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Research Paper

RACK1 down-regulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells

Pages 2295-2303 | Published online: 01 Dec 2009

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Bowen Liu, Cong Wang, Pengxiang Chen, Bo Cheng & Yufeng Cheng. (2018) RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression. OncoTargets and Therapy 11, pages 211-220.
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Articles from other publishers (21)

Monika M. Gladka, Arwa Kohela, Bas Molenaar, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Veerle Kremer, Harmjan R. Vos, Manon M. H. Huibers, Jody J. Haigh, Danny Huylebroeck, Reinier A. Boon, Mauro Giacca & Eva van Rooij. (2021) Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner. Nature Communications 12:1.
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Ya‐Ping Liu, Can‐Can Zheng, Yun‐Na Huang, Ming‐Liang He, Wen Wen Xu & Bin Li. (2021) Molecular mechanisms of chemo‐ and radiotherapy resistance and the potential implications for cancer treatment. MedComm 2:3, pages 315-340.
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Xinyan Chen, Shanhui Liao, Yaara Makaros, Qiong Guo, Zhongliang Zhu, Rina Krizelman, Karin Dahan, Xiaoming Tu, Xuebiao Yao, Itay Koren & Chao Xu. (2021) Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nature Chemical Biology 17:3, pages 254-262.
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Xue-Yang Li, Yi Hu, Nian-Shuang Li, Jian-Hua Wan, Yin Zhu & Nong-Hua Lu. (2019) RACK1 Acts as a Potential Tumor Promoter in Colorectal Cancer. Gastroenterology Research and Practice 2019, pages 1-8.
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Ta Xiao, Wei Zhu, Wei Huang, Shan-Shan Lu, Xin-Hui Li, Zhi-Qiang Xiao & Hong Yi. (2018) RACK1 promotes tumorigenicity of colon cancer by inducing cell autophagy. Cell Death & Disease 9:12.
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Jon P Day, Ellanor Whiteley, Michael Freeley, Aideen Long, Beatrice Malacrida, Patrick Kiely & George S Baillie. (2018) RAB40C regulates RACK1 stability via the ubiquitin–proteasome system. Future Science OA 4:7, pages FSO317.
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Sai Liu, JiaJia Liu, Jiongke Wang, Junxin Cheng, Xin Zeng, Ning Ji, Jing Li & Qianming Chen. (2018) RACK1 is an organ-specific prognostic predictor in OSCC. Oral Oncology 76, pages 22-26.
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Bowen Liu, Cong Wang, Pengxiang Chen, Lu Wang & Yufeng Cheng. (2017) RACK1 promotes radiation resistance in esophageal cancer via regulating AKT pathway and Bcl-2 expression. Biochemical and Biophysical Research Communications 491:3, pages 622-628.
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Jie Lei, Qi Li, Ying Gao, Lei Zhao & Yanbo Liu. (2016) Increased PKCα activity by Rack1 overexpression is responsible for chemotherapy resistance in T-cell acute lymphoblastic leukemia-derived cell line. Scientific Reports 6:1.
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Xuefeng Zhang, Na Liu, Danhua Ma, Ling Liu, Lu Jiang, Yu Zhou, Xin Zeng, Jing Li & Qianming Chen. (2016) Receptor for activated C kinase 1 (RACK1) promotes the progression of OSCC via the AKT/mTOR pathway. International Journal of Oncology 49:2, pages 539-548.
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Weijia Cai & Haifeng Yang. (2016) The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions. Cell Division 11:1.
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Xin Huang, Suxia Geng, Jianyu Weng, Zesheng Lu, Lingji Zeng, Minming Li, Chengxin Deng, Xiuli Wu, Yangqiu Li & Xin Du. (2015) Analysis of the expression of PHTF1 and related genes in acute lymphoblastic leukemia. Cancer Cell International 15:1.
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J-J Li & D Xie. (2014) RACK1, a versatile hub in cancer. Oncogene 34:15, pages 1890-1898.
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Line M. Myklebust, Ole Horvli & Arnt J. Raae. (2015) RACK1 (receptor for activated C-kinase 1) interactions with spectrin repeat elements. Journal of Molecular Recognition 28:1, pages 49-58.
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Shaoju Jin, Yishuang Mu, Xiaodong Wang, Zhenru Liu, Lihong Wan, Yao Xiong, Yuanyuan Zhang, Liming Zhou & Li Li. (2014) Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma. Molecular Biology Reports 41:5, pages 3393-3399.
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Fengqing Hu, Zhen Tao, Mingsong Wang, Guoqing Li, Yunjiao Zhang, Hong Zhong, Haibo Xiao, Xiao Xie & Mei Ju. (2013) RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma. Tumor Biology 34:6, pages 3893-3899.
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Andrew S. Gilder, Yong-Bin Chen, Ramon J. JacksonIIIIII, Jin Jiang & Joseph F. Maher. (2013) Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1. Biochemical and Biophysical Research Communications 440:3, pages 431-436.
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Hong Ji, David W. Greening, Thomas W. Barnes, Justin W. Lim, Bow J. Tauro, Alin Rai, Rong Xu, Christopher Adda, Suresh Mathivanan, Wei Zhao, Yanhong Xue, Tao Xu, Hong-Jian Zhu & Richard J. Simpson. (2013) Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. PROTEOMICS 13:10-11, pages 1672-1686.
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Shuo Shi, Yue-Zhen Deng, Jiang-Sha Zhao, Xiao-Dan Ji, Jun Shi, Yu-Xiong Feng, Guo Li, Jing-Jing Li, Di Zhu, H. Phillip Koeffler, Yun Zhao & Dong Xie. (2012) RACK1 Promotes Non-small-cell Lung Cancer Tumorigenicity through Activating Sonic Hedgehog Signaling Pathway. Journal of Biological Chemistry 287:11, pages 7845-7858.
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Line M. MyklebustLars A. AkslenJan Erik VarhaugJohan R. Lillehaug. (2011) Receptor for Activated Protein C Kinase 1 (RACK1) Is Overexpressed in Papillary Thyroid Carcinoma. Thyroid 21:11, pages 1217-1225.
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Laure Yatime, Kim Langemach Hein, Jakob Nilsson & Poul Nissen. (2011) Structure of the RACK1 Dimer from Saccharomyces cerevisiae. Journal of Molecular Biology 411:2, pages 486-498.
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