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Research Paper

Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy

Pages 1561-1566 | Published online: 01 Oct 2008

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Milan Misovic, Dusan Milenkovic, Tamara Martinovic, Darko Ciric, Vladimir Bumbasirevic & Tamara Kravic-Stevovic. (2013) Short-term Exposure to UV-A, UV-B, and UV-C Irradiation Induces Alteration in Cytoskeleton and Autophagy in Human Keratinocytes. Ultrastructural Pathology 37:4, pages 241-248.
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Shu-Chi Wang, Chu-Chiao Wu, Yuan-Yaw Wei, Ji-Hong Hong & Chi-Shiun Chiang. (2011) Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. International Journal of Radiation Biology 87:4, pages 432-442.
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Articles from other publishers (35)

Alice Y. Ho, Shervin Tabrizi, Samantha A. Dunn & Heather L. McArthur. (2021) Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer. Breast Cancer Research and Treatment 191:2, pages 229-241.
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Wenbing Wu, Jingying Dong, Hui Gou, Ruiman Geng, Xiaolong Yang, Dan Chen, Bin Xiang, Zhengkun Zhang, Sichong Ren, Lihong Chen & Ji Liu. (2021) EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells. Journal of Cellular and Molecular Medicine 25:16, pages 7913-7921.
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Hernán Mauricio Rivera, Esther Natalia Muñoz, Daniel Osuna, Mauro Florez, Michael Carvajal & Luis Alberto Gómez. (2021) Reciprocal Changes in miRNA Expression with Pigmentation and Decreased Proliferation Induced in Mouse B16F1 Melanoma Cells by l-Tyrosine and 5-Bromo-2′-Deoxyuridine. International Journal of Molecular Sciences 22:4, pages 1591.
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Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon & Qinghua Zhou. (2021) Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nature Communications 12:1.
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Sheikh Ahmad Umar & Sheikh Abdullah Tasduq. (2020) Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress. RSC Advances 10:60, pages 36317-36336.
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Vera Chesnokova & Shlomo Melmed. (2020) Peptide Hormone Regulation of DNA Damage Responses. Endocrine Reviews 41:4.
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Witold Kozak, Sebastian Demkowicz, Mateusz Daśko, Janusz Rachon & Janusz Rak. (2020) Modifications at the C(5) position of pyrimidine nucleosides. Russian Chemical Reviews 89:3, pages 281-310.
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Alice Y. Ho, Christopher A. Barker, Brittany B. Arnold, Simon N. Powell, Zishuo I. Hu, Ayca Gucalp, Lizza Lebron‐Zapata, Hannah Y. Wen, Cindy Kallman, Alessandro D'Agnolo, Zhigang Zhang, Jessica Flynn, Samantha A. Dunn & Heather L. McArthur. (2019) A phase 2 clinical trial assessing the efficacy and safety of pembrolizumab and radiotherapy in patients with metastatic triple‐negative breast cancer. Cancer 126:4, pages 850-860.
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Shervin Tabrizi, Susan McDuff & Alice Y. Ho. (2019) Combining Radiation Therapy with Immune Checkpoint Blockadein Breast Cancer. Current Breast Cancer Reports 11:4, pages 203-216.
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Timothy Kinsella, Howard Safran, Susan Wiersma, Thomas DiPetrillo, Andrew Schumacher, Kayla Rosati, John Vatkevich, Lawrence W. Anderson, Kimberly D. Hill, Charles Kunos & Jerry M. Collins. (2019) Phase I and Pharmacology Study of Ropidoxuridine (IPdR) as Prodrug for Iododeoxyuridine-Mediated Tumor Radiosensitization in Advanced GI Cancer Undergoing Radiation. Clinical Cancer Research 25:20, pages 6035-6043.
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Mohd Kamil, Ejazul Haque, Snober S. Mir, Safia Irfan, Adria Hasan, Saba Sheikh, Shamshad Alam, Kausar M. Ansari & Aamir Nazir. (2019) Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53. Anti-Cancer Agents in Medicinal Chemistry 19:2, pages 184-193.
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Samanta Makurat, Paulina Spisz, Witold Kozak, Janusz Rak & Magdalena Zdrowowicz. (2019) 5-Iodo-4-thio-2′-Deoxyuridine as a Sensitizer of X-ray Induced Cancer Cell Killing. International Journal of Molecular Sciences 20:6, pages 1308.
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Francesca Nazio, Emiliano Maiani & Francesco Cecconi. 2018. Ubiquitination Governing DNA Repair - Implications in Health and Disease. Ubiquitination Governing DNA Repair - Implications in Health and Disease.
Feng Wang, Xiaojun Xia, Chunying Yang, Jianliang Shen, Junhua Mai, Han-Cheon Kim, Dickson Kirui, Ya'an Kang, Jason B. Fleming, Eugene J. Koay, Sankar Mitra, Mauro Ferrari & Haifa Shen. (2018) SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy . Clinical Cancer Research 24:13, pages 3176-3185.
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Jean-Baptiste Gorin, Jérémie Ménager, Yannick Guilloux, Jean-François Chatal, Joëlle Gaschet & Michel Chérel. 2018. Resistance to Ibritumomab in Lymphoma. Resistance to Ibritumomab in Lymphoma 119 137 .
Juha M.T. Hyttinen, Janusz Błasiak, Minna Niittykoski, Kati Kinnunen, Anu Kauppinen, Antero Salminen & Kai Kaarniranta. (2017) DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells—Implications for age-related macular degeneration (AMD). Ageing Research Reviews 36, pages 64-77.
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Kai-Yu Liu, Yu-Qian Xia, Jing Zhou, Zu-Wen Chen, Dandan Lu, Ning-Zhao Zhang, Xu-Sheng Liu, Hui Ai & Li-Lin Zhou. (2016) MOLECULAR CHARACTERIZATION OF AUTOPHAGY-RELATED GENE 5 FROM Spodoptera exigua AND EXPRESSION ANALYSIS UNDER VARIOUS STRESS CONDITIONS . Archives of Insect Biochemistry and Physiology 92:4, pages 225-241.
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J. Liu & J. Debnath. 2016. 1 53 .
Magdalena Zdrowowicz, Lidia Chomicz, Justyna Miloch, Justyna Wiczk, Janusz Rak, Gabriel Kciuk & Krzysztof Bobrowski. (2015) Reactivity Pattern of Bromonucleosides Induced by 2-Hydroxypropyl Radicals: Photochemical, Radiation Chemical, and Computational Studies. The Journal of Physical Chemistry B 119:22, pages 6545-6554.
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Piotr Czarny, Elzbieta Pawlowska, Jolanta Bialkowska-Warzecha, Kai Kaarniranta & Janusz Blasiak. (2015) Autophagy in DNA Damage Response. International Journal of Molecular Sciences 16:2, pages 2641-2662.
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Shi-Meng Zhang, Zeng-Fu Shang & Ping-Kun Zhou. (2015) Autophagy as the effector and player in DNA damage response of cells to genotoxicants. Toxicology Research 4:3, pages 613-622.
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Magdalena Zdrowowicz, Barbara Michalska, Agnieszka Zylicz-Stachula & Janusz Rak. (2014) Photoinduced Single Strand Breaks and Intrastrand Cross-Links in an Oligonucleotide Labeled with 5-Bromouracil. The Journal of Physical Chemistry B 118:19, pages 5009-5016.
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Larissa Dyugovskaya, Slava Berger, Andrey Polyakov & Lena Lavie. (2014) The development of giant phagocytes in long-term neutrophil cultures. Journal of Leukocyte Biology 96:4, pages 511-521.
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Justyna Wiczk, Justyna Miloch & Janusz Rak. (2014) DHPLC and MS studies of a photoinduced intrastrand cross-link in DNA labeled with 5-bromo-2′-deoxyuridine. Journal of Photochemistry and Photobiology B: Biology 130, pages 86-92.
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Justyna Wiczk, Justyna Miloch & Janusz Rak. (2013) UV-Induced Strand Breaks in Double-Stranded DNA Labeled with 5-Bromouracil: Frank or Secondary?. The Journal of Physical Chemistry Letters 4:22, pages 4014-4018.
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Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Yi-An Chen, Yi-Shiou Chiou, Sheng-Yow Ho, Pinpin Lin & Ying-Jan Wang. (2013) Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo. PLoS ONE 8:10, pages e76340.
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Xiao-Dong Zhu. (2013) Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells. Oncology Reports.
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Wonseok Yang, Ji-hyun Ju, Kyung-min Lee, KeeSoo Nam, Sunhwa Oh & Incheol Shin. (2013) Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression. Experimental Cell Research 319:3, pages 122-133.
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Reshma Rangwala & Ravi Amaravadi. 2013. Cell Death Signaling in Cancer Biology and Treatment. Cell Death Signaling in Cancer Biology and Treatment 87 116 .
Min-Jin Lim, Ji-Yeon Ahn, Youngsoo Han, Chi-ho Yu, Mi-Hyoung Kim, Sae-lo-oom Lee, Dae-Seog Lim & Jie-Young Song. (2012) Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. The International Journal of Biochemistry & Cell Biology 44:8, pages 1214-1222.
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Alicia M. Bolt & Walter T. Klimecki. (2012) Autophagy in toxicology: self-consumption in times of stress and plenty. Journal of Applied Toxicology 32:7, pages 465-479.
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Li-Hsin Chen, Pei-Ming Chu, Yi-Jang Lee, Pang-Hsien Tu, Chin-Wen Chi, Hsin-Chen Lee & Shih-Hwa Chiou. (2012) Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death. International Journal of Molecular Sciences 13:1, pages 1209-1224.
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Alexandra N Giatromanolaki, Georgios St Charitoudis, Nikolaos E Bechrakis, Vassilios P Kozobolis, Michael I Koukourakis, Michael H Foerster & Efthimios L Sivridis. (2011) Autophagy patterns and prognosis in uveal melanomas. Modern Pathology 24:8, pages 1036-1045.
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Humberto Rodriguez-Rocha, Aracely Garcia-Garcia, Mihalis I. Panayiotidis & Rodrigo Franco. (2011) DNA damage and autophagy. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 158-166.
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David A. Gewirtz, Molly L. Hilliker & Eden N. Wilson. (2009) Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells. Radiotherapy and Oncology 92:3, pages 323-328.
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