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Research Paper

IDO inhibits T-cell function through suppressing Vav1 expression and activation

Pages 1402-1408 | Published online: 15 Jul 2009

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Debbie M Ferns, Ido P Kema, Marrije R Buist, Hans W Nijman, Gemma G Kenter & Ekaterina S Jordanova. (2015) Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival. OncoImmunology 4:2.
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Articles from other publishers (30)

Parviz Azimnasab-sorkhabi, Maryam Soltani-asl, Túlio Teruo Yoshinaga, Maria Lucia Zaidan Dagli, Cristina de Oliveira Massoco & Jose Roberto Kfoury Junior. (2023) Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment. Molecular Biology Reports 50:7, pages 6133-6145.
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Jianguo Lai, Yuchen Cao, Jiexin Zhang, Jinglong Wang, Yawen Du, Yan He, Yuting Luo & Ning Liao. (2023) Machine Learning and Pan‐Cancer Analysis of Tertiary Lymphoid Structures: A Potential Target for Survival and Drug Treatment. Advanced Therapeutics.
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Matthew B. Watowich, Mark R. Gilbert & Mioara Larion. (2023) T cell exhaustion in malignant gliomas. Trends in Cancer 9:4, pages 270-292.
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Yi Wang, Yuya Wang, Yifei Ren, Qi Zhang, Ping Yi & Chunming Cheng. (2022) Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer. Seminars in Cancer Biology 86, pages 542-565.
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Ana Ivanovska, Mengyu Wang, Tarlan Eslami Arshaghi, Georgina Shaw, Joel Alves, Andrew Byrne, Steven Butterworth, Russell Chandler, Laura Cuddy, James Dunne, Shane Guerin, Rob Harry, Aidan McAlindan, Ronan A. Mullins & Frank Barry. (2022) Manufacturing Mesenchymal Stromal Cells for the Treatment of Osteoarthritis in Canine Patients: Challenges and Recommendations. Frontiers in Veterinary Science 9.
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Fangfang Huang, Erick Thokerunga, Fajian He, Xinyu Zhu, Zi Wang & Jiancheng Tu. (2022) Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases. Stem Cell Research & Therapy 13:1.
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Yu Chen & Yongsheng Li. 2022. Cancer Immunology and Immunotherapy. Cancer Immunology and Immunotherapy 137 196 .
Elham Safarzadeh, Ali Mohammadi, Behzad Mansoori, Pascal H. G. Duijf, Shahryar Hashemzadeh, Vahid Khaze, Tohid Kazemi, Afshin Derakhshani, Nicola Silvestris & Behzad Baradaran. (2021) STAT3 Silencing and TLR7/8 Pathway Activation Repolarize and Suppress Myeloid-Derived Suppressor Cells From Breast Cancer Patients. Frontiers in Immunology 11.
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Flavia Castellano & Valérie Molinier-Frenkel. (2020) Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes. Frontiers in Cell and Developmental Biology 8.
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Robert D. Leone & Jonathan D. Powell. (2020) Metabolism of immune cells in cancer. Nature Reviews Cancer 20:9, pages 516-531.
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Paola De Cicco, Giuseppe Ercolano & Angela Ianaro. (2020) The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion. Frontiers in Immunology 11.
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Alireza Labani-Motlagh, Mehrnoush Ashja-Mahdavi & Angelica Loskog. (2020) The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses. Frontiers in Immunology 11.
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Xiaoyun Li, Mathias Wenes, Pedro Romero, Stanley Ching-Cheng Huang, Sarah-Maria Fendt & Ping-Chih Ho. (2019) Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. Nature Reviews Clinical Oncology 16:7, pages 425-441.
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Nan-Sun Kim, Timothy Torrez & William Langridge. (2019) LPS enhances CTB-INSULIN induction of IDO1 and IL-10 synthesis in human dendritic cells. Cellular Immunology 338, pages 32-42.
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Charlotte Domblides, Lydia Lartigue & Benjamin Faustin. (2019) Control of the Antitumor Immune Response by Cancer Metabolism. Cells 8:2, pages 104.
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Konstantin Knoblich, Sara Cruz Migoni, Susan M. Siew, Elizabeth Jinks, Baksho Kaul, Hannah C. Jeffery, Alfie T. Baker, Muath Suliman, Katerina Vrzalikova, Hisham Mehenna, Paul G. Murray, Francesca Barone, Ye H. Oo, Philip N. Newsome, Gideon Hirschfield, Deirdre Kelly, Steven P. Lee, Biju Parekkadan, Shannon J. Turley & Anne L. Fletcher. (2018) The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation. PLOS Biology 16:9, pages e2005046.
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Nevena Gajovic, Milena Jurisevic, Jelena Pantic, Gordana Radosavljevic, Nebojsa Arsenijevic, Miodrag L Lukic & Ivan Jovanovic. (2018) Attenuation of NK cells facilitates mammary tumor growth in streptozotocin-induced diabetes in mice. Endocrine-Related Cancer 25:4, pages 493-507.
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P-H Huang, P-J Lu, L-Y Ding, P-C Chu, W-Y Hsu, C-S Chen, C-C Tsao, B-H Chen, C-T Lee, Y-S Shan & C-S Chen. (2016) TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. Oncogene 36:16, pages 2202-2214.
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Bo Gao, Xueming Zhang, Yongming Huang, Zhengpeng Yang, Yuguo Zhang, Weihui Zhang, Zu-hua Gao & Dongbo Xue. (2017) Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. PLOS ONE 12:3, pages e0174142.
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Runmei Li, Hui Li, Qian Sun, Liang Liu, Chen Zhang & Xiubao Ren. (2017) Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway. Molecular Immunology 81, pages 102-107.
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Shu Su & Baorui Liu. 2017. Personalized Management of Gastric Cancer. Personalized Management of Gastric Cancer 115 130 .
Alison Spellman & Shou-Ching Tang. (2016) Immunotherapy for breast cancer: past, present, and future. Cancer and Metastasis Reviews 35:4, pages 525-546.
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Fangxuan Li, Jinchao Huang, Shixia Li, Hui Li, Jinpu Yu, Xiubao Ren & Juntian Liu. (2014) The subsets of dendritic cells and memory T cells correspond to indoleamine 2,3-dioxygenase in stomach tumor microenvironment. Tumor Biology 35:9, pages 8691-8698.
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Rupeng Zhang, Hui Liu, Fangxuan Li, Hui Li, Jinpu Yu & Xiubao Ren. (2013) The Correlation Between the Subsets of Tumor Infiltrating Memory T Cells and the Expression of Indoleamine 2,3-Dioxygenase in Gastric Cancer. Digestive Diseases and Sciences 58:12, pages 3494-3502.
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Jinpu Yu, Weijiao Du, Fang Yan, Yue Wang, Hui Li, Shui Cao, Wenwen Yu, Chun Shen, Juntian Liu & Xiubao Ren. (2013) Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer. The Journal of Immunology 190:7, pages 3783-3797.
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Jingyan Sun, Jinpu Yu, Hui Li, Lili Yang, Feng Wei, Wenwen Yu, Juntian Liu & Xiubao Ren. (2011) Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells. Journal of Experimental & Clinical Cancer Research 30:1.
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Diana Vavrincova-Yaghi, Leo E. Deelman, Harry Goor, Marc Seelen, Ido P. Kema, Annemieke Smit-van Oosten, Dick Zeeuw, Robert H. Henning & Maria Sandovici. (2011) Gene therapy with adenovirus-delivered indoleamine 2,3-dioxygenase improves renal function and morphology following allogeneic kidney transplantation in rat. The Journal of Gene Medicine 13:7-8, pages 373-381.
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Jinpu Yu, Jingyan Sun, Shizhen Emily Wang, Hui Li, Shui Cao, Yizi Cong, Juntian Liu & Xiubao Ren. (2011) Upregulated Expression of Indoleamine 2, 3-Dioxygenase in Primary Breast Cancer Correlates with Increase of Infiltrated Regulatory T Cells In Situ and Lymph Node Metastasis . Clinical and Developmental Immunology 2011, pages 1-10.
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Hatem Soliman, Melanie Mediavilla-Varela & Scott Antonia. (2010) Indoleamine 2,3-Dioxygenase. The Cancer Journal 16:4, pages 354-359.
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Fu-Ling Zhou, Wang-Gang Zhang, Yong-Chang Wei, Shan Meng, Gai-Gai Bai, Bai-Yan Wang, Hui-Yun Yang, Wei Tian, Xin Meng, Hui Zhang & She-Ping Chen. (2010) Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia. Journal of Biological Chemistry 285:20, pages 15010-15015.
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