391
Views
26
CrossRef citations to date
0
Altmetric
Research Paper

Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-Cysteine

Pages 959-964 | Published online: 26 May 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Zbigniew Darzynkiewicz, Hong Zhao, H. Dorota Halicka, Paulina Rybak, Jurek Dobrucki & Donald Wlodkowic. (2012) DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis. Critical Reviews in Clinical Laboratory Sciences 49:5-6, pages 199-217.
Read now
Wang Li, Lynn T. Frame, Karlene A. Hoo, Yuan Li, Nicholas D'Cunha & Everardo Cobos. (2011) Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro. Leukemia & Lymphoma 52:12, pages 2380-2390.
Read now
Shu-Chi Wang, Chu-Chiao Wu, Yuan-Yaw Wei, Ji-Hong Hong & Chi-Shiun Chiang. (2011) Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. International Journal of Radiation Biology 87:4, pages 432-442.
Read now

Articles from other publishers (23)

Amit Singh, Shivangi Bora, Sonia Khurana, Pankaj Kumar, Niloy Sarkar, Ritushree Kukreti, Shrikant Kukreti & Mahima Kaushik. (2023) Advance nanotherapeutic approach for systemic co-delivery of mitoxantrone loaded chitosan coated PLGA nanoparticles to improve the chemotherapy against human non-small cell lung cancer. Journal of Drug Delivery Science and Technology 84, pages 104523.
Crossref
Homa Ahmadzadeh, Mehran Ahmadi, Asal Golchin, Faezeh Malakoti, Masomeh Maleki, Forough Alemi, Mohammadreza Bazavar & Bahman Yousefi. (2022) Investigating the Role of Thymoquinone in Increasing the Rate of Cisplatin-Induced Apoptosis through Oxidative DNA Damage in Saso-2 Cancer Cells. Drug Research 72:03, pages 171-176.
Crossref
Anushi Shukla, Neha Bunkar, Rajat Kumar, Arpit Bhargava, Rajnarayan Tiwari, Koel Chaudhury, Irina Y. Goryacheva & Pradyumna K. Mishra. (2019) Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms. Science of The Total Environment 656, pages 760-777.
Crossref
Akshay V. BhatShainan HoraAnanya PalSudhakar JhaReshma Taneja. (2018) Stressing the (Epi)Genome: Dealing with Reactive Oxygen Species in Cancer. Antioxidants & Redox Signaling 29:13, pages 1273-1292.
Crossref
Xin Long, Robert B. Gerbing, Todd A. Alonzo & Michele S. Redell. (2017) Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children’s Oncology Group report. Oncotarget 8:52, pages 90037-90049.
Crossref
Andrzej Pawlik, Mariusz Andrzej Szczepanski, Anna Klimaszewska-Wisniewska, Lidia Gackowska, Agnieszka Zuryn & Alina Grzanka. (2016) Cytoskeletal reorganization and cell death in mitoxantrone-treated lung cancer cells. Acta Histochemica 118:8, pages 784-796.
Crossref
Jaqueline Cesar Rocha, Franciele Faccio Busatto, Lisiane Knob de Souza & Jenifer Saffi. (2016) Influence of nucleotide excision repair on mitoxantrone cytotoxicity. DNA Repair 42, pages 33-43.
Crossref
Benny J. Evison, Brad E. Sleebs, Keith G. Watson, Don R. Phillips & Suzanne M. Cutts. (2016) Mitoxantrone, More than Just Another Topoisomerase II Poison. Medicinal Research Reviews 36:2, pages 248-299.
Crossref
Mohamed E. Ashour, Reham Atteya & Sherif F. El-Khamisy. (2015) Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nature Reviews Cancer 15:3, pages 137-151.
Crossref
Chung Soo Lee, Sang Won Kwak, Yun Jeong Kim, Seon Ae Lee, Eon Sob Park, Soon Chul Myung, Wonyong Kim, Min Sung Lee & Jeong Jae Lee. (2012) Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. European Journal of Pharmacology 683:1-3, pages 54-62.
Crossref
Hong Zhao, Paulina Rybak, Jurek Dobrucki, Frank Traganos & Zbigniew Darzynkiewicz. (2012) Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide. Cytometry Part A 81A:1, pages 45-51.
Crossref
Benny J. Evison, Mile Pastuovic, Rebecca A. Bilardi, Robert A. Forrest, Paul P. Pumuye, Brad E. Sleebs, Keith G. Watson, Don R. Phillips & Suzanne M. Cutts. (2011) M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe. Biochemical Pharmacology 82:11, pages 1604-1618.
Crossref
Chung S. Lee, Yun J. Kim, Wonyong Kim & Soon C. Myung. (2011) Guanylate Cyclase Activator YC-1 Enhances TRAIL-Induced Apoptosis in Human Epithelial Ovarian Carcinoma Cells via Activation of Apoptosis-Related Proteins. Basic & Clinical Pharmacology & Toxicology 109:4, pages 283-291.
Crossref
Zbigniew Darzynkiewicz, Frank Traganos, Hong Zhao, H. Dorota Halicka, Joanna Skommer & Donald Wlodkowic. 2011. Recent Advances in Cytometry, Part B - Advances in Applications. Recent Advances in Cytometry, Part B - Advances in Applications 115 147 .
Sun-Joo Lee, Yun Jeong Kim, Chung Soo Lee & Jaeman Bae. (2009) Combined application of camptothecin and the guanylate cyclase activator YC-1: Impact on cell death and apoptosis-related proteins in ovarian carcinoma cell lines. Chemico-Biological Interactions 181:2, pages 185-192.
Crossref
Richard Sullivan & Charles H. Graham. (2009) Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1. Molecular Cancer Therapeutics 8:6, pages 1702-1713.
Crossref
Hong Zhao, Frank Traganos, Jurek Dobrucki, Donald Wlodkowic & Zbigniew Darzynkiewicz. (2009) Induction of DNA damage response by the supravital probes of nucleic acids. Cytometry Part A 75A:6, pages 510-519.
Crossref
Sang Won HaYun Jeong KimWonyong KimChung Soo Lee. (2009) Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa. The Korean Journal of Physiology and Pharmacology 13:2, pages 115.
Crossref
Hong Zhao, Frank Traganos & Zbigniew Darzynkiewicz. (2008) Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase. Cytometry Part A 73A:6, pages 480-489.
Crossref
Daniel J. Smart, H. Dorota Halicka, Gabriele Schmuck, Frank Traganos, Zbigniew Darzynkiewicz & Gary M. Williams. (2008) Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 641:1-2, pages 43-47.
Crossref
Che-Jen Hsiao, Tsia-Kun Li, Ya-Ling Chan, Ling-Wei Hsin, Cho-Hwa Liao, Chien-Hua Lee, Ping-Chiang Lyu & Jih-Hwa Guh. (2008) WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers. Biochemical Pharmacology 75:4, pages 847-856.
Crossref
Anne Zuse, Helge Prinz, Klaus Müller, Peter Schmidt, Eckhard G. Günther, Frank Schweizer, Jochen H.M. Prehn & Marek Los. (2007) 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. European Journal of Pharmacology 575:1-3, pages 34-45.
Crossref
Toshiki Tanaka, Xuan Huang, H. Dorota Halicka, Hong Zhao, Frank Traganos, Anthony P. Albino, Wei Dai & Zbigniew Darzynkiewicz. (2007) Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry Part A 71A:9, pages 648-661.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.