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Brief Communication

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

Pages 815-818 | Published online: 23 Sep 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Yingmin Nie, Jingjie Yang, Shuai Liu, Ruiqi Sun, Huihui Chen, Nan Long, Rui Jiang & Chunshan Gui. (2020) Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokinetics. Xenobiotica 50:3, pages 297-317.
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Ruba Al-Abdulla, Laura Perez-Silva, Lorena Abete, Marta R. Romero, Oscar Briz & Jose J. G. Marin. (2019) Unraveling ‘The Cancer Genome Atlas’ information on the role of SLC transporters in anticancer drug uptake. Expert Review of Clinical Pharmacology 12:4, pages 329-341.
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Ela Cerovska, Katerina Elsnerova, Radka Vaclavikova & Pavel Soucek. (2017) The role of membrane transporters in ovarian cancer chemoresistance and prognosis. Expert Opinion on Drug Metabolism & Toxicology 13:7, pages 741-753.
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Sylvia Chen, Natalia Sutiman, Clara Zhenxian Zhang, Yingnan Yu, Shirley Lam, Chiea Chuen Khor & Balram Chowbay. (2016) Pharmacogenetics of irinotecan, doxorubicin and docetaxel transporters in Asian and Caucasian cancer patients: a comparative review. Drug Metabolism Reviews 48:4, pages 502-540.
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Candido G Da Silva, Richard J Honeywell, Henk Dekker & Godefridus J Peters. (2015) Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters. Expert Opinion on Drug Metabolism & Toxicology 11:5, pages 703-717.
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Kai Zhan, Juan Yao, Jiujiu Huang, Guangming Zhou, Wenjian Li, Lixin Chen & Mei Hong. (2013) Effect of X-ray irradiation on expression of organic anion transporting polypeptides. International Journal of Radiation Biology 89:10, pages 832-840.
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Insoo Yoon, Seungyon Han, Young-Hee Choi, Hee-Eun Kang, Hyun-Jong Cho, Jung Sun Kim, Chang-Koo Shim, Suk-Jae Chung, Saeho Chong & Dae-Duk Kim. (2012) Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats. Xenobiotica 42:11, pages 1110-1119.
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Lan-Xiang Wu, Cheng-Xian Guo, Qiang Qu, Jing Yu, Wang-Qing Chen, Guo Wang, Lan Fan, Qing Li, Wei Zhang & Hong-Hao Zhou. (2012) Effects of natural products on the function of human organic anion transporting polypeptide 1B1. Xenobiotica 42:4, pages 339-348.
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Anna Koenen, Heyo K Kroemer, Markus Grube & Henriette E Meyer zu Schwabedissen. (2011) Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions. Expert Review of Clinical Pharmacology 4:6, pages 729-742.
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Christina Fahrmayr, Martin F. Fromm & Jörg König. (2010) Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects. Drug Metabolism Reviews 42:3, pages 380-401.
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Raffaele Longo, Mario D'Andrea, Roberta Sarmiento & Giampietro Gasparini. (2010) Pharmacogenetics in breast cancer: focus on hormone therapy, taxanes, trastuzumab and bevacizumab. Expert Opinion on Investigational Drugs 19:sup1, pages S41-S50.
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Jürgen Kindla, Martin F Fromm & Jörg König. (2009) In vitro evidence for the role of OATP and OCT uptake transporters in drug–drug interactions. Expert Opinion on Drug Metabolism & Toxicology 5:5, pages 489-500.
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Anne T Nies, Matthias Schwab & Dietrich Keppler. (2008) Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. Expert Opinion on Drug Metabolism & Toxicology 4:5, pages 545-568.
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Annick Seithel, Hartmut Glaeser, Martin F Fromm & Jörg König. (2008) The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members. Expert Opinion on Drug Metabolism & Toxicology 4:1, pages 51-64.
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Robert O'Connor, Martin Clynes, Paul Dowling, Norma O'Donovan & Lorraine O'Driscoll. (2007) Drug resistance in cancer – searching for mechanisms, markers and therapeutic agents. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 805-817.
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Dhananjay Pal & Ashim K. Mitra. (2006) CYP3A4 and MDR Mediated Interactions in Drug Therapy. Clinical Research and Regulatory Affairs 23:3-4, pages 125-163.
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Nicola F Smith, William D Figg & Alex Sparreboom. (2005) Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opinion on Drug Metabolism & Toxicology 1:3, pages 429-445.
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