405
Views
119
CrossRef citations to date
0
Altmetric
Review

mda-7/IL-24, A Novel Cancer Selective Apoptosis Inducing Cytokine Gene: From the Laboratory into the Clinic

Pages 22-36 | Published online: 01 Mar 2003

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jun-Jie Liu, Bao-Fu Zhang, Xiao-Xing Yin, Dong-Sheng Pei, Zhi-Xia Yang, Jie-Hui Di, Fei-Fei Chen, Hui-Zhong Li, Wei Xu, Yong-Ping Wu & Jun-Nian Zheng. (2012) EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF RGD-mda-7, A HIS-TAGGED mda-7/IL-24 MUTANT PROTEIN. Journal of Immunoassay and Immunochemistry 33:4, pages 352-368.
Read now
Robert Eager, Lindsey Harle & John Nemunaitis. (2008) Ad-MDA-7; INGN 241: a review of preclinical and clinical experience. Expert Opinion on Biological Therapy 8:10, pages 1633-1643.
Read now
Devanand Sarkar, Irina V Lebedeva, Pankaj Gupta, Luni Emdad, Moira Sauane, Paul Dent, David T Curiel & Paul B Fisher. (2007) Melanoma differentiation associated gene-7 (mda-7)/IL-24: a ‘magic bullet’ for cancer therapy?. Expert Opinion on Biological Therapy 7:5, pages 577-586.
Read now
Rebecca Kristeleit, Lindsay Stimson, Paul Workman & Wynne Aherne. (2004) Histone modification enzymes: novel targets for cancer drugs. Expert Opinion on Emerging Drugs 9:1, pages 135-154.
Read now
Francis J Dumont. (2004) IL-10-related cellular cytokines and their receptors: new targets for inflammation and cancer therapy. Expert Opinion on Therapeutic Patents 14:3, pages 281-299.
Read now

Articles from other publishers (114)

Anjan K. Pradhan, Praveen Bhoopathi, Santanu Maji, Amit Kumar, Chunqing Guo, Padmanabhan Mannangatti, Jiong Li, Xiang-Yang Wang, Devanand Sarkar, Luni Emdad, Swadesh K. Das & Paul B. Fisher. (2022) Enhanced Cancer Therapy Using an Engineered Designer Cytokine Alone and in Combination With an Immune Checkpoint Inhibitor. Frontiers in Oncology 12.
Crossref
Jinkal Modi, Abhishek Roy, Anjan K. Pradhan, Amit Kumar, Sarmistha Talukdar, Praveen Bhoopathi, Santanu Maji, Padmanabhan Mannangatti, Daniel Sanchez De La Rosa, Jiong Li, Chunqing Guo, Mark A. Subler, Jolene J. Windle, Webster K. Cavenee, Devanand Sarkar, Xiang-Yang Wang, Swadesh K. Das, Luni Emdad & Paul B. Fisher. (2021) Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein. International Journal of Molecular Sciences 23:1, pages 72.
Crossref
Rajeswari Raguraman, Akhil Srivastava, Anupama Munshi & Rajagopal Ramesh. (2021) Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer. Advanced Drug Delivery Reviews 178, pages 113918.
Crossref
Praveen Bhoopathi, Anjan K. Pradhan, Santanu Maji, Swadesh K. Das, Luni Emdad & Paul B. Fisher. (2021) Theranostic Tripartite Cancer Terminator Virus for Cancer Therapy and Imaging. Cancers 13:4, pages 857.
Crossref
Yong He, Seonghwan Hwang, Yeni Ait Ahmed, Dechun Feng, Na Li, Marcelle Ribeiro, Fouad Lafdil, Tatiana Kisseleva, Gyongyi Szabo & Bin Gao. (2020) Immunopathobiology and therapeutic targets related to cytokines in liver diseases. Cellular & Molecular Immunology 18:1, pages 18-37.
Crossref
Shumin Zhang, Jingping Zhang, Dongmei Guo, Chao Peng, Mi Tian, Desheng Pei, Qiyuan Wang, Fumo Yang, Junji Cao & Yang Chen. (2021) Biotoxic effects and gene expression regulation of urban PM2.5 in southwestern China. Science of The Total Environment 753, pages 141774.
Crossref
Rajagopal Ramesh, Rebaz Ahmed & Anupama Munshi. 2021. Tumor Microenvironment. Tumor Microenvironment 99 110 .
Luni Emdad, Praveen Bhoopathi, Sarmistha Talukdar, Anjan K. Pradhan, Devanand Sarkar, Xiang-Yang Wang, Swadesh K. Das & Paul B. Fisher. (2020) Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic. Seminars in Cancer Biology 66, pages 140-154.
Crossref
M. Maleknia, A. Valizadeh, S. M. S. Pezeshki & N. Saki. (2019) Immunomodulation in leukemia: cellular aspects of anti-leukemic properties. Clinical and Translational Oncology 22:1, pages 1-10.
Crossref
Udai S. Kammula & Michael T. Lotze. 2020. Cutaneous Melanoma. Cutaneous Melanoma 1267 1299 .
Marina A. Plotnikova, Sergey A. Klotchenko, Artem A. Kiselev, Andrey N. Gorshkov, Anna-Polina S. Shurygina, Kirill A. Vasilyev, Urszula Uciechowska-Kaczmarzyk, Sergey A. Samsonov, Alexey L. Kovalenko & Andrey V. Vasin. (2019) Meglumine acridone acetate, the ionic salt of CMA and N-methylglucamine, induces apoptosis in human PBMCs via the mitochondrial pathway. Scientific Reports 9:1.
Crossref
Anjan K. Pradhan, Praveen Bhoopathi, Sarmistha Talukdar, Swadesh K. Das, Luni Emdad, Devanand Sarkar, Andrei I. Ivanov & Paul B. Fisher. (2019) Mechanism of internalization of MDA-7/IL-24 protein and its cognate receptors following ligand-receptor docking. Oncotarget 10:49, pages 5103-5117.
Crossref
Anjan K. PradhanPraveen BhoopathiSarmistha TalukdarDanielle ScheunemannDevanand SarkarWebster K. Cavenee, Swadesh K. DasLuni EmdadPaul B. Fisher. (2019) MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF. Proceedings of the National Academy of Sciences 116:12, pages 5687-5692.
Crossref
Udai S. Kammula & Michael T. Lotze. 2019. Cutaneous Melanoma. Cutaneous Melanoma 1 33 .
Shu Chun Chang & Jeak Ling Ding. (2018) Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1870:2, pages 165-175.
Crossref
Amanda R. Burmeister & Ian Marriott. (2018) The Interleukin-10 Family of Cytokines and Their Role in the CNS. Frontiers in Cellular Neuroscience 12.
Crossref
Luni Emdad, Swadesh K. Das, Xiang‐Yang Wang, Devanand Sarkar & Paul B. Fisher. (2018) Cancer terminator viruses ( CTV ): A better solution for viral‐based therapy of cancer . Journal of Cellular Physiology 233:8, pages 5684-5695.
Crossref
Chao Ma, Ling‑Ling Zhao, Heng‑Jun Zhao, Jiu‑Wei Cui, Wei Li & Nan‑Ya Wang. (2018) Lentivirus‑mediated MDA7/IL24 expression inhibits the proliferation of hepatocellular carcinoma cells. Molecular Medicine Reports.
Crossref
Mitchell E. Menezes, Praveen Bhoopathi, Anjan K. Pradhan, Luni Emdad, Swadesh K. Das, Chunqing Guo, Xiang-Yang Wang, Devanand Sarkar & Paul B. Fisher. 2018. 143 182 .
Dixon H. Xu, Ziwen Zhu, Huaping Xiao, Mark R. Wakefield, Qian Bai, Michael B. Nicholl, Vivi A. Ding & Yujiang Fang. (2017) Unveil the mysterious mask of cytokine-based immunotherapy for melanoma. Cancer Letters 394, pages 43-51.
Crossref
Anjan K. Pradhan, Sarmistha Talukdar, Praveen Bhoopathi, Xue-Ning Shen, Luni Emdad, Swadesh K. Das, Devanand Sarkar & Paul B. Fisher. (2017) mda-7/IL-24 Mediates Cancer Cell–Specific Death via Regulation of miR-221 and the Beclin-1 Axis . Cancer Research 77:4, pages 949-959.
Crossref
Anjan K. Pradhan, Luni Emdad, Swadesh K. Das, Devanand Sarkar & Paul B. Fisher. 2017. miRNA and Cancer. miRNA and Cancer 25 52 .
Jun Shao, Bing Zhang, Jia-Jun Yu, Chun-Yan Wei, Wen-Jie Zhou, Kai-Kai Chang, Hui-Li Yang, Li-Ping Jin, Xiao-Yong Zhu & Ming-Qing Li. (2016) Macrophages promote the growth and invasion of endometrial stromal cells by downregulating IL-24 in endometriosis. Reproduction 152:6, pages 673-682.
Crossref
Mohammad Hossein Bakhshi Aliabad, Shahnaz Kheirandish, Zeynab Zarezadeh, Nasim Saeidi, Hamid Kabiri, Zahra Khazaei, Hossein Sahamifar, Fatemeh Taghvaei, Sepideh Jafarzadeh, Masoud Zare, Sajad Bahrami-Babaheidar & Mahta Mazaheri. (2016) Micro-RNAs and Their Roles in Breast Cancer Pathogenesis; An Updated Review Article. International Journal of Basic Science in Medicine 1:2, pages 48-52.
Crossref
Hui Hu, Tao Wang, Jiaojiao Chen, Fang Yu, Huilin Liu, Zhenyu Zuo, Zhonghua Yang & Handong Fan. (2016) Screening and identification of proteins interacting with IL-24 by the yeast two-hybrid screen, Co-IP, and FRET assays. Anti-Cancer Drugs 27:4, pages 318-327.
Crossref
Daming Zuo, John Subjeck & Xiang-Yang Wang. (2016) Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications. Frontiers in Immunology 7.
Crossref
Jian Zhang, Aiyou Sun, Rui Xu, Xinyi Tao, Yuguo Dong, Xinxin Lv & Dongzhi Wei. (2016) Cell-penetrating and endoplasmic reticulum-locating TAT-IL-24-KDEL fusion protein induces tumor apoptosis. Journal of Cellular Physiology 231:1, pages 84-93.
Crossref
Samaneh Bina, Fatemeh Shenavar, Mahboobeh Khodadad, Mohammad Reza Haghshenas, Mojtaba Mortazavi, Mohammad-Reza Fattahi, Nasrollah Erfani & Seyed Younes Hosseini. (2015) Impact of RGD Peptide Tethering to IL24/mda-7 (Melanoma Differentiation Associated Gene-7) on Apoptosis Induction in Hepatocellular Carcinoma Cells. Asian Pacific Journal of Cancer Prevention 16:14, pages 6073-6080.
Crossref
Swadesh K. Das, Mitchell E. Menezes, Shilpa Bhatia, Xiang-Yang Wang, Luni Emdad, Devanand Sarkar & Paul B. Fisher. (2015) Gene Therapies for Cancer: Strategies, Challenges and Successes. Journal of Cellular Physiology 230:2, pages 259-271.
Crossref
H Tian, D Zhang, Z Gao, H Li, B Zhang, Q Zhang, L Li, Q Cheng, D Pei & J Zheng. (2014) MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis. Cancer Gene Therapy 21:10, pages 416-426.
Crossref
Maninder Sandey, R. Curtis Bird, Swadesh K. Das, Devanand Sarkar, David T. Curiel, Paul B. Fisher & Bruce F. Smith. (2014) Characterization of the canine mda-7 gene, transcripts and expression patterns. Gene 547:1, pages 23-33.
Crossref
Rupesh Dash, Praveen Bhoopathi, Swadesh K. Das, Siddik Sarkar, Luni Emdad, Santanu Dasgupta, Devanand Sarkar & Paul B. Fisher. (2014) Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction. Cancer Research 74:2, pages 563-574.
Crossref
Mehri Hajikhan Mirzaei & Abdolreza Esmaeilzadeh. (2014) Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of thyroid carcinoma. Journal of Medical Hypotheses and Ideas 8:1, pages 7-13.
Crossref
Mitchell E. Menezes, Shilpa Bhatia, Praveen Bhoopathi, Swadesh K. Das, Luni Emdad, Santanu Dasgupta, Paul Dent, Xiang-Yang Wang, Devanand Sarkar & Paul B. Fisher. 2014. Anticancer Genes. Anticancer Genes 127 153 .
Jun Shao, Ming-Qing Li, Yu-Han Meng, Kai-Kai Chang, Ying Wang, Li Zhang & Da-Jin Li. (2013) Estrogen promotes the growth of decidual stromal cells in human early pregnancy. MHR: Basic science of reproductive medicine 19:10, pages 655-664.
Crossref
Shili Xu, Takashi Oshima, Toshio Imada, Munetaka Masuda, Bikash Debnath, Fedora Grande, Antonio Garofalo & Nouri Neamati. (2013) Stabilization of MDA-7/IL-24 for colon cancer therapy. Cancer Letters 335:2, pages 421-430.
Crossref
Sujit K. Bhutia, Swadesh K. Das, Belal Azab, Mitchell E. Menezes, Paul Dent, Xiang-Yang Wang, Devanand Sarkar & Paul B. Fisher. (2013) Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24. International Journal of Cancer, pages n/a-n/a.
Crossref
Alexander O. Tarakanov & Alla V. Borisova. 2013. Advances in Applied Self-Organizing Systems. Advances in Applied Self-Organizing Systems 321 341 .
Hui TianLiantao LiBaofu ZhangJiehui DiFeifei ChenHuizhong LiJunjie LiuDongsheng PeiJunnian Zheng. (2012) Critical Role of Lysine 123 in the Ubiquitin-Mediated Degradation of MDA-7/IL-24. Journal of Interferon & Cytokine Research 32:12, pages 575-582.
Crossref
Rounak Nande, Altomare Di Benedetto, Pierpaolo Aimola, Flavia De Carlo, Miranda Carper, Charlene D. Claudio, Jim Denvir, Jagan Valluri, Gary C. Duncan & Pier Paolo Claudio. (2012) Targeting a Newly Established Spontaneous Feline Fibrosarcoma Cell Line by Gene Transfer. PLoS ONE 7:5, pages e37743.
Crossref
Sujit K. Bhutia, Swadesh K. Das, Timothy P. Kegelman, Belal Azab, Rupesh Dash, Zhao-zhong Su, Xiang-Yang Wang, Federica Rizzi, Saverio Bettuzzi, Seok-Geun Lee, Paul Dent, Steven Grant, David T. Curiel, Devanand Sarkar & Paul B. Fisher. (2012) mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer. Journal of Cellular Physiology 227:5, pages 1805-1813.
Crossref
L Chai, S Liu, Q Mao, D Wang, X Li, X Zheng & H Xia. (2011) A novel conditionally replicating adenoviral vector with dual expression of IL-24 and arresten inserted in E1 and the region between E4 and fiber for improved melanoma therapy. Cancer Gene Therapy 19:4, pages 247-254.
Crossref
Dong-Sheng PeiZhi-Xia YangBao-Fu ZhangXiao-Xing YinLian-Tao LiHui-Zhong LiJun-Nian Zheng. (2012) Enhanced Apoptosis-Inducing Function of MDA-7/IL-24 RGD Mutant Via the Increased Adhesion to Tumor Cells . Journal of Interferon & Cytokine Research 32:2, pages 66-73.
Crossref
Hayato Tamai, Koichi MiyakeHiroki Yamaguchi, Miyuki Takatori, Kazuo Dan, Koiti Inokuchi & Takashi Shimada. (2012) AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice. Blood 119:1, pages 64-71.
Crossref
Jesse M. Jaynes & Gregory C. Bernard. 2012. Small Wonders: Peptides for Disease Control. Small Wonders: Peptides for Disease Control 21 45 .
Yunfeng Ma, Hai-Dan Chen, Yubin Wang, Qilong Wang, Yingying Li, Yinglan Zhao & Xiao-lian Zhang. (2011) Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes and Infection 13:12-13, pages 1099-1110.
Crossref
Bao-Fu ZhangJun-Jie LiuDong-Sheng PeiZhi-Xia YangJie-Hui DiFei-Fei ChenHui-Zhong LiWei XuYong-Ping WuJun-Nian Zheng. (2011) Potent Antitumor Effect Elicited by RGD- mda-7 , an mda-7 /IL-24 Mutant, via Targeting the Integrin Receptor of Tumor Cells . Cancer Biotherapy and Radiopharmaceuticals 26:5, pages 647-655.
Crossref
Jie Liang, Ru-Lin Huang, Qian Huang, Zhi Peng, Pei-Hua Zhang & Zhi-Xian Wu. (2011) Adenovirus-Mediated Human Interleukin 24 (MDA-7/IL-24) Selectively Suppresses Proliferation and Induces Apoptosis in Keloid Fibroblasts. Annals of Plastic Surgery 66:6, pages 660-666.
Crossref
R M Eager & J Nemunaitis. (2011) Clinical development directions in oncolytic viral therapy. Cancer Gene Therapy 18:5, pages 305-317.
Crossref
Xinjian LiuQijun QianPing XuFrank WolfJufeng ZhangDabing ZhangChuanyuan LiQian Huang. (2011) A Novel Conditionally Replicating “Armed” Adenovirus Selectively Targeting Gastrointestinal Tumors with Aberrant wnt Signaling . Human Gene Therapy 22:4, pages 427-437.
Crossref
Neill Patani, Anthony Douglas-Jones, Robert Mansel, Wen Jiang & Kefah Mokbel. (2010) Tumour suppressor function of MDA-7/IL-24 in human breast cancer. Cancer Cell International 10:1.
Crossref
Kanga Rani SelvadurayAmmu K. RadhakrishnanMethil Kannan KuttyKalanithi Nesaretnam. (2010) Palm Tocotrienols Inhibit Proliferation of Murine Mammary Cancer Cells and Induce Expression of Interleukin-24 mRNA. Journal of Interferon & Cytokine Research 30:12, pages 909-916.
Crossref
Paul Dent, Adly Yacoub, Hossein A. Hamed, Margaret A. Park, Rupesh Dash, Sujit K. Bhutia, Devanand Sarkar, Xiang-Yang Wang, Pankaj Gupta, Luni Emdad, Irina V. Lebedeva, Moira Sauane, Zhao-zhong Su, Mohamed Rahmani, William C. Broaddus, Harold F. Young, Maciej S. Lesniak, Steven Grant, David T. Curiel & Paul B. Fisher. (2010) The development of MDA-7/IL-24 as a cancer therapeutic. Pharmacology & Therapeutics 128:2, pages 375-384.
Crossref
Rupesh Dash, Sujit K. Bhutia, Belal Azab, Zhao-zhong Su, Bridget A. Quinn, Timothy P. Kegelmen, Swadesh K. Das, Keetae Kim, Seok-Geun Lee, Margaret A. Park, Adly Yacoub, Mohammed Rahmani, Luni Emdad, Igor P. Dmitriev, Xiang-Yang Wang, Devanand Sarkar, Steven Grant, Paul Dent, David T. Curiel & Paul B. Fisher. (2010) mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity. Cytokine & Growth Factor Reviews 21:5, pages 381-391.
Crossref
Daniela Barretto Barbosa Trivella, José Ribamar Ferreira-Júnior, Laure Dumoutier, Jean-Christophe Renauld & Igor Polikarpov. (2010) Structure and function of interleukin-22 and other members of the interleukin-10 family. Cellular and Molecular Life Sciences 67:17, pages 2909-2935.
Crossref
Jun Kai Fan, Na Wei, Miao Ding, Jin Fa Gu, Xin Ran Liu, Bing Hua Li, Rong Qi, Wei Dan Huang, Yu Hua Li, Xiao Quan Xiong, Jian Wang, Run Sheng Li & Xin Yuan Liu. (2010) Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene. International Journal of Cancer 127:3, pages 707-717.
Crossref
Na WeiJun Kai FanJin Fa GuXin Yuan Liu. (2010) Double-Regulated Oncolytic Adenovirus-Mediated Interleukin-24 Overexpression Exhibits Potent Antitumor Activity on Gastric Adenocarcinoma. Human Gene Therapy 21:7, pages 855-864.
Crossref
Hossein A Hamed, Adly Yacoub, Margaret A Park, Patrick J Eulitt, Rupesh Dash, Devanand Sarkar, Igor P Dmitriev, Maciej S Lesniak, Khalid Shah, Steven Grant, David T Curiel, Paul B Fisher & Paul Dent. (2010) Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma. Molecular Therapy 18:6, pages 1130-1142.
Crossref
Sujit K. Bhutia, Rupesh Dash, Swadesh K. Das, Belal Azab, Zhao-zhong Su, Seok-Geun Lee, Steven Grant, Adly Yacoub, Paul Dent, David T. Curiel, Devanand Sarkar & Paul B. Fisher. (2010) Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24. Cancer Research 70:9, pages 3667-3676.
Crossref
Adly Yacoub, Hossein A. Hamed, Jeremy Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Ogretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher & Paul Dent. (2010) PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda -7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells . Cancer Research 70:3, pages 1120-1129.
Crossref
Adelaide Greco, Altomare Di Benedetto, Candace M Howard, Sarah Kelly, Rounak Nande, Yulia Dementieva, Michele Miranda, Arturo Brunetti, Marco Salvatore, Luigi Claudio, Devanand Sarkar, Paul Dent, David T Curiel, Paul B Fisher & Pier P Claudio. (2010) Eradication of Therapy-resistant Human Prostate Tumors Using an Ultrasound-guided Site-specific Cancer Terminator Virus Delivery Approach. Molecular Therapy 18:2, pages 295-306.
Crossref
Nancy Poindexter, Rajagopal Ramesh, Suhendan Ekmekcioglu, Julie Ellerhorst, Kevin Kim & Elizabeth A. Grimm. 2010. Gene-Based Therapies for Cancer. Gene-Based Therapies for Cancer 181 202 .
L N Kaliberova, V Krendelchtchikova, D K Harmon, C R Stockard, A S Petersen, J M Markert, G Y Gillespie, W E Grizzle, D J Buchsbaum & S A Kaliberov. (2009) CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma. Cancer Gene Therapy 16:10, pages 794-805.
Crossref
Margaret A. Park, Teneille Walker, Aditi Pandya Martin, Jeremy Allegood, Nicollaq Vozhilla, Luni Emdad, Devanand Sarkar, Mohammed Rahmani, Martin Graf, Adly Yacoub, Costas Koumenis, Sarah Spiegel, David T. Curiel, Christina Voelkel-Johnson, Steven Grant, Paul B. Fisher & Paul Dent. (2009) MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism. Molecular Cancer Therapeutics 8:5, pages 1280-1291.
Crossref
Yu-mei Wu, Kang-jian Zhang, Xue-tian Yue, Yi-qiang Wang, Yi Yang, Gong-chu Li, Na Li & Yi-gang Wang. (2009) Enhancement of tumor cell death by combining cisplatin with an oncolytic adenovirus carrying MDA-7/IL-24. Acta Pharmacologica Sinica 30:4, pages 467-477.
Crossref
Bin Xiao, Wei Li, Jun Yang, Gang Guo, Xu-Hu Mao & Quan-Ming Zou. (2008) RGD-IL-24, A Novel Tumor-Targeted Fusion Cytokine: Expression, Purification and Functional Evaluation. Molecular Biotechnology 41:2, pages 138-144.
Crossref
S. Kreis, D. Philippidou, C. Margue & I. Behrmann. (2008) IL-24: a classic cytokine and/or a potential cure for cancer?. Journal of Cellular and Molecular Medicine 12:6a, pages 2505-2510.
Crossref
Anupama Sahoo, Yun Min Jung, Ho-Keun Kwon, Hwa-Jung Yi, Suho Lee, Sunghoe Chang, Zee-Yong Park, Ki-Chul Hwang & Sin-Hyeog Im. (2008) A Novel Splicing Variant of Mouse Interleukin (IL)-24 Antagonizes IL-24-induced Apoptosis. Journal of Biological Chemistry 283:43, pages 28860-28872.
Crossref
Irina V. Lebedeva, Zhao-zhong Su, Nichollaq Vozhilla, Lejuan Chatman, Devanand Sarkar, Paul Dent, Mohammad Athar & Paul B. Fisher. (2008) Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis. Molecular Cancer Therapeutics 7:7, pages 2042-2050.
Crossref
Pankaj Gupta, Luni Emdad, Irina V. Lebedeva, Devanand Sarkar, Paul Dent, David T. Curiel, Jeffrey Settleman & Paul B. Fisher. (2008) Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva. Journal of Cellular Physiology 215:3, pages 827-836.
Crossref
Ping Gao, Xiaolei Sun, Xing Chen, Yanping Wang, Barbara A. Foster, John Subjeck, Paul B. Fisher & Xiang-Yang Wang. (2008) Secretable Chaperone Grp170 Enhances Therapeutic Activity of a Novel Tumor Suppressor, mda-7 /IL-24 . Cancer Research 68:10, pages 3890-3898.
Crossref
D Sarkar, Z-z Su, E-S Park, N Vozhilla, P Dent, D T Curiel & P B Fisher. (2008) A cancer terminator virus eradicates both primary and distant human melanomas. Cancer Gene Therapy 15:5, pages 293-302.
Crossref
Jingjing Luo, Qingmei Xia, Rui Zhang, Chen Lv, Wei Zhang, Yingxin Wang, Qiang Cui, Li Liu, Rong Cai & Cheng Qian. (2008) Treatment of Cancer with a Novel Dual-Targeted Conditionally Replicative Adenovirus Armed with mda-7/IL-24 Gene . Clinical Cancer Research 14:8, pages 2450-2457.
Crossref
Adly Yacoub, Margaret A. Park, Pankaj Gupta, Mohammed Rahmani, Guo Zhang, Hossein Hamed, David Hanna, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Moira Sauane, Nicollaq Vozhilla, Sarah Spiegel, Costas Koumenis, Martin Graf, David T. Curiel, Steven Grant, Paul B. Fisher & Paul Dent. (2008) Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Molecular Cancer Therapeutics 7:2, pages 297-313.
Crossref
B Gopalan, M Shanker, A Scott, C D Branch, S Chada & R Ramesh. (2007) MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin–proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity. Cancer Gene Therapy 15:1, pages 1-8.
Crossref
Ulrich R. Hengge. 2008. Grundlagen der Molekularen Medizin. Grundlagen der Molekularen Medizin 379 394 .
Alexander O. Tarakanov. 2008. Advances in Applied Self-organizing Systems. Advances in Applied Self-organizing Systems 271 290 .
Began Gopalan, Manish Shanker, Sunil Chada & Rajagopal Ramesh. (2007) MDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo. Molecular Cancer 6:1.
Crossref
Ichiro Tahara, Koichi Miyake, Hideki Hanawa, Toshiyuki Kurai, Yukihiko Hirai, Masamichi Ishizaki, Eiji Uchida, Takashi Tajiri & Takashi Shimada. (2007) Systemic Cancer Gene Therapy Using Adeno-associated Virus Type 1 Vector Expressing MDA-7/IL24. Molecular Therapy 15:10, pages 1805-1811.
Crossref
Yasuhisa Oida, Began Gopalan, Ryo Miyahara, Cynthia D. Branch, Paul Chiao, Sunil Chada & Rajagopal Ramesh. (2007) Inhibition of nuclear factor-κB augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation. Molecular Cancer Therapeutics 6:4, pages 1440-1449.
Crossref
Aaron T. Smith, Meredith R. Livingston, Antonello Mai, Patrizia Filetici, Sherry F. Queener & William J. SullivanJr.Jr.. (2007) Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii . Antimicrobial Agents and Chemotherapy 51:3, pages 1109-1111.
Crossref
Irina V. LebedevaIlyas WashingtonDevanand SarkarJennifer A. ClarkRobert L. FinePaul Dent, David T. Curiel, Nicholas J. TurroPaul B. Fisher. (2007) Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas. Proceedings of the National Academy of Sciences 104:9, pages 3484-3489.
Crossref
I V Lebedeva, Z-Z Su, L Emdad, A Kolomeyer, D Sarkar, S Kitada, S Waxman, J C Reed & P B Fisher. (2006) Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells. Oncogene 26:5, pages 733-744.
Crossref
Luni Emdad, Irina V. Lebedeva, Zao-Zhong Su, Pankaj Gupta, Devanand Sarkar, Jeffrey Settleman & Paul B. Fisher. (2007) Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy. Journal of Cellular Physiology 210:2, pages 549-559.
Crossref
Moira Sauane, Pankaj Gupta, Irina V. Lebedeva, Zao-zhong Su, Devanand Sarkar, Aaron Randolph, Kristoffer Valerie, Rahul V. Gopalkrishnan & Paul B. Fisher. (2006) N-Glycosylation of MDA-7/IL-24 Is Dispensable for Tumor Cell–Specific Apoptosis and “Bystander” Antitumor Activity. Cancer Research 66:24, pages 11869-11877.
Crossref
Pankaj Gupta, Mark R. Walter, Zao-zhong Su, Irina V. Lebedeva, Luni Emdad, Aaron Randolph, Kristoffer Valerie, Devanand Sarkar & Paul B. Fisher. (2006) BiP/GRP78 Is an Intracellular Target for MDA-7/IL-24 Induction of Cancer-Specific Apoptosis. Cancer Research 66:16, pages 8182-8191.
Crossref
Luni Emdad, Devanand Sarkar, Irina V. Lebedeva, Zao-zhong Su, Pankaj Gupta, Parameshwar J. Mahasreshti, Paul Dent, David T. Curiel & Paul B. Fisher. (2006) Ionizing radiation enhances adenoviral vector expressingmda-7/IL-24-mediated apoptosis in human ovarian cancer. Journal of Cellular Physiology 208:2, pages 298-306.
Crossref
Ghazaleh Sadri-Vakili & Jang-Ho J Cha. (2006) Mechanisms of Disease: histone modifications in Huntington's disease. Nature Clinical Practice Neurology 2:6, pages 330-338.
Crossref
Z-Z Su, I V Lebedeva, D Sarkar, L Emdad, P Gupta, S Kitada, P Dent, J C Reed & P B Fisher. (2005) Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2. Oncogene 25:16, pages 2339-2348.
Crossref
Irina V. Lebedeva, Devanand Sarkar, Zao-Zhong Su, Rahul V. Gopalkrishnan, Mohammad Athar, Aaron Randolph, Kristoffer Valerie, Paul Dent & Paul B. Fisher. (2006) Molecular Target-Based Therapy of Pancreatic Cancer. Cancer Research 66:4, pages 2403-2413.
Crossref
Vanesa Martín, Federico Herrera, Pilar Carrera-Gonzalez, Guillermo García-Santos, Isaac Antolín, Jezabel Rodriguez-Blanco & Carmen Rodriguez. (2006) Intracellular Signaling Pathways Involved in the Cell Growth Inhibition of Glioma Cells by Melatonin. Cancer Research 66:2, pages 1081-1088.
Crossref
Pablo López Bergam, Anindita Bhoumik & Ze’ev Ronai. 2006. From Melanocytes to Melanoma. From Melanocytes to Melanoma 119 147 .
Paul B. Fisher. (2005) Is mda-7/IL-24 a “Magic Bullet” for Cancer? . Cancer Research 65:22, pages 10128-10138.
Crossref
Fernando Abarzua, Masakiyo Sakaguchi, Mikiro Takaishi, Yasutomo Nasu, Kyouhei Kurose, Shin Ebara, Masahiro Miyazaki, Masayoshi Namba, Hiromi Kumon & Nam-ho Huh. (2005) Adenovirus-Mediated Overexpression of REIC/Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH2-Kinase. Cancer Research 65:21, pages 9617-9622.
Crossref
Zhaozhong Su, Luni Emdad, Moira Sauane, Irina V Lebedeva, Devanand Sarkar, Pankaj Gupta, C David James, Aaron Randolph, Kirstoffer Valerie, Mark R Walter, Paul Dent & Paul B Fisher. (2005) Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene 24:51, pages 7552-7566.
Crossref
Milin R. Acharya, Alex Sparreboom, Jürgen Venitz & William D. Figg. (2005) Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review. Molecular Pharmacology 68:4, pages 917-932.
Crossref
P Gallo, S Dharmapuri, B Cipriani & P Monaci. (2005) Adenovirus as vehicle for anticancer genetic immunotherapy. Gene Therapy 12:S1, pages S84-S91.
Crossref
Began Gopalan, Anya Litvak, Sikha Sharma, Abner M. Mhashilkar, Sunil Chada & Rajagopal Ramesh. (2005) Activation of the Fas-FasL Signaling Pathway by MDA-7/IL-24 Kills Human Ovarian Cancer Cells. Cancer Research 65:8, pages 3017-3024.
Crossref
Eric C. LaCasse, Martin Holcik, Robert G. Korneluk & Alex E. MacKenzie. 2010. Apoptosis in Health and Disease. Apoptosis in Health and Disease 1 48 .
Mai Wang & Peng Liang. (2005) Interleukin-24 and its receptors. Immunology 114:2, pages 166-170.
Crossref
Irina V Lebedeva, Zao-zhong Su, Devanand Sarkar, Rahul V Gopalkrishnan, Samuel Waxman, Adly Yacoub, Paul Dent & Paul B Fisher. (2004) Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis. Oncogene 24:4, pages 585-596.
Crossref
Alex W. Tong, John Nemunaitis, Dan Su, Yuan Zhang, Casey Cunningham, Neil Senzer, George Netto, Dawn Rich, Abner Mhashilkar, Karen Parker, Keith Coffee, Rajagopal Ramesh, Suhendan Ekmekcioglu, Elizabeth A. Grimm, Jill van Wart Hood, James Merritt & Sunil Chada. (2005) Intratumoral Injection of INGN 241, a Nonreplicating Adenovector Expressing the Melanoma-Differentiation Associated Gene-7 (mda-7/IL24): Biologic Outcome in Advanced Cancer Patients. Molecular Therapy 11:1, pages 160-172.
Crossref
Irina V. Lebedeva, Moira Sauane, Rahul V. Gopalkrishnan, Devanand Sarkar, Zhao-zhong Su, Pankaj Gupta, John Nemunaitis, Casey Cunningham, Adly Yacoub, Paul Dent & Paul B. Fisher. (2005) mda-7/IL-24: Exploiting Cancer's Achilles' Heel. Molecular Therapy 11:1, pages 4-18.
Crossref
Alexander O. Tarakanov, Larisa B. Goncharova & Oleg A. Tarakanov. 2005. Advances in Artificial Life. Advances in Artificial Life 510 519 .
Larisa B. Goncharova, Yannick Jacques, Carlos Martin-Vide, Alexander O. Tarakanov & Jonathan I. Timmis. 2005. Artificial Immune Systems. Artificial Immune Systems 72 85 .
Rajagopal RameshIsao ItoYuji SaitoZheng WuAbner M. MhashikarDeborah R. WilsonCynthia D. BranchJack A. RothSunil Chada. (2004) Local and Systemic Inhibition of Lung Tumor Growth After Nanoparticle-Mediated mda-7/IL-24 Gene Delivery . DNA and Cell Biology 23:12, pages 850-857.
Crossref
Sunil Chada, Abner M. Mhashilkar, Rajagopal Ramesh, John B. Mumm, R. Bryan Sutton, Dora Bocangel, Mingzhong Zheng, Elizabeth A. Grimm & Suhendan Ekmekcioglu. (2004) Bystander activity of Ad-mda7: Human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism. Molecular Therapy 10:6, pages 1085-1095.
Crossref
Moira Sauane, Rahul V Gopalkrishnan, Heng-tong Choo, Pankaj Gupta, Irina V Lebedeva, Adly Yacoub, Paul Dent & Paul B Fisher. (2004) Mechanistic aspects of mda-7/IL-24 cancer cell selectivity analysed via a bacterial fusion protein. Oncogene 23:46, pages 7679-7690.
Crossref
Shogo Shinohara & Jay L Rothstein. (2004) Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an autocrine growth factor for epithelial cells. Oncogene 23:45, pages 7571-7579.
Crossref
Matthew Allen, Barbara Pratscher, Florian Roka, Clemens Krepler, Volker Wacheck, Christian Schöfer, Hubert Pehamberger, Markus Müller & Trevor Lucas. (2004) Loss of Novel mda-7 Splice Variant (mda-7s) Expression is Associated with Metastatic Melanoma11Work carried out in Vienna, Austria.. Journal of Investigative Dermatology 123:3, pages 583-588.
Crossref
Junya Fukuoka, Takeshi Fujii, Joanna H. Shih, Tatiana Dracheva, Daoud Meerzaman, Audrey Player, Kyeong Hong, Sharon Settnek, Ajay Gupta, Kenneth Buetow, Stephen Hewitt, William D. Travis & Jin Jen. (2004) Chromatin Remodeling Factors and BRM/BRG1 Expression as Prognostic Indicators in Non-Small Cell Lung Cancer. Clinical Cancer Research 10:13, pages 4314-4324.
Crossref
Moira Sauane, Irina V. Lebedeva, Zao-zhong Su, Heng-tong Choo, Aaron Randolph, Kristoffer Valerie, Paul Dent, Rahul V. Gopalkrishnan & Paul B. Fisher. (2004) Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory Pathways. Cancer Research 64:9, pages 2988-2993.
Crossref
Dong-chul Kang, Rahul V Gopalkrishnan, Lin Lin, Aaron Randolph, Kristoffer Valerie, Sidney Pestka & Paul B Fisher. (2003) Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. Oncogene 23:9, pages 1789-1800.
Crossref
Kerry A Sieger, Abner M Mhashilkar, Alexis Stewart, R.Bryan Sutton, Randall W Strube, Si Yi Chen, Abujiang Pataer, Stephen G Swisher, Elizabeth A Grimm, Rajagopal Ramesh & Sunil Chada. (2004) The Tumor Suppressor Activity of MDA-7/IL-24 Is Mediated by Intracellular Protein Expression in NSCLC Cells. Molecular Therapy 9:3, pages 355-367.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.