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Research Paper

Ozone ameliorates methotrexate-induced intestinal injury in rats

Pages 1623-1628 | Published online: 01 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Hanaa M. Tashkandi, Hanan S. Althagafy, Fatima A. Jaber, Turki Alamri, Nouf S. Al-Abbas, Nehad A. Shaer, Steve Harakeh & Emad H. M. Hassanein. (2023) Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF-κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals. Immunopharmacology and Immunotoxicology 0:0, pages 1-9.
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Maha Yehia Kamel, Sabreen Mahmoud Ahmed, Walaa Yehia Abdelzaher, Nermeen N. Welson & Asmaa Mohamed Abdel-Aziz. (2022) Role of IL-6/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung/intestinal tissues damage in rats. Immunopharmacology and Immunotoxicology 44:1, pages 35-46.
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Ron Shaoul, Dalia Moati, Betty Schwartz, Yulia Pollak & Igor Sukhotnik. (2018) Effect of Pomegranate Juice on Intestinal Recovery Following Methotrexate-Induced Intestinal Damage in a Rat Model. Journal of the American College of Nutrition 37:5, pages 406-414.
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Yusuf Yucel, Suzan Tabur, Orhan Gozeneli, Sezen Kocarslan, Ahmet Seker, Hasan Buyukaslan, Emin Şavik, Alpay Aktumen, Abdullah Ozgonul, Ali Uzunkoy & Nurten Aksoy. (2016) The effects of lycopene on intestinal injury due to methotrexate in rats. Redox Report 21:3, pages 113-118.
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Articles from other publishers (32)

Mustafa Ahmed Abdel-Reheim, Gaber F. Ali, Emad H. M. Hassanein & Wafaa R. Mohamed. (2023) Role of Nrf2/HO-1, PPAR-γ, and cytoglobin signals in the pathogenesis of methotrexate-induced testicular intoxication in rats and the protective effect of diacerein. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Susan Sabbagh, Zahra Eslamifar, Mehdi Goudarzi & Ali Ebrahimzadeh. (2023) Gallic Acid Protects Against Methotrexate - Induced Intestinal Mucositis; Oxidative Stress, Histopathology and Inflammatory Status. Jundishapur Journal of Natural Pharmaceutical Products In Press:In Press.
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Luis Fernando Delgadillo-Valero, Estefani Yaquelin Hernández-Cruz & José Pedraza-Chaverri. (2023) The Protective Role of Ozone Therapy in Kidney Disease: A Review. Life 13:3, pages 752.
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Junhua Huang, Alan Yaw Min Hwang, Yuting Jia, Brian Kim, Melania Iskandar, Ali Ibrahim Mohammed & Nicola Cirillo. (2022) Experimental Chemotherapy-Induced Mucositis: A Scoping Review Guiding the Design of Suitable Preclinical Models. International Journal of Molecular Sciences 23:23, pages 15434.
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Emad H.M. Hassanein, Hanan S. Althagafy, Ahmed M. Atwa, Magy R. Kozman, Mohamed.I. Kotb El-Sayed & Ayman A. Soubh. (2022) Taurine attenuated methotrexate-induced intestinal injury by regulating NF-κB/iNOS and Keap1/Nrf2/HO-1 signals. Life Sciences 311, pages 121180.
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Qing-Qing Yu, Heng Zhang, Yujin Guo, Baoqin Han & Pei Jiang. (2022) The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis. Oxidative Medicine and Cellular Longevity 2022, pages 1-29.
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Emad H.M. Hassanein, Esam Omar Kamel, Fares E.M. Ali & Marwa Abdel-Raheim Ahmed. (2021) Berberine and/or zinc protect against methotrexate-induced intestinal damage: Role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways. Life Sciences 281, pages 119754.
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Breno Fernando Martins de Almeida, Lidiana Zanetti Amatti, Giovanna Gati de Souza, Luana Venâncio Garcia, Daniela Fernandez Montechiesi, Fernanda Saules Ignácio, Paula Lima de Oliveira, Letícia Ramos Costa, Beatriz Perez Floriano, Maria Rachel Melo Bosculo, Jean Guilherme Fernandes Joaquim & Camila Peres Rubio. (2021) Effect of uterine ozone therapy and anticoagulant sampling on oxidative stress parameters in mares. Research in Veterinary Science 136, pages 503-511.
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Tal Koppelmann, Yulia Pollak, Yoav Ben-Shahar, Gregory Gorelik & Igor Sukhotnik. (2021) The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model. Nutrients 13:3, pages 888.
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Catia Scassellati, Antonio Carlo Galoforo, Cristian Bonvicini, Ciro Esposito & Giovanni Ricevuti. (2020) Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Research Reviews 63, pages 101138.
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Hua‐An Cai, Xi Tao, Li‐Jun Zheng, Liang Huang, Yan Peng, Ruo‐Yi Liao & Yi‐Min Zhu. (2020) Ozone alleviates ischemia/reperfusion injury by inhibiting mitochondrion‐mediated apoptosis pathway in SH‐SY5Y cells. Cell Biology International 44:4, pages 975-984.
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Rulin DENİZ, Yakup BAYKUŞ, Muhammet Bora UZUNER & Yasemen ADALI. (2020) The effects of ozone therapy on postoperative adhesions and ovarian functions: An experimental study. Journal of Surgery and Medicine.
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Bernardino Clavo, Francisco Rodríguez-Esparragón, Delvys Rodríguez-Abreu, Gregorio Martínez-Sánchez, Pedro Llontop, David Aguiar-Bujanda, Leandro Fernández-Pérez & Norberto Santana-Rodríguez. (2019) Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects. Antioxidants 8:12, pages 588.
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S Karale & J. V. Kamath. (2017) NARINGIN ATTENUATES METHOTREXATE INDUCED INTESTINAL INJURY AND OXIDATIVE STRESS IN WISTAR RATS. INDIAN DRUGS 54:12, pages 58-64.
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Merih Onal, Cagdas Elsurer, Nebil Selimoglu, Mustafa Yilmaz, Ender Erdogan, Jale Bengi Celik, Oznur Kal & Ozkan Onal. (2017) Ozone Prevents Cochlear Damage From Ischemia-Reperfusion Injury in Guinea Pigs. Artificial Organs 41:8, pages 744-752.
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Altug KucukgulSuat ErdoganRamazan GonenciGonca Ozan. (2016) Beneficial effects of nontoxic ozone on H 2 O 2 -induced stress and inflammation . Biochemistry and Cell Biology 94:6, pages 577-583.
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Tunay Kurtoglu, Selim Durmaz, Cagdas Akgullu, Hasan Gungor, Ufuk Eryilmaz, Ibrahim Meteoglu, Aslihan Karul & Mehmet Boga. (2015) Ozone preconditioning attenuates contrast-induced nephropathy in rats. Journal of Surgical Research 195:2, pages 604-611.
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Ozkan Onal, Fahri Yetisir, A. Ebru Salman Sarer, N. Dilara Zeybek, C. Oztug Onal, Banu Yurekli, H. Tugrul Celik, Ayse Sirma & Mehmet Kılıc. (2015) Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in the Rat. Mediators of Inflammation 2015, pages 1-8.
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Umit Kaldirim, Bulent Uysal, Ramazan Yuksel, Enis Macit, Yusuf E Eyi, Mehmet Toygar, Salim K Tuncer, Sukru Ardic, Ibrahim Arziman, Ibrahim Aydin, Yesim Oztas, Yildirim Karslioglu & Turgut Topal. (2014) Ozone therapy ameliorates paraquat-induced lung injury in rats. Experimental Biology and Medicine 239:12, pages 1699-1704.
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Igor Sukhotnik, Tatiana Geyer, Yulia Pollak, Jorge G. Mogilner, Arnold G. Coran & Drora Berkowitz. (2014) The Role of Wnt/β-Catenin Signaling in Enterocyte Turnover during Methotrexate-Induced Intestinal Mucositis in a Rat. PLoS ONE 9:11, pages e110675.
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Bassel Haj, Igor Sukhotnik, Ron Shaoul, Yulia Pollak, Arnold G. Coran, Arie Bitterman & Ibrahim Matter. (2013) Effect of ozone on intestinal recovery following intestinal ischemia–reperfusion injury in a rat. Pediatric Surgery International 30:2, pages 181-188.
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Igor Sukhotnik, Yulia Pollak, Arnold G Coran, Janna Pilatov, Jacob Bejar, Jorge G Mogilner & Drora Berkowitz. (2014) Glutamine attenuates the inhibitory effect of methotrexate on TLR signaling during intestinal chemotherapy-induced mucositis in a rat. Nutrition & Metabolism 11:1, pages 17.
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Can Acipayam, Ibrahim Bayram, Kenan Daglioglu, Figen Doran, Sema Yilmaz, Gülay Sezgin, Berna Totan Ateş, Ayşe Ozkan & Atila Tanyeli. (2014) The Protective Effect of Hesperidin on Methotrexate-Induced Intestinal Epithelial Damage in Rats: An Experimental Study. Medical Principles and Practice 23:1, pages 45-52.
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Changying Chen, Li Tian, Mingzhi Zhang, Qiaozhi Sun, Xudong Zhang, Xiaodan Li, Xiaoqin Cao, Qianqian Liu, Xiang Li & Li Hao. (2013) Protective Effect of Amifostine on High-Dose Methotrexate-Induced Small Intestinal Mucositis in Mice. Digestive Diseases and Sciences 58:11, pages 3134-3143.
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B.H. Bakkal, F.A. Gultekin, B. Guven, U.O. Turkcu, S. Bektas & M. Can. (2013) Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats. Brazilian Journal of Medical and Biological Research 46:9, pages 789-796.
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Sevgi Kılıc, Selma Emre, Ahmet Metin, Semra Isıkoglu & Ozcan Erel. (2013) Effect of the systemic use of methotrexate on the oxidative stress and paraoxonase enzyme in psoriasis patients. Archives of Dermatological Research 305:6, pages 495-500.
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Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G. Coran & Igor Sukhotnik. (2012) Reversal of severe methotrexate-induced intestinal damage using enteral n -3 fatty acids . British Journal of Nutrition 109:1, pages 89-98.
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F. A. Gultekin, B. H. Bakkal, B. Guven, I. Tasdoven, S. Bektas, M. Can & M. Comert. (2012) Effects of ozone oxidative preconditioning on radiation-induced organ damage in rats. Journal of Radiation Research 54:1, pages 36-44.
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Bulent Uysal, Suzi Demirbag, Yavuz Poyrazoglu, Tuncer Cayci, Narter Yesildaglar, Ahmet Guven, Ilhami Sürer & Ahmet Korkmaz. (2012) Medical ozone therapy decreases postoperative uterine adhesion formation in rats. Archives of Gynecology and Obstetrics 286:5, pages 1201-1207.
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Husamettin Gul, Bulent Uysal, Erdinc Cakir, Halil Yaman, Enis Macit, Ali Osman Yildirim, Yusuf Emrah Eyi, Umit Kaldirim, Emin Oztas, Emin Ozgur Akgul, Tuncer Cayci, Mehmet Ozler, Turgut Topal, Sukru Oter, Ahmet Korkmaz, Mehmet Toygar & Suzi Demirbag. (2012) The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. Environmental Toxicology and Pharmacology 34:1, pages 81-86.
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Mmalebuso L. Mokoena, Christiaan B. Brink, Brian H. Harvey & Douglas W. Oliver. (2010) Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences. Medicinal Chemistry Research 20:9, pages 1687-1695.
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Akihiko SUGIYAMA, Hideto KIMURASatoshi OGAWAKazushige YOKOTA & Takashi TAKEUCHI. (2011) Effects of Polyphenols from Seed Shells of Japanese Horse Chestnut (Aesculus turbinata BLUME) on Methotrexate-Induced Intestinal Injury in Rats. Journal of Veterinary Medical Science 73:5, pages 673-678.
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