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Clinical Study

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

Pages 1352-1359 | Published online: 01 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Jieying Chen & Guangyu Tang. (2019) PIM-1 kinase: a potential biomarker of triple-negative breast cancer. OncoTargets and Therapy 12, pages 6267-6273.
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Ezekiel Maloney, Tanya Khokhlova, Venu G. Pillarisetty, George R. Schade, Elizabeth A. Repasky, Yak-Nam Wang, Lorenzo Giuliani, Matteo Primavera & Joo Ha Hwang. (2017) Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy. International Reviews of Immunology 36:6, pages 338-351.
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Yuan-Bo Wu, Di Lu, Zhi-Feng He & Chan-Guan Jin. (2016) PIM1 polymorphism and PIM1 expression as predisposing factors of esophageal squamous cell carcinoma in the Asian population. OncoTargets and Therapy 9, pages 2919-2925.
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Nidhi Singh, Prasenjit Das, Siddhartha Datta Gupta, Peush Sahni, R. M. Pandey, Surabhi Gupta, Shyam S. Chauhan & Anoop Saraya. (2013) Prognostic Significance of Extracellular Matrix Degrading Enzymes—Cathepsin L and Matrix Metalloproteases-2 [MMP-2] in Human Pancreatic Cancer. Cancer Investigation 31:7, pages 461-471.
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Sailay Siddiqi & Mark A Sussman. (2013) Cell and gene therapy for severe heart failure patients: The time and place for Pim-1 kinase. Expert Review of Cardiovascular Therapy 11:8, pages 949-957.
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Dapeng Xu, Michael G. Cobb, Lily Gavilano, Sam M. Witherspoon, Daniel Williams, Catherine D. White, Pietro Taverna, Brian K. Bednarski, Hong Jin Kim, Albert S. Baldwin & Antonio T. Baines. (2013) Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine. Cancer Biology & Therapy 14:6, pages 492-501.
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Priyanka Sharma, Anoop Saraya, Prerna Gupta & Rinu Sharma. (2013) Decreased levels of circulating and tissue miR-107 in human esophageal cancer. Biomarkers 18:4, pages 322-330.
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Anna Lena Merkel, Eric Meggers & Matthias Ocker. (2012) PIM1 kinase as a target for cancer therapy. Expert Opinion on Investigational Drugs 21:4, pages 425-436.
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Cristiana Pistol Tanase, Monica Neagu, Radu Albulescu, Eleonora Codorean & Simona Olimpia Dima. (2009) Biomarkers in the diagnosis and early detection of pancreatic cancer. Expert Opinion on Medical Diagnostics 3:5, pages 533-546.
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Articles from other publishers (71)

Komala Ingle, Joseph F. LaComb, Lee M. Graves, Antonio T. Baines & Agnieszka B. Bialkowska. (2023) AUM302, a novel triple kinase PIM/PI3K/mTOR inhibitor, is a potent in vitro pancreatic cancer growth inhibitor. PLOS ONE 18:11, pages e0294065.
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Avinoam Nevler, Saed Khalilieh, Harish Lavu, Wilbur Bowne & Charles J Yeo. (2023) Hypercapnic Tissue Gene Expression and Survival in Early-Stage Pancreatic Ductal Adenocarcinoma. Journal of the American College of Surgeons 236:4, pages 913-922.
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Paul J. Smith, Stephanie R. McKeown & Laurence H. Patterson. (2022) Targeting DNA topoisomerase IIα ( TOP2A ) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs ( uHAPs ) . IUBMB Life 75:1, pages 40-54.
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Xavier León, Jacinto García, Albert Pujol, Julia de Juan, Rosselin Vásquez, Miquel Quer & Mercedes Camacho. (2022) Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy. European Archives of Oto-Rhino-Laryngology 279:7, pages 3679-3684.
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Sutapa Mahata, Pranab K. Sahoo, Ranita Pal, Sinjini Sarkar, Tanuma Mistry, Sushmita Ghosh & Vilas D. Nasare. (2022) PIM1/STAT3 axis: a potential co-targeted therapeutic approach in triple-negative breast cancer. Medical Oncology 39:7.
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Lin Lai, Xinyu Chen, Ge Tian, Renba Liang, Xishan Chen, Yuelan Qin, Kaihua Chen & Xiaodong Zhu. (2022) Clinical Significance of Pim-1 in Human Cancers: A Meta-analysis of Association with Prognosis and Clinicopathological Characteristics. Cancer Control 29, pages 107327482211062.
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Iman M. Ahmad, Alicia J. Dafferner, Kelly A. O’Connell, Kamiya Mehla, Bradley E. Britigan, Michael A. Hollingsworth & Maher Y. Abdalla. (2021) Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma. Cancers 13:9, pages 2264.
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Gillian Moore, Clara Lightner, Samira Elbai, Lauren Brady, Siobhan Nicholson, Ronan Ryan, Katie E. O’Sullivan, Kenneth J. O’Byrne, Carmen Blanco-Aparicio, Sinead Cuffe, Michael O’Neill, Susan Heavey, Stephen P. Finn & Kathy Gately. (2021) Co-Targeting PIM Kinase and PI3K/mTOR in NSCLC. Cancers 13:9, pages 2139.
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Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali & Hassan Niknejad. (2021) Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin. Stem Cell Research & Therapy 12:1.
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David E Ebeid, Farid G Khalafalla, Kathleen M Broughton, Megan M Monsanto, Carolina Y Esquer, Veronica Sacchi, Nirmala Hariharan, Kelli I Korski, Maryam Moshref, Jacqueline Emathinger, Christopher T Cottage, Pearl J Quijada, Jonathan H Nguyen, Roberto AlvarezJrJr, Mirko Völkers, Mathias H Konstandin, Bingyan J Wang, Fareheh Firouzi, Julian M Navarrete, Natalie A Gude, Marie-Jose Goumans & Mark A Sussman. (2021) Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling. Cardiovascular Research 117:1, pages 201-211.
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Yanan Li, Ying Cheng, Maoqi Zhang, Xiaoli He, Li Kong, Kexiang Zhou, Yunfu Zhou, Lin Li, Hongqi Tian, Xiaomin Song & Yukun Cui. (2020) A New Compound with Increased Antitumor Activity by Cotargeting MEK and Pim-1. iScience, pages 101254.
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Qian Li, Chuanwu Jiang, Yan Wang, Minghua Wei, Huijin Zheng, Yanqi Xu, Xuegang Xu, Fengyu Jia, Kai Liu, Gang Sun, Jianhua Zang & Ping Mo. (2020) RETRACTED ARTICLE: Resibufogenin suppresses tumor growth and inhibits glycolysis in ovarian cancer by modulating PIM1. Naunyn-Schmiedeberg's Archives of Pharmacology 392:12, pages 1477-1489.
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Faramarz Rahmatizadeh, Shiva Gholizadeh-Ghaleh Aziz, Khodadad KhodadadiMaryam Lale AtaeiEsmaeil EbrahimieJafar Soleimani RadMaryam Pashaiasl. (2019) Bidirectional and Opposite Effects of Naïve Mesenchymal Stem Cells Ontumor Growth and Progression. Advanced Pharmaceutical Bulletin 9:4, pages 539-558.
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Maher Y. Abdalla, Iman M. Ahmad, Satyanarayana Rachagani, Kasturi Banerjee, Christopher M. Thompson, H. Carlo Maurer, Kenneth P. Olive, Katie L. Bailey, Bradley E. Britigan & Sushil Kumar. (2019) Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition. Translational Research 207, pages 56-69.
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Lianjing Cao, Fan Wang, Shouying Li, Xinyue Wang, Dingzhi Huang & Richeng Jiang. (2019) PIM1 kinase promotes cell proliferation, metastasis and tumor growth of lung adenocarcinoma by potentiating the c-MET signaling pathway. Cancer Letters 444, pages 116-126.
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Kaili Liu, Hui Gao, Qiaoyun Wang, Longyuan Wang, Bin Zhang, Zhiwu Han, Xuehong Chen, Mei Han & Mingquan Gao. (2018) Retracted: Hispidulin suppresses cell growth and metastasis by targeting PIM 1 through JAK 2/ STAT 3 signaling in colorectal cancer . Cancer Science 109:5, pages 1369-1381.
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Bin Zhao, Lei Liu, Jun Mao, Zhiwei Zhang, Qifei Wang & Quanlin Li. (2018) PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis. Cell Death & Disease 9:3.
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Mirosława Koronkiewicz, Zdzisław Chilmonczyk, Zygmunt Kazimerczuk & Andrzej Orzeszko. (2018) Deoxynucleosides with benzimidazoles as aglycone moiety are potent anticancer agents. European Journal of Pharmacology 820, pages 146-155.
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Shi Wen, Bohan Zhan, Jianghua Feng, Weize Hu, Xianchao Lin, Jianxi Bai & Heguang Huang. (2017) Non-invasively predicting differentiation of pancreatic cancer through comparative serum metabonomic profiling. BMC Cancer 17:1.
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Lubna Swellmeen, Rand Shahin, Yusuf Al-Hiari, Amani Alamiri, Alaa Hasan & Omar Shaheen. (2017) Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors. Bioorganic & Medicinal Chemistry 25:17, pages 4855-4875.
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Manuel-Pedro Jiménez-García, Antonio Lucena-Cacace, María-José Robles-Frías, Irene Ferrer, Maja Narlik-Grassow, Carmen Blanco-Aparicio & Amancio Carnero. (2017) Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus. Oncotarget 8:35, pages 58872-58886.
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Shuya Wang, Zhengyi Cao, Junhui Xue, Hui Li, Wei Jiang, Yuning Cheng, Gang Li & Xiaowei Zhang. (2017) A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. Journal of Biological Chemistry 292:20, pages 8207-8222.
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Amany Mawas, Vishwa Amatya, Rui Suzuki, Kei Kushitani, Mouchira Mohi El-Din & Yukio Takeshima. (2017) PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells. International Journal of Oncology.
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Jianwei Xu, Guangbing Xiong, Zhe Cao, Hua Huang, Tianxiao Wang, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Taiping Zhang & Yupei Zhao. (2016) PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value. Journal of Experimental & Clinical Cancer Research 35:1.
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Manuel Pedro Jiménez-García, Antonio Lucena-Cacace, María José Robles-Frías, Maja Narlik-Grassow, Carmen Blanco-Aparicio & Amancio Carnero. (2016) The role of PIM1/PIM2 kinases in tumors of the male reproductive system. Scientific Reports 6:1.
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Shuai Mou, Guangbin Wang, Ding Ding, Dongdong Yu, Yi Pei, Songling Teng & Qin Fu. (2016) Expression and function of PIM kinases in osteosarcoma. International Journal of Oncology 49:5, pages 2116-2126.
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Hao Gu, Mingzhu Liu, Changmao Ding, Xin Wang, Rui Wang, Xinyu Wu & Ruitai Fan. (2016) Hypoxia‐responsive miR‐124 and miR‐144 reduce hypoxia‐induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM 1 . Cancer Medicine 5:6, pages 1174-1182.
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F F Blanco, M Jimbo, J Wulfkuhle, I Gallagher, J Deng, L Enyenihi, N Meisner-Kober, E Londin, I Rigoutsos, J A Sawicki, M V Risbud, A K Witkiewicz, P A McCue, W Jiang, H Rui, C J Yeo, E Petricoin, J M Winter & J R Brody. (2015) The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene 35:19, pages 2529-2541.
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Zi-Ran Wei, Chao Liang, Dan Feng, Ya-Jun Cheng, Wei-Min Wang, De-Jun Yang, Yue-Xiang Wang & Qing-Ping Cai. (2016) Low tristetraprolin expression promotes cell proliferation and predicts poor patients outcome in pancreatic cancer. Oncotarget 7:14, pages 17737-17750.
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Vishwa Amatya, Amany Mawas, Kei Kushitani, Mouchira Mohi El-Din & Yukio Takeshima. (2016) Differential microRNA expression profiling of mesothelioma and expression analysis of miR-1 and miR-214 in mesothelioma. International Journal of Oncology.
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S. Kreuz, K. B. Holmes, R. M. Tooze & P. F. Lefevre. (2015) Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. Molecular Cancer 14:1.
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Noel A. Warfel & Andrew S. Kraft. (2015) PIM kinase (and Akt) biology and signaling in tumors. Pharmacology & Therapeutics 151, pages 41-49.
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