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Clinical Study

The HIF-1α C1772T polymorphism may be associated with susceptibility to clinically localized prostate cancer but not with elevated expression of hypoxic biomarkers

Pages 118-124 | Published online: 15 Jan 2009

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Kaiyuan Yu, Luxia Xiang, Shaoxun Li, Shuaibin Wang, Chaohao Chen & Haiqi Mu. (2019) HIF1α promotes prostate cancer progression by increasing ATG5 expression. Animal Cells and Systems 23:5, pages 326-334.
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Yanwei Ye, Min Wang, Shuang Hu, Yingqiang Shi, Xiefu Zhang, Ye Zhou, Chunlin Zhao, Guojun Wang, Jianguo Wen & Hong Zong. (2014) Hypoxia-Inducible Factor-1α C1772T Polymorphism and Cancer Risk: A Meta-Analysis Including 18,334 Subjects. Cancer Investigation 32:4, pages 126-135.
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Haiyong Gu, Wanshan Qiu, Yijun Shi, Suocheng Chen & Jun Yin. (2014) Variant alleles of VEGF and risk of esophageal cancer and lymph node metastasis. Biomarkers 19:3, pages 252-258.
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Michael Vainrib, Maya Golan, Sharon Amir, Duyen T. Dang, Long H. Dang, Anat Bar-Shira, Avi Orr-Urtreger, Haim Matzkin & Nicola J. Mabjeesh. (2012) HIF1A C1772T polymorphism leads to HIF-1α mRNA overexpression in prostate cancer patients. Cancer Biology & Therapy 13:9, pages 720-726.
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Articles from other publishers (34)

Mohsen Saravani, Mahnaz Sandoughi, Zohreh Heidary, Ghasem Ebrahimi, Solmaz Mirzamohammadi, Mohammad Haddadi & Mohammad Hadi Nematollahi. (2021) HIF-1α and VEGF polymorphisms and systemic lupus erythematosus susceptibility. Meta Gene 30, pages 100982.
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Mariyah Pressley, Jill A. Gallaher, Joel S. Brown, Michal R. Tomaszewski, Punit Borad, Mehdi Damaghi, Robert J. Gillies & Christopher J. Whelan. (2021) Cycling hypoxia selects for constitutive HIF stabilization. Scientific Reports 11:1.
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Jitender Prasad, Binita Goswami, Srinivas H. Gowda, Nikhil Gupta, Shilpa Kumar, Kiran Agarwal, Pravesh Mehra, Bindiya K. Pahuja & Anju Chauhan. (2018) Does Hypoxia-Inducible Factor -1 α (HIF-1α) C1772T polymorphism predict short-term prognosis in patients with oral squamous cell carcinoma (OSCC)?. Journal of Oral Pathology & Medicine 47:7, pages 660-664.
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Jin-Bo Chen, Meng Zhang, Yu Cui, Pei-Hua Liu, Yan-Wei Qi, Chao Li, Xu Cheng, Wen-Biao Ren, Qia-Qia Li, Long-Fei Liu, Min-Feng Chen, He-Qun Chen & Xiong-Bing Zu. (2018) Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies. Frontiers in Physiology 9.
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Avelino Fraga, Ricardo Ribeiro, André Coelho, José Ramon Vizcaíno, Helena Coutinho, José Manuel Lopes, Paulo Príncipe, Carlos Lobato, Carlos Lopes & Rui Medeiros. (2017) Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer. BMC Urology 17:1.
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Xiao-Dong Li, Hao Zi, Cheng Fang & Xian-Tao Zeng. (2017) Association between HIF1A rs11549465 polymorphism and risk of prostate cancer: a meta-analysis . Oncotarget 8:27, pages 44910-44916.
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I. Gladek, J. Ferdin, S. Horvat, G. A. Calin & T. Kunej. (2017) HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies . Genes, Chromosomes and Cancer 56:6, pages 439-452.
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Mariana Burgos & Rodrigo Cabrera. (2017) Influencia del polimorfismo rs11549465 de HIF-1α en los niveles de hemoglobina y lactato en pacientes de cirugía cardiovascular. Revista de la Facultad de Medicina 65:2, pages 253-260.
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Armelle Meunier, Victoria Anastasia Belle, Niamh McDermott, Karla Rivera-Figueroa, Antoinette Perry, Thomas Lynch, Kathrine Røe Redalen & Laure Marignol. (2016) Hypoxia regulates Notch-3 mRNA and receptor activation in prostate cancer cells. Heliyon 2:5, pages e00104.
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Md. T Anam, Alokta Ishika, Md. B Hossain & Jesmin. (2015) A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers. Biomarker Research 3:1.
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Sivakamasundari Pichu, Jayalalitha Sathiyamoorthy, Ezhilarasi Krishnamoorthy, Dhamodharan Umapathy & Vijay Viswanathan. (2015) Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers. Diabetes Research and Clinical Practice 109:3, pages 533-540.
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Sarika Sharma, Ruhi Kapahi, Vasudha Sambyal, Kamlesh Guleria, Mridu Manjari, Meena Sudan, Manjit Singh Uppal & Neeti Rajan Singh. (2014) No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians. Asian Pacific Journal of Cancer Prevention 15:22, pages 9973-9978.
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Qing Yan, Pin Chen, Songtao Wang, Ning Liu, Peng Zhao & Aihua Gu. (2014) Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies. BMC Cancer 14:1.
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Yanqiong Liu, Jingzhe Sui, Limin Zhai, Shi Yang, Li Huang, Liying Huang, Cuiju Mo, Junrong Wu, Shan Li & Xue Qin. (2014) Genetic polymorphisms in hypoxia-inducible factor-1a gene and its association with HBV-related hepatocellular carcinoma in a Chinese population. Medical Oncology 31:10.
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Gang Wu, Wen-Feng Yan, Yuan-Zeng Zhu & Pei-Chun Sun. (2014) Hypoxia-inducible factor-1α (HIF-1α) C1772T polymorphism significantly contributes to the risk of malignancy from a meta-analysis. Tumor Biology 35:5, pages 4113-4122.
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Xin Hu, Yuan Fang, Jun Zheng, Yazhou He, Xin Zan, Sen Lin, Xi Li, Hao Li & Chao You. (2013) The association between HIF-1α polymorphism and cancer risk: a systematic review and meta-analysis. Tumor Biology 35:2, pages 903-916.
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Avelino Fraga, Ricardo Ribeiro, Paulo Príncipe, Carlos Lobato, Francisco Pina, Joaquina Maurício, Cátia Monteiro, Hugo Sousa, F. Calais da Silva, Carlos Lopes & Rui Medeiros. (2014) The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration. European Journal of Cancer 50:2, pages 359-365.
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Pengfei He, Qi Han, Jiajia Liu, Dongjuan Liu, Xin Zhao, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng, Jing Li, Jiayi Wang & Qianming Chen. (2013) The Association between Hypoxia-Inducible Factor-1 ? Gene C1772T Polymorphism and Cancer Risk: A Meta-Analysis of 37 Case-Control Studies. PLoS ONE 8:12, pages e83441.
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Xi Yang, Hong-Cheng Zhu, Chi Zhang, Qin Qin, Jia Liu, Li-Ping Xu, Lian-Jun Zhao, Qu Zhang, Jing Cai, Jian-Xin Ma, Hong-Yan Cheng & Xin-Chen Sun. (2013) HIF-1α 1772 C/T and 1790 G/A Polymorphisms Are Significantly Associated with Higher Cancer Risk: An Updated Meta-Analysis from 34 Case-Control Studies. PLoS ONE 8:11, pages e80396.
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Derek Hennessey, Lynn M. Martin, Anne Atzberger, Thomas H. Lynch, Donal Hollywood & Laure Marignol. (2013) Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 31:7, pages 1106-1116.
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Jie Liu & Hong-xin Zhang. (2013) 1790 G/A polymorphism, but not 1772 C/T polymorphism, is significantly associated with Cancers: An update study. Gene 523:1, pages 58-63.
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Dawei Li, Jikai Liu, Wenhua Zhang, Juchao Ren, Lei Yan, Hainan Liu & Zhonghua Xu. (2013) Association between HIF1A P582S and A588T Polymorphisms and the Risk of Urinary Cancers: A Meta-Analysis. PLoS ONE 8:5, pages e63445.
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Weranja K. B. Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S. Baldwin & Oneel Patel. (2013) The Role of Hypoxia-Inducible Factor 1α in Determining the Properties of Castrate-Resistant Prostate Cancers. PLoS ONE 8:1, pages e54251.
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Pu Li, Qiang Cao, Peng-Fei Shao, Hong-Zhou Cai, Hai Zhou, Jia-Wei Chen, Chao Qin, Zheng-Dong Zhang, Xiao-Bing Ju & Chang-Jun Yin. (2012) Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population. Asian Journal of Andrology 14:6, pages 864-869.
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James C. Forde, Antoinette S. Perry, Kevin Brennan, Lynn M. Martin, Mark P. Lawler, Thomas H. Lynch, Donal Hollywood & Laure Marignol. (2012) Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 30:6, pages 912-919.
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E. K. Amankwah, T. A. Sellers & J. Y. Park. (2012) Gene variants in the angiogenesis pathway and prostate cancer. Carcinogenesis 33:7, pages 1259-1269.
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Jiawei ChenYilong WuPengfei ShaoQiang CaoChao QinPu LiQi DingJian ZhuMeilin WangZhengdong ZhangJie LiChangjun Yin. (2012) Association Between VHL Single Nucleotide Polymorphism (rs779805) and the Susceptibility to Prostate Cancer in Chinese . DNA and Cell Biology 31:5, pages 790-796.
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Wu-Hsien Kuo, Chuen-Ming Shih, Chiao-Wen Lin, Wei-Erh Cheng, Shuo-Chueh Chen, Wei Chen & Yao-Ling Lee. (2012) Association of hypoxia inducible factor-1α polymorphisms with susceptibility to non–small-cell lung cancer. Translational Research 159:1, pages 42-50.
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Soo Jung Lee, Jong Gwang Kim, Sang Kyun Sohn, Yee Soo Chae, Joon Ho Moon, Byung Woog Kang, Jun Seok Park, Jin Young Park & Gyu Seog Choi. (2010) No association of the hypoxia-inducible factor-1α gene polymorphisms with survival in patients with colorectal cancer. Medical Oncology 28:4, pages 1032-1037.
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Ruth Foley, Laure Marignol, John P. Keane, Thomas H. Lynch & Donal Hollywood. (2010) Androgen hypersensitivity in prostate cancer: Molecular perspectives on androgen deprivation therapy strategies. The Prostate 71:5, pages 550-557.
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Kojiro Yano. (2010) Gene expression correlation analysis predicts involvement of high‐ and low‐confidence risk genes in different stages of prostate carcinogenesis. The Prostate 70:16, pages 1746-1759.
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Tongfeng Zhao, Jing Lv, Jiangpei Zhao & Marius Nzekebaloudou. (2009) Hypoxia-inducible factor-1α gene polymorphisms and cancer risk: a meta-analysis. Journal of Experimental & Clinical Cancer Research 28:1.
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Seyed S. Dianat, Markus Margreiter, Elisabeth Eckersberger, Julia Finkelstein, Franklin Kuehas, Ralf Herwig, Mohsen Ayati, Herbert Lepor & Bob Djavan. (2009) Gene polymorphisms and prostate cancer: the evidence. BJU International 104:11, pages 1560-1572.
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Ece Konac, Irem Dogan, Hacer Ilke Onen, Ahmet Selim Yurdakul, Can Ozturk, Ayhan Varol & Abdullah Ekmecki. (2009) Genetic Variations in the Hypoxia-Inducible Factor-1αGene and Lung Cancer. Experimental Biology and Medicine 234:9, pages 1109-1116.
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