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Research Paper

Oral administration of Pyrrolidine Dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice

Pages 514-521 | Published online: 15 Mar 2009

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Angelika Schmitt, Anne-Lena Brändle, Pascal Herzog, Franziska Röchner, Annunziata Fragasso & Barbara Munz. (2020) Effects of the anti-oxidant PDTC in combination with a single bout of treadmill running on murine skeletal muscle. Redox Report 25:1, pages 70-79.
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Jian-Wei Gu, Emily Young, Sharla G. Patterson, Kristina L. Makey, Jeremy Wells, Min Huang, Kevan B. Tucker & Lucio Miele. (2011) Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice. Cancer Biology & Therapy 11:10, pages 910-917.
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Emily Young, Lucio Miele, Kevan B. Tucker, Min Huang, Jeremy Wells & Jian-Wei Gu. (2010) SU11248, A selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells. Cancer Biology & Therapy 10:7, pages 703-711.
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Angelika Schmitt, Anne-Lena Haug, Franziska Schlegel, Annunziata Fragasso & Barbara Munz. (2018) Effects of 10 weeks of regular running exercise with and without parallel PDTC treatment on expression of genes encoding sarcomere-associated proteins in murine skeletal muscle. Cell Stress and Chaperones 23:5, pages 1041-1054.
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Humberto Riera, Valéry Afonso, Pascal Collin & Abderrahim Lomri. (2015) A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937. PLOS ONE 10:5, pages e0127571.
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Xiaodong Zheng, Jieqiang Lv, Qi Shen, Yumei Chen, Qingfeng Zhou, Wenwen Zhang & Xueqiong Zhu. (2014) Synergistic Effect of Pyrrolidine Dithiocarbamate and Cisplatin in Human Cervical Carcinoma. Reproductive Sciences 21:10, pages 1319-1325.
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Kevan B. Tucker, Kristina L. Makey, Edmund Chinchar, Min Huang, Natale Sheehan, Srinivasan Vijayakumar & Jian-Wei Gu. (2014) EGCG Suppresses Melanoma Tumor Angiogenesis and Growth without Affecting Angiogenesis and VEGF Expression in the Heart and Skeletal Muscles in Mice. Journal of Cancer Research Updates 3:1.
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Jian-Wei Gu, Kristina L Makey, Kevan B Tucker, Edmund Chinchar, Xiaowen Mao, Ivy Pei, Emily Y Thomas & Lucio Miele. (2013) EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression. Vascular Cell 5:1, pages 9.
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Y.-F. Li, X.-B. Xu, X.-H. Chen, G. Wei, B. He & J.-D. Wang. (2012) The nuclear factor-?B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice. Human Reproduction 27:7, pages 2096-2106.
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Witold Lasek. (2012) Synergistic cytotoxic effect of sulindac and pyrrolidine dithiocarbamate against ovarian cancer cells. Oncology Reports.
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Christudas Morais, Glenda Gobe, David W. Johnson & Helen Healy. (2009) Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor. Angiogenesis 12:4, pages 365-379.
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