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Research Paper

Evidence that photoactivated pheophorbide a causes in human cancer cells a photodynamic effect involving lipid peroxidation

Pages 1318-1327 | Published online: 15 Jul 2009

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P. N. Weindl, P. A. Weindl, E. Schmidt, L. Pleger, D. Messinger, K. Aulrich, B. Schade, M. Lehmann & G. Bellof. (2023) Photosensitisation and green egg yolks in laying hens caused by the feeding of ensiled alfalfa leaves. British Poultry Science 64:2, pages 242-251.
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Andrew M. Korolchuk, Vladimir A. Zolottsev & Alexander Y. Misharin. (2023) Conjugates of Tetrapyrrolic Macrocycles as Potential Anticancer Target-Oriented Photosensitizers. Topics in Current Chemistry 381:2.
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Assunta Saide, Gennaro Riccio, Adrianna Ianora & Chiara Lauritano. (2023) The Diatom Cylindrotheca closterium and the Chlorophyll Breakdown Product Pheophorbide a for Photodynamic Therapy Applications. Applied Sciences 13:4, pages 2590.
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Abhishek Sharma, Prishita Singh & Prateek Srivastava. 2023. Insights into the World of Diatoms: From Essentials to Applications. Insights into the World of Diatoms: From Essentials to Applications 1 20 .
Jun Young Ha, Gibum Yi, Hwan Hee Bae, Young Sam Go, Yu Jin Kim, Kwang Min Lee, Chang Oh Hong & Keun Ki Kim. (2022) Isolation, identification, and apoptosis activity of the photosensitizer methyl pheophorbide A from Perilla frutescens leaves. Applied Biological Chemistry 65:1.
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Xin Liu, Shupei Liu, Bingjie Mai, Xiaomin Su, Xiaoyu Guo, Yawei Chang, Wenzhuo Dong, Weiqing Wang & Xiaolan Feng. (2022) Synergistic gentamicin-photodynamic therapy against resistant bacteria in burn wound infections. Photodiagnosis and Photodynamic Therapy 39, pages 103034.
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Jihye Kim, Epameinondas Gousopoulos, Teresa M. Faleschini, Matthias Hamburger, Olivier Potterat & Michael Detmar. (2022) Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomedicine & Pharmacotherapy 147, pages 112664.
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Joana Assunção, Helena M. Amaro, F. Xavier Malcata & Ana Catarina Guedes. 2022. The Pharmacological Potential of Cyanobacteria. The Pharmacological Potential of Cyanobacteria 201 256 .
Assunta Saide, Chiara Lauritano & Adrianna Ianora. (2020) Pheophorbide a: State of the Art. Marine Drugs 18:5, pages 257.
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Andrêssa Silva Fernandes, Pricila Pinheiro Nass, Álisson Oliveira & Leila Queiroz Zepka. 2020. Pigments from Microalgae Handbook. Pigments from Microalgae Handbook 391 420 .
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Erjia Wang, Markus Santhosh Braun & Michael Wink. (2019) Chlorophyll and Chlorophyll Derivatives Interfere with Multi-Drug Resistant Cancer Cells and Bacteria. Molecules 24:16, pages 2968.
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Ying Li, Beili Hao, Ishfaq Muhammad, Yuanyuan Zhang, Yang Yang, Chenxi Shi, Yicong Chang, Rui Li, Changwen Li & Fangping Liu. (2019) Acetaminophen-induced reduction in glutathione-S-transferase A1 in hepatocytes: A role for hepatic nuclear factor 1α and its response element. Biochemical and Biophysical Research Communications 516:1, pages 251-257.
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Suneel K. Kandagatla, Robin Tate Uhl, Tyler N. Graf, Nicholas H. Oberlies & Gregory M. Raner. (2019) Pheophorbide Derivatives Isolated From Açaí Berries ( Euterpea oleracea ) Activate an Antioxidant Response Element In Vitro . Natural Product Communications 14:6, pages 1934578X1985244.
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Valentina Rapozzi, Francesca D’Este & Luigi E. Xodo. (2019) Molecular pathways in cancer response to photodynamic therapy. Journal of Porphyrins and Phthalocyanines 23:04n05, pages 410-418.
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Julien Massiot, Véronique Rosilio, Nada Ibrahim, Akihisa Yamamoto, Valérie Nicolas, Oleg Konovalov, Motomu Tanaka & Ali Makky. (2018) Newly Synthesized Lipid–Porphyrin Conjugates: Evaluation of Their Self‐Assembling Properties, Their Miscibility with Phospholipids and Their Photodynamic Activity In Vitro. Chemistry – A European Journal 24:72, pages 19179-19194.
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Gopalan Subashini, Kalieswaran Vidhya, Thangaraj Arasakumar, Jayaraman Angayarkanni, Easwaran Murugesh, Arjunan Saravanan, Piramanayagam Shanmughavel & Palathurai Subramaniam Mohan. (2018) Quinoline‐Based Imidazole Derivative as Heme Oxygenase‐1 Inhibitor: A Strategy for Cancer Treatment. ChemistrySelect 3:13, pages 3680-3686.
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Julien Massiot, Ali Makky, Florent Di Meo, David Chapron, Patrick Trouillas & Véronique Rosilio. (2017) Impact of lipid composition and photosensitizer hydrophobicity on the efficiency of light-triggered liposomal release. Physical Chemistry Chemical Physics 19:18, pages 11460-11473.
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Jun Lee, Kyoung Sub Kim & Kun Na. (2016) Caffeic acid-coated multifunctional magnetic nanoparticles for the treatment and bimodal imaging of tumours. Journal of Photochemistry and Photobiology B: Biology 160, pages 210-216.
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Andrés M. Durantini, Lana E. Greene, Richard Lincoln, Sol R. Martínez & Gonzalo Cosa. (2016) Reactive Oxygen Species Mediated Activation of a Dormant Singlet Oxygen Photosensitizer: From Autocatalytic Singlet Oxygen Amplification to Chemicontrolled Photodynamic Therapy. Journal of the American Chemical Society 138:4, pages 1215-1225.
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Nora L. Krutz, Jennifer Hennen, Corinna Korb, Mario T. Schellenberger, G. Frank Gerberick & Brunhilde Blömeke. (2015) Activation of the Endoperoxide Ascaridole Modulates Its Sensitizing Capacity. Toxicological Sciences 147:2, pages 515-523.
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Emilia Della Pietra, Francesca Simonella, Benjamin Bonavida, Luigi Emilio Xodo & Valentina Rapozzi. (2015) Repeated sub-optimal photodynamic treatments with pheophorbide a induce an epithelial mesenchymal transition in prostate cancer cells via nitric oxide. Nitric Oxide 45, pages 43-53.
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Emilia Della Pietra & Valentina Rapozzi. 2015. Nitric Oxide and Cancer: Pathogenesis and Therapy. Nitric Oxide and Cancer: Pathogenesis and Therapy 227 246 .
Valentina Rapozzi, Sonia Zorzet, Marina Zacchigna, Emilia Della Pietra, Susanna Cogoi & Luigi E Xodo. (2014) Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies. Molecular Cancer 13:1.
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Supratim Ghosh, Kamil B. Ucer, Ralph D'AgostinoJr.Jr., Ken Grant, Joseph Sirintrapun, Michael J. Thomas, Roy Hantgan, Manish Bharadwaj & William H. Gmeiner. (2014) Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine: Nanotechnology, Biology and Medicine 10:2, pages 451-461.
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Valentina Rapozzi, Emilia Della Pietra, Sonia Zorzet, Marina Zacchigna, Benjamin Bonavida & Luigi Emilio Xodo. (2013) Nitric oxide-mediated activity in anti-cancer photodynamic therapy. Nitric Oxide 30, pages 26-35.
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G. Sherifa, M.A. Saad Zaghloul, O.F. Elsayed, A. Rueck, R. Steiner, A.I. Abdelaziz & M.H. Abdel-Kader. (2013) Functional characterization of Fospeg, and its impact on cell cycle upon PDT of Huh7 hepatocellular carcinoma cell model. Photodiagnosis and Photodynamic Therapy 10:1, pages 87-94.
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Valentina Rapozzi, Sonia Zorzet, Marina Zacchigna, Sara Drioli & Luigi E. Xodo. (2012) The PDT activity of free and pegylated pheophorbide a against an amelanotic melanoma transplanted in C57/BL6 mice. Investigational New Drugs 31:1, pages 192-199.
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Valentina Rapozzi, Kazuo Umezawa & Luigi E. Xodo. (2011) Role of NF-κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy. Lasers in Surgery and Medicine 43:7, pages 575-585.
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Ngoc-Ha Bui-Xuan, Patrick Ming-Kuen Tang, Chun-Kwok Wong, Judy Yuet-Wa Chan, Karen Ka Yan Cheung, Jonney Lei Jiang & Kwok-Pui Fung. (2011) Pheophorbide a: A photosensitizer with immunostimulating activities on mouse macrophage RAW 264.7 cells in the absence of irradiation. Cellular Immunology 269:1, pages 60-67.
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Ngoc-Ha Bui-Xuan, Patrick Ming-Kuen Tang, Chun-Kwok Wong & Kwok-Pui Fung. (2010) Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231. Journal of Ethnopharmacology 131:1, pages 95-103.
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