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Cancer Biology & Therapy Volume 8, 2009 - Issue 13
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Review

Functional targeting of the MUC1 oncogene in human cancers

Donald W. KufeCorrespondence[email protected]
Pages 1197-1203 | Published online: 01 Jul 2009

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Dina Stroopinsky, Donald Kufe & David Avigan. (2016) MUC1 in hematological malignancies. Leukemia & Lymphoma 57:11, pages 2489-2498.
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Afshin Amini, Anahid Ehteda, Samar Masoumi Moghaddam, Javed Akhter, Krishna Pillai & David Lawson Morris. (2013) Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). OncoTargets and Therapy 6, pages 403-409.
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Pamela E Constantinou, Brian P Danysh, Neeraja Dharmaraj & Daniel D Carson. (2011) Transmembrane mucins as novel therapeutic targets. Expert Review of Endocrinology & Metabolism 6:6, pages 835-848.
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Jeffrey Schlom. (2010) The MUC1-C oncoprotein as a target in hematologic malignancies. Cancer Biology & Therapy 10:5, pages 492-494.
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Articles from other publishers (85)

Guanqiang Ma, Xiangyan Liu & Mo Shi. (2023) MUC1 promotes lymph node metastasis in esophageal squamous cell carcinoma by downregulating DNAJB6 expression . Environmental Toxicology.
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Kayvon Pedram, D. Judy Shon, Gabrielle S. Tender, Natalia R. Mantuano, Jason J. Northey, Kevin J. Metcalf, Simon P. Wisnovsky, Nicholas M. Riley, Giovanni C. Forcina, Stacy A. Malaker, Angel Kuo, Benson M. George, Caitlyn L. Miller, Kerriann M. Casey, José G. Vilches-Moure, Michael J. Ferracane, Valerie M. Weaver, Heinz Läubli & Carolyn R. Bertozzi. (2023) Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Nature Biotechnology.
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Fareesa Aftab, Alice Rodriguez-Fuguet, Luis Silva, Ikei S. Kobayashi, Jiao Sun, Katerina Politi, Elena Levantini, Wei Zhang, Susumu S. Kobayashi & Wen Cai Zhang. (2023) An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. British Journal of Cancer 128:9, pages 1647-1664.
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Anastasiya N. Shishparenok, Vitalina V. Furman & Dmitry D. Zhdanov. (2023) DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors. Cancers 15:7, pages 2151.
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Yoshihiro Morimoto, Nami Yamashita, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Satoshi Ishikawa, Atrayee Bhattacharya, Atsushi Fushimi, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky, Constantine Mitsiades & Donald Kufe. (2023) MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells. Journal for ImmunoTherapy of Cancer 11:2, pages e006238.
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Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, Reshma Ravindran Nair & Lekshmi R. Nath. (2022) Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma. Current Cancer Drug Targets 22:9, pages 725-740.
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Nami Yamashita & Donald Kufe. (2022) Addiction of Cancer Stem Cells to MUC1-C in Triple-Negative Breast Cancer Progression. International Journal of Molecular Sciences 23:15, pages 8219.
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Sang W. Hyun, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum & Erik P. Lillehoj. (2021) The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling. Journal of Biological Chemistry 297:5, pages 101337.
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Jeong-A ParkSangkyu ParkHan-Bum ParkMyung-Kwan HanYounghee Lee. (2021) MUC1-C Contributes to the Maintenance of Human Embryonic Stem Cells and Promotes Somatic Cell Reprogramming. Stem Cells and Development.
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Nicolas Jonckheere, Audrey Vincent, Bernadette Neve & Isabelle Van Seuningen. (2021) Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:1, pages 188538.
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Qi Wang, Huiru Zou, Yue Wang, Jianwei Shang, Li Yang & Jun Shen. (2021) CCR7-CCL21 axis promotes the cervical lymph node metastasis of tongue squamous cell carcinoma by up-regulating MUC1. Journal of Cranio-Maxillofacial Surgery 49:7, pages 562-569.
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Iwona Radziejewska, Katarzyna Supruniuk & Anna Bielawska. (2021) Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells. European Journal of Pharmacology 902, pages 174119.
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Fariba Maleki, Farzaneh Rezazadeh & Kambiz Varmira. (2021) MUC1-Targeted Radiopharmaceuticals in Cancer Imaging and Therapy. Molecular Pharmaceutics 18:5, pages 1842-1861.
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Shane Patrick Flanagan, Ronen Fogel, Adrienne Lesley Edkins, Lance St. John Ho & Janice Limson. (2021) Nonspecific nuclear uptake of anti-MUC1 aptamers by dead cells: the role of cell viability monitoring in aptamer targeting of membrane-bound protein cancer biomarkers. Analytical Methods 13:9, pages 1191-1203.
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Marijo Bilusic, Sheri McMahon, Ravi A Madan, Fatima Karzai, Yo-Ting Tsai, Renee N Donahue, Claudia Palena, Caroline Jochems, Jennifer L Marté, Charalampos Floudas, Julius Strauss, Jason Redman, Houssein Abdul Sater, Shahrooz Rabizadeh, Patrick Soon-Shiong, Jeffrey Schlom & James L Gulley. (2021) Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy vaccine in patients with metastatic castration-resistant prostate cancer (mCRPC). Journal for ImmunoTherapy of Cancer 9:3, pages e002374.
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Alexandre Detappe, Clélia Mathieu, Caining Jin, Michael P. Agius, Marie-Charlotte Diringer, Vu-Long Tran, Xavier Pivot, Francois Lux, Olivier Tillement, Donald Kufe & Peter P. Ghoroghchian. (2020) Anti-MUC1-C Antibody–Conjugated Nanoparticles Potentiate the Efficacy of Fractionated Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics 108:5, pages 1380-1389.
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Wei Gong, Belize Ekmu, Xinmei Wang, Yanli Lu & Li Wan. (2020) AGR2-induced glucose metabolism facilitated the progression of endometrial carcinoma via enhancing the MUC1/HIF-1α pathway. Human Cell 33:3, pages 790-800.
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Emrah Eroglu, Thomas Michel, Wolfgang F. Graier & Roland Malli. (2020) Yes (again) to local NO. Nature Chemical Biology 16:6, pages 606-607.
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Tsuyoshi Hata, Hasan Rajabi, Masaaki Yamamoto, Caining Jin, Rehan Ahmad, Yan Zhang, Ling Kui, Wei Li, Yota Yasumizu, Deli Hong, Masaaki Miyo, Masayuki Hiraki, Takahiro Maeda, Yozo Suzuki, Hidekazu Takahashi, Mehmet Samur & Donald Kufe. (2019) Targeting MUC1-C Inhibits TWIST1 Signaling in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics 18:10, pages 1744-1754.
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Zhentao Liu, Chengyin Lu, Hongkang Hu, Zheng Cai, Qiang Liang, Wei Sun, Lei Jiang & Guohan Hu. (2019) LINC00909 promotes tumor progression in human glioma through regulation of miR-194/MUC1-C axis. Biomedicine & Pharmacotherapy 116, pages 108965.
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Razan Sheta, Magdalena Bachvarova, Elizabeth Macdonald, Stephane Gobeil, Barbara Vanderhyden & Dimcho Bachvarov. (2019) The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression. International Journal of Molecular Sciences 20:9, pages 2264.
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Nicolas Jonckheere & Isabelle Van Seuningen. (2018) Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. Journal of Translational Medicine 16:1.
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Priyanka Grover, Sritama Nath, Monica D. Nye, Ru Zhou, Mohammad Ahmad & Pinku Mukherjee. (2018) SMAD4-independent activation of TGF-β signaling by MUC1 in a human pancreatic cancer cell line. Oncotarget 9:6, pages 6897-6910.
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Elliot C Woods, FuiBoon Kai, J Matthew Barnes, Kayvon Pedram, Michael W Pickup, Michael J Hollander, Valerie M Weaver & Carolyn R Bertozzi. (2017) A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. eLife 6.
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A R Pyzer, D Stroopinsky, J Rosenblatt, E Anastasiadou, H Rajabi, A Washington, A Tagde, J-H Chu, M Coll, A L Jiao, L T Tsai, D E Tenen, L Cole, K Palmer, A Ephraim, R K Leaf, M Nahas, A Apel, M Bar-Natan, S Jain, M McMasters, L Mendez, J Arnason, B A Raby, F Slack, D Kufe & D Avigan. (2017) MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs. Leukemia 31:12, pages 2780-2790.
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Ryan J. King, Fang Yu & Pankaj K. Singh. (2017) Genomic alterations in mucins across cancers. Oncotarget 8:40, pages 67152-67168.
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Li Yin, Ashujit Tagde, Reddy Gali, Yu-Tzu Tai, Teru Hideshima, Kenneth Anderson, David Avigan & Donald Kufe. (2017) MUC1-C is a target in lenalidomide resistant multiple myeloma. British Journal of Haematology 178:6, pages 914-926.
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Hasan Rajabi, Masayuki Hiraki, Ashujit Tagde, Maroof Alam, Audrey Bouillez, Camilla L. Christensen, Mehmet Samur, Kwok-Kin Wong & Donald Kufe. (2017) MUC1-C activates EZH2 expression and function in human cancer cells. Scientific Reports 7:1.
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Hasan Rajabi & Donald Kufe. (2017) MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:1, pages 117-122.
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A Bouillez, H Rajabi, C Jin, M Samur, A Tagde, M Alam, M Hiraki, T Maeda, X Hu, D Adeegbe, S Kharbanda, K-K Wong & D Kufe. (2017) MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small-cell lung cancer. Oncogene 36:28, pages 4037-4046.
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H-L Huang, H-Y Wu, P-C Chu, I-L Lai, P-H Huang, S K Kulp, S-L Pan, C-M Teng & C-S Chen. (2017) Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Oncogenesis 6:7, pages e359-e359.
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Rui Hou, Luo Jiang, Dawo Liu, Bei Lin, Zhenhua Hu, Jian Gao, Danye Zhang, Shulan Zhang & Masao Iwamori. (2017) Lewis(y) antigen promotes the progression of epithelial ovarian cancer by stimulating MUC1 expression. International Journal of Molecular Medicine.
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M Hiraki, T Maeda, A Bouillez, M Alam, A Tagde, K Hinohara, Y Suzuki, T Markert, M Miyo, K Komura, R Ahmad, H Rajabi & D Kufe. (2016) MUC1-C activates BMI1 in human cancer cells. Oncogene 36:20, pages 2791-2801.
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Bhairavi N. Vajaria & Prabhudas S. Patel. (2016) Glycosylation: a hallmark of cancer?. Glycoconjugate Journal 34:2, pages 147-156.
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Juan Wang, Shufang Zhang, Weihua Ni, Xiaoyu Zhai, Fei Xie, Hongyan Yuan, Sujun Gao & Guixiang Tai. (2017) Development and application of a double- antibody sandwich ELISA kit for the detection of serum MUC1 in lung cancer patients. Cancer Biomarkers 17:4, pages 369-376.
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Armando Orlandi, Carmela Di Dio, Maria Alessandra Calegari & Carlo Barone. (2016) Paradox CA 15–3 increase in metastatic breast cancer patients treated with everolimus: a change of paradigm in a case series. Biomarkers in Medicine 10:11, pages 1191-1195.
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Andreia M. Sousa, Paul M. Grandgenett, Leonor David, Raquel Almeida, Michael Anthony Hollingsworth & Filipe Santos-Silva. (2016) Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis. APMIS 124:11, pages 913-924.
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V Genitsch, I Zlobec, G N Thalmann & A Fleischmann. (2016) MUC1 is upregulated in advanced prostate cancer and is an independent prognostic factor. Prostate Cancer and Prostatic Diseases 19:3, pages 242-247.
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Ryan Hanson & Michael Hollingsworth. (2016) Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling). Biomolecules 6:3, pages 34.
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Lijuan Yin, Fang Fang, Xinglei Song, Yan Wang, Gaoxiang Huang, Jie Su, Ning Hui & Jian Lu. (2016) The pro-adhesive and pro-survival effects of glucocorticoid in human ovarian cancer cells. Journal of Molecular Endocrinology 57:1, pages 61-72.
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Masayuki Hiraki, Yozo Suzuki, Maroof Alam, Kunihiko Hinohara, Masanori Hasegawa, Caining Jin, Surender Kharbanda & Donald Kufe. (2016) MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors. Scientific Reports 6:1.
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Boqi Hu, Juan Wang, Yingying Guo, Tanxiu Chen, Weihua Ni, Hongyan Yuan, Nannan Zhang, Fei Xie & Guixiang Tai. (2016) Pre-clinical toxicity and immunogenicity evaluation of a MUC1–MBP/BCG anti-tumor vaccine. International Immunopharmacology 33, pages 108-118.
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Audrey Bouillez, Hasan Rajabi, Sean Pitroda, Caining Jin, Maroof Alam, Akriti Kharbanda, Ashujit Tagde, Kwok-Kin Wong & Donald Kufe. (2016) Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas. Cancer Research 76:6, pages 1538-1548.
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Mo Shi, Dong Chen, Dong Yang & Xiang-yan Liu. (2015) CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1. Journal of Experimental & Clinical Cancer Research 34:1.
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Lili Zhang, Marianne Gallup, Lorna Zlock, Yu Ting Feeling Chen, Walter E Finkbeiner & Nancy A McNamara. (2014) Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro . The Journal of Pathology 234:1, pages 60-73.
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