Shay Weiss, Kamran Waidha, Saravanakumar Rajendran, Daniel Benharroch, Jannat Khalilia, Haim Levy, Elad Bar-David, Avi Golan-Goldhirsh, Jacob Gopas & Amir Ben-Shmuel. (2023) In Vitro and In Vivo Therapeutic Potential of 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2. International Journal of Molecular Sciences 24:9, pages 8327.
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Suchismita Muduli, Avi Golan-Goldhirsh, Jacob Gopas & Michael Danilenko. (2022) Cytotoxicity of Thioalkaloid-Enriched Nuphar lutea Extract and Purified 6,6′-Dihydroxythiobinupharidine in Acute Myeloid Leukemia Cells: The Role of Oxidative Stress and Intracellular Calcium. Pharmaceuticals 15:4, pages 410.
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Priyanka Kriplani & Kumar Guarve. 2022. 71 97 .

Lima Rodrigues, Santosh G. Tilve & Mahesh S. Majik. (2021) Synthetic access to thiolane-based therapeutics and biological activity studies. European Journal of Medicinal Chemistry 224, pages 113659.
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Qi Yin, Xiaolu Wen, Yiwei Chen, Xiangnan Gong & Lin Hu. (2021) Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes. Organic Letters 23:19, pages 7529-7534.
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Thiago A. Grigolo, Ariana R. Subhit & Joel M. Smith. (2021) Regioselective Asymmetric Alkynylation of N -Alkyl Pyridiniums . Organic Letters 23:17, pages 6703-6708.
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Kamran Waidha, Udi Zurgil, Efrat Ben-Zeev, Jacob Gopas, Saravanakumar Rajendran & Avi Golan-Goldhirsh. (2021) Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea. Molecules 26:16, pages 4743.
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Kamran Waidha, Nikhil Ponnoor Anto, Divya Ram Jayaram, Avi Golan-Goldhirsh, Saravanakumar Rajendran, Etta Livneh & Jacob Gopas. (2021) 6,6′-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity. Molecules 26:9, pages 2785.
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Diego Caprioglio, Stefano Salamone, Federica Pollastro & Alberto Minassi. (2021) Biomimetic Approaches to the Synthesis of Natural Disesquiterpenoids: An Update. Plants 10:4, pages 677.
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Hila Winer, Janet Ozer, Yonat Shemer, Irit Reichenstein, Brit Eilam-Frenkel, Daniel Benharroch, Avi Golan-Goldhirsh & Jacob Gopas. (2020) Nuphar lutea Extracts Exhibit Anti-Viral Activity against the Measles Virus. Molecules 25:7, pages 1657.
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Hisashi Matsuda, Seikou Nakamura, Souichi Nakashima, Masashi Fukaya & Masayuki Yoshikawa. (2019) Biofunctional Effects of Thiohemiaminal-Type Dimeric Sesquiterpene Alkaloids from <i>Nuphar</i> Plants. Chemical and Pharmaceutical Bulletin 67:7, pages 666-674.
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Dan Henry Levy, Iain L. C. Chapple, Lior Shapira, Avi Golan-Goldhirsh, Jacob Gopas & David Polak. (2019) Nupharidine enhances Aggregatibacter actinomycetemcomitans clearance by priming neutrophils and augmenting their effector functions . Journal of Clinical Periodontology 46:1, pages 62-71.
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Ghader babaei, Azadeh Aliarab, Sina Abroon, Yusof Rasmi & Shiva Gholizadeh- Ghaleh Aziz. (2018) Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity. Biomedicine & Pharmacotherapy 106, pages 239-246.
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Pei-Qiang Huang. 2018. Efficiency in Natural Product Total Synthesis. Efficiency in Natural Product Total Synthesis 67 158 .

T. A. Fedotcheva, O. P. Sheichenko, V. V. Anufrieva, V. I. Sheichenko, N. I. Fedotcheva & N. L. Shimanovskii. (2017) Preparation of Nuflein - an Alkaloid from the Yellow Waterlily Nuphar Lutea - and its Cytotoxic Action on Cultures of Normal and Tumorous Human Cells. Pharmaceutical Chemistry Journal 51:7, pages 590-595.
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Jacob J. Lacharity, Jeremy Fournier, Ping Lu, Artur K. Mailyan, Aaron T. Herrmann & Armen Zakarian. (2017) Total Synthesis of Unsymmetrically Oxidized Nuphar Thioalkaloids via Copper-Catalyzed Thiolane Assembly. Journal of the American Chemical Society 139:38, pages 13272-13275.
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Jiangjiang QIN, Wei WANG & Ruiwen ZHANG. (2017) Novel natural product therapeutics targeting both inflammation and cancer. Chinese Journal of Natural Medicines 15:6, pages 401-416.
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Hui Li, Timothy J. Cooke, Alexander Korotkov, Charles W. Chapman, Alan Eastman & Jimmy Wu. (2017) Stereoselective Synthesis and Biological Evaluation of C1-Epimeric and Desmethyl Monomeric Nuphar Analogues. The Journal of Organic Chemistry 82:5, pages 2648-2655.
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J Gopas, E Stern, U Zurgil, J Ozer, A Ben-Ari, G Shubinsky, A Braiman, R Sinay, J Ezratty, V Dronov, S Balachandran, D Benharroch & E Livneh. (2016) Reed-Sternberg cells in Hodgkin’s lymphoma present features of cellular senescence. Cell Death & Disease 7:11, pages e2457-e2457.
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Norihiro Tada, Daniel J. Jansen, Matthew P. Mower, Megan M. Blewett, Jeffrey C. Umotoy, Benjamin F. Cravatt, Dennis W. Wolan & Ryan A. Shenvi. (2016) Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore . ACS Central Science 2:6, pages 401-408.
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Hui Li, Alexander Korotkov, Charles W. Chapman, Alan Eastman & Jimmy Wu. (2016) Enantioselective Formal Syntheses of 11 Nuphar Alkaloids and Discovery of Potent Apoptotic Monomeric Analogues. Angewandte Chemie International Edition 55:10, pages 3509-3513.
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Alexander Korotkov, Hui Li, Charles W. Chapman, Haoran Xue, John B. MacMillan, Alan Eastman & Jimmy Wu. (2015) Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids. Angewandte Chemie International Edition 54:36, pages 10604-10607.
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Ping Lu, Aaron T. Herrmann & Armen Zakarian. (2015) Toward the Synthesis of Nuphar Sesquiterpene Thioalkaloids: Stereodivergent Rhodium-Catalyzed Synthesis of the Thiolane Subunit . The Journal of Organic Chemistry 80:15, pages 7581-7589.
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Kendra R. Vann, Carl A. Sedgeman, Jacob Gopas, Avi Golan-Goldhirsh & Neil Osheroff. (2015) Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases. Biochemistry 54:29, pages 4531-4541.
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J. Ozer, T. Levi, A. Golan-Goldhirsh & J. Gopas. (2015) Anti-inflammatory effect of a Nuphar lutea partially purified leaf extract in murine models of septic shock. Journal of Ethnopharmacology 161, pages 86-91.
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Daniel J Jansen & Ryan A Shenvi. (2014) Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery. Future Medicinal Chemistry 6:10, pages 1127-1148.
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Daniel J. Jansen & Ryan A. Shenvi. (2013) Synthesis of (−)-Neothiobinupharidine. Journal of the American Chemical Society 135:4, pages 1209-1212.
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Christophe Wiart. 2013. Lead Compounds from Medicinal Plants for the Treatment of Cancer. Lead Compounds from Medicinal Plants for the Treatment of Cancer 1 95 .

Lital Ozer, Joseph El-On, Avi Golan-Goldhirsh & Jacob Gopas. (2010) Leishmania major: Anti-leishmanial activity of Nuphar lutea extract mediated by the activation of transcription factor NF-κB. Experimental Parasitology 126:4, pages 510-516.
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Nuphar lutea thioalkaloids inhibit the nuclear factor κappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide

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