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Research Paper

Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells

Pages 1584-1590 | Published online: 01 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Sören Weidemann, Daniel Perez, Jakob R. Izbicki, Michael Neipp, Hamid Mofid, Thies Daniels, Ulf Nahrstedt, Frank Jacobsen, Christian Bernreuther, Ronald Simon, Stefan Steurer, Eike Burandt, Andreas H. Marx, Till Krech, Till S. Clauditz & Kristina Jansen. (2021) Mesothelin is Commonly Expressed in Pancreatic Adenocarcinoma but Unrelated to Cancer Aggressiveness. Cancer Investigation 39:9, pages 711-720.
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Raúl Ortiz, José Prados, Consolación Melguizo, José L Arias, M Adolfina Ruiz, Pablo J Álvarez, Octavio Caba, Raquel Luque, Ana Segura & Antonia Aránega. (2012) 5-Fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer. International Journal of Nanomedicine 7, pages 95-107.
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Yu-Hung Huang, Joseph A. Cozzitorto, Nathan G. Richards, Ahmed A. Eltoukhy, Charles J. Yeo, Robert Langer, Daniel G. Anderson, Jonathan R. Brody & Janet A. Sawicki. (2010) CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity. Cancer Biology & Therapy 10:9, pages 878-884.
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Shayna L Showalter, Sarah Charles, Justin Belin, Joseph Cozzitorto, Peter Einstein, Nathan G Richards, Patricia K Sauter, Eugene P Kennedy, Agnes Witkiewicz, Jonathan R Brody & Charles J Yeo. (2010) Identifying pancreatic cancer patients for targeted treatment: the challenges and limitations of the current selection process and vision for the future. Expert Opinion on Drug Delivery 7:3, pages 273-284.
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Articles from other publishers (37)

Matteo Ardini, Riccardo Vago, Maria Serena Fabbrini & Rodolfo Ippoliti. (2022) From Immunotoxins to Suicide Toxin Delivery Approaches: Is There a Clinical Opportunity?. Toxins 14:9, pages 579.
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Sören Weidemann, Pauline Gagelmann, Natalia Gorbokon, Maximilian Lennartz, Anne Menz, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Niclas C. Blessin, Christoph Fraune, Katharina Möller, Christian Bernreuther, Patrick Lebok, Till S. Clauditz, Frank Jacobsen, Jakob R. Izbicki, Kristina Jansen, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Sarah Minner, Eike Burandt, Rainer H. Krech, David Dum, Till Krech, Andreas H. Marx & Ronald Simon. (2021) Mesothelin Expression in Human Tumors: A Tissue Microarray Study on 12,679 Tumors. Biomedicines 9:4, pages 397.
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Yuriy Khodarovich, Darya Rakhmaninova, German Kagarlitskiy, Anastasia Baryshnikova & Sergey Deyev. (2020) Growth Retardation of Poorly Transfectable Tumor by Multiple Injections of Plasmids Encoding PE40 Based Targeted Toxin Complexed with Polyethylenimine. Current Gene Therapy 20:4, pages 289-296.
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Jiajun Xu, Muye He, Xinyu Hou, Yan Wang, Chenting Shou, Xiaoran Cai, Zeting Yuan, Yu Yin, Minbo Lan, Kaiyan Lou, Yuzheng Zhao, Yi Yang, Xianjun Chen & Feng Gao. (2019) Safe and Efficacious Diphtheria Toxin-Based Treatment for Melanoma: Combination of a Light-On Gene-Expression System and Nanotechnology. Molecular Pharmaceutics 17:1, pages 301-315.
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Margaret J. Lange, Terri D. Lyddon & Marc C. Johnson. (2019) Diphtheria Toxin A-Resistant Cell Lines Enable Robust Production and Evaluation of DTA-Encoding Lentiviruses. Scientific Reports 9:1.
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Olga Kutova, Evgenii Guryev, Evgeniya Sokolova, Razan Alzeibak & Irina Balalaeva. (2019) Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency. Cancers 11:1, pages 68.
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Amer Elias, Natasha Gritsenko, Rena Gorovits, Itay Spector, Gali Prag, Ezra Yagil & Mikhail Kolot. (2018) Anti-cancer binary system activated by bacteriophage HK022 integrase. Oncotarget 9:44, pages 27487-27501.
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Federico Nichetti, Antonio Marra, Francesca Corti, Alessandro Guidi, Alessandra Raimondi, Natalie Prinzi, Filippo de Braud & Sara Pusceddu. (2018) The Role of Mesothelin as a Diagnostic and Therapeutic Target in Pancreatic Ductal Adenocarcinoma: A Comprehensive Review. Targeted Oncology 13:3, pages 333-351.
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Riccardo Vago, Veronica Collico, Stefania Zuppone, Davide Prosperi & Miriam Colombo. (2016) Nanoparticle-mediated delivery of suicide genes in cancer therapy. Pharmacological Research 111, pages 619-641.
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Jessica Pahle & Wolfgang Walther. 2016. Current Strategies in Cancer Gene Therapy. Current Strategies in Cancer Gene Therapy 95 110 .
Baoshun Lin, Anding Gao, Rui Zhang, Hongyu Ma, Haifeng Shen, Qiong Hu, Hua Zhang, Meng Zhao, Xiaopeng Lan & Kuancan Liu. (2015) Use of a Novel Integrase-Deficient Lentivirus for Targeted Anti-Cancer Therapy With Survivin Promoter-Driven Diphtheria Toxin A. Medicine 94:31, pages e1301.
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Renee M. TholeyShruti LalMasaya JimboRichard A. BurkhartFernando F. BlancoJoseph A. CozzitortoJosh D. EisenbergWei JiangChristine A. Iacobuzio-DonahueAgnieszka K. WitkiewiczMelissa GlbertCharles J. YeoJonathan R. BrodyJanet A. SawickiJordan M. Winter. (2015) MUC1 Promoter–Driven DTA as a Targeted Therapeutic Strategy against Pancreatic Cancer. Molecular Cancer Research 13:3, pages 439-448.
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Andrada Seicean. (2015) New targeted therapies in pancreatic cancer. World Journal of Gastroenterology 21:20, pages 6127.
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Zachary W. Kendrick, Matthew A. Firpo, Robert C. Repko, Courtney L. Scaife, Douglas G. Adler, Kenneth M. Boucher & Sean J. Mulvihill. (2014) Serum IGFBP2 and MSLN as diagnostic and prognostic biomarkers for pancreatic cancer. HPB 16:7, pages 670-676.
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Patricia Ohana, Imad Matouk, Doron Amit, Michal Gilon & Abraham Hochberg. 2014. Gene Therapy of Cancer. Gene Therapy of Cancer 107 122 .
Chandrashekhar D. Kamat, Ron B. Shmueli, Nick Connis, Charles M. Rudin, Jordan J. Green & Christine L. Hann. (2013) Poly(β-amino ester) Nanoparticle Delivery of TP53 Has Activity against Small Cell Lung Cancer In Vitro and In Vivo . Molecular Cancer Therapeutics 12:4, pages 405-415.
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Joel C. Sunshine, Daniel Y. Peng & Jordan J. Green. (2012) Uptake and Transfection with Polymeric Nanoparticles Are Dependent on Polymer End-Group Structure, but Largely Independent of Nanoparticle Physical and Chemical Properties. Molecular Pharmaceutics 9:11, pages 3375-3383.
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Renee Tholey, Janet A. Sawicki & Jonathan R. Brody. (2012) Molecular-Based and Alternative Therapies for Pancreatic Cancer. The Cancer Journal 18:6, pages 665-673.
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Ron B. Shmueli, Joel C. Sunshine, Zhenhua Xu, Elia J. Duh & Jordan J. Green. (2012) Gene delivery nanoparticles specific for human microvasculature and macrovasculature. Nanomedicine: Nanotechnology, Biology and Medicine 8:7, pages 1200-1207.
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Feng Yang, Chen Jin, Sabin Subedi, Chong Lek Lee, Qiang Wang, Yongjian Jiang, Ji Li, Yang Di & Deliang Fu. (2012) Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment. Cancer Treatment Reviews 38:6, pages 566-579.
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Raúl Ortiz, Jose Prados, Consolación Melguizo, Ana R. Rama, Pablo J. Álvarez, Fernando Rodríguez-Serrano, Octavio Caba, Houria Boulaiz & Antonia Aranega. (2012) Gef gene therapy enhances the therapeutic efficacy of cytotoxics in colon cancer cells. Biomedicine & Pharmacotherapy 66:7, pages 563-567.
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Elena M. Glinka. (2012) Eukaryotic expression vectors bearing genes encoding cytotoxic proteins for cancer gene therapy. Plasmid 68:2, pages 69-85.
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Jordan M. Winter, Laura H. Tang, David S. Klimstra, Murray F. Brennan, Jonathan R. Brody, Flavio G. Rocha, Xiaoyu Jia, Li-Xuan Qin, Michael I. D’Angelica, Ronald P. DeMatteo, Yuman Fong, William R. Jarnagin, Eileen M. O’Reilly & Peter J. Allen. (2012) A Novel Survival-Based Tissue Microarray of Pancreatic Cancer Validates MUC1 and Mesothelin as Biomarkers. PLoS ONE 7:7, pages e40157.
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Jordan J. Green. (2012) 2011 Rita Schaffer Lecture: Nanoparticles for Intracellular Nucleic Acid Delivery. Annals of Biomedical Engineering 40:7, pages 1408-1418.
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Katherina ZakikhanyAndroulla Efstratiou. (2012) Diphtheria in Europe: current problems and new challenges. Future Microbiology 7:5, pages 595-607.
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Christopher M Hine, Andrei Seluanov & Vera Gorbunova. (2012) Rad51 Promoter-Targeted Gene Therapy Is Effective for In Vivo Visualization and Treatment of Cancer. Molecular Therapy 20:2, pages 347-355.
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Jonathan R. Brody, David W. Rittenhouse, Agnieszka K. Witkiewicz & Charles J. Yeo. 2012. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract 123 134.e3 .
David W. Rittenhouse, Oeendree Mukherjee, Nathan G. Richards, Charles J. Yeo, Agnieszka K. Witkiewicz & Jonathan R. Brody. 2012. Caveolins in Cancer Pathogenesis, Prevention and Therapy. Caveolins in Cancer Pathogenesis, Prevention and Therapy 43 52 .
Kyung-Dong Bae. (2011) The Evolution and Value of Diphtheria Vaccine. KSBB Journal 26:6, pages 491-504.
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Ana R. Rama, Jose Prados, Consolacion Melguizo, Miguel Burgos, Pablo J. Alvarez, Fernando Rodriguez-Serrano, Juan L. Ramos & A. Aranega. (2011) Synergistic antitumoral effect of combination E gene therapy and Doxorubicin in MCF-7 breast cancer cells. Biomedicine & Pharmacotherapy 65:4, pages 260-270.
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Harish Lavu & Charles J. Yeo. 2011. Current Surgical Therapy. Current Surgical Therapy 422 429 .
Assaf Shapira & Itai Benhar. (2010) Toxin-Based Therapeutic Approaches. Toxins 2:11, pages 2519-2583.
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Nathan G. Richards, David W. Rittenhouse, Boris Freydin, Joseph A. Cozzitorto, Dane Grenda, Hallgeir Rui, Greg Gonye, Eugene P. Kennedy, Charles J. Yeo, Jonathan R. Brody & Agnieszka K. Witkiewicz. (2010) HuR Status is a Powerful Marker for Prognosis and Response to Gemcitabine-Based Chemotherapy for Resected Pancreatic Ductal Adenocarcinoma Patients. Annals of Surgery 252:3, pages 499-506.
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Jose Prados, Consolación Melguizo, Ana Rosa Rama, Rául Ortiz, Ana Segura, Houria Boulaiz, Celia Vélez, Octavio Caba, Juan Luís Ramos & Antonia Aránega. (2009) Gef gene therapy enhances the therapeutic efficacy of doxorubicin to combat growth of MCF-7 breast cancer cells. Cancer Chemotherapy and Pharmacology 66:1, pages 69-78.
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Joel Sunshine, Jordan J. Green, Kerry P. Mahon, Fan Yang, Ahmed A. Eltoukhy, David N. Nguyen, Robert Langer & Daniel G. Anderson. (2009) Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy. Advanced Materials 21:48, pages 4947-4951.
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Raúl Ortiz, Jose Prados, Consolacion Melguizo, Ana R. Rama, Ana Segura, Fernando Rodríguez-Serrano, Houria Boulaiz, Fidel Hita, Antonio Martinez-Amat, Roberto Madeddu, Juan L. Ramos & Antonia Aranega. (2009) The cytotoxic activity of the phage E protein suppress the growth of murine B16 melanomas in vitro and in vivo. Journal of Molecular Medicine 87:9, pages 899-911.
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Yu-Hung Huang, Gregory T. Zugates, Weidan Peng, David Holtz, Charles Dunton, Jordan J. Green, Naushad Hossain, Michael R. Chernick, Robert F. PaderaJr.Jr., Robert Langer, Daniel G. Anderson & Janet A. Sawicki. (2009) Nanoparticle-Delivered Suicide Gene Therapy Effectively Reduces Ovarian Tumor Burden in Mice. Cancer Research 69:15, pages 6184-6191.
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