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Clinical Study

Increase of telomerase activity and hTERT expression in myelodysplastic syndromes

Pages 883-889 | Published online: 15 May 2009

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Sangeetha Venugopal & Mikkael A. Sekeres. (2023) Raising the bar for lower-risk myelodysplastic syndromes. Leukemia & Lymphoma 64:6, pages 1082-1091.
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Articles from other publishers (28)

Uwe Platzbecker, Valeria Santini, Pierre Fenaux, Mikkael A Sekeres, Michael R Savona, Yazan F Madanat, Maria Díez-Campelo, David Valcárcel, Thomas Illmer, Anna Jonášová, Petra Bělohlávková, Laurie J Sherman, Tymara Berry, Souria Dougherty, Sheetal Shah, Qi Xia, Libo Sun, Ying Wan, Fei Huang, Annat Ikin, Shyamala Navada, Faye Feller, Rami S Komrokji & Amer M Zeidan. (2023) Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet.
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Lara K. Rotter, Shai Shimony, Kelly Ling, Evan Chen, Rory M. Shallis, Amer M. Zeidan & Maximilian Stahl. (2023) Epidemiology and Pathogenesis of Myelodysplastic Syndrome. The Cancer Journal 29:3, pages 111-121.
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Chen Wang & David A. Sallman. (2023) Current Therapeutic Landscape in Lower Risk Myelodysplastic Syndromes. Current Treatment Options in Oncology 24:5, pages 387-408.
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Tales Henrique Andrade da Mota, Ricardo Camargo, Estefânia Rodrigues Biojone, Ana Flávia Reis Guimarães, Fabio Pittella-Silva & Diêgo Madureira de Oliveira. (2023) The Relevance of Telomerase and Telomere-Associated Proteins in B-Acute Lymphoblastic Leukemia. Genes 14:3, pages 691.
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Mathieu Meunier & Sophie Park. (2022) Lower‐risk myelodysplastic syndromes: Current treatment options for anemia. eJHaem 3:4, pages 1091-1099.
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Sara Cruciani, Giuseppe Garroni, Renzo Pala, Ana Rita Pinheiro Barcessat, Federica Facchin, Carlo Ventura, Claudio Fozza & Margherita Maioli. (2022) Melatonin finely tunes proliferation and senescence in hematopoietic stem cells. European Journal of Cell Biology 101:3, pages 151251.
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Alexandre Bazinet & Guillermo Montalban Bravo. (2022) New Approaches to Myelodysplastic Syndrome Treatment. Current Treatment Options in Oncology 23:5, pages 668-687.
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Ali Rafat, Khadijeh Dizaji Asl, Zeinab Mazloumi, Ali Akbar Movassaghpour, Raheleh Farahzadi, Babak Nejati & Hojjatollah Nozad Charoudeh. (2022) Telomerase‐based therapies in haematological malignancies. Cell Biochemistry and Function 40:2, pages 127-140.
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Ioannis Chanias, Kristina Stojkov, Gregor Th. Stehle, Michael Daskalakis, Helena Simeunovic, Linet Muthoni Njue, Annatina S. Schnegg-Kaufmann, Naomi A. Porret, Ramanjaneyulu Allam, Tata Nageswara Rao, Rudolf Benz, Axel Ruefer, Adrian Schmidt, Marcel Adler, Alicia Rovo, Stefan Balabanov, Georg Stuessi, Ulrike Bacher & Nicolas Bonadies. (2021) Myelodysplastic Syndromes in the Postgenomic Era and Future Perspectives for Precision Medicine. Cancers 13:13, pages 3296.
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Yumei Liu, Chen Yang, Hua Xue, Fang Ye, Wanling Sun, Jingbo Wang, Weiwei Qi, Haiyue Niu, Luoming Hua, Huaquan Wang, Bing Han & Zonghong Shao. (2021) Stanozolol improves the progression-free survival of patients with high-risk myelodysplastic syndrome after decitabine treatment. International Journal of Hematology 113:6, pages 807-814.
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Anna A. Plyasova & Dmitry D. Zhdanov. (2021) Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes. Biomedicines 9:5, pages 526.
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Mikkael A. Sekeres. (2021) Parsing the Paradox of Myelodysplastic Syndromes. Journal of Clinical Oncology 39:1, pages 4-6.
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David P. Steensma, Pierre Fenaux, Koen Van Eygen, Azra Raza, Valeria Santini, Ulrich Germing, Patricia Font, Maria Diez-Campelo, Sylvain Thepot, Edo Vellenga, Mrinal M. Patnaik, Jun Ho Jang, Helen Varsos, Jacqueline Bussolari, Esther Rose, Laurie Sherman, Libo Sun, Ying Wan, Souria Dougherty, Fei Huang, Faye Feller, Aleksandra Rizo & Uwe Platzbecker. (2021) Imetelstat Achieves Meaningful and Durable Transfusion Independence in High Transfusion–Burden Patients With Lower-Risk Myelodysplastic Syndromes in a Phase II Study. Journal of Clinical Oncology 39:1, pages 48-56.
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Hei Cheul Jeung, Sun Young Rha, Sang Joon Shin, Joong Bae Ahn, Kyu Hyun Park, Tae Soo Kim, Jin Ju Kim, Jae Kyung Roh & Hyun Cheol Chung. (2017) Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer. Oncology Letters 14:2, pages 2385-2392.
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Wen Dong, Lei Wu, Houfang Sun, Xiubao Ren, Pearlie K. Epling-Burnette & Lili Yang. (2016) MDS shows a higher expression of hTERT and alternative splice variants in unactivated T-cells. Oncotarget 7:44, pages 71904-71914.
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Muhammad Ramlee, Jing Wang, Wei Toh & Shang Li. (2016) Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes 7:8, pages 50.
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Claudia Bruedigam & Steven W. Lane. (2016) Telomerase in hematologic malignancies. Current Opinion in Hematology 23:4, pages 346-353.
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Limengmeng Wang, Haowen Xiao, Xing Zhang, Chong Wang & He Huang. (2014) The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation. Journal of Hematology & Oncology 7:1.
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Wen Dong, Yaqin Qian & Lili Yang. (2014) Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes. Leukemia Research 38:7, pages 830-835.
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Hee-Je Kim, Eun-Jeong Choi, Hyun-Jung Sohn, So-Hye Park, Woo-Sung Min & Tai-Gyu Kim. (2013) Combinatorial molecular marker assays of WT1 , survivin , and TERT at initial diagnosis of adult acute myeloid leukemia . European Journal of Haematology 91:5, pages 411-422.
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Antonella Poloni, Federica Serrani, Eleonora Berardinelli, Giulia Maurizi, Marianna Mariani, Benedetta Costantini, Silvia Trappolini, Stefania Mancini, Attilio Olivieri & Pietro Leoni. (2013) Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome. Leukemia Research 37:11, pages 1538-1544.
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Beate Vajen, Kathrin Thomay & Brigitte Schlegelberger. (2013) Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia. Cancers 5:4, pages 857-874.
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L Yang, A Mailloux, D E Rollison, J S Painter, J Maciejewski, R L Paquette, T P Loughran, K McGraw, H Makishima, R Radhakrishnan, S Wei, X Ren, R Komrokji, A F List & P K Epling-Burnette. (2012) Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency. Leukemia 27:4, pages 897-906.
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Carlos Santamaría, Fernando Ramos, Noemi Puig, Eva Barragán, Raquel de Paz, Carme Pedro, Andrés Insunza, Mar Tormo, Consuelo del Cañizo, María Diez-Campelo, Blanca Xicoy, Eduardo Salido, Javier Sánchez del Real, Montserrat Hernández, Carmen Chillón, Guillermo F. Sanz, Ramón García-Sanz, Jesús F. San Miguel & Marcos González. (2012) Simultaneous analysis of the expression of 14 genes with individual prognostic value in myelodysplastic syndrome patients at diagnosis: WT1 detection in peripheral blood adversely affects survival. Annals of Hematology 91:12, pages 1887-1895.
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P. L. GREENBERG. (2012) Molecular and genetic features of myelodysplastic syndromes. International Journal of Laboratory Hematology 34:3, pages 215-222.
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Bernhard Lüscher. (2012) MAD1 and its life as a MYC antagonist: An update. European Journal of Cell Biology 91:6-7, pages 506-514.
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Adam J. Linley, Murrium Ahmad & Robert C. Rees. (2011) Tumour-associated antigens: considerations for their use in tumour immunotherapy. International Journal of Hematology 93:3, pages 263-273.
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Kathrin Lange, Lisa Holm, Kirsten Vang Nielsen, Andreas Hahn, Winfried Hofmann, Hans Kreipe, Brigitte Schlegelberger & Gudrun Göhring. (2009) Telomere shortening and chromosomal instability in myelodysplastic syndromes. Genes, Chromosomes and Cancer 49:3, pages 260-269.
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