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Research Paper

Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells

Pages 577-586 | Published online: 01 May 2008

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Crystal N. Marconett, Travis J. Morgenstern, Adrianna K. San Roman, Shyam N. Sundar, Ankur K. Singhal & Gary L. Firestone. (2010) BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biology & Therapy 10:4, pages 397-405.
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Articles from other publishers (29)

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Jiayu Gao, Weiping Yin & Olivia Corcoran. (2019) From Scutellaria barbata to BZL101 in Cancer Patients: Phytochemistry, Pharmacology, and Clinical Evidence . Natural Product Communications 14:10, pages 1934578X1988064.
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Jun Peng. (2013) Chloroform fraction of Scutellaria barbata D. Don promotes apoptosis and suppresses proliferation in human colon cancer cells. Molecular Medicine Reports.
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Vivian Chen, Richard E. Staub, Scott Baggett, Ramesh Chimmani, Mary Tagliaferri, Isaac Cohen & Emma Shtivelman. (2012) Identification and Analysis of the Active Phytochemicals from the Anti-Cancer Botanical Extract Bezielle. PLoS ONE 7:1, pages e30107.
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Gang Wang, Fei Wang & Ji-Kai Liu. (2011) Two New Phenols from Scutellaria barbata. Molecules 16:2, pages 1402-1408.
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Brian Y. Y. Wong & Hannah H. L. Wong. 2011. Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Materia Medica 155 177 .
Gihyun Lee, Hankyum Kim, Hyojung Lee, Minkyu Shin, Moochang Hong & Hyunsu Bae. (2010) Effects of Scutellaria barbata on cisplatin induced nephrotoxicity in mice. Molecular & Cellular Toxicology 6:3, pages 255-259.
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Ruth Chu, Xiaoyue Zhao, Chandi Griffin, Richard E. Staub, Mark Shoemaker, Joan Climent, Dale Leitman, Isaac Cohen, Emma Shtivelman & Sylvia Fong. (2010) Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid. International Journal of Cancer 127:5, pages 1209-1219.
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Ngoc-Ha Bui-Xuan, Patrick Ming-Kuen Tang, Chun-Kwok Wong & Kwok-Pui Fung. (2010) Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231. Journal of Ethnopharmacology 131:1, pages 95-103.
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Alejandra T. Perez, Banu Arun, Debu Tripathy, Mary A. Tagliaferri, Heather S. Shaw, Gretchen G. Kimmick, Isaac Cohen, Emma Shtivelman, Katherine A. Caygill, Deborah Grady, Mark Schactman & Charles L. Shapiro. (2010) A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Research and Treatment 120:1, pages 111-118.
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Guan-Yu Chen, Hsiao-Chiao Shiah, Hung-Ju Su, Chi-Yuan Chen, Yung-Jen Chuang, Wen-Hsin Lo, Jie-Len Huang, Ching-Kuang Chuang, Shiaw-Min Hwang & Yu-Chen Hu. (2009) Baculovirus Transduction of Mesenchymal Stem Cells Triggers the Toll-Like Receptor 3 Pathway. Journal of Virology 83:20, pages 10548-10556.
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Brian Y.Y. Wong, Dinh L. Nguyen, Tianxian Lin, Hannah H.L. Wong, Alessandro Cavalcante, Norman M. Greenberg, Randy P. Hausted & Jianping Zheng. (2009) Chinese medicinal herb Scutellaria barbata modulates apoptosis and cell survival in murine and human prostate cancer cells and tumor development in TRAMP mice. European Journal of Cancer Prevention 18:4, pages 331-341.
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