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Research Paper

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors’ anticancer efficacy

Pages 1952-1958 | Published online: 01 Dec 2008

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Marcel A. Deken, Jules Gadiot, Ekaterina S. Jordanova, Ruben Lacroix, Melissa van Gool, Paula Kroon, Cristina Pineda, Marnix H. Geukes Foppen, Richard Scolyer, Ji-Ying Song, Inge Verbrugge, Christoph Hoeller, Reinhard Dummer, John B. A. G. Haanen, Georgina V. Long & Christian U. Blank. (2016) Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma. OncoImmunology 5:12.
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Zhuo Ma, Lingjun Zhu, Xuan Luo, Sulan Zhai, Ping Li & Xuerong Wang. (2012) Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells. Cancer Biology & Therapy 13:11, pages 1009-1017.
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Ayodele Ayoola, Amit Barochia, Kiran Belani & Chandra P. Belani. (2012) Primary and Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer: An Update. Cancer Investigation 30:5, pages 433-446.
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Yikun Li, Songqing Fan, Junghui Koo, Ping Yue, Zhuo (Georgia) Chen, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri & Shi-Yong Sun. (2012) Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer. Cancer Biology & Therapy 13:5, pages 272-280.
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Cheng-Xiong Xu, Liqun Zhao, Ping Yue, Guofu Fang, Hui Tao, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri & Shi-Yong Sun. (2011) Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy. Cancer Biology & Therapy 12:6, pages 549-555.
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Xuerong Wang & Shi-Yong Sun. (2009) Enhancing mTOR-targeted cancer therapy. Expert Opinion on Therapeutic Targets 13:10, pages 1193-1203.
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