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Research Paper

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Pages 923-929 | Published online: 15 May 2009

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Read on this site (5)

Hanru Wang, Mark S. Geier & Gordon S. Howarth. (2016) Prebiotics: A Potential Treatment Strategy for the Chemotherapy-damaged Gut?. Critical Reviews in Food Science and Nutrition 56:6, pages 946-956.
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Suzanne Mashtoub, Benjamin Feo, Alexandra L. Whittaker, Kerry A. Lymn, Daniel Martinez-Puig & Gordon S. Howarth. (2015) Oral Nucleotides Only Minimally Improve 5-Fluorouracil-Induced Mucositis in Rats. Nutrition and Cancer 67:6, pages 994-1000.
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Mona A. El-Ghazaly, Rania M. El-Hazek & Mohamed T. Khayyal. (2015) Protective effect of the herbal preparation, STW 5, against intestinal damage induced by gamma radiation in rats. International Journal of Radiation Biology 91:2, pages 150-156.
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Hanru Wang, Caitlin L. Brook, Alexandra L. Whittaker, Andrew Lawrence, Roger Yazbeck & Gordon S. Howarth. (2013) Effects of Streptococcus thermophilus TH-4 in a rat model of doxorubicin-induced mucositis. Scandinavian Journal of Gastroenterology 48:8, pages 959-968.
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Karl Rüdiger Wiebelitz & André-Michael Beer. (2012) Phytotherapy of chronic abdominal pain following pancreatic carcinoma surgery: a single case observation. International Journal of General Medicine 5, pages 845-848.
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Cailan Li, Jianhui Xie, Jiahao Wang, Ying Cao, Min Pu, Qihai Gong & Qiang Lu. (2022) Therapeutic effects and mechanisms of plant-derived natural compounds against intestinal mucositis. Frontiers in Pharmacology 13.
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Huiping WEN, Weimin LEI, Jing HOU & Leqin KE. (2022) Main components of ethyl acetate extract of Chimonanthus salicifolius and its effects on intestinal mucositis in mice induced by 5-fluorouracil. Food Science and Technology 42.
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Thais G. Moreira, Davide Mangani, Laura M. Cox, Jeffrey Leibowitz, Eduardo. L. C. Lobo, Mariana A. Oliveira, Christian D. Gauthier, Brenda N. Nakagaki, Valerie Willocq, Anya Song, Lydia Guo, David C. A. Lima, Gopal Murugaiyan, Oleg Butovsky, Galina Gabriely, Ana C. Anderson, Rafael M. Rezende, Ana Maria C. Faria & Howard L. Weiner. (2021) PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nature Communications 12:1.
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Mahira Zeeshan, Ayesha Atiq, Qurat Ul Ain, Jawad Ali, Salman Khan & Hussain Ali. (2021) Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and oxidative stress. Inflammopharmacology 29:5, pages 1539-1553.
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Deepak Vishnu S. K, Palraj Ranganathan, Syang-Peng Rwei, Cattaleeya Pattamaprom, Thavuduraj Kavitha & Perumal Sarojini. (2020) New reductant-free synthesis of gold nanoparticles-doped chitosan-based semi-IPN nanogel: A robust nanoreactor for exclusively sensitive 5-fluorouracil sensor. International Journal of Biological Macromolecules 148, pages 79-88.
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Xiao-xia Yan, Hai-long Li, Yi-ting Zhang, Shou-yan Wu, Heng-lei Lu, Xiao-lu Yu, Fan-guo Meng, Jian-hua Sun & Li-kun Gong. (2019) A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice. Acta Pharmacologica Sinica 41:3, pages 348-357.
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Roger Yazbeck, Ruth J Lindsay, Mark S Geier, Ross N Butler & Gordon S Howarth. (2019) Prebiotics Fructo-, Galacto-, and Mannan-Oligosaccharide Do Not Protect against 5-Fluorouracil–Induced Intestinal Mucositis in Rats. The Journal of Nutrition 149:12, pages 2164-2173.
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Canhong Wang, Shuai Wang, Deqian Peng, Zhangxin Yu, Peng Guo & Jianhe Wei. (2019) Agarwood Extract Mitigates Intestinal Injury in Fluorouracil-Induced Mice. Biological and Pharmaceutical Bulletin 42:7, pages 1112-1119.
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Hannah R. Wardill, Wim J.E. Tissing, Hannelouise Kissow & Andrea M. Stringer. (2019) Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets. Current Opinion in Supportive & Palliative Care 13:2, pages 119-133.
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Canhong Wang, Shuxian Yang, Li Gao, Lili Wang & Li Cao. (2018) Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice. Food & Function 9:5, pages 2695-2704.
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N.S. Oh, J.Y. Lee, J.M. Lee, K.W. Lee & Y. Kim. (2017) Mulberry leaf extract fermented with Lactobacillus acidophilus A4 ameliorates 5-fluorouracil-induced intestinal mucositis in rats . Letters in Applied Microbiology 64:6, pages 459-468.
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Hans-Dieter Allescher & Heba Abdel-Aziz. (2017) Mechanism of Action of STW 5 in Functional Dyspepsia and IBS: The Origin of Multi-Target. Digestive Diseases 35:Suppl. 1, pages 18-24.
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Shikandar D. Bukkitgar & Nagaraj P. Shetti. (2016) Electrochemical behavior of an anticancer drug 5-fluorouracil at methylene blue modified carbon paste electrode. Materials Science and Engineering: C 65, pages 262-268.
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Raja A.H Kuchay. (2016) A review of complementary therapies for chemotherapy induced gastrointestinal mucositis. Drug Discoveries & Therapeutics 10:6, pages 292-299.
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Juliana E Bajic, Georgina L Eden, Lorrinne S Lampton, Ker Y Cheah, Kerry A Lymn, Jinxin V Pei, Andrea J Yool & Gordon S Howarth. (2016) Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World Journal of Gastroenterology 22:37, pages 8322.
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M Mardani, SM Afra, N Tanideh, A Andisheh Tadbir, F Modarresi, O Koohi-Hosseinabadi, A Iraji & M Sepehrimanesh. (2016) Hydroalcoholic extract of Carum carvi L. in oral mucositis: a clinical trial in male golden hamsters . Oral Diseases 22:1, pages 39-45.
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Yuling Chen, Hong Zheng, Jingze Zhang, Lei Wang, Zhaoxiang Jin & Wenyuan Gao. (2016) Reparative activity of costunolide and dehydrocostus in a mouse model of 5-fluorouracil-induced intestinal mucositis. RSC Advances 6:7, pages 5249-5258.
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Edvande Xavier dos Santos Filho, Paulo Henrique Marcelino Ávila, Carla Caroline Cunha Bastos, Aline Carvalho Batista, Letícia Nasser Naves, Ricardo Neves Marreto, Eliana Martins Lima, Elismauro Frascisco Mendonça & Marize Campos Valadares. (2016) Curcuminoids from Curcuma longa L. reduced intestinal mucositis induced by 5-fluorouracil in mice: Bioadhesive, proliferative, anti-inflammatory and antioxidant effects. Toxicology Reports 3, pages 55-62.
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Daniel Reinke, Stamatiki Kritas, Panagiotis Polychronopoulos, Alexios L. Skaltsounis, Nektarios Aligiannis & Cuong D. Tran. (2015) Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice. Gastroenterology Research and Practice 2015, pages 1-9.
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Paulo Henrique Marcelino de Ávila, Renato Ivan de Ávila, Edvande Xavier dos Santos Filho, Carla Caroline Cunha Bastos, Aline Carvalho Batista, Elismauro Francisco Mendonça, Raphael Caixeta Serpa, Ricardo Neves Marreto, Andrezza Furquim da Cruz, Eliana Martins Lima & Marize Campos Valadares. (2015) Mucoadhesive formulation of Bidens pilosa L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice. Toxicology Reports 2, pages 563-573.
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Taku Yamashita, Koji Araki, Masayuki Tomifuji, Daisuke Kamide, Yuya Tanaka & Akihiro Shiotani. (2014) A traditional Japanese medicine—Hangeshashinto (TJ-14)—alleviates chemoradiation-induced mucositis and improves rates of treatment completion. Supportive Care in Cancer 23:1, pages 29-35.
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Kaya Yoshida, Masami Yoshioka, Hirohiko Okamura, Satomi Moriyama, Kazuyoshi Kawazoe, Daniel Grenier & Daisuke Hinode. (2014) Preventive Effect of Daiokanzoto (TJ-84) on 5-Fluorouracil-Induced Human Gingival Cell Death through the Inhibition of Reactive Oxygen Species Production. PLoS ONE 9:11, pages e112689.
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Yasser Elkerm & Rashad Tawashi. (2014) Date Palm Pollen as a Preventative Intervention in Radiation- and Chemotherapy-Induced Oral Mucositis. Integrative Cancer Therapies 13:6, pages 468-472.
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Ya Shi Zhan, Si Wei Tan, Wei Mao, Jie Jiang, Hui Ling Liu & Bin Wu. (2014) Chemotherapy mediates intestinal injury via p53/p53 upregulated modulator of apoptosis (PUMA) signaling pathway. Journal of Digestive Diseases 15:8, pages 425-434.
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Suzanne Mashtoub, Bang V. Hoang, Megan Vu, Kerry A. Lymn, Christine Feinle-Bisset & Gordon S. Howarth. (2013) Clinical and Structural Effects of Traditional Chinese Medicine and the Herbal Preparation, Iberogast, in a Rat Model of Ulcerative Colitis. Journal of Evidence-Based Complementary & Alternative Medicine 19:1, pages 10-19.
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Suzanne Mashtoub, Cuong D Tran & Gordon S Howarth. (2013) Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats. Experimental Biology and Medicine 238:11, pages 1305-1317.
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Hanru Wang, Susan E. P. Bastian & Gordon S. Howarth. (2013) Newly Developed Synbiotics and the Chemotherapy-Damaged Gut. Journal of Evidence-Based Complementary & Alternative Medicine 18:3, pages 198-208.
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Zhenze Liu, Jun Xi, Sven Schröder, Weigang Wang, Tianpei Xie, Zhugang Wang, Shisan Bao & Jian Fei. (2013) Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-12.
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Suzanne M Abimosleh, Cuong D Tran & Gordon S Howarth. (2012) Emu Oil: A novel therapeutic for disorders of the gastrointestinal tract?. Journal of Gastroenterology and Hepatology 27:5, pages 857-861.
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Tania Marchbank, Ehighale Ojobo, Christopher J. Playford & Raymond J. Playford. (2011) Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury . British Journal of Nutrition 105:9, pages 1303-1310.
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Matthias C. Schauer, Bernhard Holzmann, Matthias Peiper, Helmut Friess, Wolfram Trudo Knoefel & Joerg Theisen. (2010) Interleukin-10 and -12 Predict Chemotherapy-Associated Toxicity in Esophageal Adenocarcinoma. Journal of Thoracic Oncology 5:11, pages 1849-1854.
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Nabile Boukhettala, Ayman Ibrahim, Sophie Claeyssens, Magali Faure, Florence Le Pessot, Jacques Vuichoud, Alain Lavoinne, Denis Breuillé, Pierre Déchelotte & Moïse Coëffier. (2009) A Diet Containing Whey Protein, Glutamine, and TGFβ Modulates Gut Protein Metabolism During Chemotherapy-Induced Mucositis in Rats. Digestive Diseases and Sciences 55:8, pages 2172-2181.
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