional Mediator of Cancer Progression. Biomolecules 11:12, pages 1850.
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Yuqing Zhang, Jingxuan Yang, Michael S. Bronze, Courtney W. Houchen & Min Li. (2021) Interplay of Tumor Microenvironment Factors and Cancer Stem Cell Enrichment in Pancreatic Ductal Adenocarcinoma. Gastroenterology 161:6, pages 1800-1802.
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Palanisamy Nallasamy, Rama Krishna Nimmakayala, Saswati Karmakar, Frank Leon, Parthasarathy Seshacharyulu, Imayavaramban Lakshmanan, Satyanarayana Rachagani, Kavita Mallya, Chunmeng Zhang, Quan P. Ly, Molly S. Myers, Lindenberger Josh, Corinn E. Grabow, Shailendra K. Gautam, Sushil Kumar, Subodh M. Lele, Maneesh Jain, Surinder K. Batra & Moorthy P. Ponnusamy. (2021) Pancreatic Tumor Microenvironment Factor Promotes Cancer Stemness via SPP1–CD44 Axis. Gastroenterology 161:6, pages 1998-2013.e7.
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Audrey M Hendley, Arjun A Rao, Laura Leonhardt, Sudipta Ashe, Jennifer A Smith, Simone Giacometti, Xianlu L Peng, Honglin Jiang, David I Berrios, Mathias Pawlak, Lucia Y Li, Jonghyun Lee, Eric A Collisson, Mark S Anderson, Gabriela K Fragiadakis, Jen Jen Yeh, Chun Jimmie Ye, Grace E Kim, Valerie M Weaver & Matthias Hebrok. (2021) Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. eLife 10.
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Hannah R. Moorman, Dakota Poschel, John D. Klement, Chunwan Lu, Priscilla S. Redd & Kebin Liu. (2020) Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation. Cancers 12:11, pages 3379.
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Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy, Julia Rochotte, Alexia Brunel, David Schlaepfer, Jérome Cros, Cindy Neuzillet, Manon Strehaiano, Amandine Alard, Richard Tomasini, Vinothini Rajeeve, Aurélie Perraud, Muriel Mathonnet, Oliver MT Pearce, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet & Christine Jean. (2020) FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer . EMBO Molecular Medicine 12:11.
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Andrii Khomiak, Marius Brunner, Maximilian Kordes, Stina Lindblad, Rainer Christoph Miksch, Daniel Öhlund & Ivonne Regel. (2020) Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer. Cancers 12:11, pages 3234.
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Christina R Adams, Htet Htwe Htwe, Timothy Marsh, Aprilgate L Wang, Megan L Montoya, Lakshmipriya Subbaraj, Aaron D Tward, Nabeel Bardeesy & Rushika M Perera. (2019) Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. eLife 8.
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Oskar Franklin, Ola Billing, Daniel Öhlund, Anette Berglund, Carl Herdenberg, Wanzhong Wang, Urban Hellman & Malin Sund. (2018) Novel prognostic markers within the CD44‐stromal ligand network in pancreatic cancer. The Journal of Pathology: Clinical Research 5:2, pages 130-141.
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Junyu Cao, Jie Li, Liankang Sun, Tao Qin, Ying Xiao, Ke Chen, Weikun Qian, Wanxing Duan, Jianjun Lei, Jiguang Ma, Qingyong Ma & Liang Han. (2018) Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1. Molecular Oncology 13:2, pages 228-245.
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Xingwen Han, Wenji Wang, Jingjing He, Lei Jiang & Xun Li. (2019) Osteopontin as a biomarker for osteosarcoma therapy and prognosis (Review). Oncology Letters.
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Artur Anisiewicz, Beata Filip-Psurska, Agata Pawlik, Anna Nasulewicz-Goldeman, Tomasz Piasecki, Konrad Kowalski, Magdalena Maciejewska, Joanna Jarosz, Joanna Banach, Diana Papiernik, Andrzej Mazur, Andrzej Kutner, Jeanette A Maier & Joanna Wietrzyk. (2019) Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours. Aging and disease 10:5, pages 977.
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R. Gehlig. (2019) Ossifikationsprozesse als treibende Kräfte für die Krebserkrankung. Der Merkurstab 72:5, pages 364-370.
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Agata Pawlik, Artur Anisiewicz, Beata Filip-Psurska, Marcin Nowak, Eliza Turlej, Justyna Trynda, Joanna Banach, Paweł Gretkierewicz & Joanna Wietrzyk. (2018) Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer. International Journal of Molecular Sciences 19:7, pages 2116.
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Hailin Zhao, Qian Chen, Azeem Alam, Jiang Cui, Ka Chun Suen, Aurelie Pac Soo, Shiori Eguchi, Jianteng Gu & Daqing Ma. (2018) The role of osteopontin in the progression of solid organ tumour. Cell Death & Disease 9:3.
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Tomoya Iida, Kohei Wagatsuma, Daisuke Hirayama & Hiroshi Nakase. (2017) Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?. International Journal of Molecular Sciences 19:1, pages 7.
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Emma Eriksson, Ioanna Milenova, Jessica Wenthe, Magnus Ståhle, Justyna Leja-Jarblad, Gustav Ullenhag, Anna Dimberg, Raphael Moreno, Ramon Alemany & Angelica Loskog. (2017) Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus. Clinical Cancer Research 23:19, pages 5846-5857.
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Hannah M. Komar, Phil A. Hart, Zobeida Cruz-Monserrate, Darwin L. Conwell & Gregory B. Lesinski. (2017) Local and Systemic Expression of Immunomodulatory Factors in Chronic Pancreatitis. Pancreas 46:8, pages 986-993.
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Valerya Feygenzon, Shelly Loewenstein, Nir Lubezky, Metsada Pasmanic-Chor, Osnat Sher, Joseph M. Klausner & Guy Lahat. (2017) Unique cellular interactions between pancreatic cancer cells and the omentum. PLOS ONE 12:6, pages e0179862.
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Sven H Loosen, Ulf P Neumann, Christian Trautwein, Christoph Roderburg & Tom Luedde. (2017) Current and future biomarkers for pancreatic adenocarcinoma. Tumor Biology 39:6, pages 101042831769223.
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Samantha Lynn HamiltonBlake FerandoAsha Sarah EapenJennifer Chian YuAnita Rose Joy. (2016) Cancer Secretome May Influence BSP and DSP Expression in Human Salivary Gland Cells. Journal of Histochemistry & Cytochemistry 65:3, pages 139-151.
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Martin C. Whittle & Sunil R. Hingorani. 2017. RUNX Proteins in Development and Cancer. RUNX Proteins in Development and Cancer 333 352 .
Sebastian Rasch, Irena Valantiene, Artautas Mickevicius, Sebastian Beer, Jonas Rosendahl, Richard M. Charnley & Stuart M. Robinson. (2016) Chronic pancreatitis: Do serum biomarkers provide an association with an inflammageing phenotype?. Pancreatology 16:5, pages 708-714.
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Thomas E. Kruger, Andrew H. Miller, Andrew K. Godwin & Jinxi Wang. (2014) Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers. Critical Reviews in Oncology/Hematology 89:2, pages 330-341.
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Li Zhao, Yalin Wang, Nan Qu, Chen Huang & Lijun Chen. (2012) Significance of Plasma Osteopontin Levels in Patients with Bladder Urothelial Carcinomas. Molecular Diagnosis & Therapy 16:5, pages 311-316.
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Amy L. Collins, Jonathan Rock, Lavina Malhotra, Wendy L. Frankel & Mark Bloomston. (2012) Osteopontin Expression is Associated with Improved Survival in Patients with Pancreatic Adenocarcinoma. Annals of Surgical Oncology 19:8, pages 2673-2678.
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