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Research Paper

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

Pages 1496-1506 | Published online: 01 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Yuqian Liao, Yulu Liao, Jun Li, Yong Li & Ying Fan. (2023) The Prognostic Role of HuR Varies Between Different Subtypes of Breast Cancer Patients: Data Mining and Retrospective Analysis. Breast Cancer: Targets and Therapy 15, pages 135-146.
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Sheikh Mohammad Umar, Sushmita Patra, Akanksha Kashyap, Arundhathi Dev J R, Lalit Kumar & Chandra Prakash Prasad. (2022) Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells. Nutrition and Cancer 74:4, pages 1497-1510.
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Articles from other publishers (71)

Jennifer M. Finan, Thomas L. Sutton, Dan A. Dixon & Jonathan R. Brody. (2023) Targeting the RNA-Binding Protein HuR in Cancer. Cancer Research 83:21, pages 3507-3516.
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Benjamin Philipp Joseph, Verena Weber, Lisa Knüpfer, Alejandro Giorgetti, Mercedes Alfonso-Prieto, Sybille Krauß, Paolo Carloni & Giulia Rossetti. (2023) Low Molecular Weight Inhibitors Targeting the RNA-Binding Protein HuR. International Journal of Molecular Sciences 24:17, pages 13127.
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Zheng Li, Yaming Li, Dianwen Han, Xiaolong Wang, Chen Li, Tong Chen, Wenhao Li, Yiran Liang, Dan Luo, Bing Chen, Lijuan Wang, Wenjing Zhao & Qifeng Yang. (2023) circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells. Cell Death & Disease 14:7.
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Lanjing Wei, Qi Zhang, Cuncong Zhong, Lily He, Yuxia Zhang, Ahlam M. Armaly, Jeffrey Aubé, Danny R. Welch, Liang Xu & Xiaoqing Wu. (2023) Functional inhibition of the RNA ‐binding protein HuR sensitizes triple‐negative breast cancer to chemotherapy . Molecular Oncology.
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Meghna Mehta, Rajeswari Raguraman, Rajagopal Ramesh & Anupama Munshi. (2022) RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer. Advanced Drug Delivery Reviews 191, pages 114569.
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Wei Li, Xiaolan Deng & Jianjun Chen. (2022) RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer. Seminars in Cancer Biology 86, pages 664-677.
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Yanyan Wang, Yun-Ling Tai, Grayson Way, Jing Zeng, Derrick Zhao, Lianyong Su, Xixian Jiang, Kaitlyn G. Jackson, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Weidong Chen, Xiang-Yang Wang, Arun J. Sanyal, Phillip B. Hylemon & Huiping Zhou. (2022) RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression. Cell & Bioscience 12:1.
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Mengmeng Yu, Yuxing Qu, Haili Zhang & Xiaojun Wang. (2022) Roles of ANP32 proteins in cell biology and viral replication. Animal Diseases 2:1.
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Ying Chen, Hai Qin & Lufeng Zheng. (2022) Research progress on RNA−binding proteins in breast cancer. Frontiers in Oncology 12.
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Xiaoqing Wu & Liang Xu. (2022) The RNA-binding protein HuR in human cancer: A friend or foe?. Advanced Drug Delivery Reviews 184, pages 114179.
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Haijian Cai, Dandan Zheng, Yizhu Yao, Lehe Yang, Xiaoying Huang & Liangxing Wang. (2022) Roles of Embryonic Lethal Abnormal Vision-Like RNA Binding Proteins in Cancer and Beyond. Frontiers in Cell and Developmental Biology 10.
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Dimitrios Goutas, Alexandros Pergaris, Constantinos Giaginis & Stamatios Theocharis. (2022) HuR as Therapeutic Target in Cancer: What the Future Holds. Current Medicinal Chemistry 29:1, pages 56-65.
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Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Jennifer Calano, Vibha Pathak, Larry Bratton, Rakesh H. Vekariya, Sixue Zhang, Edward Ofori, Emily N. Hayward, David Namkoong, David K. Crossman, Michael R. Crowley, Peter H. King, James Mobley & Louis B. Nabors. (2021) Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors. Cancer Research 81:8, pages 2220-2233.
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Natalia Filippova & Louis B. Nabors. (2020) ELAVL1 Role in Cell Fusion and Tunneling Membrane Nanotube Formations with Implication to Treat Glioma Heterogeneity. Cancers 12:10, pages 3069.
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Christopher W. Schultz, Ranjan Preet, Teena Dhir, Dan A. Dixon & Jonathan R. Brody. (2020) Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR). WIREs RNA 11:3.
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Daniel Andrade, Meghna Mehta, James Griffith, Sangphil Oh, Joshua Corbin, Anish Babu, Supriyo De, Allshine Chen, Yan D. Zhao, Sanam Husain, Sudeshna Roy, Liang Xu, Jeffrey Aube, Ralf Janknecht, Myriam Gorospe, Terence Herman, Rajagopal Ramesh & Anupama Munshi. (2019) HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A. Cancers 11:12, pages 2014.
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Jian Cai, Huaiming Wang, Xiaodong Jiao, Rongkang Huang, Qiyuan Qin, Jianwei Zhang, Honglei Chen, Dan Feng, Xin Tian & Hui Wang. (2019) The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6. Molecular Cancer Therapeutics 18:7, pages 1243-1254.
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Mingxia Wu, Christy W.S. Tong, Wei Yan, Kenneth K.W. To & William C.S. Cho. (2019) The RNA Binding Protein HuR: a Promising Drug Target for Anticancer Therapy. Current Cancer Drug Targets 19:5, pages 382-399.
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Kazuhiro Toyota, Yoshiaki Murakami, Naru Kondo, Kenichiro Uemura, Naoya Nakagawa, Shinya Takahashi & Taijiro Sueda. (2018) Cytoplasmic Hu-Antigen R (HuR) Expression is Associated with Poor Survival in Patients with Surgically Resected Cholangiocarcinoma Treated with Adjuvant Gemcitabine-Based Chemotherapy. Annals of Surgical Oncology 25:5, pages 1202-1210.
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Georgia Levidou, Ioly Kotta-Loizou, Jason Tasoulas, Thomas Papadopoulos & Stamatios Theocharis. (2018) Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas. Disease Markers 2018, pages 1-13.
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Guan-Liang Lin, Huei-Ju Ting, Ta-Chien Tseng, Vivian Juang & Yu-Li Lo. (2017) Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PLOS ONE 12:10, pages e0185625.
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Ranganayaki Muralidharan, Meghna Mehta, Rebaz Ahmed, Sudeshna Roy, Liang Xu, Jeffrey Aubé, Allshine Chen, Yan Daniel Zhao, Terence Herman, Rajagopal Ramesh & Anupama Munshi. (2017) HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. Scientific Reports 7:1.
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Sheng Tan, Keshuo Ding, Qing-Yun Chong, Junsong Zhao, Yuan Liu, Yunying Shao, Yuanyuan Zhang, Qing Yu, Zirui Xiong, Weijie Zhang, Min Zhang, Gaopeng Li, Xiaoni Li, Xiangjun Kong, Akhlaq Ahmad, Zhengsheng Wu, Qiang Wu, Xiaodong Zhao, Peter E. Lobie & Tao Zhu. (2017) Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. Journal of Biological Chemistry 292:33, pages 13551-13564.
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Jaclyn F. Hechtman & Christine Iacobuzio-Donahue. 2017. Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set. Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set 139 149.e3 .
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Ioly Kotta-Loizou, Spyridon N. Vasilopoulos, Robert H.A. Coutts & Stamatios Theocharis. (2016) Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment. Neoplasia 18:11, pages 674-688.
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Meghna Mehta, Kanthesh Basalingappa, James N. Griffith, Daniel Andrade, Anish Babu, Narsireddy Amreddy, Ranganayaki Muralidharan, Myriam Gorospe, Terence Herman, Wei-Qun Ding, Rajagopal Ramesh & Anupama Munshi. (2016) HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy. Oncotarget 7:40, pages 64820-64835.
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Yu-Hung Huang, Weidan Peng, Narumi Furuuchi, Jacquelyn Gerhart, Kelly Rhodes, Neelanjan Mukherjee, Masaya Jimbo, Gregory E. Gonye, Jonathan R. Brody, Robert C. Getts & Janet A. Sawicki. (2016) Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth. Cancer Research 76:6, pages 1549-1559.
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Jingjing Ge, Na Chang, Zhongxin Zhao, Lei Tian, Xianghui Duan, Lin Yang & Liying Li. (2016) Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1. Scientific Reports 6:1.
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C. Zurla, J. Jung & P. J. Santangelo. (2016) Can we observe changes in mRNA “state”? Overview of methods to study mRNA interactions with regulatory proteins relevant in cancer related processes. The Analyst 141:2, pages 548-562.
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Constantinos Giaginis, Paraskevi Alexandrou, Ioanna Delladetsima, Ioannis Karavokyros, Eugene Danas, Athina Giagini, Efstratios Patsouris & Stamatios Theocharis. (2015) Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions. Pathology & Oncology Research 22:1, pages 189-196.
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John Henry Barbe, Kevin M. O’Hayer & Jonathan R. Brody. 2016. Cancer Therapeutic Targets. Cancer Therapeutic Targets 1 13 .
Zhonghua Wang, Akash Bhattacharya & Dmitri N. Ivanov. (2015) Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation. PLOS ONE 10:9, pages e0138780.
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Aldona Jakstaite. (2015) HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer. World Journal of Gastroenterology 21:46, pages 13004.
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Constantinos Giaginis, Paraskevi Alexandrou, Nikolaos Tsoukalas, Ioannis Sfiniadakis, Nikolaos Kavantzas, Emmanuel Agapitos, Efstratios Patsouris & Stamatios Theocharis. (2014) Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients’ survival. Tumor Biology 36:1, pages 315-327.
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Dandan Wang, Min Wang, Chang’e Hu, Ting Shuang, Yingying Zhou & Xiaoyu Yan. (2014) Expression of the ELAV-like protein HuR in the cytoplasm is associated with endometrial carcinoma progression. Tumor Biology 35:12, pages 11939-11947.
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Patrick T. Reilly, Yun Yu, Ali Hamiche & Lishun Wang. (2014) Cracking the ANP32 whips: Important functions, unequal requirement, and hints at disease implications. BioEssays 36:11, pages 1062-1071.
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Ioly Kotta-Loizou, Constantinos Giaginis & Stamatios Theocharis. (2014) Clinical significance of HuR expression in human malignancy. Medical Oncology 31:9.
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Shruti Lal, Richard A. Burkhart, Neil Beeharry, Vikram Bhattacharjee, Eric R. Londin, Joseph A. Cozzitorto, Carmella Romeo, Masaya Jimbo, Zoë A. Norris, Charles J. Yeo, Janet A. Sawicki, Jordan M. Winter, Isidore Rigoutsos, Timothy J. Yen & Jonathan R. Brody. (2014) HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells. Cancer Research 74:4, pages 1128-1140.
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Cong Zhang, Guoliang Xue, Jingwang Bi, Ming Geng, Huili Chu, Yaping Guan, Jun Wang & Baocheng Wang. (2013) Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma. Tumor Biology 35:1, pages 73-80.
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Jun Wang, Dali Li, Baocheng Wang & Yun Wu. (2013) Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy. Breast Cancer Research and Treatment 141:2, pages 213-224.
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Hoin Kang, Chongtae Kim, Heejin Lee, Wook Kim & Eun Lee. (2013) Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance. International Journal of Molecular Sciences 14:8, pages 17204-17220.
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Zhongpeng Zhu, Baocheng Wang, Jingwang Bi, Cong Zhang, Yan Guo, Huili Chu, Xiuju Liang, Chen Zhong & Jun Wang. (2013) Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer. Tumor Biology 34:4, pages 2299-2308.
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Jun Wang, Yan Guo, Huili Chu, Yaping Guan, Jingwang Bi & Baocheng Wang. (2013) Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis. International Journal of Molecular Sciences 14:5, pages 10015-10041.
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Elisa Latorre, Toma Tebaldi, Gabriella Viero, Antonino Maria Spartà, Alessandro Quattrone & Alessandro Provenzani. (2012) Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Molecular Cancer 11:1.
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John L McElwee, Sunish Mohanan, Obi L Griffith, Heike C Breuer, Lynne J Anguish, Brian D Cherrington, Ashley M Palmer, Louise R Howe, Venkataraman Subramanian, Corey P Causey, Paul R Thompson, Joe W Gray & Scott A Coonrod. (2012) Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. BMC Cancer 12:1.
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Andrew Barker, Michael R. Epis, Corrine J. Porter, Benjamin R. Hopkins, Matthew C. J. Wilce, Jackie A. Wilce, Keith M. Giles & Peter J. Leedman. (2012) Sequence requirements for RNA binding by HuR and AUF1. The Journal of Biochemistry 151:4, pages 423-437.
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Michael R. Epis, Andrew Barker, Keith M. Giles, Dianne J. Beveridge & Peter J. Leedman. (2011) The RNA-binding Protein HuR Opposes the Repression of ERBB-2 Gene Expression by MicroRNA miR-331-3p in Prostate Cancer Cells. Journal of Biological Chemistry 286:48, pages 41442-41454.
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Wei‐Ning Lin, Chih‐Chung Lin, Hsin‐Yi Cheng & Chuen‐Mao Yang. (2011) Regulation of cyclooxygenase‐2 and cytosolic phospholipase A 2 gene expression by lipopolysaccharide through the RNA‐binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen‐activated protein kinases . British Journal of Pharmacology 163:8, pages 1691-1706.
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Mira Heinonen, Annabrita Hemmes, Kaisa Salmenkivi, Kotb Abdelmohsen, Suvi‐Tuuli Vilén, Marko Laakso, Marjut Leidenius, Tuula Salo, Sampsa Hautaniemi, Myriam Gorospe, Päivi Heikkilä, Caj Haglund & Ari Ristimäki. (2011) Role of RNA binding protein HuR in ductal carcinoma in situ of the breast . The Journal of Pathology 224:4, pages 529-539.
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Robert Calaluce, Matthew M Gubin, J Wade Davis, Joseph D Magee, Jing Chen, Yuki Kuwano, Myriam Gorospe & Ulus Atasoy. (2010) The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer. BMC Cancer 10:1.
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Timothy K. Williams, Christina L. Costantino, Nikolai A. Bildzukewicz, Nathan G. Richards, David W. Rittenhouse, Lisa Einstein, Joseph A. Cozzitorto, Judith C. Keen, Abhijit Dasgupta, Myriam Gorospe, Gregory E. Gonye, Charles J. Yeo, Agnieszka K. Witkiewicz & Jonathan R. Brody. (2010) pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs. PLoS ONE 5:11, pages e15455.
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