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Research Paper

Regulation of drug resistance by human pregnane X receptor in breast cancer

Pages 1265-1272 | Published online: 01 Jul 2009

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Sachin Sudhakar Wazalwar, Anita Ravindra Banpurkar & Franc Perdih. (2023) Synthesis, crystal structure and molecular docking study of novel isoxazole derivatives as CYP450 inhibitors in search of anticancer agents. Journal of Biomolecular Structure and Dynamics 41:19, pages 9476-9491.
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Erika Cecchin, Elena De Mattia & Giuseppe Toffoli. (2016) Nuclear receptors and drug metabolism for the personalization of cancer therapy. Expert Opinion on Drug Metabolism & Toxicology 12:3, pages 291-306.
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Amina I Shehu, Guangming Li, Wen Xie & Xiaochao Ma. (2016) The pregnane X receptor in tuberculosis therapeutics. Expert Opinion on Drug Metabolism & Toxicology 12:1, pages 21-30.
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Articles from other publishers (29)

Sanaz Barzegar & Saeed Pirouzpanah. (2023) Zinc finger proteins and ATP ‐binding cassette transporter‐dependent multidrug resistance . European Journal of Clinical Investigation.
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Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett-Miller & Taosheng Chen. (2023) The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation. Acta Pharmaceutica Sinica B 13:11, pages 4523-4534.
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Gerardo Vázquez-Gómez, Jiří Petráš, Zdeněk Dvořák & Jan Vondráček. (2023) Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis. Biochemical Pharmacology 216, pages 115797.
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Yuan Liang, Yiyao Gong, Qiuyan Jiang, Yifan Yu & Jie Zhang. (2023) Environmental endocrine disruptors and pregnane X receptor action: A review. Food and Chemical Toxicology 179, pages 113976.
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Stamatios Theocharis, Constantinos Giaginis, Stefania Gourzi, Paraskevi Alexandrou, Gerasimos Tsourouflis, Panagiotis Sarantis, Eugene Danas, Artemis Michail, Nikolaos Tsoukalas, Alexandros Pergaris, Panagiotis K. Politis & Lydia Nakopoulou. (2021) High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma. Diagnostics 11:11, pages 1946.
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Aikaterini Skandalaki, Panagiotis Sarantis & Stamatios Theocharis. (2021) Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment. Biomolecules 11:8, pages 1142.
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Dirk Theile & Pauline Wizgall. (2021) Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?. Naunyn-Schmiedeberg's Archives of Pharmacology 394:8, pages 1621-1632.
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Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud & Jeff L. Staudinger. (2020) Associations between Pregnane X Receptor and Breast Cancer Growth and Progression. Cells 9:10, pages 2295.
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Tomohiro Nabekura, Tatsuya Kawasaki, Misuzu Jimura, Koichi Mizuno & Yuichi Uwai. (2020) Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein. Biochemistry and Biophysics Reports 21, pages 100727.
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Juan Pablo Rigalli, Guillermo Nicolás Tocchetti & Johanna Weiss. (2019) Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects. Current Medicinal Chemistry 26:7, pages 1079-1112.
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Bryan Mackowiak, Jessica Hodge, Sydney Stern & Hongbing Wang. (2018) The Roles of Xenobiotic Receptors: Beyond Chemical Disposition. Drug Metabolism and Disposition 46:9, pages 1361-1371.
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Swetlana Gautam, Priyanka Singh, Manjari Singh, Subhadeep Roy, Jitendra K. Rawat, Rajnish K. Yadav, Uma Devi, Pushpraj S. Gupta, Shubhini A. Saraf & Gaurav Kaithwas. (2018) Rifaximin, a pregnane X receptor (PXR) activator regulates apoptosis in a murine model of breast cancer. RSC Advances 8:7, pages 3512-3521.
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Yan Dong, Zhe Wang, Gan-feng Xie, Chong Li, Wen-wei Zuo, Gang Meng, Cheng-ping Xu & Jian-jun Li. (2017) Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer. Molecular Cancer 16:1.
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Peter O. Oladimeji, Wenwei Lin, C. Trent Brewer & Taosheng Chen. (2017) Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Scientific Reports 7:1.
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Ping Zhang, Wentao Zhu, Dezhen Wang, Jin Yan, Yao Wang & Lin He. (2017) Enantioselective Effects of Metalaxyl Enantiomers on Breast Cancer Cells Metabolic Profiling Using HPLC-QTOF-Based Metabolomics. International Journal of Molecular Sciences 18:1, pages 142.
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Elena De Mattia, Erika Cecchin, Rossana Roncato & Giuseppe Toffoli. (2016) Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine. Pharmacogenomics 17:14, pages 1547-1571.
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Satyanarayana R. Pondugula, Petr Pavek & Sridhar Mani. (2016) Pregnane X Receptor and Cancer: Context-Specificity is Key. Nuclear Receptor Research 3.
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Ioannis Koutsounas, Constantinos Giaginis, Paraskevi Alexandrou, Adamantia Zizi-Serbetzoglou, Efstratios Patsouris, Gregorios Kouraklis & Stamatios Theocharis. (2015) Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma. Pancreas 44:7, pages 1134-1140.
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Salvador Alonso, Meng Su, Jace W. Jones, Sudipto Ganguly, Maureen A. Kane, Richard J. Jones & Gabriel Ghiaur. (2015) Human bone marrow niche chemoprotection mediated by cytochrome p450 enzymes. Oncotarget 6:17, pages 14905-14912.
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Renata Silva, Vânia Vilas-Boas, Helena Carmo, Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Maria de Lourdes Bastos & Fernando Remião. (2015) Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy. Pharmacology & Therapeutics 149, pages 1-123.
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Wei Zhuo, Lei Hu, Jinfeng Lv, Hongbing Wang, Honghao Zhou & Lan Fan. (2014) Role of pregnane X receptor in chemotherapeutic treatment. Cancer Chemotherapy and Pharmacology 74:2, pages 217-227.
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EN-QI QIAO & HONG-JIAN YANG. (2014) Effect of pregnane X receptor expression on drug resistance in breast cancer. Oncology Letters 7:4, pages 1191-1196.
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ENQI QIAO, MINGHUA JI, JIANZHONG WU, RONG MA, XIAOHUA ZHANG, YUEJUN HE, QUANBIN ZHA, XUE SONG, LI-WEI ZHU & JINHAI TANG. (2013) Expression of the PXR gene in various types of cancer and drug resistance. Oncology Letters 5:4, pages 1093-1100.
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Tingting Zhou, Shuyan Cong, Shiying Sun, Hongmiao Sun, Renlong Zou, Shengli Wang, Chunyu Wang, Jiao Jiao, Kiminobu Goto, Hajime Nawata, Toshihiko Yanase & Yue Zhao. (2013) Identification of endocrine disrupting chemicals activating SXR-mediated transactivation of CYP3A and CYP7A1. Molecular and Cellular Endocrinology 365:1, pages 36-43.
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Satyanarayana R. Pondugula & Sridhar Mani. (2013) Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response. Cancer Letters 328:1, pages 1-9.
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Yakun Chen, Yong Tang, Changxiong Guo, Jiuhui Wang, Debasish Boral & Daotai Nie. (2012) Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochemical Pharmacology 83:8, pages 1112-1126.
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Laleh Amiri-Kordestani, Agnes Basseville, Karen Kurdziel, Antonio Tito Fojo & Susan E. Bates. (2012) Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies. Drug Resistance Updates 15:1-2, pages 50-61.
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Ami Oguro, Koichi Sakamoto, Yoshihiko Funae & Susumu Imaoka. (2011) Overexpression of CYP3A4, but not of CYP2D6, Promotes Hypoxic Response and Cell Growth of Hep3B Cells. Drug Metabolism and Pharmacokinetics 26:4, pages 407-415.
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Yakun Chen, Yong Tang, Gregory T. Robbins & Daotai Nie. (2010) Camptothecin Attenuates Cytochrome P450 3A4 Induction by Blocking the Activation of Human Pregnane X Receptor. Journal of Pharmacology and Experimental Therapeutics 334:3, pages 999-1008.
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