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Research Paper

Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway

Pages 1729-1736 | Published online: 15 Sep 2009

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Read on this site (4)

Fang Gao, Chengsuo Huang, Yiping Zhang, Ruirui Sun, Yujie Zhang, Huijun Wang & Shu Zhang. (2016) Combination targeted therapy of VEGFR inhibitor, sorafenib, with an mTOR inhibitor, sirolimus induced a remakable response of rapid progressive Uterine PEComa. Cancer Biology & Therapy 17:6, pages 595-598.
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Emanuela Palmerini, Anna Paioli & Stefano Ferrari. (2014) Emerging therapeutic targets for synovial sarcoma. Expert Review of Anticancer Therapy 14:7, pages 791-806.
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Juan Martin-Liberal, Ian Judson & Charlotte Benson. (2013) Antiangiogenic approach in soft-tissue sarcomas. Expert Review of Anticancer Therapy 13:8, pages 975-982.
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Bruno Vincenzi, Marianna Silletta, Gaia Schiavon, Anna Maria Frezza, Raimondo Del Vescovo, Bruno Beomonte Zobel, Daniele Santini, Angelo Paolo Dei Tos & Giuseppe Tonini. (2013) Sorafenib and dacarbazine in soft tissue sarcoma: a single institution experience. Expert Opinion on Investigational Drugs 22:1, pages 1-7.
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Xiao Feng, Ya-Lan Huang, Zhen Zhang, Ning Wang, Qing Yao, Li-Juan Pang, Feng Li & Yan Qi. (2021) The role of SYT-SSX fusion gene in tumorigenesis of synovial sarcoma. Pathology - Research and Practice 222, pages 153416.
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Maximilian M. L. Knott, Tilman L. B. Hölting, Shunya Ohmura, Thomas Kirchner, Florencia Cidre-Aranaz & Thomas G. P. Grünewald. (2020) Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies. Cancer and Metastasis Reviews 38:4, pages 625-642.
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Emira Ayroldi, Maria Grazia Petrillo, Maria Cristina Marchetti, Lorenza Cannarile, Simona Ronchetti, Erika Ricci, Luigi Cari, Nicola Avenia, Sonia Moretti, Efisio Puxeddu & Carlo Riccardi. (2018) Long glucocorticoid-induced leucine zipper regulates human thyroid cancer cell proliferation. Cell Death & Disease 9:3.
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Yunjie Zhang, Gangcan Li, Xin Liu, Yanping Song, Jia Xie, Guang Li, Jingjing Ren, Hao Wang, Jiao Mou, Jinqian Dai, Feng Liu & Liang Guo. (2018) Sorafenib inhibited cell growth through the MEK/ERK signaling pathway in acute promyelocytic leukemia cells. Oncology Letters.
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Melek M.E. Sunay, Jeremy B. Foote, James M. Leatherman, Justin P. Edwards, Todd D. Armstrong, Christopher J. Nirschl, Jessica Hicks & Leisha A. Emens. (2017) Sorafenib combined with HER-2 targeted vaccination can promote effective T cell immunity in vivo. International Immunopharmacology 46, pages 112-123.
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Changliang Peng, Hui Zhao, Wei Chen, Yan Song, Xiaoying Wang, Ji Li, Yong Qiao, Dongjin Wu, Shengzhong Ma, Xiuwen Wang & Chunzheng Gao. (2016) Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma. Oncotarget 7:41, pages 66822-66834.
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Myrella Vlenterie, Melissa H. S. Hillebrandt-Roeffen, Esther W. M. Schaars, Uta E. Flucke, Emmy D. G. Fleuren, Anna C. Navis, William P. J. Leenders, Yvonne M. H. Versleijen-Jonkers & Winette T. A. van der Graaf. (2016) Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients. Annals of Surgical Oncology 23:9, pages 2745-2752.
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Olga Martinho, Marcelo Campos, Guilherme Ribeiro, Valter Penna, Emílio C. Curcelli, Marcus V. Olivieri, Sandra Morini, Cristovam Scapulatempo, Lucas F. Abrahão-Machado & Rui M. Reis. (2016) Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas. Pathobiology 83:1, pages 41-46.
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Francisco Martínez-Jiménez & Marc A. Marti-Renom. (2015) Ligand-Target Prediction by Structural Network Biology Using nAnnoLyze. PLOS Computational Biology 11:3, pages e1004157.
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S.N. Dumont, D. Yang, A.G. Dumont, D. Reynoso, J-Y. Blay & J.C. Trent. (2014) Targeted polytherapy in small cell sarcoma and its association with doxorubicin. Molecular Oncology 8:8, pages 1458-1468.
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Yusuke Minami, Shinji Kohsaka, Masumi Tsuda, Kazuhiro Yachi, Nobuaki Hatori, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Akio Minami, Norimasa Iwasaki & Shinya Tanaka. (2014) SS 18‐ SSX ‐regulated miR‐17 promotes tumor growth of synovial sarcoma by inhibiting p21 WAF 1/ CIP 1 . Cancer Science 105:9, pages 1152-1159.
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HONG ZHANG, ZHIHONG LI & KAIZHONG WANG. (2014) Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. Oncology Reports 31:4, pages 1954-1960.
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J. Martín-Liberal, A. López-Pousa, J. Martín Broto, R. Cubedo, O. Gallego, E. Brendel, O. M. Tirado & X. García del Muro. (2013) Phase I trial of sorafenib in combination with ifosfamide in patients with advanced sarcoma: a Spanish group for research on sarcomas (GEIS) study. Investigational New Drugs 32:2, pages 287-294.
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Yali Zhang, Zonglou Guo & Lihong Xu. (2014) Tributyltin induces a G2/M cell cycle arrest in human amniotic cells via PP2A inhibition-mediated inactivation of the ERK1/2 cascades. Environmental Toxicology and Pharmacology 37:2, pages 812-818.
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Jürgen Radons. 2014. Inflammation and Cancer. Inflammation and Cancer 259 313 .
Wei-Ye Shi, Chang-Yan Che & Li Liu. (2013) Human Interleukin 23 Receptor Induces Cell Apoptosis in Mammalian Cells by Intrinsic Mitochondrial Pathway Associated with the Down-Regulation of RAS/Mitogen-Activated Protein Kinase and Signal Transducers and Activators of Transcription factor 3 Signaling Pathways. International Journal of Molecular Sciences 14:12, pages 24656-24669.
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Samer Salah, Sameer Yaser, Ahmed Salem, Abdellatif Al Mousa, Areej Abu Sheikha & Iyad Sultan. (2013) Factors influencing survival in metastatic synovial sarcoma: importance of patterns of metastases and the first-line chemotherapy regimen. Medical Oncology 30:3.
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Teddy S Nagaria, Julia L Williams, Charles Leduc, Jeremy A Squire, Peter A Greer & Waheed Sangrar. (2013) Flavopiridol Synergizes with Sorafenib to Induce Cytotoxicity and Potentiate Antitumorigenic Activity in EGFR/HER-2 and Mutant RAS/RAF Breast Cancer Model Systems. Neoplasia 15:8, pages 939-IN27.
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Nian‐Kang Sun, Shang‐Lang Huang, Ting‐Chang Chang & Chuck C.‐K. Chao. (2013) Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk‐1‐dependent Mcl‐1 transcription and inducing Akt/GSK3β‐dependent protein degradation. Journal of Cellular Biochemistry 114:8, pages 1819-1831.
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Mikhail Bekarev, Elisabeth C. Elsinger, Esperanza Villanueva-Siles, Ross M. Borzykowski & David S. Geller. (2013) Synovial Sarcoma of the Foot. The Journal of Foot and Ankle Surgery 52:4, pages 513-517.
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Oussama Karroum, Lionel Mignion, Julie Kengen, Linda Karmani, Philippe Lev?que, Pierre Danhier, Julie Magat, Anne Bol, Daniel Labar, Vincent Gr?goire, Caroline Bouzin, Olivier Feron, Bernard Gallez & B?n?dicte F. Jordan. (2013) Multimodal imaging of tumor response to sorafenib combined with radiation therapy: comparison between diffusion-weighted MRI, choline spectroscopy and 18 F-FLT PET imaging . Contrast Media & Molecular Imaging 8:3, pages 274-280.
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Victor Hugo Villar, Oliver V?gler, Jordi Mart?nez-Serra, Rafael Ramos, Silvia Calabuig-Fari?as, Antonio Guti?rrez, Francisca Barcel?Javier Mart?n-Broto & Regina Alemany. (2012) Nilotinib Counteracts P-Glycoprotein-Mediated Multidrug Resistance and Synergizes the Antitumoral Effect of Doxorubicin in Soft Tissue Sarcomas. PLoS ONE 7:5, pages e37735.
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Chandrajit P. Raut, Yves Boucher, Dan G. Duda, Jeffrey A. Morgan, Richard Quek, Marek Ancukiewicz, Johanna Lahdenranta, J. Paul Eder, George D. Demetri & Rakesh K. Jain. (2012) Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948). PLoS ONE 7:2, pages e26331.
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Jorge Quesada & Robert Amato. (2012) The Molecular Biology of Soft-Tissue Sarcomas and Current Trends in Therapy. Sarcoma 2012, pages 1-16.
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Juan Martín Liberal, Laura Lagares-Tena, Miguel Sáinz-Jaspeado, Silvia Mateo-Lozano, Xavier García del Muro & Oscar M. Tirado. (2012) Targeted Therapies in Sarcomas: Challenging the Challenge. Sarcoma 2012, pages 1-13.
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Kevin B. Jones, Malay Haldar, Joshua D. Schiffman, Lisa Cannon-AlbrightStephen L. Lessnick, Sunil Sharma, Mario R. Capecchi & R. Lor Randall. (2011) Of Mice and Men: Opportunities to Use Genetically Engineered Mouse Models of Synovial Sarcoma for Preclinical Cancer Therapeutic Evaluation. Cancer Control 18:3, pages 196-203.
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Tzu-Ching Kuo, Hsing-Pang Lu & Chuck C.-K. Chao. (2011) The tyrosine kinase inhibitor sorafenib sensitizes hepatocellular carcinoma cells to taxol by suppressing the HURP protein. Biochemical Pharmacology 82:2, pages 184-194.
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Mengde Cao, Yiling Xu, Je-in Youn, Roniel Cabrera, Xiaokui Zhang, Dmitry Gabrilovich, David R Nelson & Chen Liu. (2011) Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model. Laboratory Investigation 91:4, pages 598-608.
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Xinchang Lu, Xiaodong Tang, Wei Guo, Tingting Ren & Hui Zhao. (2010) Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway. Journal of Surgical Oncology 102:7, pages 821-826.
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Guo-Qing Tang, Tai-Qiang Yan, Wei Guo, Ting-Ting Ren, Chang-Liang Peng, Hui Zhao, Xin-Chang Lu, Fu-Long Zhao & Xiaoguang Han. (2010) (?)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells. Journal of Cancer Research and Clinical Oncology 136:8, pages 1179-1185.
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