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Research Paper

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotides correlates with tumor drug uptake

Pages 1490-1495 | Published online: 01 Sep 2008

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Read on this site (1)

Beth K. Neilsen, Danielle E. Frodyma, Robert E. Lewis & Kurt W. Fisher. (2017) KSR as a therapeutic target for Ras-dependent cancers. Expert Opinion on Therapeutic Targets 21:5, pages 499-509.
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Articles from other publishers (12)

Talina Mohapatra & Manjusha Dixit. (2022) IQ Motif Containing GTPase Activating Proteins (IQGAPs), A-Kinase Anchoring Proteins (AKAPs) and Kinase Suppressor of Ras Proteins (KSRs) in Scaffolding Oncogenic Pathways and Their Therapeutic Potential. ACS Omega 7:50, pages 45837-45848.
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Manuel Jurado, Óscar Castaño & Antonio Zorzano. (2021) Stochastic modulation evidences a transitory EGF-Ras-ERK MAPK activity induced by PRMT5. Computers in Biology and Medicine 133, pages 104339.
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Hyuk Moon & Simon Weonsang Ro. (2021) Ras Mitogen-activated Protein Kinase Signaling and Kinase Suppressor of Ras as Therapeutic Targets for Hepatocellular Carcinoma. Journal of Liver Cancer 21:1, pages 1-11.
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Nayana Devang, Adyashree Pani & G.K. Rajanikant. 2021. Protein Kinases in Drug Discovery. Protein Kinases in Drug Discovery 121 185 .
Elizabeth A. Germino, Joseph P. Miller, Lauri Diehl, Carter J. Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H. Miner & Andrey S. Shaw. (2018) Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer. PLOS ONE 13:3, pages e0194998.
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Danielle Frodyma, Beth Neilsen, Diane Costanzo-Garvey, Kurt Fisher & Robert Lewis. (2017) Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras. F1000Research 6, pages 1621.
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L Benhaim, W Zhang, T Wakatsuki, D Yang, A Gerger, P Bohanes, D Paez, F Loupakis, M J LaBonte, Y Ning, R El-Khoueiry, R Ladner, P Wilson, H Zhang, G Giamas, J Stebbing & H J Lenz. (2014) Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer. The Pharmacogenomics Journal 15:3, pages 235-240.
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Hua Zhang, Nicos Angelopoulos, Yichen Xu, Arnhild Grothey, Joao Nunes, Justin Stebbing & Georgios Giamas. (2015) Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer. Breast Cancer Research and Treatment 151:3, pages 555-568.
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J Stebbing, H Zhang, Y Xu, L C Lit, A R Green, A Grothey, Y Lombardo, M Periyasamy, K Blighe, W Zhang, J A Shaw, I O Ellis, H J Lenz & G Giamas. (2014) KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene 34:16, pages 2103-2114.
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Hua Zhang, Andrew Photiou, Arnhild Grothey, Justin Stebbing & Georgios Giamas. (2012) The role of pseudokinases in cancer. Cellular Signalling 24:6, pages 1173-1184.
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Hussein Echrish, Leigh A. Madden, John Greenman & Anthony Maraveyas. (2011) The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis. Cancers 3:1, pages 267-284.
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Joanne L. Yu, Rosie Xing, Chloe Milsom & Janusz Rak. (2010) Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1. Thrombosis Research 126:1, pages e6-e10.
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