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Research Paper

The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells

Pages 689-696 | Published online: 01 Jun 2008

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Qiao-Ling Yao, Mei-Fen Zhang, Chu-Huai Wang, Fen Hu, Ai-Ping Lan, Rui-Xian Guo, Pei-Xi Chen & Jian-Qiang Feng. (2011) Protective effects of early hypoxic post-conditioning in cultured cortical neurons. Brain Injury 25:6, pages 604-613.
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Mozhgan Khorasani Motlagh, Meissam Noroozifar, Rana N. S. Sodhi & Heinz‐Bernhard Kraatz. (2022) Development of a Bacterial Enzyme‐Based Biosensor for the Detection and Quantification of Selenate. Chemistry – A European Journal 28:51.
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Safa A. Aljuhr, Gamal Abdelaziz, Adli A. Selim, Wafaa A. Zaghary & Tamer M. Sakr. (2022) Anti-cancer, anti-inflammatory and antioxidant effects of Vit-A/C@SeNPs in mutual diethylnitrosamine and carbon tetrachloride induced hepatocellular damage in albino rats. Journal of Drug Delivery Science and Technology 75, pages 103723.
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Safa A. Aljuhr, Gamal Abdelaziz, Basma M. Essa, Wafaa A. Zaghary & Tamer M. Sakr. (2021) Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/C@SeNPs in rats: Synthesis, characterization, biochemical, radio-biodistribution, molecular and histopathological studies. Bioorganic Chemistry 117, pages 105412.
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Jung-Hyun Cho, Seulah Lee, Hyeyoung Jeon, Ah Hyun Kim, Wonjong Lee, Yujeong Lee, Seonguk Yang, Jeanho Yun, Young-Suk Jung & Jaewon Lee. (2020) Tetrabromobisphenol A-Induced Apoptosis in Neural Stem Cells Through Oxidative Stress and Mitochondrial Dysfunction. Neurotoxicity Research 38:1, pages 74-85.
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Mohammed Muzibur Rahman. 2020. Importance of Selenium in the Environment and Human Health. Importance of Selenium in the Environment and Human Health.
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Wei Zhang, Restituto Tocmo & Kirk L. Parkin. (2020) Synergistic effects of S-alkenylmercaptocysteine (CySSR) species derived from Allium tissue and selenium on inducing apoptosis in ER− breast cancer cells. Journal of Functional Foods 65, pages 103786.
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Pablo Garnica, Ignacio Encío, Daniel Plano, Juan A. Palop & Carmen Sanmartín. (2019) Organoseleno cytostatic derivatives: Autophagic cell death with AMPK and JNK activation. European Journal of Medicinal Chemistry 175, pages 234-246.
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Nural Pastacı Özsobacı, Dilek Düzgün Ergün, Sinem Durmuş, Matem Tunçdemir, Hafize Uzun, Remise Gelişgen & Derviş Özçelik. (2018) Selenium supplementation ameliorates electromagnetic field-induced oxidative stress in the HEK293 cells. Journal of Trace Elements in Medicine and Biology 50, pages 572-579.
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Soni Khandelwal, Mallory Boylan, Julian Spallholz & Lauren Gollahon. (2018) Cytotoxicity of Selenium Immunoconjugates against Triple Negative Breast Cancer Cells. International Journal of Molecular Sciences 19:11, pages 3352.
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Su Jin Kim, Tae Hwan Noh, Sujin Son, Do Hyun Kim, Wooseong Kim, Yunna Lee, Jieun Choo, Gwangbeom Heo, Min Jae Kim, Hae Young Chung, Yunjin Jung, Jee Hyung Jung, Hyung Ryong Moon & Eunok Im. (2018) Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. Cell Death & Disease 9:9.
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Sanjay Mishra, Amit Kumar Mani Tiwari & Abbas Ali Mahdi. 2018. Biomedical Applications of Metals. Biomedical Applications of Metals 277 295 .
Xiangrong Geng, Joseph McDermott, Joseph Lundgren, Liu Liu, Kan-Jen Tsai, Jian Shen & Zijuan Liu. (2017) Role of AQP9 in transport of monomethyselenic acid and selenite. BioMetals 30:5, pages 747-755.
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Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy & Faisal Thayyullathil. (2017) Reactive oxygen species and cancer paradox: To promote or to suppress?. Free Radical Biology and Medicine 104, pages 144-164.
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Desirée Bartolini, Luca Sancineto, Andreza Fabro de Bem, Kenneth D. Tew, Claudio Santi, Rafael Radi, Pierangelo Toquato & Francesco Galli. 2017. Selenium and Selenoproteins in Cancer. Selenium and Selenoproteins in Cancer 259 302 .
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Míriam Tarrado-Castellarnau, Roldán Cortés, Miriam Zanuy, Josep Tarragó-Celada, Ibrahim H. Polat, Richard Hill, Teresa W.M. Fan, Wolfgang Link & Marta Cascante. (2015) Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition. Pharmacological Research 102, pages 218-234.
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Aristi P. Fernandes & Valentina Gandin. (2015) Selenium compounds as therapeutic agents in cancer. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:8, pages 1642-1660.
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Peng Bao, Zheng Chen, Ren-Zhong Tai, Han-Ming Shen, Francis L. Martin & Yong-Guan Zhu. (2015) Selenite-Induced Toxicity in Cancer Cells Is Mediated by Metabolic Generation of Endogenous Selenium Nanoparticles. Journal of Proteome Research 14:2, pages 1127-1136.
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Peng Bao, Song-Can Chen & Ke-Qing Xiao. (2015) Dynamic equilibrium of endogenous selenium nanoparticles in selenite-exposed cancer cells: a deep insight into the interaction between endogenous SeNPs and proteins. Molecular BioSystems 11:12, pages 3355-3361.
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Shauna M. McKelvey, Karina A. Horgan & Richard A. Murphy. (2015) Chemical form of selenium differentially influences DNA repair pathways following exposure to lead nitrate. Journal of Trace Elements in Medicine and Biology 29, pages 151-169.
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Emil Rudolf, Kateřina Řezáčová & Miroslav Červinka. (2014) Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts. Toxicology Letters 231:1, pages 29-37.
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Kejian Shi, Qian Jiang, Zhushi Li, Lei Shan, Feng Li, JiaJia An, Yang Yang & Caimin Xu. (2013) Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo. Journal of Hematology & Oncology 6:1.
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Vellaisamy Selvaraj, Justin Tomblin, Mindy Yeager Armistead & Elizabeth Murray. (2013) Selenium (sodium selenite) causes cytotoxicity and apoptotic mediated cell death in PLHC-1 fish cell line through DNA and mitochondrial membrane potential damage. Ecotoxicology and Environmental Safety 87, pages 80-88.
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Min-Sup Lee, Jae-Il Kim, Tadanobu Utsuki, Nam-Gyu Park & Hyeung-Rak Kim. (2012) Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells. Fitoterapia 83:6, pages 1060-1067.
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V. Chatzakos, A.K. Rundlöf, D. Ahmed, P.J. de Verdier & J. Flygare. (2012) Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite. Biochemical Pharmacology 84:5, pages 712-721.
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Věra Králová, Soňa Benešová, Miroslav Červinka & Emil Rudolf. (2012) Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicology in Vitro 26:2, pages 258-268.
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Mikael Björnstedt & Aristi P. Fernandes. (2010) Selenium in the prevention of human cancers. EPMA Journal 1:3, pages 389-395.
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Věra Králová, Miroslav Červinka & Emil Rudolf. (2010) ROS mediate selenite-induced apoptosis in colon cancer cells. Open Life Sciences 5:2.
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Eric Olm, Aristi P. Fernandes, Christina Hebert, Anna-Klara Rundlöf, Erik H. Larsen, Olof Danielsson & Mikael Björnstedt. (2009) Extracellular thiol-assisted selenium uptake dependent on the x c − cystine transporter explains the cancer-specific cytotoxicity of selenite . Proceedings of the National Academy of Sciences 106:27, pages 11400-11405.
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