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Research Paper

The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration

Pages 677-688 | Published online: 01 Jun 2008

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Read on this site (3)

Jaap D van Buul, Dirk Geerts & Stephan Huveneers. (2014) Rho GAPs and GEFs. Cell Adhesion & Migration 8:2, pages 108-124.
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Xiaodong Song, Meirong Wang, Lixia Zhang, Jinjin Zhang, Xiuwen Wang, Wenbo Liu, Xinbin Gu & Changjun Lv. (2012) Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin. Toxicology Mechanisms and Methods 22:9, pages 679-686.
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Articles from other publishers (36)

Céline Prunier, Philippe Chavrier & Mathieu Boissan. (2023) Mechanisms of action of NME metastasis suppressors – a family affair. Cancer and Metastasis Reviews.
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Francesco Paolo Pennino, Masanao Murakami, Massimo Zollo & Erle S. Robertson. (2021) The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit. Oncogenesis 10:4.
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Bokyung Kim & Kong-Joo Lee. (2021) Activation of Nm23-H1 to suppress breast cancer metastasis via redox regulation. Experimental & Molecular Medicine 53:3, pages 346-357.
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Dohun Kim, Yujin Kim, Bo Bin Lee, Dongho Kim, Ok-Jun Lee, Pildu Jeong, Wun-Jae Kim, Eun Yoon Cho, Joungho Han, Young Mog Shim & Duk-Hwan Kim. (2020) Negative Effect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer. Journal of Clinical Medicine 9:10, pages 3067.
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Gemma Puts, Stuart Jarrett, Mary Leonard, Nicolette Matsangos, Devin Snyder, Ying Wang, Richard Vincent, Benjamin Portney, Rachel Abbotts, Lena McLaughlin, Michal Zalzman, Feyruz Rassool & David Kaetzel. (2020) Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR. International Journal of Molecular Sciences 21:16, pages 5896.
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Sara Pepe, Márta Korbonits & Donato Iacovazzo. (2019) Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects. Journal of Endocrinology 240:2, pages R21-R45.
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M. Kathryn Leonard, Marián Novak, Devin Snyder, Grace Snow, Nidhi Pamidimukkala, Joseph R. McCorkle, Xiuwei H. Yang & David M. Kaetzel. (2019) The metastasis suppressor NME1 inhibits melanoma cell motility via direct transcriptional induction of the integrin beta-3 gene. Experimental Cell Research 374:1, pages 85-93.
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Vedrana Filić, Maja Marinović, Marko Šoštar & Igor Weber. (2018) Modulation of small GTPase activity by NME proteins. Laboratory Investigation 98:5, pages 589-601.
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Paul V Attwood & Richmond Muimo. (2018) The actions of NME1/NDPK-A and NME2/NDPK-B as protein kinases. Laboratory Investigation 98:3, pages 283-290.
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Mathieu Boissan, Uwe Schlattner & Marie-Lise Lacombe. (2018) The NDPK/NME superfamily: state of the art. Laboratory Investigation 98:2, pages 164-174.
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Saurabh Pandey & Erle S Robertson. (2018) Oncogenic Epstein–Barr virus recruits Nm23-H1 to regulate chromatin modifiers. Laboratory Investigation 98:2, pages 258-268.
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Choon-Yee Tan & Christina L Chang. (2018) NDPKA is not just a metastasis suppressor – be aware of its metastasis-promoting role in neuroblastoma. Laboratory Investigation 98:2, pages 219-227.
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Zongzhu Zheng, Ruihua Tian & Ping Wang. (2017) Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma. World Journal of Surgical Oncology 15:1.
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Wen-Teish Chang, Cheng-Hung Chuang, Wan-Ju Lee & Chin-Shiu Huang. (2016) Extract of Monascus purpureus CWT715 Fermented from Sorghum Liquor Biowaste Inhibits Migration and Invasion of SK-Hep-1 Human Hepatocarcinoma Cells. Molecules 21:12, pages 1691.
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Marián Novak, Mary Kathryn Leonard, Xiuwei H. Yang, Anjan Kowluru, Alexey M. Belkin & David M. Kaetzel. (2015) Metastasis suppressor NME 1 regulates melanoma cell morphology, self‐adhesion and motility via induction of fibronectin expression . Experimental Dermatology 24:6, pages 455-461.
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Yao Tong, Lisa Y. Yung & Yung H. Wong. (2015) Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis. Cancer Letters 361:2, pages 207-217.
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Nikolina Vlatković, Shie-Hong Chang & Mark T. Boyd. (2014) Janus-faces of NME–oncoprotein interactions. Naunyn-Schmiedeberg's Archives of Pharmacology 388:2, pages 175-187.
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Huei-Yan Chen, Te-Cheng Yueh, Yi-Chuan Chen, Chien-Hao Huang, Chih-Min Yang & Miao-Lin Hu. (2013) Antimetastatic Effects of α-Carotene and Possible Mechanisms of Action in Human Hepatocarcinoma SK-Hep-1 Cells. Journal of Agricultural and Food Chemistry 61:43, pages 10368-10376.
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Natascia Marino, Joji Nakayama, Joshua W. Collins & Patricia S. Steeg. (2012) Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene. Cancer and Metastasis Reviews 31:3-4, pages 593-603.
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Hermann Bauer, Sabrina Schindler, Yves Charron, Jürgen Willert, Barica Kusecek & Bernhard G. Herrmann. (2012) The Nucleoside Diphosphate Kinase Gene Nme3 Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance. PLoS Genetics 8:3, pages e1002567.
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Chin-Shiu Huang, Shih-Chieh Lyu, Jen-Yin Chen & Miao-Lin Hu. (2011) The anti-metastatic efficacy of β-ionone and the possible mechanisms of action in human hepatocarcinoma SK-Hep-1 cells. British Journal of Nutrition 107:5, pages 631-638.
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Junghee Lim, Giyong Jang, Seeun Kang, Guewha Lee, Do Thi Thuy Nga, Do Thi Lan Phuong, Hyuncheol Kim, Wael El-Rifai, H. Earl Ruley & Daewoong Jo. (2011) Cell-Permeable NM23 Blocks the Maintenance and Progression of Established Pulmonary Metastasis. Cancer Research 71:23, pages 7216-7225.
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Patricia S. Steeg, Massimo Zollo & Thomas Wieland. (2011) A critical evaluation of biochemical activities reported for the nucleoside diphosphate kinase/Nm23/Awd family proteins: opportunities and missteps in understanding their biological functions. Naunyn-Schmiedeberg's Archives of Pharmacology 384:4-5, pages 331-339.
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Natascia Marino, Jean-Claude Marshall & Patricia S. Steeg. (2011) Protein–protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1. Naunyn-Schmiedeberg's Archives of Pharmacology 384:4-5, pages 351-362.
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Arnaud Bruneel, Dominique Wendum, Valérie Labas, Odile Mulner-Lorillon, Joelle Vinh, Nelly Bosselut, Eric Ballot, Bruno Baudin, Chantal Housset, Sandrine Dabernat, Marie-Lise Lacombe & Mathieu Boissan. (2011) Proteomic analysis of NME1/NDPK A null mouse liver: evidence for a post-translational regulation of annexin IV and EF-1Bα. Naunyn-Schmiedeberg's Archives of Pharmacology 384:4-5, pages 407-419.
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Marian Novak, Stuart G. Jarrett, Joseph R. McCorkle, Isabel Mellon & David M. Kaetzel. (2011) Multiple mechanisms underlie metastasis suppressor function of NM23-H1 in melanoma. Naunyn-Schmiedeberg's Archives of Pharmacology 384:4-5, pages 433-438.
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Guan-Jhong Huang, Jeng-Shyan Deng, Shyh-Shyun Huang & Miao-Lin Hu. (2011) Hispolon Induces Apoptosis and Cell Cycle Arrest of Human Hepatocellular Carcinoma Hep3B Cells by Modulating ERK Phosphorylation. Journal of Agricultural and Food Chemistry 59:13, pages 7104-7113.
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Angela Y. Wehr, Emma E. Furth, Vineet Sangar, Ian A. Blair & Kenneth H. Yu. (2011) Analysis of the Human Pancreatic Stellate Cell Secreted Proteome. Pancreas 40:4, pages 557-566.
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Camille Deplagne, Evelyne Peuchant, Isabelle Moranvillier, Pierre Dubus & Sandrine Dabernat. (2011) The Anti-Metastatic nm23-1 Gene Is Needed for the Final Step of Mammary Duct Maturation of the Mouse Nipple. PLoS ONE 6:4, pages e18645.
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John D. LapekJr.Jr., Gregory Tombline & Alan E. Friedman. (2010) Mass Spectrometry Detection of Histidine Phosphorylation on NM23-H1. Journal of Proteome Research 10:2, pages 751-755.
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Hui Guo, Kejun Nan, Tinghua Hu, Jie Meng, Wentao Hui, Xiaozhan Zhang, Haixia Qin & Chenguang Sui. (2010) Prognostic significance of co-expression of nm23 and p57 protein in hepatocellular carcinoma. Hepatology Research 40:11, pages 1107-1116.
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Andrew R. Conery, Sanja Sever & Ed Harlow. (2010) Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis. Proceedings of the National Academy of Sciences 107:35, pages 15461-15466.
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K.T. Wright, R. Seabright, A. Logan, A.J. Lilly, F. Khanim, C.M. Bunce & W.E.B. Johnson. (2010) Extracellular Nm23H1 stimulates neurite outgrowth from dorsal root ganglia neurons in vitro independently of nerve growth factor supplementation or its nucleoside diphosphate kinase activity. Biochemical and Biophysical Research Communications 398:1, pages 79-85.
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Rajeev Kaul, Masanao Murakami, Pankaj Kumar & Erle S. Robertson. 2010. Cancer Genome and Tumor Microenvironment. Cancer Genome and Tumor Microenvironment 233 271 .
Rajeev Kaul, Masanao Murakami, Ke Lan, Tathagata Choudhuri & Erle S. Robertson. (2009) EBNA3C Can Modulate the Activities of the Transcription Factor Necdin in Association with Metastasis Suppressor Protein Nm23-H1. Journal of Virology 83:10, pages 4871-4883.
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Lin Jin, Ge Liu, Chuan-hai Zhang, Chun-hua Lu, Sheng Xiong, Mei-Ying Zhang, Qiu-Ying Liu, Feng Ge, Qing-Yu He, Kaio Kitazato, Nobuyuki Kobayashi & Yi-Fei Wang. (2009) Nm23-H1 regulates the proliferation and differentiation of the human chronic myeloid leukemia K562 cell line: A functional proteomics study. Life Sciences 84:13-14, pages 458-467.
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