Citations (50)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Zengliang Zhang, Nan Li, Xing Wei, Bingyao Chen, Yinglong Zhang, Yantao Zhao, Xiantong Hu & Shuxun Hou. (2020) GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4. Bioscience, Biotechnology, and Biochemistry 84:2, pages 279-289.
Read now
Read now
Kyle A Emmitte. (2013) mGlu5 negative allosteric modulators: a patent review (2010 – 2012). Expert Opinion on Therapeutic Patents 23:4, pages 393-408.
Read now
Read now
Sylvain Célanire & Brice Campo. (2012) Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders. Expert Opinion on Drug Discovery 7:3, pages 261-280.
Read now
Read now
Articles from other publishers (47)
Amani Alqahtani, Mengxi Wang, Mimi Lou & Houda Alachkar. (2023) Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia. Clinical and Translational Science 16:10, pages 1828-1841.
Crossref
Crossref
Maryam N. ALNasser, Ayman M. AlSaadi, Alison Whitby, Dong-Hyun Kim, Ian R. Mellor & Wayne G. Carter. (2023) Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress. Life 13:4, pages 1019.
Crossref
Crossref
Kristen R. Spencer, Daniella E. Portal, Joseph Aisner, Mark N. Stein, Jyoti Malhotra, Weichung Shih, Nancy Chan, Ann W. Silk, Shridar Ganesan, Susan Goodin, Murugesan Gounder, Hongxia Lin, Jiadong Li, Robert Cerchio, Christina Marinaro, Suzie Chen & Janice M. Mehnert. (2023) A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850. Oncotarget 14:1, pages 302-315.
Crossref
Crossref
Sofia Schnell, Ellen Knierim, Petra Bittigau, Jakob Kreye, Kathrin Hauptmann, Patrick Hundsdoerfer, Susanne Morales-Gonzalez, Markus Schuelke & Marc Nikolaus. (2023) Hodgkin Lymphoma Cell Lines and Tissues Express mGluR5: A Potential Link to Ophelia Syndrome and Paraneoplastic Neurological Disease. Cells 12:4, pages 606.
Crossref
Crossref
Ann W. Silk, Biren Saraiya, Roman Groisberg, Nancy Chan, Kristen Spencer, Eugenia Girda, Weichung Shih, Marisa Palmeri, Tracie Saunders, Robert M. Berman, Vlad Coric, Suzie Chen, Andrew Zloza, Joshua Vieth, Janice M. Mehnert & Jyoti Malhotra. (2022) A phase Ib dose-escalation study of troriluzole (BHV-4157), an oral glutamatergic signaling modulator, in combination with nivolumab in patients with advanced solid tumors. European Journal of Medical Research 27:1.
Crossref
Crossref
Kevinn Eddy, Mohamad Naser Eddin, Anna Fateeva, Stefano Vito Boccadamo Pompili, Raj Shah, Saurav Doshi & Suzie Chen. (2022) Implications of a Neuronal Receptor Family, Metabotropic Glutamate Receptors, in Cancer Development and Progression. Cells 11:18, pages 2857.
Crossref
Crossref
Marc Nikolaus, Arend Koch, Werner Stenzel, Sefer Elezkurtaj, Felix Sahm, Anna Tietze, Laura Stöffler, Jakob Kreye, Pablo Hernáiz Driever, Ulrich W. Thomale, Angela M. Kaindl, Markus Schuelke & Ellen Knierim. (2022) Atypical NMDA receptor expression in a diffuse astrocytoma, MYB- or MYBL1-altered as a trigger for autoimmune encephalitis. Acta Neuropathologica 144:2, pages 385-389.
Crossref
Crossref
Giada Cellot, Audrey Franceschi Biagioni & Laura Ballerini. (2021) Nanomedicine and graphene-based materials: advanced technologies for potential treatments of diseases in the developing nervous system. Pediatric Research 92:1, pages 71-79.
Crossref
Crossref
A V. Lebedeva, S. G. Burd, P. N. Vlasov, N. A. Ermolenko, I. A. Zhidkova, S. K. Zyryanov, I. Yu. Kovaleva, D. R. Naskhletashvili, N. Yu. Perunova, I. G. Rudakova, R. K. Shikhkerimov & M. A. Yamin. (2021) Treatment of epilepsy associated with primary and metastatic brain tumors. Epilepsy and paroxysmal conditions 13:3, pages 286-304.
Crossref
Crossref
Kevinn Eddy & Suzie Chen. (2021) Glutamatergic Signaling a Therapeutic Vulnerability in Melanoma. Cancers 13:15, pages 3874.
Crossref
Crossref
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell & Kevin Joseph. (2021) Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. Cell Death & Disease 12:8.
Crossref
Crossref
Yona Goldshmit, Rita Perelroizen, Alex Yakovchuk, Evgeni Banyas, Lior Mayo, Sari David, Amit Benbenishty, Pablo Blinder, Moshe Shalom & Angela Ruban. (2021) Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo. Scientific Reports 11:1.
Crossref
Crossref
Falko Lange, Julia Hörnschemeyer & Timo Kirschstein. (2021) Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy. Cells 10:5, pages 1226.
Crossref
Crossref
Shenghao Guo, Yanni Gu, Jiayin Qu & Anne Le. 2021. The Heterogeneity of Cancer Metabolism. The Heterogeneity of Cancer Metabolism
229
248
.
Linjing Mu & Simon M. Ametamey. 2021. PET and SPECT of Neurobiological Systems. PET and SPECT of Neurobiological Systems
427
481
.
G Dönmez Yalçın & M Colak. (2020) SIRT4 prevents excitotoxicity via modulating glutamate metabolism in glioma cells. Human & Experimental Toxicology 39:7, pages 938-947.
Crossref
Crossref
Antonietta Coppola, Alessia Zarabla, Andrea Maialetti, Veronica Villani, Tatiana Koudriavtseva, Emilio Russo, Agostino Nozzolillo, Chiara Sueri, Vincenzo Belcastro, Simona Balestrini, Edoardo Ferlazzo, Diana Giannarelli, Leonilda Bilo & Marta Maschio. (2020) Perampanel Confirms to Be Effective and Well-Tolerated as an Add-On Treatment in Patients With Brain Tumor-Related Epilepsy (PERADET Study). Frontiers in Neurology 11.
Crossref
Crossref
Federico Cucchiara, Francesco Pasqualetti, Filippo Sean Giorgi, Romano Danesi & Guido Bocci. (2020) Epileptogenesis and oncogenesis: An antineoplastic role for antiepileptic drugs in brain tumours?. Pharmacological Research 156, pages 104786.
Crossref
Crossref
Haowei Yi, Geoff Talmon & Jing Wang. (2020) Glutamate in cancers: from metabolism to signaling. The Journal of Biomedical Research 34:4, pages 260.
Crossref
Crossref
Nandakumar Dalavaikodihalli Nanjaiah, Palaniswamy Ramaswamy, Kalyan Goswami, Hurmath Fathima K & Monjuri Borkotokey. (2019) Survival of glioblastoma cells in response to endogenous and exogenous oxidative challenges: possible implication of NMDA receptor‐mediated regulation of redox homeostasis. Cell Biology International 43:12, pages 1443-1452.
Crossref
Crossref
Russell L. Blaylock. (2019) Accelerated cancer aggressiveness by viral oncomodulation: New targets and newer natural treatments for cancer control and treatment. Surgical Neurology International 10, pages 199.
Crossref
Crossref
Tu Nguyen, Brian James Kirsch, Ryoichi Asaka, Karim Nabi, Addison Quinones, Jessica Tan, Marjorie Justine Antonio, Felipe Camelo, Ting Li, Stephanie Nguyen, Giang Hoang, Kiet Nguyen, Sunag Udupa, Christos Sazeides, Yao-An Shen, Amira Elgogary, Juvenal Reyes, Liang Zhao, Andre Kleensang, Kaisorn Lee Chaichana, Thomas Hartung, Michael J. Betenbaugh, Suely K. Marie, Jin G. Jung, Tian-Li Wang, Edward Gabrielson & Anne Le. (2019) Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer. Cell Reports 27:2, pages 491-501.e6.
Crossref
Crossref
Koichi Matsuda. 2019. Genome-Wide Association Studies. Genome-Wide Association Studies
87
144
.
Li Wei, Fei He, Wen Zhang, Wenhua Chen & Bo Yu. (2018) Bioinformatics analysis of microarray data to reveal the pathogenesis of diffuse intrinsic pontine glioma. Biological Research 51:1.
Crossref
Crossref
Carrie Bowman Dalley, Barbara Wroblewska, Barry B. Wolfe & Jarda T. Wroblewski. (2018) The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability. Journal of Pharmacology and Experimental Therapeutics 367:1, pages 59-70.
Crossref
Crossref
Janice M. Mehnert, Ann W. Silk, J. H. Lee, Liesel Dudek, Byeong-Seon Jeong, Jiadong Li, Jason M. Schenkel, Evita Sadimin, Michael Kane, Hongxia Lin, Weichung J. Shih, Andrew Zloza, Suzie Chen & James S. Goydos. (2018) A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma. Pigment Cell & Melanoma Research 31:4, pages 534-540.
Crossref
Crossref
Xiao Xu Bai, Li Gu, Hui Min Yang, Shao Song Xi, Ning Xia, Song Zhang & Hong Zhang. (2018) Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson’s disease model. Toxicology Letters 288, pages 71-81.
Crossref
Crossref
Magdalena Gorska-Ponikowska, Ugo Perricone, Alicja Kuban-Jankowska, Giosuè Lo Bosco & Giampaolo Barone. (2017) 2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor. Journal of Cellular Physiology 232:11, pages 3030-3049.
Crossref
Crossref
Mery Stefani Leivas Pereira, Fábio Klamt, Chairini Cássia Thomé, Paulo Valdeci Worm & Diogo Losch de Oliveira. (2017) Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas. Oncotarget 8:13, pages 22279-22298.
Crossref
Crossref
Lumeng J. Yu, Brian A. Wall, Janet Wangari-Talbot & Suzie Chen. (2017) Metabotropic glutamate receptors in cancer. Neuropharmacology 115, pages 193-202.
Crossref
Crossref
Lumeng J. Yu, Brian A. Wall, Janet Wangari-Talbot & Suzie Chen. 2017. mGLU Receptors. mGLU Receptors
161
182
.
Allison L. Isola & Suzie Chen. (2016) Exosomes: The Link between GPCR Activation and Metastatic Potential?. Frontiers in Genetics 7.
Crossref
Crossref
Kun Wang, Jinmin Zhao, Maolin He, Mitra Fowdur, Tenglong Jiang & Shuju Luo. (2015) Association of GRM4 gene polymorphisms with susceptibility and clinicopathological characteristics of osteosarcoma in Guangxi Chinese population. Tumor Biology 37:1, pages 1105-1112.
Crossref
Crossref
Junya Toguchida. 2016. Osteosarcoma. Osteosarcoma
3
17
.
Shuo Wang, Xing Wei, Bingyao Chen, Min Zhao, Guangze Song, Zengliang Zhang & Nan Li. (2015) Expression of metabotropic glutamate receptor 4 in osteosarcoma. Molecular and Clinical Oncology.
Crossref
Crossref
T Gelb, S Pshenichkin, O C Rodriguez, H A Hathaway, E Grajkowska, J O DiRaddo, B Wroblewska, R P Yasuda, C Albanese, B B Wolfe & J T Wroblewski. (2014) Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas. Oncogene 34:21, pages 2711-2720.
Crossref
Crossref
Gabriel Wajnberg, Benilton S. Carvalho, Carlos G. Ferreira & Fabio Passetti. (2015) Combined Analysis of SNP Array Data Identifies Novel CNV Candidates and Pathways in Ependymoma and Mesothelioma. BioMed Research International 2015, pages 1-10.
Crossref
Crossref
Martin Wilson, Simrandip K. Gill, Lesley MacPherson, Martin English, Theodoros N. Arvanitis & Andrew C. Peet. (2014) Noninvasive Detection of Glutamate Predicts Survival in Pediatric Medulloblastoma. Clinical Cancer Research 20:17, pages 4532-4539.
Crossref
Crossref
Andrzej Stepulak, Radoslaw Rola, Krzysztof Polberg & Chrysanthy Ikonomidou. (2014) Glutamate and its receptors in cancer. Journal of Neural Transmission 121:8, pages 933-944.
Crossref
Crossref
Chaoyin Jiang, Hua Chen, Lei Shao & Yang Dong. (2014) GRM4 gene polymorphism is associated with susceptibility and prognosis of osteosarcoma in a Chinese Han population. Medical Oncology 31:7.
Crossref
Crossref
Wu Yang, He Maolin, Zhao Jinmin & Wang Zhe. (2014) High expression of metabotropic glutamate receptor 4: correlation with clinicopathologic characteristics and prognosis of osteosarcoma. Journal of Cancer Research and Clinical Oncology 140:3, pages 419-426.
Crossref
Crossref
Mariana P.C. Ribeiro, Isabel Nunes-Correia, Armanda E. Santos & José B.A. Custódio. (2014) The combination of glutamate receptor antagonist MK-801 with tamoxifen and its active metabolites potentiates their antiproliferative activity in mouse melanoma K1735-M2 cells. Experimental Cell Research 321:2, pages 288-296.
Crossref
Crossref
Linjing Mu & Simon M. Ametamey. 2014. PET and SPECT of Neurobiological Systems. PET and SPECT of Neurobiological Systems
409
443
.
Sharon A Savage, Lisa Mirabello, Zhaoming Wang, Julie M Gastier-Foster, Richard Gorlick, Chand Khanna, Adrienne M Flanagan, Roberto Tirabosco, Irene L Andrulis, Jay S Wunder, Nalan Gokgoz, Ana Patiño-Garcia, Luis Sierrasesúmaga, Fernando Lecanda, Nilgün Kurucu, Inci Ergurhan Ilhan, Neriman Sari, Massimo Serra, Claudia Hattinger, Piero Picci, Logan G Spector, Donald A Barkauskas, Neyssa Marina, Silvia Regina Caminada de Toledo, Antonio S Petrilli, Maria Fernanda Amary, Dina Halai, David M Thomas, Chester Douglass, Paul S Meltzer, Kevin Jacobs, Charles C Chung, Sonja I Berndt, Mark P Purdue, Neil E Caporaso, Margaret Tucker, Nathaniel Rothman, Maria Teresa Landi, Debra T Silverman, Peter Kraft, David J Hunter, Nuria Malats, Manolis Kogevinas, Sholom Wacholder, Rebecca Troisi, Lee Helman, Joseph F Fraumeni, Meredith Yeager, Robert N Hoover & Stephen J Chanock. (2013) Genome-wide association study identifies two susceptibility loci for osteosarcoma. Nature Genetics 45:7, pages 799-803.
Crossref
Crossref
Leo Veenman, Julia Bode, Michal Gaitner, Beatriz Caballero, Yelena Pe'er, Sivan Zeno, Silke Kietz, Wilfried Kugler, Max Lakomek & Moshe Gavish. (2012) Effects of 18-kDa translocator protein knockdown on gene expression of glutamate receptors, transporters, and metabolism, and on cell viability affected by glutamate. Pharmacogenetics and Genomics 22:8, pages 606-619.
Crossref
Crossref
Jessica Teh & Suzie Chen. (2011) Metabotropic glutamate receptors and cancerous growth. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1:2, pages 211-220.
Crossref
Crossref
Kyu Yeong Choi, Kai Chang, James M. Pickel, John D. BadgerIIII & Katherine W. Roche. (2011) Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proceedings of the National Academy of Sciences 108:37, pages 15219-15224.
Crossref
Crossref